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Entry version 107 (10 Apr 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Acetyl-CoA decarbonylase/synthase complex subunit alpha 3

Gene

cdhA3

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: methanogenesis from acetate

This protein is involved in the pathway methanogenesis from acetate, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway methanogenesis from acetate and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi72Iron-sulfur 1 (4Fe-4S); shared with dimeric partnerUniRule annotation1
Metal bindingi75Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi76Iron-sulfur 1 (4Fe-4S); shared with dimeric partnerUniRule annotation1
Metal bindingi78Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi83Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi93Iron-sulfur 2 (4Fe-4S)UniRule annotation1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei116Carbon monoxide; via tele nitrogenUniRule annotation1
Metal bindingi249Nickel-iron-sulfur (Ni-4Fe-4S); via tele nitrogenUniRule annotation1
Metal bindingi277Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1
Metal bindingi322Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1
Metal bindingi416Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi419Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi422Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi426Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi454Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi457Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi460Iron-sulfur 4 (4Fe-4S)UniRule annotation1
Metal bindingi464Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi522Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1
Metal bindingi551Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1
Metal bindingi586Nickel-iron-sulfur (Ni-4Fe-4S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processMethanogenesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Nickel

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MACE188937:G1FZT-4694-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00642

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acetyl-CoA decarbonylase/synthase complex subunit alpha 3UniRule annotation (EC:1.2.7.4UniRule annotation)
Short name:
ACDS complex subunit alpha 3UniRule annotation
Alternative name(s):
ACDS complex carbon monoxide dehydrogenase subunit alpha 3UniRule annotation
Short name:
ACDS CODH subunit alpha 3UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdhA3UniRule annotation
Ordered Locus Names:MA_4399
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri188937 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002487 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550761 – 805Acetyl-CoA decarbonylase/synthase complex subunit alpha 3Add BLAST805

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8THW2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha2epsilon2)4-beta8-(gamma1delta1)8.UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8THW2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8THW2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini407 – 4354Fe-4S ferredoxin-type 1UniRule annotationAdd BLAST29
Domaini445 – 4744Fe-4S ferredoxin-type 2UniRule annotationAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.UniRule annotation

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ni-containing carbon monoxide dehydrogenase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG02428 Archaea
COG1152 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8THW2

KEGG Orthology (KO)

More...
KOi
K00192

Database of Orthologous Groups

More...
OrthoDBi
1404at2157

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8THW2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1060.10, 1 hit
3.40.50.2030, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_01137 CdhA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR004460 CDHA
IPR004137 HCP/CODH
IPR009051 Helical_ferredxn
IPR016099 Prismane-like_a/b-sand
IPR011254 Prismane-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30109 PTHR30109, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13187 Fer4_9, 1 hit
PF03063 Prismane, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46548 SSF46548, 1 hit
SSF56821 SSF56821, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00314 cdhA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8THW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLTTGSFS IEDLESVQIT INNIVGAAKE AAEEKAKELG PMGPTAMAGL
60 70 80 90 100
ASYRSWNLLL LDRYEPVLTP MCDQCCYCTY GPCDLSGNKR GACGIDMAGQ
110 120 130 140 150
TGREFFLRVI TGTACHAAHG RHLLDHVIEV FGEDLPLNLG ESNVLTPNVT
160 170 180 190 200
ICTGLSPKTL GECRAPMEYV EEQLTQLLAT IHAGQESAEI DYDSKALFSG
210 220 230 240 250
SLDHVGMEVS DIAQVSAYDF PKADPEAPLI EIGMGSIDKS KPLIVAIGHN
260 270 280 290 300
VAGVTYIMDY MEENNLTDKM EIAGLCCTAF DMTRYKEADR RAPYAKIVGS
310 320 330 340 350
LAKELKVIRS GMPDVIVVDE QCVRGDVLSE SMKLKIPVIA SNEKIMMGLP
360 370 380 390 400
DRTDADVDSI VEEIKSGAIP GCVMLDYDKL GELIPKIAEV MAPIRDAEGI
410 420 430 440 450
TAIPTDEEFK VYIDKCVKCG ECMLACPEEL DIPEALEYAA KGSYEYLEAL
460 470 480 490 500
HDVCIGCRRC EQVCKKEIPI LNVLEKAAQK SISEEKGWVR SGRGQASDAE
510 520 530 540 550
IRAEGLNLVM GTTPGIIAII GCPNYPAGTK DVYNIAEEFL KRNYLVVVSG
560 570 580 590 600
CSAMDIGMYK DDDGKTLYER YPGTFSGGGL LNTGSCVSNA HITGAAEKVA
610 620 630 640 650
GIFAQRTLAG NLAEVADYTL NRVGACGLAW GAYSQKAASI GTGCNIYGIP
660 670 680 690 700
AVLGPHSSKY RRALIAKTYE EDKWKVFDAR DGSEMNIPPA PEFLLTTAET
710 720 730 740 750
WQEALPMMAK ACIRPSDNNM GRSIKLTHWM ELSKKYLGVE PEDWWKFVRN
760 770 780 790 800
EADLPLAKRE ELLKRLEAEQ GWEIDWKRKK IISGPKIKFD VSAQPTNLKR

LCKEA
Length:805
Mass (Da):87,993
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B1B9B32B56C56CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM07741.1

NCBI Reference Sequences

More...
RefSeqi
WP_011024278.1, NC_003552.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAM07741; AAM07741; MA_4399

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1476293

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mac:MA_4399

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM07741.1
RefSeqiWP_011024278.1, NC_003552.1

3D structure databases

ProteinModelPortaliQ8THW2
SMRiQ8THW2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8THW2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM07741; AAM07741; MA_4399
GeneIDi1476293
KEGGimac:MA_4399

Phylogenomic databases

eggNOGiarCOG02428 Archaea
COG1152 LUCA
InParanoidiQ8THW2
KOiK00192
OrthoDBi1404at2157
PhylomeDBiQ8THW2

Enzyme and pathway databases

UniPathwayi
UPA00642

BioCyciMACE188937:G1FZT-4694-MONOMER

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.40.50.2030, 2 hits
HAMAPiMF_01137 CdhA, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR004460 CDHA
IPR004137 HCP/CODH
IPR009051 Helical_ferredxn
IPR016099 Prismane-like_a/b-sand
IPR011254 Prismane-like_sf
PANTHERiPTHR30109 PTHR30109, 1 hit
PfamiView protein in Pfam
PF13187 Fer4_9, 1 hit
PF03063 Prismane, 2 hits
SUPFAMiSSF46548 SSF46548, 1 hit
SSF56821 SSF56821, 1 hit
TIGRFAMsiTIGR00314 cdhA, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACDA3_METAC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8THW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: April 10, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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