UniProtKB - Q8TF72 (SHRM3_HUMAN)
Protein Shroom3
SHROOM3
Functioni
Caution
GO - Molecular functioni
- actin filament binding Source: GO_Central
GO - Biological processi
- actin filament organization Source: GO_Central
- apical protein localization Source: HGNC-UCL
- cell morphogenesis Source: HGNC-UCL
- cellular pigment accumulation Source: HGNC-UCL
- epithelial cell development Source: InterPro
- neural tube closure Source: InterPro
- pattern specification process Source: HGNC-UCL
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-binding, Developmental protein |
Biological process | Cell shape |
Enzyme and pathway databases
PathwayCommonsi | Q8TF72 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Shroom3Alternative name(s): Shroom-related protein Short name: hShrmL |
Gene namesi | Name:SHROOM3 Synonyms:KIAA1481, SHRML ORF Names:MSTP013 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30422, SHROOM3 |
MIMi | 604570, gene |
neXtProti | NX_Q8TF72 |
VEuPathDBi | HostDB:ENSG00000138771.14 |
Subcellular locationi
Plasma membrane
- Apical cell membrane By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- cytoskeleton By similarity
Other locations
- adherens junction By similarity
Note: Colocalizes with F-actin in stress fibers and adherens junctions.By similarity
Cytoskeleton
- cortical actin cytoskeleton Source: GO_Central
- cytoskeleton Source: HGNC-UCL
- microtubule Source: UniProtKB-KW
Plasma Membrane
- apical plasma membrane Source: HGNC-UCL
Other locations
- adherens junction Source: HGNC-UCL
- apical junction complex Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 57619 |
OpenTargetsi | ENSG00000138771 |
PharmGKBi | PA147357295 |
Miscellaneous databases
Pharosi | Q8TF72, Tbio |
Genetic variation databases
BioMutai | SHROOM3 |
DMDMi | 300669666 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286066 | 1 – 1996 | Protein Shroom3Add BLAST | 1996 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 213 | PhosphoserineBy similarity | 1 | |
Modified residuei | 439 | PhosphoserineCombined sources | 1 | |
Modified residuei | 443 | PhosphoserineCombined sources | 1 | |
Modified residuei | 816 | PhosphoserineCombined sources | 1 | |
Modified residuei | 890 | PhosphoserineCombined sources | 1 | |
Modified residuei | 910 | PhosphoserineCombined sources | 1 | |
Modified residuei | 913 | PhosphoserineCombined sources | 1 | |
Modified residuei | 970 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1069 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1072 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1221 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1441 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8TF72 |
jPOSTi | Q8TF72 |
MassIVEi | Q8TF72 |
MaxQBi | Q8TF72 |
PaxDbi | Q8TF72 |
PeptideAtlasi | Q8TF72 |
PRIDEi | Q8TF72 |
ProteomicsDBi | 74572 [Q8TF72-1] 74573 [Q8TF72-2] |
PTM databases
iPTMneti | Q8TF72 |
PhosphoSitePlusi | Q8TF72 |
SwissPalmi | Q8TF72 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138771, Expressed in pancreas and 193 other tissues |
ExpressionAtlasi | Q8TF72, baseline and differential |
Genevisiblei | Q8TF72, HS |
Organism-specific databases
HPAi | ENSG00000138771, Tissue enhanced (salivary) |
Interactioni
Subunit structurei
Interacts with F-actin (By similarity).
Interacts with ROCK1 (PubMed:22493320).
