UniProtKB - Q8TF72 (SHRM3_HUMAN)

BLAST

>sp|Q8TF72|SHRM3_HUMAN Protein Shroom3 OS=Homo sapiens OX=9606 GN=SHROOM3 PE=1 SV=2
MMRTTEDFHKPSATLNSNTATKGRYIYLEAFLEGGAPWGFTLKGGLEHGEPLIISKVEEG
GKADTLSSKLQAGDEVVHINEVTLSSSRKEAVSLVKGSYKTLRLVVRRDVCTDPGHADTG
ASNFVSPEHLTSGPQHRKAAWSGGVKLRLKHRRSEPAGRPHSWHTTKSGEKQPDASMMQI
SQGMIGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGAYPPCHLSPA
KSTGSIDQLSHFHNKRDSAYSSFSTSSSILEYPHPGISGRERSGSMDNTSARGGLLEGMR
QADIRYVKTVYDTRRGVSAEYEVNSSALLLQGREARASANGQGYDKWSNIPRGKGVPPPS
WSQQCPSSLETATDNLPPKVGAPLPPARSDSYAAFRHRERPSSWSSLDQKRLCRPQANSL
GSLKSPFIEEQLHTVLEKSPENSPPVKPKHNYTQKAQPGQPLLPTSIYPVPSLEPHFAQV
PQPSVSSNGMLYPALAKESGYIAPQGACNKMATIDENGNQNGSGRPGFAFCQPLEHDLLS
PVEKKPEATAKYVPSKVHFCSVPENEEDASLKRHLTPPQGNSPHSNERKSTHSNKPSSHP
HSLKCPQAQAWQAGEDKRSSRLSEPWEGDFQEDHNANLWRRLEREGLGQSLSGNFGKTKS
AFSSLQNIPESLRRHSSLELGRGTQEGYPGGRPTCAVNTKAEDPGRKAAPDLGSHLDRQV
SYPRPEGRTGASASFNSTDPSPEEPPAPSHPHTSSLGRRGPGPGSASALQGFQYGKPHCS
VLEKVSKFEQREQGSQRPSVGGSGFGHNYRPHRTVSTSSTSGNDFEETKAHIRFSESAEP
LGNGEQHFKNGELKLEEASRQPCGQQLSGGASDSGRGPQRPDARLLRSQSTFQLSSEPER
EPEWRDRPGSPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLELGAPVASRSWRPR
PSSAHVGLRSPEASASASPHTPRERHSVTPAEGDLARPVPPAARRGARRRLTPEQKKRSY
SEPEKMNEVGIVEEAEPAPLGPQRNGMRFPESSVADRRRLFERDGKACSTLSLSGPELKQ
FQQSALADYIQRKTGKRPTSAAGCSLQEPGPLRERAQSAYLQPGPAALEGSGLASASSLS
SLREPSLQPRREATLLPATVAETQQAPRDRSSSFAGGRRLGERRRGDLLSGANGGTRGTQ
RGDETPREPSSWGARAGKSMSAEDLLERSDVLAGPVHVRSRSSPATADKRQDVLLGQDSG
FGLVKDPCYLAGPGSRSLSCSERGQEEMLPLFHHLTPRWGGSGCKAIGDSSVPSECPGTL
DHQRQASRTPCPRPPLAGTQGLVTDTRAAPLTPIGTPLPSAIPSGYCSQDGQTGRQPLPP
YTPAMMHRSNGHTLTQPPGPRGCEGDGPEHGVEEGTRKRVSLPQWPPPSRAKWAHAARED
SLPEESSAPDFANLKHYQKQQSLPSLCSTSDPDTPLGAPSTPGRISLRISESVLRDSPPP
HEDYEDEVFVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDFPPPPPHTVCEAQLD
SEDPEGPRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSIKGSEAESTPPSFMSV
HAQLAGSLGGQPAPIQTQSLSHDPVSGTQGLEKKVSPDPQKSSEDIRTEALAKEIVHQDK
SLADILDPDSRLKTTMDLMEGLFPRDVNLLKENSVKRKAIQRTVSSSGCEGKRNEDKEAV
SMLVNCPAYYSVSAPKAELLNKIKEMPAEVNEEEEQADVNEKKAELIGSLTHKLETLQEA
KGSLLTDIKLNNALGEEVEALISELCKPNEFDKYRMFIGDLDKVVNLLLSLSGRLARVEN
VLSGLGEDASNEERSSLYEKRKILAGQHEDARELKENLDRRERVVLGILANYLSEEQLQD
YQHFVKMKSTLLIEQRKLDDKIKLGQEQVKCLLESLPSDFIPKAGALALPPNLTSEPIPA
GGCTFSGIFPTLTSPL

