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Entry version 164 (13 Feb 2019)
Sequence version 3 (18 May 2010)
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Protein

Serine/threonine-protein kinase haspin

Gene

HASPIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Constitutive activity that does not require phosphorylation. Specifically inhibited by 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine (CHR-6494).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei511ATP1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei649Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi490 – 498ATPPROSITE-ProRule annotationBy similarity9
Nucleotide bindingi606 – 611ATP6
Nucleotide bindingi649 – 654ATP6
Nucleotide bindingi687 – 689ATP3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • histone kinase activity (H3-T3 specific) Source: UniProtKB
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8TF76

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase haspin (EC:2.7.11.1)
Alternative name(s):
Germ cell-specific gene 2 protein
H-haspin
Haploid germ cell-specific nuclear protein kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HASPINImported
Synonyms:GSG2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177602.5

Human Gene Nomenclature Database

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HGNCi
HGNC:19682 HASPIN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609240 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF76

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi492E → A: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation. 1 Publication1
Mutagenesisi511K → A: Strongly reduced enzyme activity. 1 Publication1
Mutagenesisi651H → A: Strongly reduced enzyme activity, markedly reduced affinity for histone H3. 2 Publications1
Mutagenesisi707D → L: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation. 1 Publication1
Mutagenesisi709D → N: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation. 1 Publication1
Mutagenesisi713G → F: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation. 1 Publication1
Mutagenesisi716D → L: Markedly reduced histone H3 phosphorylation. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000177602

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134909705

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075163

Drug and drug target database

More...
DrugBanki
DB04604 5-iodotubercidin
DB07995 N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2028

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HASPIN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439330

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000859891 – 798Serine/threonine-protein kinase haspinAdd BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei58PhosphoserineCombined sources1
Modified residuei93Phosphoserine; by AURKBCombined sources1 Publication1
Modified residuei97PhosphothreonineCombined sources1
Modified residuei143Phosphoserine; by AURKB1 Publication1
Modified residuei147PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis.By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TF76

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TF76

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TF76

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TF76

PeptideAtlas

More...
PeptideAtlasi
Q8TF76

PRoteomics IDEntifications database

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PRIDEi
Q8TF76

ProteomicsDB human proteome resource

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ProteomicsDBi
74576
74577 [Q8TF76-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8TF76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TF76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177602 Expressed in 79 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TF76 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA027422
HPA030698

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123814, 34 interactors

Database of interacting proteins

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DIPi
DIP-38174N

Protein interaction database and analysis system

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IntActi
Q8TF76, 13 interactors

Molecular INTeraction database

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MINTi
Q8TF76

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325290

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8TF76

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1798
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VUWX-ray1.80A465-798[»]
2WB8X-ray2.15A452-798[»]
3DLZX-ray1.85A465-798[»]
3E7VX-ray2.00A471-798[»]
3F2NX-ray1.80A465-798[»]
3FMDX-ray2.00A470-798[»]
3IQ7X-ray2.00A465-798[»]
4OUCX-ray1.90A465-798[»]
4QTCX-ray1.40A465-798[»]
5HTBX-ray1.70A465-798[»]
5HTCX-ray1.50A465-798[»]
6G34X-ray1.76A465-798[»]
6G35X-ray1.55A465-798[»]
6G36X-ray1.46A465-798[»]
6G37X-ray1.48A465-798[»]
6G38X-ray1.47A465-798[»]
6G39X-ray1.45A465-798[»]
6G3AX-ray1.43A465-798[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8TF76

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TF76

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TF76

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini484 – 798Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST315

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2464 Eukaryota
COG5072 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168256

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG049009

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TF76

KEGG Orthology (KO)

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KOi
K16315

Identification of Orthologs from Complete Genome Data

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OMAi
LCQHSLF

Database of Orthologous Groups

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OrthoDBi
110058at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TF76

