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Entry version 109 (07 Oct 2020)
Sequence version 1 (01 Jun 2002)
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Protein
Submitted name:

Cell surface protein

Gene

MA_4297

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cell surface proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:MA_4297Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri188937 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002487 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini437 – 509PKDInterPro annotationAdd BLAST73
Domaini914 – 995PKDInterPro annotationAdd BLAST82
Domaini1003 – 1087PKDInterPro annotationAdd BLAST85
Domaini1349 – 1418PKDInterPro annotationAdd BLAST70
Domaini1437 – 1522PKDInterPro annotationAdd BLAST86
Domaini1526 – 1593PKDInterPro annotationAdd BLAST68
Domaini1797 – 1817EF-handInterPro annotationAdd BLAST21

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_246522_0_0_2

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TI59

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TI59

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits
2.60.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR025666, PQQ-like_dom
IPR018391, PQQ_beta_propeller_repeat
IPR002372, PQQ_repeat
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13360, PQQ_2, 2 hits
PF13570, PQQ_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00089, PKD, 6 hits
SM00564, PQQ, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299, SSF49299, 6 hits
SSF50998, SSF50998, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS50093, PKD, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TI59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKHTLKIFL ICLTLLLVTA AQPVLGSDWA QFQRDVYNTG VTADRAPITD
60 70 80 90 100
PMNSTLSWEY KLGANVDSAP IVAGDMMYAL AGNNHIYAFN RTTGELVWEE
110 120 130 140 150
STSGSLGFLI GNAAVGNGTV FVPTSNGKIF AFDAQTGSPK WNKTVSSYTY
160 170 180 190 200
NQIDTPITYS DGKIYFGEAM GQSRNYFCLD ENGNQVWSRP ATTKVSSQGP
210 220 230 240 250
YYWAGATVIG DYLVYGDNDG HIVSVNKDTG TDIAEINVSE EFGVDCKEIR
260 270 280 290 300
SSILYVEDLG RVYFTSTGGY CFALGFNPAD GTFKTSDKHS VNIAYTSTTT
310 320 330 340 350
PAYYNGRIYI GSGEIMKANG NGVYCLDADL TGVIWNYPVG GTGLVQSSPA
360 370 380 390 400
ISTYYDNGDG EVYIYFTVNA KPIGGVYCLK DLPGSTSPEL VWSYVESGKT
410 420 430 440 450
DFSLPGVAIS DGWVYYGTDN KYIFGLTTPD LQVPEAPTAD FSATPVSGEA
460 470 480 490 500
PLTVSFTDLS MGDGITTWAW DFDSDGNVDS SEQNPSYTYN DAGSYTVKLT
510 520 530 540 550
VSNENGSDVL EIPEMITVKE TVVSDDTWYQ FHKDAQHSGY SSSDAPDSAD
560 570 580 590 600
LAWIAEPLNN TYSLVPSSSV VIAEGMVFGL CNGPVDDYGN PLTSEGQLVA
610 620 630 640 650
FDENTGEEIW NVTVMAPEWG SWSCPAYDDG KVFASAGKNT YCVNASTGDI
660 670 680 690 700
IWTFQNPSEL ASCNGGPSIG DGKVFASDWD GGNYYCLDEN TGELLWTFKI
710 720 730 740 750
DGLYAQSTPA YKDDRVYLSG WTTVNAVYCV NATTGELIWE NEELSSNPCG
760 770 780 790 800
SITVTEEGLY LSIYSFGTED GFYKLDLTDG HEIWGRPDIP PTDSTPAVVN
810 820 830 840 850
