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Entry version 138 (13 Feb 2019)
Sequence version 1 (01 Jun 2002)
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Protein

WAS/WASL-interacting protein family member 2

Gene

WIPF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.2 Publications

Miscellaneous

Access to the profilin-binding site is masked in the full-length protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WAS/WASL-interacting protein family member 2
Alternative name(s):
WASP-interacting protein-related protein
WIP- and CR16-homologous protein
WIP-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WIPF2
Synonyms:WICH, WIRE
ORF Names:PP10631
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171475.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30923 WIPF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609692 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF74

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
147179

Open Targets

More...
OpenTargetsi
ENSG00000171475

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409210

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WIPF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60390855

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000659751 – 440WAS/WASL-interacting protein family member 2Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TF74

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TF74

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TF74

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TF74

PeptideAtlas

More...
PeptideAtlasi
Q8TF74

PRoteomics IDEntifications database

More...
PRIDEi
Q8TF74

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74574
74575 [Q8TF74-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TF74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171475 Expressed in 243 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TF74 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TF74 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024000
HPA024001
HPA024467

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interaction was seen with WASF2 and WASF3.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127043, 20 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8TF74

Protein interaction database and analysis system

More...
IntActi
Q8TF74, 7 interactors

Molecular INTeraction database

More...
MINTi
Q8TF74

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320924

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TF74

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TF74

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 53WH2PROSITE-ProRule annotationAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 52Binds actinSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 17Poly-ProAdd BLAST16
Compositional biasi177 – 182Poly-Pro6
Compositional biasi250 – 254Poly-Pro5
Compositional biasi296 – 299Poly-Pro4
Compositional biasi311 – 314Poly-Pro4
Compositional biasi325 – 330Poly-Pro6
Compositional biasi340 – 345Poly-Pro6
Compositional biasi359 – 363Poly-Pro5
Compositional biasi370 – 377Poly-Pro8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the verprolin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4462 Eukaryota
ENOG4111FVT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155557

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231914

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG060210

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TF74

KEGG Orthology (KO)

More...
KOi
K19475

Identification of Orthologs from Complete Genome Data

More...
OMAi
PMHSSKA

Database of Orthologous Groups

More...
OrthoDBi
1265175at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TF74

TreeFam database of animal gene trees

More...
TreeFami
TF332135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003124 WH2_dom
IPR028294 WIPF2

The PANTHER Classification System

More...
PANTHERi
PTHR23202:SF3 PTHR23202:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02205 WH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00246 WH2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51082 WH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPIPPPPPPP PGPPPPPTFH QANTEQPKLS RDEQRGRGAL LQDICKGTKL
60 70 80 90 100
KKVTNINDRS APILEKPKGS SGGYGSGGAA LQPKGGLFQG GVLKLRPVGA
110 120 130 140 150
KDGSENLAGK PALQIPSSRA AAPRPPVSAA SGRPQDDTDS SRASLPELPR
160 170 180 190 200
MQRPSLPDLS RPNTTSSTGM KHSSSAPPPP PPGRRANAPP TPLPMHSSKA
210 220 230 240 250
PAYNREKPLP PTPGQRLHPG REGPPAPPPV KPPPSPVNIR TGPSGQSLAP
260 270 280 290 300
PPPPYRQPPG VPNGPSSPTN ESAPELPQRH NSLHRKTPGP VRGLAPPPPT
310 320 330 340 350
SASPSLLSNR PPPPARDPPS RGAAPPPPPP VIRNGARDAP PPPPPYRMHG
360 370 380 390 400
SEPPSRGKPP PPPSRTPAGP PPPPPPPLRN GHRDSITTVR SFLDDFESKY
410 420 430 440
SFHPVEDFPA PEEYKHFQRI YPSKTNRAAR GAPPLPPILR
Length:440
Mass (Da):46,289
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7386B44F995AD798
GO
Isoform 2 (identifier: Q8TF74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.

