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Protein

WAS/WASL-interacting protein family member 2

Gene

WIPF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.2 Publications

Miscellaneous

Access to the profilin-binding site is masked in the full-length protein.

GO - Molecular functioni

  • actin filament binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
WAS/WASL-interacting protein family member 2
Alternative name(s):
WASP-interacting protein-related protein
WIP- and CR16-homologous protein
WIP-related protein
Gene namesi
Name:WIPF2
Synonyms:WICH, WIRE
ORF Names:PP10631
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000171475.13
HGNCiHGNC:30923 WIPF2
MIMi609692 gene
neXtProtiNX_Q8TF74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi147179
OpenTargetsiENSG00000171475
PharmGKBiPA162409210

Polymorphism and mutation databases

BioMutaiWIPF2
DMDMi60390855

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659751 – 440WAS/WASL-interacting protein family member 2Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ8TF74
MaxQBiQ8TF74
PaxDbiQ8TF74
PeptideAtlasiQ8TF74
PRIDEiQ8TF74
ProteomicsDBi74574
74575 [Q8TF74-2]

PTM databases

iPTMnetiQ8TF74
PhosphoSitePlusiQ8TF74

Expressioni

Tissue specificityi

Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.2 Publications

Gene expression databases

BgeeiENSG00000171475 Expressed in 243 organ(s), highest expression level in secondary oocyte
CleanExiHS_WIPF2
ExpressionAtlasiQ8TF74 baseline and differential
GenevisibleiQ8TF74 HS

Organism-specific databases

HPAiHPA024000
HPA024001
HPA024467

Interactioni

Subunit structurei

Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interaction was seen with WASF2 and WASF3.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127043, 20 interactors
ELMiQ8TF74
IntActiQ8TF74, 7 interactors
MINTiQ8TF74
STRINGi9606.ENSP00000320924

Structurei

3D structure databases

ProteinModelPortaliQ8TF74
SMRiQ8TF74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 53WH2PROSITE-ProRule annotationAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 52Binds actinSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 17Poly-ProAdd BLAST16
Compositional biasi177 – 182Poly-Pro6
Compositional biasi250 – 254Poly-Pro5
Compositional biasi296 – 299Poly-Pro4
Compositional biasi311 – 314Poly-Pro4
Compositional biasi325 – 330Poly-Pro6
Compositional biasi340 – 345Poly-Pro6
Compositional biasi359 – 363Poly-Pro5
Compositional biasi370 – 377Poly-Pro8

Sequence similaritiesi

Belongs to the verprolin family.Curated

Phylogenomic databases

eggNOGiKOG4462 Eukaryota
ENOG4111FVT LUCA
GeneTreeiENSGT00910000144192
HOGENOMiHOG000231914
HOVERGENiHBG060210
InParanoidiQ8TF74
KOiK19475
OMAiPMHSSKA
OrthoDBiEOG091G16MU
PhylomeDBiQ8TF74
TreeFamiTF332135

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
IPR028294 WIPF2
PANTHERiPTHR23202:SF3 PTHR23202:SF3, 1 hit
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPIPPPPPPP PGPPPPPTFH QANTEQPKLS RDEQRGRGAL LQDICKGTKL
60 70 80 90 100
KKVTNINDRS APILEKPKGS SGGYGSGGAA LQPKGGLFQG GVLKLRPVGA
110 120 130 140 150
KDGSENLAGK PALQIPSSRA AAPRPPVSAA SGRPQDDTDS SRASLPELPR
160 170 180 190 200
MQRPSLPDLS RPNTTSSTGM KHSSSAPPPP PPGRRANAPP TPLPMHSSKA
210 220 230 240 250
PAYNREKPLP PTPGQRLHPG REGPPAPPPV KPPPSPVNIR TGPSGQSLAP
260 270 280 290 300
PPPPYRQPPG VPNGPSSPTN ESAPELPQRH NSLHRKTPGP VRGLAPPPPT
310 320 330 340 350
SASPSLLSNR PPPPARDPPS RGAAPPPPPP VIRNGARDAP PPPPPYRMHG
360 370 380 390 400
SEPPSRGKPP PPPSRTPAGP PPPPPPPLRN GHRDSITTVR SFLDDFESKY
410 420 430 440
SFHPVEDFPA PEEYKHFQRI YPSKTNRAAR GAPPLPPILR
Length:440
Mass (Da):46,289
Last modified:June 1, 2002 - v1
Checksum:i7386B44F995AD798
GO
Isoform 2 (identifier: Q8TF74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.