TreeFam database of animal gene trees

More...
TreeFami
TF313895

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 12 Publications (identifier: Q8TF76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASLPGPGS RLFRTYGAAD GRRQRRPGRE AAQWFPPQDR RRFFNSSGSS
60 70 80 90 100
DASIGDPSQS DDPDDPDDPD FPGSPVRRRR RRPGGRVPKD RPSLTVTPKR
110 120 130 140 150
WKLRARPSLT VTPRRLGLRA RPPQKCSTPC GPLRLPPFPS RDSGRLSPDL
160 170 180 190 200
SVCGQPRDGD ELGISASLFS SLASPCPGSP TPRDSVISIG TSACLVAASA
210 220 230 240 250
VPSGLHLPEV SLDRASLPCS QEEATGGAKD TRMVHQTRAS LRSVLFGLMN
260 270 280 290 300
SGTPEDSEFR ADGKNMRESC CKRKLVVGNG PEGPGLSSTG KRRATGQDSC
310 320 330 340 350
QERGLQEAVR REHQEASVPK GRIVPRGIDR LERTRSSRKS KHQEATETSL
360 370 380 390 400
LHSHRFKKGQ KLGKDSFPTQ DLTPLQNVCF WTKTRASFSF HKKKIVTDVS
410 420 430 440 450
EVCSIYTTAT SLSGSLLSEC SNRPVMNRTS GAPSSWHSSS MYLLSPLNTL
460 470 480 490 500
SISNKKASDA EKVYGECSQK GPVPFSHCLP TEKLQRCEKI GEGVFGEVFQ
510 520 530 540 550
TIADHTPVAI KIIAIEGPDL VNGSHQKTFE EILPEIIISK ELSLLSGEVC
560 570 580 590 600
NRTEGFIGLN SVHCVQGSYP PLLLKAWDHY NSTKGSANDR PDFFKDDQLF
610 620 630 640 650
IVLEFEFGGI DLEQMRTKLS SLATAKSILH QLTASLAVAE ASLRFEHRDL
660 670 680 690 700
HWGNVLLKKT SLKKLHYTLN GKSSTIPSCG LQVSIIDYTL SRLERDGIVV
710 720 730 740 750
FCDVSMDEDL FTGDGDYQFD IYRLMKKENN NRWGEYHPYS NVLWLHYLTD
760 770 780 790
KMLKQMTFKT KCNTPAMKQI KRKIQEFHRT MLNFSSATDL LCQHSLFK
Length:798
Mass (Da):88,495
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0EDF8F0C58ADA31
GO
Isoform 21 Publication (identifier: Q8TF76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-314: Q → H
     315-798: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:314
Mass (Da):33,850
Checksum:i7F8CC086036ED24E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti273R → S in BAB71255 (PubMed:14702039).Curated1
Sequence conflicti339K → E in AAH47457 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04054076V → E1 PublicationCorresponds to variant dbSNP:rs11653889Ensembl.1
Natural variantiVAR_04054182R → C4 PublicationsCorresponds to variant dbSNP:rs9907144Ensembl.1
Natural variantiVAR_040542145R → H1 PublicationCorresponds to variant dbSNP:rs55991903Ensembl.1
Natural variantiVAR_027405204G → D3 PublicationsCorresponds to variant dbSNP:rs220462Ensembl.1
Natural variantiVAR_040543283G → S1 PublicationCorresponds to variant dbSNP:rs56224301Ensembl.1
Natural variantiVAR_040544301Q → L1 PublicationCorresponds to variant dbSNP:rs55649477Ensembl.1
Natural variantiVAR_027406328I → T3 PublicationsCorresponds to variant dbSNP:rs220461Ensembl.1
Natural variantiVAR_027407378V → A3 PublicationsCorresponds to variant dbSNP:rs3809806Ensembl.1
Natural variantiVAR_027408422N → D. Corresponds to variant dbSNP:rs7223226Ensembl.1
Natural variantiVAR_040545706M → V1 PublicationCorresponds to variant dbSNP:rs56134695Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050671314Q → H in isoform 2. 1 Publication1
Alternative sequenceiVSP_050672315 – 798Missing in isoform 2. 1 PublicationAdd BLAST484