Note: No experimental confirmation available.
Show »
Length:290
Mass (Da):30,840
Checksum:iB671793BBDD9B787
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MWR2A8MWR2_HUMAN
WAS/WASL-interacting protein family...
WIPF2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKM5J3QKM5_HUMAN
WAS/WASL-interacting protein family...
WIPF2
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQS0J3QQS0_HUMAN
WAS/WASL-interacting protein family...
WIPF2
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSA3J3KSA3_HUMAN
WAS/WASL-interacting protein family...
WIPF2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ15232 differs from that shown. Reason: Frameshift at position 373.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82Q → H in CAD24007 (PubMed:12213210).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0129671 – 150Missing in isoform 2. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB043786 mRNA Translation: BAB85113.1
AJ431177 mRNA Translation: CAD24007.1
AF370396 mRNA Translation: AAQ15232.1 Frameshift.
AK289578 mRNA Translation: BAF82267.1
AK289779 mRNA Translation: BAF82468.1
AK290301 mRNA Translation: BAF82990.1
AK315836 mRNA Translation: BAF98727.1
AL834239 mRNA Translation: CAH56360.1
BC065551 mRNA Translation: AAH65551.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11364.1 [Q8TF74-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7807

NCBI Reference Sequences

More...
RefSeqi
NP_573571.1, NM_133264.4 [Q8TF74-1]
XP_005257140.1, XM_005257083.2 [Q8TF74-1]
XP_005257141.1, XM_005257084.2 [Q8TF74-1]
XP_011522715.1, XM_011524413.1 [Q8TF74-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.421622
Hs.705989
Hs.731598

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323571; ENSP00000320924; ENSG00000171475 [Q8TF74-1]
ENST00000583130; ENSP00000462350; ENSG00000171475 [Q8TF74-1]
ENST00000585043; ENSP00000462826; ENSG00000171475 [Q8TF74-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
147179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:147179

UCSC genome browser

More...
UCSCi
uc002hug.2 human [Q8TF74-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043786 mRNA Translation: BAB85113.1
AJ431177 mRNA Translation: CAD24007.1
AF370396 mRNA Translation: AAQ15232.1 Frameshift.
AK289578 mRNA Translation: BAF82267.1
AK289779 mRNA Translation: BAF82468.1
AK290301 mRNA Translation: BAF82990.1
AK315836 mRNA Translation: BAF98727.1
AL834239 mRNA Translation: CAH56360.1
BC065551 mRNA Translation: AAH65551.1
CCDSiCCDS11364.1 [Q8TF74-1]
PIRiJC7807
RefSeqiNP_573571.1, NM_133264.4 [Q8TF74-1]
XP_005257140.1, XM_005257083.2 [Q8TF74-1]
XP_005257141.1, XM_005257084.2 [Q8TF74-1]
XP_011522715.1, XM_011524413.1 [Q8TF74-2]
UniGeneiHs.421622
Hs.705989
Hs.731598

3D structure databases

ProteinModelPortaliQ8TF74
SMRiQ8TF74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127043, 20 interactors
ELMiQ8TF74
IntActiQ8TF74, 7 interactors
MINTiQ8TF74
STRINGi9606.ENSP00000320924

PTM databases

iPTMnetiQ8TF74
PhosphoSitePlusiQ8TF74

Polymorphism and mutation databases

BioMutaiWIPF2
DMDMi60390855

Proteomic databases

EPDiQ8TF74
jPOSTiQ8TF74
MaxQBiQ8TF74
PaxDbiQ8TF74
PeptideAtlasiQ8TF74
PRIDEiQ8TF74
ProteomicsDBi74574
74575 [Q8TF74-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323571; ENSP00000320924; ENSG00000171475 [Q8TF74-1]
ENST00000583130; ENSP00000462350; ENSG00000171475 [Q8TF74-1]
ENST00000585043; ENSP00000462826; ENSG00000171475 [Q8TF74-1]
GeneIDi147179
KEGGihsa:147179
UCSCiuc002hug.2 human [Q8TF74-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
147179
DisGeNETi147179
EuPathDBiHostDB:ENSG00000171475.13

GeneCards: human genes, protein and diseases

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GeneCardsi
WIPF2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0018966
HGNCiHGNC:30923 WIPF2
HPAiHPA024000
HPA024001
HPA024467
MIMi609692 gene
neXtProtiNX_Q8TF74
OpenTargetsiENSG00000171475
PharmGKBiPA162409210

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4462 Eukaryota
ENOG4111FVT LUCA
GeneTreeiENSGT00940000155557
HOGENOMiHOG000231914
HOVERGENiHBG060210
InParanoidiQ8TF74
KOiK19475
OMAiPMHSSKA
OrthoDBi1265175at2759
PhylomeDBiQ8TF74
TreeFamiTF332135

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WIPF2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WIPF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
147179

Protein Ontology

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PROi
PR:Q8TF74

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171475 Expressed in 243 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8TF74 baseline and differential
GenevisibleiQ8TF74 HS

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
IPR028294 WIPF2
PANTHERiPTHR23202:SF3 PTHR23202:SF3, 1 hit
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWIPF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF74
Secondary accession number(s): A8K0L3
, Q658J8, Q71RE1, Q8TE44
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2002
Last modified: February 13, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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