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History
Entry version 128 (07 Nov 2018)
Sequence version 2 (13 Jul 2010)
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Protein

Protein Shroom3

Gene

SHROOM3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator. Met-2 is more conserved than Met-1 among the orthologs.Curated

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
actin filament organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
apical protein localization Source: HGNC
cell morphogenesis Source: HGNC
cellular pigment accumulation Source: HGNC
epithelial cell development Source: InterPro
neural tube closure Source: InterPro
pattern specification process Source: HGNC
regulation of cell shape Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Developmental protein
Biological process	Cell shape

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Shroom3 Alternative name(s): Shroom-related protein Short name: hShrmL
Gene namesⁱ	Name:SHROOM3 Synonyms:KIAA1481, SHRML ORF Names:MSTP013
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138771.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30422 SHROOM3
MIMⁱ	604570 gene
neXtProtⁱ	NX_Q8TF72

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57619
Open Targets More...OpenTargetsⁱ	ENSG00000138771
PharmGKBⁱ	PA147357295

Polymorphism and mutation databases

BioMutaⁱ	SHROOM3
DMDMⁱ	300669666

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000286066	1 – 1996	Protein Shroom3Add BLAST		1996

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	213	PhosphoserineBy similarity	1
Modified residueⁱ	439	PhosphoserineCombined sources	1
Modified residueⁱ	443	PhosphoserineCombined sources	1
Modified residueⁱ	816	PhosphoserineCombined sources	1
Modified residueⁱ	890	PhosphoserineCombined sources	1
Modified residueⁱ	910	PhosphoserineCombined sources	1
Modified residueⁱ	913	PhosphoserineCombined sources	1
Modified residueⁱ	970	PhosphoserineCombined sources	1
Modified residueⁱ	1069	PhosphoserineBy similarity	1
Modified residueⁱ	1072	PhosphoserineBy similarity	1
Modified residueⁱ	1221	PhosphoserineCombined sources	1
Modified residueⁱ	1441	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8TF72
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TF72
PaxDbⁱ	Q8TF72
PeptideAtlas More...PeptideAtlasⁱ	Q8TF72
PRIDEⁱ	Q8TF72
ProteomicsDBⁱ	74572 74573 [Q8TF72-2]

PTM databases

iPTMnetⁱ	Q8TF72
PhosphoSitePlusⁱ	Q8TF72

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000138771 Expressed in 179 organ(s), highest expression level in pancreas
CleanExⁱ	HS_SHROOM3
Genevisibleⁱ	Q8TF72 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047784

HPAⁱ

HPA047784

Interactionⁱ

Subunit structureⁱ

Interacts with F-actin.By similarity

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121665, 18 interactors
IntActⁱ	Q8TF72, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q8TF72
STRINGⁱ	9606.ENSP00000296043

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TF72
SMRⁱ	Q8TF72
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 110	PDZPROSITE-ProRule annotationAdd BLAST	86
Domainⁱ	928 – 1030	ASD1PROSITE-ProRule annotationAdd BLAST	103
Domainⁱ	1669 – 1957	ASD2PROSITE-ProRule annotationAdd BLAST	289

