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UniProtKB - Q8TF72 (SHRM3_HUMAN)

Entry version 147 (29 Sep 2021)
Sequence version 2 (13 Jul 2010)
Previous versions | rss
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Protein

Protein Shroom3

Gene

SHROOM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity).

Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity).

By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator. Met-2 is more conserved than Met-1 among the orthologs.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processCell shape

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TF72

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Shroom3
Alternative name(s):
Shroom-related protein
Short name:
hShrmL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHROOM3
Synonyms:KIAA1481, SHRML
ORF Names:MSTP013
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30422, SHROOM3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604570, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TF72

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000138771

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57619

Open Targets

More...OpenTargetsi		ENSG00000138771

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA147357295

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TF72, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SHROOM3

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669666

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860661 – 1996Protein Shroom3Add BLAST1996

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei213PhosphoserineBy similarity1
Modified residuei439PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Modified residuei890PhosphoserineCombined sources1
Modified residuei910PhosphoserineCombined sources1
Modified residuei913PhosphoserineCombined sources1
Modified residuei970PhosphoserineCombined sources1
Modified residuei1069PhosphoserineBy similarity1
Modified residuei1072PhosphoserineBy similarity1
Modified residuei1221PhosphoserineCombined sources1
Modified residuei1441PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TF72

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TF72

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TF72

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TF72

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TF72

PeptideAtlas

More...PeptideAtlasi		Q8TF72

PRoteomics IDEntifications database

More...PRIDEi		Q8TF72

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74572 [Q8TF72-1]
74573 [Q8TF72-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TF72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TF72

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8TF72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138771, Expressed in pancreas and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TF72, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TF72, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138771, Tissue enhanced (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin (By similarity).

Interacts with ROCK1 (PubMed:22493320).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121665, 35 interactors

Protein interaction database and analysis system

More...IntActi		Q8TF72, 24 interactors

Molecular INTeraction database

More...MINTi		Q8TF72

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296043

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TF72, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TF72

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 110PDZPROSITE-ProRule annotationAdd BLAST86
Domaini928 – 1030ASD1PROSITE-ProRule annotationAdd BLAST103
Domaini1669 – 1957ASD2PROSITE-ProRule annotationAdd BLAST289

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni150 – 173DisorderedSequence analysisAdd BLAST24
Regioni340 – 389DisorderedSequence analysisAdd BLAST50
Regioni437 – 468DisorderedSequence analysisAdd BLAST32
Regioni568 – 629DisorderedSequence analysisAdd BLAST62
Regioni673 – 772DisorderedSequence analysisAdd BLAST100
Regioni788 – 1053DisorderedSequence analysisAdd BLAST266
Regioni1093 – 1115DisorderedSequence analysisAdd BLAST23
Regioni1137 – 1223DisorderedSequence analysisAdd BLAST87
Regioni1315 – 1573DisorderedSequence analysisAdd BLAST259
Regioni1627 – 1665DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi150 – 168Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi360 – 374Polar residuesSequence analysisAdd BLAST15
Compositional biasi446 – 461Polar residuesSequence analysisAdd BLAST16
Compositional biasi810 – 825Polar residuesSequence analysisAdd BLAST16
Compositional biasi1007 – 1031Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi1362 – 1376Polar residuesSequence analysisAdd BLAST15
Compositional biasi1453 – 1476Polar residuesSequence analysisAdd BLAST24
Compositional biasi1495 – 1513Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1520 – 1554Pro residuesSequence analysisAdd BLAST35
Compositional biasi1630 – 1646Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASD1 domain mediates F-actin binding.By similarity
The ASD2 domain mediates the interaction with ROCK1 and is required for apical constriction induction.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shroom family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUU2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157778

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002434_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TF72

Identification of Orthologs from Complete Genome Data

More...OMAi		FVKDLHP

Database of Orthologous Groups

More...OrthoDBi		29607at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TF72

TreeFam database of animal gene trees

More...TreeFami		TF333370

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR030494, Shrm3
IPR027685, Shroom_fam

