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Protein

Malate dehydrogenase

Gene

mdh

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD(P)+ = oxaloacetate + NAD(P)H.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85SubstrateBy similarity1
Binding sitei91SubstrateBy similarity1
Binding sitei98NADPBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei154SubstrateBy similarity1
Active sitei178Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 14NADPBy similarity7
Nucleotide bindingi121 – 123NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.299By similarity)
Gene namesi
Name:mdh
Ordered Locus Names:MK1069
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134861 – 317Malate dehydrogenaseAdd BLAST317

Proteomic databases

PRIDEiQ8TWG5

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1069

Structurei

3D structure databases

ProteinModelPortaliQ8TWG5
SMRiQ8TWG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00246 Archaea
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG093Z062E

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TWG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKVAVIGAT GRVGSTAAAR LALLDCVNEV TLIARPKSVD KLRGLRRDIL
60 70 80 90 100
DSLAAAQKDA EITIGCERDD YVDADVIVMT AGIPRKPGQT RLDLTKDNAA
110 120 130 140 150
IIKKYLEGVA EENPEAIVLV VTNPVDVLTY VALKVSGLPK NRVIGLGTHL
160 170 180 190 200
DSMRFKVLIA KHFNVHMSEV HTRIIGEHGD TMVPVISSTS VGGIPVTRMP
210 220 230 240 250
GWEDFDVEEA VREVKEAGQR IIETWGGSQF GPAQAITNLV RTILQDERRV
260 270 280 290 300
LTVSAYLDGE IDGIRDVCIG VPARLGREGV LEIVPIELEE DEMRAFRRSV
310
KVVKEATREA MEAISER
Length:317
Mass (Da):34,609
Last modified:June 1, 2002 - v1
Checksum:iD2AC04B7C0B6C26E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM02282.1

Genome annotation databases

EnsemblBacteriaiAAM02282; AAM02282; MK1069
KEGGimka:MK1069
PATRICifig|190192.8.peg.1123

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM02282.1

3D structure databases

ProteinModelPortaliQ8TWG5
SMRiQ8TWG5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK1069

Proteomic databases

PRIDEiQ8TWG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM02282; AAM02282; MK1069
KEGGimka:MK1069
PATRICifig|190192.8.peg.1123

Phylogenomic databases

eggNOGiarCOG00246 Archaea
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG093Z062E

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_METKA
AccessioniPrimary (citable) accession number: Q8TWG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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