Domainⁱ

The ASD1 domain mediates F-actin binding.By similarity

The ASD2 domain is required for apical constriction induction.By similarity

Sequence similaritiesⁱ

Belongs to the shroom family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410II86 Eukaryota ENOG41113GY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063061
HOGENOMⁱ	HOG000169233
HOVERGENⁱ	HBG108489
InParanoidⁱ	Q8TF72
KEGG Orthology (KO) More...KOⁱ	K18625
OMAⁱ	STHSNKP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00F1
PhylomeDBⁱ	Q8TF72
TreeFamⁱ	TF333370

Family and domain databases

InterProⁱ	View protein in InterPro IPR014800 ASD1_dom IPR014799 ASD2_dom IPR001478 PDZ IPR036034 PDZ_sf IPR030494 Shrm3 IPR027685 Shroom_fam
PANTHERⁱ	PTHR15012 PTHR15012, 1 hit PTHR15012:SF33 PTHR15012:SF33, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08688 ASD1, 1 hit PF08687 ASD2, 1 hit PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS51306 ASD1, 1 hit PS51307 ASD2, 1 hit PS50106 PDZ, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TF72-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMRTTEDFHK PSATLNSNTA TKGRYIYLEA FLEGGAPWGF TLKGGLEHGE 
        60         70         80         90        100
PLIISKVEEG GKADTLSSKL QAGDEVVHIN EVTLSSSRKE AVSLVKGSYK 
       110        120        130        140        150
TLRLVVRRDV CTDPGHADTG ASNFVSPEHL TSGPQHRKAA WSGGVKLRLK 
       160        170        180        190        200
HRRSEPAGRP HSWHTTKSGE KQPDASMMQI SQGMIGPPWH QSYHSSSSTS 
       210        220        230        240        250
DLSNYDHAYL RRSPDQCSSQ GSMESLEPSG AYPPCHLSPA KSTGSIDQLS 
       260        270        280        290        300
HFHNKRDSAY SSFSTSSSIL EYPHPGISGR ERSGSMDNTS ARGGLLEGMR 
       310        320        330        340        350
QADIRYVKTV YDTRRGVSAE YEVNSSALLL QGREARASAN GQGYDKWSNI 
       360        370        380        390        400
PRGKGVPPPS WSQQCPSSLE TATDNLPPKV GAPLPPARSD SYAAFRHRER 
       410        420        430        440        450
PSSWSSLDQK RLCRPQANSL GSLKSPFIEE QLHTVLEKSP ENSPPVKPKH 
       460        470        480        490        500
NYTQKAQPGQ PLLPTSIYPV PSLEPHFAQV PQPSVSSNGM LYPALAKESG 
       510        520        530        540        550
YIAPQGACNK MATIDENGNQ NGSGRPGFAF CQPLEHDLLS PVEKKPEATA 
       560        570        580        590        600
KYVPSKVHFC SVPENEEDAS LKRHLTPPQG NSPHSNERKS THSNKPSSHP 
       610        620        630        640        650
HSLKCPQAQA WQAGEDKRSS RLSEPWEGDF QEDHNANLWR RLEREGLGQS 
       660        670        680        690        700
LSGNFGKTKS AFSSLQNIPE SLRRHSSLEL GRGTQEGYPG GRPTCAVNTK 
       710        720        730        740        750
AEDPGRKAAP DLGSHLDRQV SYPRPEGRTG ASASFNSTDP SPEEPPAPSH 
       760        770        780        790        800