The PANTHER Classification System

More...PANTHERi		PTHR15012, PTHR15012, 1 hit
PTHR15012:SF33, PTHR15012:SF33, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRTTEDFHK PSATLNSNTA TKGRYIYLEA FLEGGAPWGF TLKGGLEHGE 
        60         70         80         90        100
PLIISKVEEG GKADTLSSKL QAGDEVVHIN EVTLSSSRKE AVSLVKGSYK 
       110        120        130        140        150
TLRLVVRRDV CTDPGHADTG ASNFVSPEHL TSGPQHRKAA WSGGVKLRLK 
       160        170        180        190        200
HRRSEPAGRP HSWHTTKSGE KQPDASMMQI SQGMIGPPWH QSYHSSSSTS 
       210        220        230        240        250
DLSNYDHAYL RRSPDQCSSQ GSMESLEPSG AYPPCHLSPA KSTGSIDQLS 
       260        270        280        290        300
HFHNKRDSAY SSFSTSSSIL EYPHPGISGR ERSGSMDNTS ARGGLLEGMR 
       310        320        330        340        350
QADIRYVKTV YDTRRGVSAE YEVNSSALLL QGREARASAN GQGYDKWSNI 
       360        370        380        390        400
PRGKGVPPPS WSQQCPSSLE TATDNLPPKV GAPLPPARSD SYAAFRHRER 
       410        420        430        440        450
PSSWSSLDQK RLCRPQANSL GSLKSPFIEE QLHTVLEKSP ENSPPVKPKH 
       460        470        480        490        500
NYTQKAQPGQ PLLPTSIYPV PSLEPHFAQV PQPSVSSNGM LYPALAKESG 
       510        520        530        540        550
YIAPQGACNK MATIDENGNQ NGSGRPGFAF CQPLEHDLLS PVEKKPEATA 
       560        570        580        590        600
KYVPSKVHFC SVPENEEDAS LKRHLTPPQG NSPHSNERKS THSNKPSSHP 
       610        620        630        640        650
HSLKCPQAQA WQAGEDKRSS RLSEPWEGDF QEDHNANLWR RLEREGLGQS 
       660        670        680        690        700
LSGNFGKTKS AFSSLQNIPE SLRRHSSLEL GRGTQEGYPG GRPTCAVNTK 
       710        720        730        740        750
AEDPGRKAAP DLGSHLDRQV SYPRPEGRTG ASASFNSTDP SPEEPPAPSH 
       760        770        780        790        800
PHTSSLGRRG PGPGSASALQ GFQYGKPHCS VLEKVSKFEQ REQGSQRPSV 
       810        820        830        840        850
GGSGFGHNYR PHRTVSTSST SGNDFEETKA HIRFSESAEP LGNGEQHFKN 
       860        870        880        890        900
GELKLEEASR QPCGQQLSGG ASDSGRGPQR PDARLLRSQS TFQLSSEPER 
       910        920        930        940        950
EPEWRDRPGS PESPLLDAPF SRAYRNSIKD AQSRVLGATS FRRRDLELGA 
       960        970        980        990       1000
PVASRSWRPR PSSAHVGLRS PEASASASPH TPRERHSVTP AEGDLARPVP 
      1010       1020       1030       1040       1050
PAARRGARRR LTPEQKKRSY SEPEKMNEVG IVEEAEPAPL GPQRNGMRFP 
      1060       1070       1080       1090       1100
