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Entry version 119 (07 Apr 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Acetyl-CoA decarbonylase/synthase complex subunit alpha 1

Gene

cdhA1

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: methanogenesis from acetate

This protein is involved in the pathway methanogenesis from acetate, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway methanogenesis from acetate and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi73Iron-sulfur 1 (4Fe-4S); shared with dimeric partnerUniRule annotation1
Metal bindingi76Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi77Iron-sulfur 1 (4Fe-4S); shared with dimeric partnerUniRule annotation1
Metal bindingi79Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi84Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi94Iron-sulfur 2 (4Fe-4S)UniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117Carbon monoxide; via tele nitrogenUniRule annotation1
Metal bindingi250Nickel-iron-sulfur (Ni-4Fe-4S); via tele nitrogenUniRule annotation1
Metal bindingi278Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1
Metal bindingi323Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1
Metal bindingi417Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi420Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi423Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi427Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi455Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi458Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi461Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi465Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi523Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1
Metal bindingi552Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1
Metal bindingi587Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processMethanogenesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Nickel

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MACE188937:G1FZT-1088-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00642

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acetyl-CoA decarbonylase/synthase complex subunit alpha 1UniRule annotation (EC:1.2.7.4UniRule annotation)
Short name:
ACDS complex subunit alpha 1UniRule annotation
Alternative name(s):
ACDS complex carbon monoxide dehydrogenase subunit alpha 1UniRule annotation
Short name:
ACDS CODH subunit alpha 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdhA1UniRule annotation
Ordered Locus Names:MA_1016
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri188937 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002487 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550741 – 806Acetyl-CoA decarbonylase/synthase complex subunit alpha 1Add BLAST806

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha2epsilon2)4-beta8-(gamma1delta1)8.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TRZ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini407 – 4364Fe-4S ferredoxin-type 1UniRule annotationAdd BLAST30
Domaini446 – 4754Fe-4S ferredoxin-type 2UniRule annotationAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ni-containing carbon monoxide dehydrogenase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_361186_0_0_2

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TRZ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCIGHNV

Database of Orthologous Groups

More...
OrthoDBi
1404at2157

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TRZ4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01916, ACS_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1060.10, 1 hit
3.40.50.2030, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_01137, CdhA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017896, 4Fe4S_Fe-S-bd
IPR017900, 4Fe4S_Fe_S_CS
IPR004460, CDHA
IPR004137, HCP/CODH
IPR009051, Helical_ferredxn
IPR016099, Prismane-like_a/b-sand
IPR011254, Prismane-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30109, PTHR30109, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03063, Prismane, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46548, SSF46548, 1 hit
SSF56821, SSF56821, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00314, cdhA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198, 4FE4S_FER_1, 1 hit
PS51379, 4FE4S_FER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TRZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLTTGSFS IEDLESVQIT INNIVGAAKE AAEEKAKELE KAGPTLFPGL
60 70 80 90 100
ESYRDDWNFK LLDRYEPVIT PMCDQCCYCT YGPCDLSGNK RGACGIDMLG
110 120 130 140 150
HNGREFFLRV ITGTACHAAH GRHLLDHLIE TFGEDLPLNL GQSNVLTPNI
160 170 180 190 200
TISTGLSPKN LGEIKPAMEF VEEQLTQLLA TVHAGQESAE IDYDSKALFS
210 220 230 240 250
GSLDHVGMEI SDVVQVAAYD FPKADPEAPL IEIGMGTIDK SKPFLCVIGH
260 270 280 290 300
NVGGVTYMMD YMEEHDLTDK MEIAGLCCTA IDLSRYKEAD RRPPYAKVIG
310 320 330 340 350
SMSKELKVIR SGMPDVIVVD EQCVRGDIVP EAQKLKIPVI ASNAKIMYGL
360 370 380 390 400
PNRTDANVDD VVEELKSGAI PGCVMLDYDK LGELCIRLTM EMGPIRDAEG
410 420 430 440 450
ITAIPTDEEF ADWVAKCADC GACMIACPEE LDIPEAMGFA KEGDFSYLEE
460 470 480 490 500
LHDQCIGCRR CEQVCKKEIP ILNIIEKVAQ KQIAEEKGWM RAGRGQVSDA
510 520 530 540 550
EIRAEGLNLV MGTTPGIIAI IGCPNYAEGT KDVYYIAEEF LKRNFIVVTT
560 570 580 590 600
GCGAMDIGMF KDEDGKTLYE RFPGGFECGG LVNIGSCVSN AHITGAAEKV
610 620 630 640 650
AAIFAQRTLE GNLAEISDYI LNRVGACGLA WGAFSQKASS IGTGCNILGI
660 670 680 690 700
PAVLGPHSSK YRRALIAKTY EEDKWKVYDA RNGQEMPIPP APEFLLTTAE
710 720 730 740 750
TWQEAIPMMA KACIRPSDNS MGRSIKLTHW MELHKKYLGK DPEDWWKFVR
760 770 780 790 800
NEADLPLAKR EALLKELESK HGWEIDWKKK KIISGPKIKF DVSAQPTNLK

RLCKEA
Length:806
Mass (Da):88,694
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D7D376E7718B0B9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM04446.1

NCBI Reference Sequences

More...
RefSeqi
WP_011021051.1, NC_003552.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAM04446; AAM04446; MA_1016

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1472906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mac:MA_1016

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM04446.1
RefSeqiWP_011021051.1, NC_003552.1

3D structure databases

SMRiQ8TRZ4
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiAAM04446; AAM04446; MA_1016
GeneIDi1472906
KEGGimac:MA_1016

Phylogenomic databases

HOGENOMiCLU_361186_0_0_2
InParanoidiQ8TRZ4
OMAiLCIGHNV
OrthoDBi1404at2157
PhylomeDBiQ8TRZ4

Enzyme and pathway databases

UniPathwayiUPA00642
BioCyciMACE188937:G1FZT-1088-MONOMER

Family and domain databases

CDDicd01916, ACS_1, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.40.50.2030, 2 hits
HAMAPiMF_01137, CdhA, 1 hit
InterProiView protein in InterPro
IPR017896, 4Fe4S_Fe-S-bd
IPR017900, 4Fe4S_Fe_S_CS
IPR004460, CDHA
IPR004137, HCP/CODH
IPR009051, Helical_ferredxn
IPR016099, Prismane-like_a/b-sand
IPR011254, Prismane-like_sf
PANTHERiPTHR30109, PTHR30109, 1 hit
PfamiView protein in Pfam
PF03063, Prismane, 2 hits
SUPFAMiSSF46548, SSF46548, 1 hit
SSF56821, SSF56821, 1 hit
TIGRFAMsiTIGR00314, cdhA, 1 hit
PROSITEiView protein in PROSITE
PS00198, 4FE4S_FER_1, 1 hit
PS51379, 4FE4S_FER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACDA1_METAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TRZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: April 7, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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