PHTSSLGRRG PGPGSASALQ GFQYGKPHCS VLEKVSKFEQ REQGSQRPSV 
       810        820        830        840        850
GGSGFGHNYR PHRTVSTSST SGNDFEETKA HIRFSESAEP LGNGEQHFKN 
       860        870        880        890        900
GELKLEEASR QPCGQQLSGG ASDSGRGPQR PDARLLRSQS TFQLSSEPER 
       910        920        930        940        950
EPEWRDRPGS PESPLLDAPF SRAYRNSIKD AQSRVLGATS FRRRDLELGA 
       960        970        980        990       1000
PVASRSWRPR PSSAHVGLRS PEASASASPH TPRERHSVTP AEGDLARPVP 
      1010       1020       1030       1040       1050
PAARRGARRR LTPEQKKRSY SEPEKMNEVG IVEEAEPAPL GPQRNGMRFP 
      1060       1070       1080       1090       1100
ESSVADRRRL FERDGKACST LSLSGPELKQ FQQSALADYI QRKTGKRPTS 
      1110       1120       1130       1140       1150
AAGCSLQEPG PLRERAQSAY LQPGPAALEG SGLASASSLS SLREPSLQPR 
      1160       1170       1180       1190       1200
REATLLPATV AETQQAPRDR SSSFAGGRRL GERRRGDLLS GANGGTRGTQ 
      1210       1220       1230       1240       1250
RGDETPREPS SWGARAGKSM SAEDLLERSD VLAGPVHVRS RSSPATADKR 
      1260       1270       1280       1290       1300
QDVLLGQDSG FGLVKDPCYL AGPGSRSLSC SERGQEEMLP LFHHLTPRWG 
      1310       1320       1330       1340       1350
GSGCKAIGDS SVPSECPGTL DHQRQASRTP CPRPPLAGTQ GLVTDTRAAP 
      1360       1370       1380       1390       1400
LTPIGTPLPS AIPSGYCSQD GQTGRQPLPP YTPAMMHRSN GHTLTQPPGP 
      1410       1420       1430       1440       1450
RGCEGDGPEH GVEEGTRKRV SLPQWPPPSR AKWAHAARED SLPEESSAPD 
      1460       1470       1480       1490       1500
FANLKHYQKQ QSLPSLCSTS DPDTPLGAPS TPGRISLRIS ESVLRDSPPP 
      1510       1520       1530       1540       1550
HEDYEDEVFV RDPHPKATSS PTFEPLPPPP PPPPSQETPV YSMDDFPPPP 
      1560       1570       1580       1590       1600
PHTVCEAQLD SEDPEGPRPS FNKLSKVTIA RERHMPGAAH VVGSQTLASR 
      1610       1620       1630       1640       1650
LQTSIKGSEA ESTPPSFMSV HAQLAGSLGG QPAPIQTQSL SHDPVSGTQG 
      1660       1670       1680       1690       1700
LEKKVSPDPQ KSSEDIRTEA LAKEIVHQDK SLADILDPDS RLKTTMDLME 
      1710       1720       1730       1740       1750
GLFPRDVNLL KENSVKRKAI QRTVSSSGCE GKRNEDKEAV SMLVNCPAYY 
      1760       1770       1780       1790       1800
SVSAPKAELL NKIKEMPAEV NEEEEQADVN EKKAELIGSL THKLETLQEA 
      1810       1820       1830       1840       1850
KGSLLTDIKL NNALGEEVEA LISELCKPNE FDKYRMFIGD LDKVVNLLLS 
      1860       1870       1880       1890       1900
LSGRLARVEN VLSGLGEDAS NEERSSLYEK RKILAGQHED ARELKENLDR 
      1910       1920       1930       1940       1950
RERVVLGILA NYLSEEQLQD YQHFVKMKST LLIEQRKLDD KIKLGQEQVK 
      1960       1970       1980       1990 
CLLESLPSDF IPKAGALALP PNLTSEPIPA GGCTFSGIFP TLTSPL