ESSVADRRRL FERDGKACST LSLSGPELKQ FQQSALADYI QRKTGKRPTS 
      1110       1120       1130       1140       1150
AAGCSLQEPG PLRERAQSAY LQPGPAALEG SGLASASSLS SLREPSLQPR 
      1160       1170       1180       1190       1200
REATLLPATV AETQQAPRDR SSSFAGGRRL GERRRGDLLS GANGGTRGTQ 
      1210       1220       1230       1240       1250
RGDETPREPS SWGARAGKSM SAEDLLERSD VLAGPVHVRS RSSPATADKR 
      1260       1270       1280       1290       1300
QDVLLGQDSG FGLVKDPCYL AGPGSRSLSC SERGQEEMLP LFHHLTPRWG 
      1310       1320       1330       1340       1350
GSGCKAIGDS SVPSECPGTL DHQRQASRTP CPRPPLAGTQ GLVTDTRAAP 
      1360       1370       1380       1390       1400
LTPIGTPLPS AIPSGYCSQD GQTGRQPLPP YTPAMMHRSN GHTLTQPPGP 
      1410       1420       1430       1440       1450
RGCEGDGPEH GVEEGTRKRV SLPQWPPPSR AKWAHAARED SLPEESSAPD 
      1460       1470       1480       1490       1500
FANLKHYQKQ QSLPSLCSTS DPDTPLGAPS TPGRISLRIS ESVLRDSPPP 
      1510       1520       1530       1540       1550
HEDYEDEVFV RDPHPKATSS PTFEPLPPPP PPPPSQETPV YSMDDFPPPP 
      1560       1570       1580       1590       1600
PHTVCEAQLD SEDPEGPRPS FNKLSKVTIA RERHMPGAAH VVGSQTLASR 
      1610       1620       1630       1640       1650
LQTSIKGSEA ESTPPSFMSV HAQLAGSLGG QPAPIQTQSL SHDPVSGTQG 
      1660       1670       1680       1690       1700
LEKKVSPDPQ KSSEDIRTEA LAKEIVHQDK SLADILDPDS RLKTTMDLME 
      1710       1720       1730       1740       1750
GLFPRDVNLL KENSVKRKAI QRTVSSSGCE GKRNEDKEAV SMLVNCPAYY 
      1760       1770       1780       1790       1800
SVSAPKAELL NKIKEMPAEV NEEEEQADVN EKKAELIGSL THKLETLQEA 
      1810       1820       1830       1840       1850
KGSLLTDIKL NNALGEEVEA LISELCKPNE FDKYRMFIGD LDKVVNLLLS 
      1860       1870       1880       1890       1900
LSGRLARVEN VLSGLGEDAS NEERSSLYEK RKILAGQHED ARELKENLDR 
      1910       1920       1930       1940       1950
RERVVLGILA NYLSEEQLQD YQHFVKMKST LLIEQRKLDD KIKLGQEQVK 
      1960       1970       1980       1990 
CLLESLPSDF IPKAGALALP PNLTSEPIPA GGCTFSGIFP TLTSPL
Length:1,996
Mass (Da):216,857
Last modified:July 13, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i735F6CD20FF64BC6
GO
Isoform 2 (identifier: Q8TF72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.
     126-153: SPEHLTSGPQHRKAAWSGGVKLRLKHRR → MAFYSTPEYDIQLARGLLSGMFLFATRR
     277-311: ISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVY → KRVKTRDLPGSQSPGRAISRKTTMPTSGGGWREKA
     312-1996: Missing.

