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Entry version 124 (18 Sep 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit A

Gene

hdrA2

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity may take place during Fe(III)-dependent anaerobic methane oxidation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme M-coenzyme B heterodisulfide reduction

This protein is involved in step 1 of the subpathway that synthesizes coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide.Curated
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydromethanophenazine:CoB--CoM heterodisulfide reductase subunit D (hdrD), Ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit B (hdrB2), Ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit A (hdrA2), Ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit C (hdrC2), Ferredoxin:CoB-CoM heterodisulfide reductase subunit A (hdrA1), Ferredoxin:CoB-CoM heterodisulfide reductase subunit B (hdrB1), Ferredoxin:CoB-CoM heterodisulfide reductase subunit C (hdrC1), Dihydromethanophenazine:CoB--CoM heterodisulfide reductase subunit E (hdrE)
This subpathway is part of the pathway coenzyme M-coenzyme B heterodisulfide reduction, which is itself part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide, the pathway coenzyme M-coenzyme B heterodisulfide reduction and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi243Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi246Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi250Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi254Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi291Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi294Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi297Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi301Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi580Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi583Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi586Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi590Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi609Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi612Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi615Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi619Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi147 – 170FADSequence analysisAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processMethanogenesis
Ligand2Fe-2S, 4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MACE188937:G1FZT-3076-MONOMER
MetaCyc:MONOMER-20159

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00647;UER00700

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit ACurated (EC:1.8.7.31 Publication, EC:1.8.98.41 Publication)
Alternative name(s):
Coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase subunit ACurated
Ferredoxin:CoB-CoM heterodisulfide reductase subunit ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hdrA21 Publication
Ordered Locus Names:MA_2868
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri188937 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002487 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001500561 – 793Ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit AAdd BLAST793

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8TM02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by growth on methanol or acetate.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The ferredoxin/F(420)H2-dependent CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA2, HdrB2 and HdrC2.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TM02

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini233 – 2644Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST32
Domaini282 – 3114Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30
Domaini571 – 6004Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30
Domaini601 – 6294Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HdrA family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG02235 Archaea
arCOG02476 Archaea
COG1148 LUCA
COG1908 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TM02

KEGG Orthology (KO)

More...
KOi
K03388

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAKHAML

Database of Orthologous Groups

More...
OrthoDBi
1148at2157

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TM02

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR039650 HdrA-like
IPR003813 MvhD/FlpD

The PANTHER Classification System

More...
PANTHERi
PTHR43498 PTHR43498, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00037 Fer4, 1 hit
PF13187 Fer4_9, 1 hit
PF02662 FlpD, 1 hit
PF07992 Pyr_redox_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TM02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIGVYICHC GLNIAGVIDV SALEAMANEL EDVVLAREVQ FLCSDSGQEG
60 70 80 90 100
IIKDIKDNKL DRVVVAACSP RLHEKTFRHV MEKAGLNPYL MEMVNIREQC
110 120 130 140 150
SWVHADDPQM ATQKAFDLIR MGVAKARFLR ELSATNSKAS RNVLIIGGGV
160 170 180 190 200
AGIEAALNLA EAGFPVTMVE KESTIGGKMA LMNEVFPTND CSICVLAPKM
210 220 230 240 250
TEVQNHPNIT LYTYSEVTDI SGSVGKFHVR VKRKPRFVLE DKCKGCVDLC
260 270 280 290 300
SGVCPVEIEN PMNYGIGKTR AIYMPIPQSV PQVVLIDPDH CVGCGLCQLA
310 320 330 340 350
CPAEAVDYEQ KPEEIEFEAG AIIVSTGYQL FDASRKKEYG FGKYPDVITN
360 370 380 390 400
MQLERMLNSA GPTGGRVLVP STGEPPKSVA FIQCVGSRDK TVGNEYCSRV
410 420 430 440 450
CCMAALKNSQ MVKERYPDTD VTIHYIDIRA AGEMYEEYYT RTQEMGVDFI
460 470 480 490 500
RGKVAEVYSG EDGRPVVRFE NTLESSVEEE AHDLVVLSTG YEPTKAAEGI
510 520 530 540 550
GRMLNLARRP DRFFASAHPK MRPVDAPVSG VFLAGCASGP KEIQVSIAQG
560 570 580 590 600
SACASKVMQL LGTGELEADP MGAHVDPDKC IGCRTCVEVC KFGKISIENK
610 620 630 640 650
KAVVDEVSCY GCGDCSAACP VGAIQMRNFE NEQILAQVRE ATAHKSQCPF
660 670 680 690 700
IVAFLCNWCS YACADLTGMS RIRYPTNIRV IRTMCSARVN PEFVLEALKG
710 720 730 740 750
GADGVLVAGC RMDECHYIHG NFDAKKRMDI LKEVIKEIGL DPKRLRTLWI
760 770 780 790
SAAEGERFSN TINEFVKELE EIGPIGSEFK QECAVPGVEE VTQ
Length:793
Mass (Da):86,918
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80204B5433039032
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM06247.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAM06247; AAM06247; MA_2868

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mac:MA_2868

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM06247.1

3D structure databases

SMRiQ8TM02
ModBaseiSearch...

Proteomic databases

PRIDEiQ8TM02

Genome annotation databases

EnsemblBacteriaiAAM06247; AAM06247; MA_2868
KEGGimac:MA_2868

Phylogenomic databases

eggNOGiarCOG02235 Archaea
arCOG02476 Archaea
COG1148 LUCA
COG1908 LUCA
InParanoidiQ8TM02
KOiK03388
OMAiTAKHAML
OrthoDBi1148at2157
PhylomeDBiQ8TM02

Enzyme and pathway databases

UniPathwayiUPA00647;UER00700
BioCyciMACE188937:G1FZT-3076-MONOMER
MetaCyc:MONOMER-20159

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR039650 HdrA-like
IPR003813 MvhD/FlpD
PANTHERiPTHR43498 PTHR43498, 1 hit
PfamiView protein in Pfam
PF00037 Fer4, 1 hit
PF13187 Fer4_9, 1 hit
PF02662 FlpD, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDRA2_METAC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TM02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2002
Last modified: September 18, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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