By similarity1 PublicationGO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 121665, 32 interactors |
IntActi | Q8TF72, 22 interactors |
MINTi | Q8TF72 |
STRINGi | 9606.ENSP00000296043 |
Miscellaneous databases
RNActi | Q8TF72, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 110 | PDZPROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 928 – 1030 | ASD1PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 1669 – 1957 | ASD2PROSITE-ProRule annotationAdd BLAST | 289 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QUU2, Eukaryota |
GeneTreei | ENSGT00940000157778 |
HOGENOMi | CLU_002434_1_0_1 |
InParanoidi | Q8TF72 |
OMAi | TSGPQHR |
OrthoDBi | 29607at2759 |
PhylomeDBi | Q8TF72 |
TreeFami | TF333370 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR014800, ASD1_dom IPR014799, ASD2_dom IPR001478, PDZ IPR036034, PDZ_sf IPR030494, Shrm3 IPR027685, Shroom_fam |
PANTHERi | PTHR15012, PTHR15012, 1 hit PTHR15012:SF33, PTHR15012:SF33, 1 hit |
Pfami | View protein in Pfam PF08688, ASD1, 1 hit PF08687, ASD2, 1 hit PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51306, ASD1, 1 hit PS51307, ASD2, 1 hit PS50106, PDZ, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMRTTEDFHK PSATLNSNTA TKGRYIYLEA FLEGGAPWGF TLKGGLEHGE
60 70 80 90 100
PLIISKVEEG GKADTLSSKL QAGDEVVHIN EVTLSSSRKE AVSLVKGSYK
110 120 130 140 150
TLRLVVRRDV CTDPGHADTG ASNFVSPEHL TSGPQHRKAA WSGGVKLRLK
160 170 180 190 200
HRRSEPAGRP HSWHTTKSGE KQPDASMMQI SQGMIGPPWH QSYHSSSSTS
210 220 230 240 250
DLSNYDHAYL RRSPDQCSSQ GSMESLEPSG AYPPCHLSPA KSTGSIDQLS
260 270 280 290 300
HFHNKRDSAY SSFSTSSSIL EYPHPGISGR ERSGSMDNTS ARGGLLEGMR
310 320 330 340 350
QADIRYVKTV YDTRRGVSAE YEVNSSALLL QGREARASAN GQGYDKWSNI
360 370 380 390 400
PRGKGVPPPS WSQQCPSSLE TATDNLPPKV GAPLPPARSD SYAAFRHRER
410 420 430 440 450
PSSWSSLDQK RLCRPQANSL GSLKSPFIEE QLHTVLEKSP ENSPPVKPKH
460 470 480 490 500
NYTQKAQPGQ PLLPTSIYPV PSLEPHFAQV PQPSVSSNGM LYPALAKESG
510 520 530 540 550
YIAPQGACNK MATIDENGNQ NGSGRPGFAF CQPLEHDLLS PVEKKPEATA
560 570 580 590 600
KYVPSKVHFC SVPENEEDAS LKRHLTPPQG NSPHSNERKS THSNKPSSHP
610 620 630 640 650
HSLKCPQAQA WQAGEDKRSS RLSEPWEGDF QEDHNANLWR RLEREGLGQS
660 670 680 690 700
LSGNFGKTKS AFSSLQNIPE SLRRHSSLEL GRGTQEGYPG GRPTCAVNTK
710 720 730 740 750
AEDPGRKAAP DLGSHLDRQV SYPRPEGRTG ASASFNSTDP SPEEPPAPSH
760 770 780 790 800
PHTSSLGRRG PGPGSASALQ GFQYGKPHCS VLEKVSKFEQ REQGSQRPSV
810 820 830 840 850
GGSGFGHNYR PHRTVSTSST SGNDFEETKA HIRFSESAEP LGNGEQHFKN
860 870 880 890 900
GELKLEEASR QPCGQQLSGG ASDSGRGPQR PDARLLRSQS TFQLSSEPER
910 920 930 940 950
EPEWRDRPGS PESPLLDAPF SRAYRNSIKD AQSRVLGATS FRRRDLELGA
960 970 980 990 1000
PVASRSWRPR PSSAHVGLRS PEASASASPH TPRERHSVTP AEGDLARPVP
1010 1020 1030 1040 1050
PAARRGARRR LTPEQKKRSY SEPEKMNEVG IVEEAEPAPL GPQRNGMRFP
1060 1070 1080 1090 1100
ESSVADRRRL FERDGKACST LSLSGPELKQ FQQSALADYI QRKTGKRPTS
1110 1120 1130 1140 1150
AAGCSLQEPG PLRERAQSAY LQPGPAALEG SGLASASSLS SLREPSLQPR
1160 1170 1180 1190 1200
REATLLPATV AETQQAPRDR SSSFAGGRRL GERRRGDLLS GANGGTRGTQ
1210 1220 1230 1240 1250
RGDETPREPS SWGARAGKSM SAEDLLERSD VLAGPVHVRS RSSPATADKR
1260 1270 1280 1290 1300
QDVLLGQDSG FGLVKDPCYL AGPGSRSLSC SERGQEEMLP LFHHLTPRWG
1310 1320 1330 1340 1350
GSGCKAIGDS SVPSECPGTL DHQRQASRTP CPRPPLAGTQ GLVTDTRAAP
1360 1370 1380 1390 1400