Note: No experimental confirmation available.
Show »
Length:290
Mass (Da):30,840
Checksum:iB671793BBDD9B787
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MWR2A8MWR2_HUMAN
WAS/WASL-interacting protein family...
WIPF2
182Annotation score:
J3QKM5J3QKM5_HUMAN
WAS/WASL-interacting protein family...
WIPF2
103Annotation score:
J3QQS0J3QQS0_HUMAN
WAS/WASL-interacting protein family...
WIPF2
79Annotation score:
J3KSA3J3KSA3_HUMAN
WAS/WASL-interacting protein family...
WIPF2
63Annotation score:

Sequence cautioni

The sequence AAQ15232 differs from that shown. Reason: Frameshift at position 373.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82Q → H in CAD24007 (PubMed:12213210).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0129671 – 150Missing in isoform 2. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043786 mRNA Translation: BAB85113.1
AJ431177 mRNA Translation: CAD24007.1
AF370396 mRNA Translation: AAQ15232.1 Frameshift.
AK289578 mRNA Translation: BAF82267.1
AK289779 mRNA Translation: BAF82468.1
AK290301 mRNA Translation: BAF82990.1
AK315836 mRNA Translation: BAF98727.1
AL834239 mRNA Translation: CAH56360.1
BC065551 mRNA Translation: AAH65551.1
CCDSiCCDS11364.1 [Q8TF74-1]
PIRiJC7807
RefSeqiNP_573571.1, NM_133264.4 [Q8TF74-1]
XP_005257140.1, XM_005257083.2 [Q8TF74-1]
XP_005257141.1, XM_005257084.2 [Q8TF74-1]
XP_011522715.1, XM_011524413.1 [Q8TF74-2]
UniGeneiHs.421622
Hs.705989
Hs.731598

Genome annotation databases

EnsembliENST00000323571; ENSP00000320924; ENSG00000171475 [Q8TF74-1]
ENST00000583130; ENSP00000462350; ENSG00000171475 [Q8TF74-1]
ENST00000585043; ENSP00000462826; ENSG00000171475 [Q8TF74-1]
GeneIDi147179
KEGGihsa:147179
UCSCiuc002hug.2 human [Q8TF74-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043786 mRNA Translation: BAB85113.1
AJ431177 mRNA Translation: CAD24007.1
AF370396 mRNA Translation: AAQ15232.1 Frameshift.
AK289578 mRNA Translation: BAF82267.1
AK289779 mRNA Translation: BAF82468.1
AK290301 mRNA Translation: BAF82990.1
AK315836 mRNA Translation: BAF98727.1
AL834239 mRNA Translation: CAH56360.1
BC065551 mRNA Translation: AAH65551.1
CCDSiCCDS11364.1 [Q8TF74-1]
PIRiJC7807
RefSeqiNP_573571.1, NM_133264.4 [Q8TF74-1]
XP_005257140.1, XM_005257083.2 [Q8TF74-1]
XP_005257141.1, XM_005257084.2 [Q8TF74-1]
XP_011522715.1, XM_011524413.1 [Q8TF74-2]
UniGeneiHs.421622
Hs.705989
Hs.731598

3D structure databases

ProteinModelPortaliQ8TF74
SMRiQ8TF74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127043, 20 interactors
ELMiQ8TF74
IntActiQ8TF74, 7 interactors
MINTiQ8TF74
STRINGi9606.ENSP00000320924

PTM databases

iPTMnetiQ8TF74
PhosphoSitePlusiQ8TF74

Polymorphism and mutation databases

BioMutaiWIPF2
DMDMi60390855

Proteomic databases

EPDiQ8TF74
MaxQBiQ8TF74
PaxDbiQ8TF74
PeptideAtlasiQ8TF74
PRIDEiQ8TF74
ProteomicsDBi74574
74575 [Q8TF74-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323571; ENSP00000320924; ENSG00000171475 [Q8TF74-1]
ENST00000583130; ENSP00000462350; ENSG00000171475 [Q8TF74-1]
ENST00000585043; ENSP00000462826; ENSG00000171475 [Q8TF74-1]
GeneIDi147179
KEGGihsa:147179
UCSCiuc002hug.2 human [Q8TF74-1]

Organism-specific databases

CTDi147179
DisGeNETi147179
EuPathDBiHostDB:ENSG00000171475.13
GeneCardsiWIPF2
H-InvDBiHIX0018966
HGNCiHGNC:30923 WIPF2
HPAiHPA024000
HPA024001
HPA024467
MIMi609692 gene
neXtProtiNX_Q8TF74
OpenTargetsiENSG00000171475
PharmGKBiPA162409210
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4462 Eukaryota
ENOG4111FVT LUCA
GeneTreeiENSGT00910000144192
HOGENOMiHOG000231914
HOVERGENiHBG060210
InParanoidiQ8TF74
KOiK19475
OMAiPMHSSKA
OrthoDBiEOG091G16MU
PhylomeDBiQ8TF74
TreeFamiTF332135

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

ChiTaRSiWIPF2 human
GeneWikiiWIPF2
GenomeRNAii147179
PROiPR:Q8TF74
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171475 Expressed in 243 organ(s), highest expression level in secondary oocyte
CleanExiHS_WIPF2
ExpressionAtlasiQ8TF74 baseline and differential
GenevisibleiQ8TF74 HS

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
IPR028294 WIPF2
PANTHERiPTHR23202:SF3 PTHR23202:SF3, 1 hit
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWIPF2_HUMAN
AccessioniPrimary (citable) accession number: Q8TF74
Secondary accession number(s): A8K0L3
, Q658J8, Q71RE1, Q8TE44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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