Length:1,996

Mass (Da):216,857

Last modified:July 13, 2010 - v2

Checksum:ⁱ735F6CD20FF64BC6

Isoform 2 (identifier: Q8TF72-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.
     126-153: SPEHLTSGPQHRKAAWSGGVKLRLKHRR → MAFYSTPEYDIQLARGLLSGMFLFATRR
     277-311: ISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVY → KRVKTRDLPGSQSPGRAISRKTTMPTSGGGWREKA
     312-1996: Missing.

« Hide

        10         20         30         40         50
MAFYSTPEYD IQLARGLLSG MFLFATRRSE PAGRPHSWHT TKSGEKQPDA 
        60         70         80         90        100
SMMQISQGMI GPPWHQSYHS SSSTSDLSNY DHAYLRRSPD QCSSQGSMES 
       110        120        130        140        150
LEPSGAYPPC HLSPAKSTGS IDQLSHFHNK RDSAYSSFST SSSILEYPHP 
       160        170        180 
GKRVKTRDLP GSQSPGRAIS RKTTMPTSGG GWREKA

Show »

Length:186

Mass (Da):20,457

Checksum:ⁱ5A9561BA6C6EF074

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2R8Y5P9	A0A2R8Y5P9_HUMAN	Protein Shroom3 Protein Shroom3	SHROOM3	1,915	Annotation score:
A0A2R8Y7T7	A0A2R8Y7T7_HUMAN	Protein Shroom3 Protein Shroom3	SHROOM3	50	Annotation score:

Sequence cautionⁱ

The sequence AAQ13515 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB84689 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	153	R → S in BAB84689 (Ref. 1) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032062	147	L → H. Corresponds to variant dbSNP:rs3821979Ensembl.	1
Natural variantⁱVAR_032063	279	G → A1 PublicationCorresponds to variant dbSNP:rs344140EnsemblClinVar.	1
Natural variantⁱVAR_032064	469	P → A1 PublicationCorresponds to variant dbSNP:rs344141EnsemblClinVar.	1
Natural variantⁱVAR_032065	1290	P → L2 PublicationsCorresponds to variant dbSNP:rs3733242Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_024965	1 – 125	Missing in isoform 2. 1 PublicationAdd BLAST	125
Alternative sequenceⁱVSP_024966	126 – 153	SPEHL…LKHRR → MAFYSTPEYDIQLARGLLSG MFLFATRR in isoform 2. 1 PublicationAdd BLAST	28
Alternative sequenceⁱVSP_024967	277 – 311	ISGRE…VKTVY → KRVKTRDLPGSQSPGRAISR KTTMPTSGGGWREKA in isoform 2. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_024968	312 – 1996	Missing in isoform 2. 1 PublicationAdd BLAST	1685

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB055660 mRNA Translation: BAB84689.1 Different initiation. AK127929 mRNA Translation: BAC87195.1 AC096743 Genomic DNA No translation available. AC107051 Genomic DNA No translation available. AC107072 Genomic DNA No translation available. AC112249 Genomic DNA No translation available. AC121158 Genomic DNA No translation available. AB040914 mRNA Translation: BAA96005.1 BC007291 mRNA Translation: AAH07291.1 AF109367 mRNA Translation: AAQ13515.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3579.2 [Q8TF72-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_065910.3, NM_020859.3 [Q8TF72-1]
UniGeneⁱ	Hs.683808 Hs.702168

Genome annotation databases

Ensemblⁱ	ENST00000296043; ENSP00000296043; ENSG00000138771 [Q8TF72-1]
GeneIDⁱ	57619
KEGGⁱ	hsa:57619
UCSC genome browser More...UCSCⁱ	uc011cbx.3 human [Q8TF72-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TF72	SHROOM3 isoform 1		PONAB		2002	UniRef90_Q8TF72
Protein Shroom3 (Fragment)		MACMU		127
Shroom family member 3		CALJA		2001
SHROOM3 isoform 1		PANTR		1996
Uncharacterized protein		CERAT		1996
+76

Protein	Similar proteins		Species	Score	Length	Source
Q8TF72	SHROOM3 isoform 1		PONAB		2002	UniRef50_Q8TF72
Protein Shroom3 (Fragment)		MACMU		127
Shroom family member 3		CALJA		2001
Uncharacterized protein		MANLE		1996
SHROOM3 isoform 1		PANTR		1996
+206