LTPIGTPLPS AIPSGYCSQD GQTGRQPLPP YTPAMMHRSN GHTLTQPPGP
1410 1420 1430 1440 1450
RGCEGDGPEH GVEEGTRKRV SLPQWPPPSR AKWAHAARED SLPEESSAPD
1460 1470 1480 1490 1500
FANLKHYQKQ QSLPSLCSTS DPDTPLGAPS TPGRISLRIS ESVLRDSPPP
1510 1520 1530 1540 1550
HEDYEDEVFV RDPHPKATSS PTFEPLPPPP PPPPSQETPV YSMDDFPPPP
1560 1570 1580 1590 1600
PHTVCEAQLD SEDPEGPRPS FNKLSKVTIA RERHMPGAAH VVGSQTLASR
1610 1620 1630 1640 1650
LQTSIKGSEA ESTPPSFMSV HAQLAGSLGG QPAPIQTQSL SHDPVSGTQG
1660 1670 1680 1690 1700
LEKKVSPDPQ KSSEDIRTEA LAKEIVHQDK SLADILDPDS RLKTTMDLME
1710 1720 1730 1740 1750
GLFPRDVNLL KENSVKRKAI QRTVSSSGCE GKRNEDKEAV SMLVNCPAYY
1760 1770 1780 1790 1800
SVSAPKAELL NKIKEMPAEV NEEEEQADVN EKKAELIGSL THKLETLQEA
1810 1820 1830 1840 1850
KGSLLTDIKL NNALGEEVEA LISELCKPNE FDKYRMFIGD LDKVVNLLLS
1860 1870 1880 1890 1900
LSGRLARVEN VLSGLGEDAS NEERSSLYEK RKILAGQHED ARELKENLDR
1910 1920 1930 1940 1950
RERVVLGILA NYLSEEQLQD YQHFVKMKST LLIEQRKLDD KIKLGQEQVK
1960 1970 1980 1990
CLLESLPSDF IPKAGALALP PNLTSEPIPA GGCTFSGIFP TLTSPL
The sequence of this isoform differs from the canonical sequence as follows:
1-125: Missing.
126-153: SPEHLTSGPQHRKAAWSGGVKLRLKHRR → MAFYSTPEYDIQLARGLLSGMFLFATRR
277-311: ISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVY → KRVKTRDLPGSQSPGRAISRKTTMPTSGGGWREKA
312-1996: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y5P9 | A0A2R8Y5P9_HUMAN | Protein Shroom3 | SHROOM3 | 1,915 | Annotation score: | ||
A0A2R8Y7T7 | A0A2R8Y7T7_HUMAN | Protein Shroom3 | SHROOM3 | 50 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 153 | R → S in BAB84689 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032062 | 147 | L → H. Corresponds to variant dbSNP:rs3821979Ensembl. | 1 | |
Natural variantiVAR_032063 | 279 | G → A1 PublicationCorresponds to variant dbSNP:rs344140EnsemblClinVar. | 1 | |
Natural variantiVAR_032064 | 469 | P → A1 PublicationCorresponds to variant dbSNP:rs344141EnsemblClinVar. | 1 | |
Natural variantiVAR_032065 | 1290 | P → L2 PublicationsCorresponds to variant dbSNP:rs3733242Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024965 | 1 – 125 | Missing in isoform 2. 1 PublicationAdd BLAST | 125 | |
Alternative sequenceiVSP_024966 | 126 – 153 | SPEHL…LKHRR → MAFYSTPEYDIQLARGLLSG MFLFATRR in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_024967 | 277 – 311 | ISGRE…VKTVY → KRVKTRDLPGSQSPGRAISR KTTMPTSGGGWREKA in isoform 2. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_024968 | 312 – 1996 | Missing in isoform 2. 1 PublicationAdd BLAST | 1685 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB055660 mRNA Translation: BAB84689.1 Different initiation. AK127929 mRNA Translation: BAC87195.1 AC096743 Genomic DNA No translation available. AC107051 Genomic DNA No translation available. AC107072 Genomic DNA No translation available. AC112249 Genomic DNA No translation available. AC121158 Genomic DNA No translation available. AB040914 mRNA Translation: BAA96005.1 BC007291 mRNA Translation: AAH07291.1 AF109367 mRNA Translation: AAQ13515.1 Different initiation. |
CCDSi | CCDS3579.2 [Q8TF72-1] |
RefSeqi | NP_065910.3, NM_020859.3 [Q8TF72-1] |
Genome annotation databases
Ensembli | ENST00000296043; ENSP00000296043; ENSG00000138771 [Q8TF72-1] |
GeneIDi | 57619 |
KEGGi | hsa:57619 |