Show »
Length:186
Mass (Da):20,457
Checksum:i5A9561BA6C6EF074
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y5P9A0A2R8Y5P9_HUMAN
Protein Shroom3
SHROOM3
1,915Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7T7A0A2R8Y7T7_HUMAN
Protein Shroom3
SHROOM3
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ13515 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB84689 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153R → S in BAB84689 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032062147L → H. Corresponds to variant dbSNP:rs3821979Ensembl.1
Natural variantiVAR_032063279G → A1 PublicationCorresponds to variant dbSNP:rs344140EnsemblClinVar.1
Natural variantiVAR_032064469P → A1 PublicationCorresponds to variant dbSNP:rs344141EnsemblClinVar.1
Natural variantiVAR_0320651290P → L2 PublicationsCorresponds to variant dbSNP:rs3733242Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0249651 – 125Missing in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_024966126 – 153SPEHL…LKHRR → MAFYSTPEYDIQLARGLLSG MFLFATRR in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_024967277 – 311ISGRE…VKTVY → KRVKTRDLPGSQSPGRAISR KTTMPTSGGGWREKA in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_024968312 – 1996Missing in isoform 2. 1 PublicationAdd BLAST1685

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB055660 mRNA Translation: BAB84689.1 Different initiation.
AK127929 mRNA Translation: BAC87195.1
AC096743 Genomic DNA No translation available.
AC107051 Genomic DNA No translation available.
AC107072 Genomic DNA No translation available.
AC112249 Genomic DNA No translation available.
AC121158 Genomic DNA No translation available.
AB040914 mRNA Translation: BAA96005.1
BC007291 mRNA Translation: AAH07291.1
AF109367 mRNA Translation: AAQ13515.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3579.2 [Q8TF72-1]

NCBI Reference Sequences

More...RefSeqi		NP_065910.3, NM_020859.3 [Q8TF72-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296043; ENSP00000296043; ENSG00000138771 [Q8TF72-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57619

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57619

UCSC genome browser

More...UCSCi		uc011cbx.3, human [Q8TF72-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055660 mRNA Translation: BAB84689.1 Different initiation.
AK127929 mRNA Translation: BAC87195.1
AC096743 Genomic DNA No translation available.
AC107051 Genomic DNA No translation available.
AC107072 Genomic DNA No translation available.
AC112249 Genomic DNA No translation available.
AC121158 Genomic DNA No translation available.
AB040914 mRNA Translation: BAA96005.1
BC007291 mRNA Translation: AAH07291.1
AF109367 mRNA Translation: AAQ13515.1 Different initiation.
CCDSiCCDS3579.2 [Q8TF72-1]
RefSeqiNP_065910.3, NM_020859.3 [Q8TF72-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FBBX-ray1.30P1240-1244[»]
6FCPX-ray1.45P1233-1247[»]
SMRiQ8TF72
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121665, 35 interactors
IntActiQ8TF72, 24 interactors
MINTiQ8TF72
STRINGi9606.ENSP00000296043

PTM databases

iPTMnetiQ8TF72
PhosphoSitePlusiQ8TF72
SwissPalmiQ8TF72

Genetic variation databases

BioMutaiSHROOM3
DMDMi300669666

Proteomic databases

EPDiQ8TF72
jPOSTiQ8TF72
MassIVEiQ8TF72
MaxQBiQ8TF72
PaxDbiQ8TF72
PeptideAtlasiQ8TF72
PRIDEiQ8TF72
ProteomicsDBi74572 [Q8TF72-1]
74573 [Q8TF72-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		62376, 59 antibodies

The DNASU plasmid repository

More...DNASUi		57619

Genome annotation databases

EnsembliENST00000296043; ENSP00000296043; ENSG00000138771 [Q8TF72-1]
GeneIDi57619
KEGGihsa:57619
UCSCiuc011cbx.3, human [Q8TF72-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57619
DisGeNETi57619

GeneCards: human genes, protein and diseases

More...GeneCardsi		SHROOM3
HGNCiHGNC:30422, SHROOM3
HPAiENSG00000138771, Tissue enhanced (salivary)
MIMi604570, gene
neXtProtiNX_Q8TF72
OpenTargetsiENSG00000138771
PharmGKBiPA147357295
VEuPathDBiHostDB:ENSG00000138771

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUU2, Eukaryota
GeneTreeiENSGT00940000157778
HOGENOMiCLU_002434_1_0_1
InParanoidiQ8TF72
OMAiFVKDLHP
OrthoDBi29607at2759
PhylomeDBiQ8TF72
TreeFamiTF333370

Enzyme and pathway databases

PathwayCommonsiQ8TF72

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57619, 2 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SHROOM3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SHROOM3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57619
PharosiQ8TF72, Tbio

Protein Ontology

More...PROi		PR:Q8TF72
RNActiQ8TF72, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138771, Expressed in pancreas and 194 other tissues
ExpressionAtlasiQ8TF72, baseline and differential
GenevisibleiQ8TF72, HS

Family and domain databases

Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR030494, Shrm3
IPR027685, Shroom_fam
PANTHERiPTHR15012, PTHR15012, 1 hit
PTHR15012:SF33, PTHR15012:SF33, 1 hit
PfamiView protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit
PS50106, PDZ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHRM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF72
Secondary accession number(s): Q5QTQ3
, Q6ZRW3, Q96IR9, Q9P247
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 13, 2010
Last modified: September 29, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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