Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Binding sitei180SubstrateUniRule annotation1
Binding sitei181NADUniRule annotation1
Binding sitei233NADUniRule annotation1
Binding sitei268NADUniRule annotation1
Binding sitei335NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi147 – 149NADUniRule annotation3
Nucleotide bindingi210 – 215NADUniRule annotation6
Nucleotide bindingi289 – 291NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-1349-MONOMER
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:MA_1275
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170031 – 411AdenosylhomocysteinaseAdd BLAST411

Interactioni

Protein-protein interaction databases

STRINGi188937.MA1275

Structurei

3D structure databases

ProteinModelPortaliQ8TRA5
SMRiQ8TRA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137 Archaea
COG0499 LUCA
InParanoidiQ8TRA5
KOiK01251
OMAiTGNRDII
OrthoDBiPOG093Z03XF
PhylomeDBiQ8TRA5

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 2 hits
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TRA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQELVESG NMKMEWARNH MPVIAIIREK FEKEKPLKGL KVGMALHVEA
60 70 80 90 100
KTAVLVETLA AGGAQVAISG CNPLSTQDDV ARALDTRKNI SCFARYGCCT
110 120 130 140 150
SEYYEAIDKV LDIEPDITID DGADLIFKLH KERTDLLPKI LGGCEETTTG
160 170 180 190 200
VHRLHAMEKE GALKMPVIAV NDAMTKYLFD NRYGTGQSAW DGINRTTNLL
210 220 230 240 250
VAGKNVVVGG YGWCGRGVAM RAAGLGANVI VTEVDPIRAL EARMDGYRVM
260 270 280 290 300
RMADAARLGE IFVTTTGNRD ILTAEHFKVM PDGAVLANSG HFNVEIDMEA
310 320 330 340 350
LTSLAKSVKT VRHNIKEYDI GDRRINVIAE GRLVNLAAGD GHPAEVMDMS
360 370 380 390 400
FANQALCVRY IAENTLLNGV HGVPRGIDTY VAKLKLESMG ISIDELTSKQ
410
ECYMTGWECG T
Length:411
Mass (Da):44,900
Last modified:June 1, 2002 - v1
Checksum:iC3221440430631F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM04694.1
RefSeqiWP_011021296.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM04694; AAM04694; MA_1275
GeneIDi1473163
KEGGimac:MA_1275

Similar proteinsi

Entry informationi

Entry nameiSAHH_METAC
AccessioniPrimary (citable) accession number: Q8TRA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health