UCSCi | uc011cbx.3, human [Q8TF72-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB055660 mRNA Translation: BAB84689.1 Different initiation. AK127929 mRNA Translation: BAC87195.1 AC096743 Genomic DNA No translation available. AC107051 Genomic DNA No translation available. AC107072 Genomic DNA No translation available. AC112249 Genomic DNA No translation available. AC121158 Genomic DNA No translation available. AB040914 mRNA Translation: BAA96005.1 BC007291 mRNA Translation: AAH07291.1 AF109367 mRNA Translation: AAQ13515.1 Different initiation. |
CCDSi | CCDS3579.2 [Q8TF72-1] |
RefSeqi | NP_065910.3, NM_020859.3 [Q8TF72-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6FBB | X-ray | 1.30 | P | 1240-1244 | [»] | |
6FCP | X-ray | 1.45 | P | 1233-1247 | [»] | |
SMRi | Q8TF72 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121665, 32 interactors |
IntActi | Q8TF72, 22 interactors |
MINTi | Q8TF72 |
STRINGi | 9606.ENSP00000296043 |
PTM databases
iPTMneti | Q8TF72 |
PhosphoSitePlusi | Q8TF72 |
SwissPalmi | Q8TF72 |
Genetic variation databases
BioMutai | SHROOM3 |
DMDMi | 300669666 |
Proteomic databases
EPDi | Q8TF72 |
jPOSTi | Q8TF72 |
MassIVEi | Q8TF72 |
MaxQBi | Q8TF72 |
PaxDbi | Q8TF72 |
PeptideAtlasi | Q8TF72 |
PRIDEi | Q8TF72 |
ProteomicsDBi | 74572 [Q8TF72-1] 74573 [Q8TF72-2] |
Protocols and materials databases
Antibodypediai | 62376, 52 antibodies |
Genome annotation databases
Ensembli | ENST00000296043; ENSP00000296043; ENSG00000138771 [Q8TF72-1] |
GeneIDi | 57619 |
KEGGi | hsa:57619 |
UCSCi | uc011cbx.3, human [Q8TF72-1] |
Organism-specific databases
CTDi | 57619 |
DisGeNETi | 57619 |
GeneCardsi | SHROOM3 |
HGNCi | HGNC:30422, SHROOM3 |
HPAi | ENSG00000138771, Tissue enhanced (salivary) |
MIMi | 604570, gene |
neXtProti | NX_Q8TF72 |
OpenTargetsi | ENSG00000138771 |
PharmGKBi | PA147357295 |
VEuPathDBi | HostDB:ENSG00000138771.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUU2, Eukaryota |
GeneTreei | ENSGT00940000157778 |
HOGENOMi | CLU_002434_1_0_1 |
InParanoidi | Q8TF72 |
OMAi | TSGPQHR |
OrthoDBi | 29607at2759 |
PhylomeDBi | Q8TF72 |
TreeFami | TF333370 |
Enzyme and pathway databases
PathwayCommonsi | Q8TF72 |
Miscellaneous databases
BioGRID-ORCSi | 57619, 2 hits in 989 CRISPR screens |
ChiTaRSi | SHROOM3, human |
GeneWikii | SHROOM3 |
GenomeRNAii | 57619 |
Pharosi | Q8TF72, Tbio |
PROi | PR:Q8TF72 |
RNActi | Q8TF72, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138771, Expressed in pancreas and 193 other tissues |
ExpressionAtlasi | Q8TF72, baseline and differential |
Genevisiblei | Q8TF72, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR014800, ASD1_dom IPR014799, ASD2_dom IPR001478, PDZ IPR036034, PDZ_sf IPR030494, Shrm3 IPR027685, Shroom_fam |
PANTHERi | PTHR15012, PTHR15012, 1 hit PTHR15012:SF33, PTHR15012:SF33, 1 hit |
Pfami | View protein in Pfam PF08688, ASD1, 1 hit PF08687, ASD2, 1 hit PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51306, ASD1, 1 hit PS51307, ASD2, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHRM3_HUMAN | |
Accessioni | Q8TF72Primary (citable) accession number: Q8TF72 Secondary accession number(s): Q5QTQ3 Q9P247 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | July 13, 2010 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families