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB039834 mRNA Translation: BAB21938.3
AF289865 mRNA Translation: AAK30300.1
AK056691 mRNA Translation: BAB71255.1
AC116914 Genomic DNA No translation available.
BC047457 mRNA Translation: AAH47457.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11036.1 [Q8TF76-1]

NCBI Reference Sequences

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RefSeqi
NP_114171.2, NM_031965.2 [Q8TF76-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.534059

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000325418; ENSP00000325290; ENSG00000177602 [Q8TF76-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83903

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83903

UCSC genome browser

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UCSCi
uc002fwp.4 human [Q8TF76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039834 mRNA Translation: BAB21938.3
AF289865 mRNA Translation: AAK30300.1
AK056691 mRNA Translation: BAB71255.1
AC116914 Genomic DNA No translation available.
BC047457 mRNA Translation: AAH47457.1
CCDSiCCDS11036.1 [Q8TF76-1]
RefSeqiNP_114171.2, NM_031965.2 [Q8TF76-1]
UniGeneiHs.534059

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VUWX-ray1.80A465-798[»]
2WB8X-ray2.15A452-798[»]
3DLZX-ray1.85A465-798[»]
3E7VX-ray2.00A471-798[»]
3F2NX-ray1.80A465-798[»]
3FMDX-ray2.00A470-798[»]
3IQ7X-ray2.00A465-798[»]
4OUCX-ray1.90A465-798[»]
4QTCX-ray1.40A465-798[»]
5HTBX-ray1.70A465-798[»]
5HTCX-ray1.50A465-798[»]
6G34X-ray1.76A465-798[»]
6G35X-ray1.55A465-798[»]
6G36X-ray1.46A465-798[»]
6G37X-ray1.48A465-798[»]
6G38X-ray1.47A465-798[»]
6G39X-ray1.45A465-798[»]
6G3AX-ray1.43A465-798[»]
ProteinModelPortaliQ8TF76
SMRiQ8TF76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123814, 34 interactors
DIPiDIP-38174N
IntActiQ8TF76, 13 interactors
MINTiQ8TF76
STRINGi9606.ENSP00000325290

Chemistry databases

BindingDBiQ8TF76
ChEMBLiCHEMBL1075163
DrugBankiDB04604 5-iodotubercidin
DB07995 N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
GuidetoPHARMACOLOGYi2028

PTM databases

iPTMnetiQ8TF76
PhosphoSitePlusiQ8TF76

Polymorphism and mutation databases

BioMutaiHASPIN
DMDMi296439330

Proteomic databases

EPDiQ8TF76
jPOSTiQ8TF76
MaxQBiQ8TF76
PaxDbiQ8TF76
PeptideAtlasiQ8TF76
PRIDEiQ8TF76
ProteomicsDBi74576
74577 [Q8TF76-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83903
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325418; ENSP00000325290; ENSG00000177602 [Q8TF76-1]
GeneIDi83903
KEGGihsa:83903
UCSCiuc002fwp.4 human [Q8TF76-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83903
EuPathDBiHostDB:ENSG00000177602.5

GeneCards: human genes, protein and diseases

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GeneCardsi
HASPIN

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0013433
HGNCiHGNC:19682 HASPIN
HPAiHPA027422
HPA030698
MIMi609240 gene
neXtProtiNX_Q8TF76
OpenTargetsiENSG00000177602
PharmGKBiPA134909705

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2464 Eukaryota
COG5072 LUCA
GeneTreeiENSGT00390000013015
HOGENOMiHOG000168256
HOVERGENiHBG049009
InParanoidiQ8TF76
KOiK16315
OMAiLCQHSLF
OrthoDBi110058at2759
PhylomeDBiQ8TF76
TreeFamiTF313895

Enzyme and pathway databases

SignaLinkiQ8TF76

Miscellaneous databases

EvolutionaryTraceiQ8TF76

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GSG2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83903

Protein Ontology

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PROi
PR:Q8TF76

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177602 Expressed in 79 organ(s), highest expression level in secondary oocyte
GenevisibleiQ8TF76 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHASP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF76
Secondary accession number(s): Q5U5K3, Q96MN1, Q9BXS7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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