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Protein

Probable L-asparaginase 4

Gene

SPAP8B6.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-asparagine + H2O = L-aspartate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46O-isoaspartyl threonine intermediateBy similarity1
Binding sitei93SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-SPO-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-asparaginase 4 (EC:3.5.1.1)
Alternative name(s):
L-asparagine amidohydrolase 4
Gene namesi
ORF Names:SPAP8B6.05c, SPBPB8B6.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBPB8B6.05c
PomBaseiSPBPB8B6.05c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000236623 – 356Probable L-asparaginase 4Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8TFF8
PaxDbiQ8TFF8
PRIDEiQ8TFF8

PTM databases

iPTMnetiQ8TFF8

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBPB8B6.05c.1

Structurei

3D structure databases

ProteinModelPortaliQ8TFF8
SMRiQ8TFF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 356Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST321

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 127Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the asparaginase 1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000044165
InParanoidiQ8TFF8
KOiK01424
OMAiNDRICSA
OrthoDBiEOG092C3Z6Q
PhylomeDBiQ8TFF8

Family and domain databases

Gene3Di3.40.50.1170, 1 hit
3.40.50.40, 1 hit
InterProiView protein in InterPro
IPR004550 AsnASE_II
IPR036152 Asp/glu_Ase-like_sf
IPR006034 Asparaginase/glutaminase-like
IPR027473 L-asparaginase_C
IPR027474 L-asparaginase_N
IPR037152 L-asparaginase_N_sf
PfamiView protein in Pfam
PF00710 Asparaginase, 1 hit
PIRSFiPIRSF001220 L-ASNase_gatD, 1 hit
PRINTSiPR00139 ASNGLNASE
SMARTiView protein in SMART
SM00870 Asparaginase, 1 hit
SUPFAMiSSF53774 SSF53774, 1 hit
TIGRFAMsiTIGR00520 asnASE_II, 1 hit
PROSITEiView protein in PROSITE
PS51732 ASN_GLN_ASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TFF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGFIVTCGI FLVLLCQLRL LSKRKSKSTP YNALLPNVTV FAMGGTIAGC
60 70 80 90 100
ANSSLEIVNY IPGSVGIEKL IEAVPAIKAI ANINGVQVTN MGSENLTPAD
110 120 130 140 150
VLKLAKLILA EVAKPNVHGI VITHGTDSLE ETAMFLDLTI STAKPIVVVG
160 170 180 190 200
AMRPSTAIGA DGPMNLLNAV AVASSNQSMG RGTLVLLNDR IGSAFYTTKT
210 220 230 240 250
NGNTLDTFKS YEAGSLGIVL NQKPFYFFSP AVPTGKVFFD IYNIKQLPRV
260 270 280 290 300
DILYGYQGLN PKLAESAVHL GAKGLVLAAM GATSWTDDGN EVISSLIREH
310 320 330 340 350
NIPVVYSHRT AEGYSSNSCL GIPSYFLNPQ KARYMLMLAI SSGYSIRDIE

GLFSIK
Length:356
Mass (Da):38,057
Last modified:June 1, 2002 - v1
Checksum:iE7935A592DB06FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAD27911.1
RefSeqiNP_001018766.1, NM_001020941.2

Genome annotation databases

EnsemblFungiiSPBPB8B6.05c.1; SPBPB8B6.05c.1:pep; SPBPB8B6.05c
GeneIDi3361187
KEGGispo:SPBPB8B6.05c

Similar proteinsi

Entry informationi

Entry nameiASPG4_SCHPO
AccessioniPrimary (citable) accession number: Q8TFF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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