GKVYLSAGTA GYSDLNTYCL NASDGKTIWV TDSSENIGDW VCSPAVADGK
860 870 880 890 900
VFTGGAAEGL FTGSSTLYAF DAETGAVIWS YKGCGGSPAV ADDMVFSTGS
910 920 930 940 950
GKLYAFKEAE VLLPEAKFSS NVSSGEAPLT VGFTDESTGE GITAWEWDFD
960 970 980 990 1000
NDGNVDSIEQ NPIHTYDNAG SYTVNLTVTS AEGSDSEVKD AYIVVSESLP
1010 1020 1030 1040 1050
ESPVANFTAT PTSGNAPLTV NFTDASTGTV SSYAWDFDND GTVDSTEQSP
1060 1070 1080 1090 1100
SHTYAAVGTY TVNLTVTGAA GSDSEVKVDL VEVSKSLVNS YSTSMNNTNP
1110 1120 1130 1140 1150
GAPDPAIPGF VGPDGDGKCL GSGPNNVVNP AFLEWASVVV DYSLANQSIN
1160 1170 1180 1190 1200
PNFADPAKAL GPVTGSNMDI VSLGDLEESQ LLAGEQPGSV TFGFDVPIAN
1210 1220 1230 1240 1250
GDGPDLALFE NGFMSGSGIF AELAFVEVST DNITFVRFPA VSLTPGLVGG
1260 1270 1280 1290 1300
YGTIDPTNVT NLVGKHVNAY GNSWGTPFDL SCLENTTEVL NGSVDLNDIN
1310 1320 1330 1340 1350
YVRVVDIPGN GFFKDSLGNP IYDAWVTWGS GGLDLEAVGV INTAYLPVSA
1360 1370 1380 1390 1400
AEFSVNVTSG YAPLTVQFTD QSTYSPTSWA WDFDNDGNVD STEQNPSYTY
1410 1420 1430 1440 1450
ATSGNYSVNL TVTNAGGSDS EVKEEYIIVS EPLPAPPITA FTATPTSGDS
1460 1470 1480 1490 1500
PLTVNFTDES TGIPSSWAWD FDNDGSIDST EQNPSYTYTS AGNYTVNLTV
1510 1520 1530 1540 1550
ANAAGSDSEV KTDYIMVSES STPAEPIAMF TADVTGGTVP LTVNFTDQSA
1560 1570 1580 1590 1600
GSPTSWFWDF GDGANSTEQN PSHTYTSAGN YTVNLTVESE AGSDFELKSD
1610 1620 1630 1640 1650
YIEVSEASGP TVTLYFDPEN SSVAENESTE ISIIASNFPA GFSGYNMTVT
1660 1670 1680 1690 1700
LDDPAVAEIV DIEYPSWALI TENSSLPATS IYLKAVDGED AVKEGAADVV
1710 1720 1730 1740 1750
LATLTVSGKE KGSANLSIGV DRLDDDSGNV IEPTFLTGKI EVTLLSPLPG
1760 1770 1780 1790 1800
QEYAPRDLDG DGLYEDLTGN GEFSFVDVVA YFHNMDWIEE NMPVEYFDFN
1810
GNGRIDFDDV VDMFAMI
Length:1,817
Mass (Da):193,663
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC55B824BF45CCEC5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM07641.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAM07641; AAM07641; MA_4297

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mac:MA_4297

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM07641.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAAM07641; AAM07641; MA_4297
KEGGimac:MA_4297

Phylogenomic databases

HOGENOMiCLU_246522_0_0_2
InParanoidiQ8TI59
PhylomeDBiQ8TI59

Family and domain databases

Gene3Di2.130.10.10, 2 hits
2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR025666, PQQ-like_dom
IPR018391, PQQ_beta_propeller_repeat
IPR002372, PQQ_repeat
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF13360, PQQ_2, 2 hits
PF13570, PQQ_3, 1 hit
SMARTiView protein in SMART
SM00089, PKD, 6 hits
SM00564, PQQ, 11 hits
SUPFAMiSSF49299, SSF49299, 6 hits
SSF50998, SSF50998, 3 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS50093, PKD, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8TI59_METAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TI59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 7, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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