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB055660 mRNA Translation: BAB84689.1 Different initiation. AK127929 mRNA Translation: BAC87195.1 AC096743 Genomic DNA No translation available. AC107051 Genomic DNA No translation available. AC107072 Genomic DNA No translation available. AC112249 Genomic DNA No translation available. AC121158 Genomic DNA No translation available. AB040914 mRNA Translation: BAA96005.1 BC007291 mRNA Translation: AAH07291.1 AF109367 mRNA Translation: AAQ13515.1 Different initiation.
CCDSⁱ	CCDS3579.2 [Q8TF72-1]
RefSeqⁱ	NP_065910.3, NM_020859.3 [Q8TF72-1]
UniGeneⁱ	Hs.683808 Hs.702168

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6FBB	X-ray	1.30	P	1240-1244	[»]
	6FCP	X-ray	1.45	P	1233-1247	[»]
ProteinModelPortalⁱ	Q8TF72
SMRⁱ	Q8TF72
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121665, 18 interactors
IntActⁱ	Q8TF72, 14 interactors
MINTⁱ	Q8TF72
STRINGⁱ	9606.ENSP00000296043

PTM databases

iPTMnetⁱ	Q8TF72
PhosphoSitePlusⁱ	Q8TF72

Polymorphism and mutation databases

BioMutaⁱ	SHROOM3
DMDMⁱ	300669666

Proteomic databases

EPDⁱ	Q8TF72
MaxQBⁱ	Q8TF72
PaxDbⁱ	Q8TF72
PeptideAtlasⁱ	Q8TF72
PRIDEⁱ	Q8TF72
ProteomicsDBⁱ	74572 74573 [Q8TF72-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296043; ENSP00000296043; ENSG00000138771 [Q8TF72-1]
GeneIDⁱ	57619
KEGGⁱ	hsa:57619
UCSCⁱ	uc011cbx.3 human [Q8TF72-1]

Organism-specific databases

CTDⁱ	57619
DisGeNETⁱ	57619
EuPathDBⁱ	HostDB:ENSG00000138771.14
GeneCardsⁱ	SHROOM3
H-InvDBⁱ	HIX0004309 HIX0163999
HGNCⁱ	HGNC:30422 SHROOM3
HPAⁱ	HPA047784
MIMⁱ	604570 gene
neXtProtⁱ	NX_Q8TF72
OpenTargetsⁱ	ENSG00000138771
PharmGKBⁱ	PA147357295
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II86 Eukaryota ENOG41113GY LUCA
GeneTreeⁱ	ENSGT00530000063061
HOGENOMⁱ	HOG000169233
HOVERGENⁱ	HBG108489
InParanoidⁱ	Q8TF72
KOⁱ	K18625
OMAⁱ	STHSNKP
OrthoDBⁱ	EOG091G00F1
PhylomeDBⁱ	Q8TF72
TreeFamⁱ	TF333370

Miscellaneous databases

ChiTaRSⁱ	SHROOM3 human
GeneWikiⁱ	SHROOM3
GenomeRNAiⁱ	57619
Protein Ontology More...PROⁱ	PR:Q8TF72
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000138771 Expressed in 179 organ(s), highest expression level in pancreas
CleanExⁱ	HS_SHROOM3
Genevisibleⁱ	Q8TF72 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR014800 ASD1_dom IPR014799 ASD2_dom IPR001478 PDZ IPR036034 PDZ_sf IPR030494 Shrm3 IPR027685 Shroom_fam
PANTHERⁱ	PTHR15012 PTHR15012, 1 hit PTHR15012:SF33 PTHR15012:SF33, 1 hit
Pfamⁱ	View protein in Pfam PF08688 ASD1, 1 hit PF08687 ASD2, 1 hit PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS51306 ASD1, 1 hit PS51307 ASD2, 1 hit PS50106 PDZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SHRM3_HUMAN
Accessionⁱ	Q8TF72Primary (citable) accession number: Q8TF72 Secondary accession number(s): Q5QTQ3 , Q6ZRW3, Q96IR9, Q9P247
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	July 13, 2010
	Last modified:	November 7, 2018
	This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8TF72 (SHRM3_HUMAN)

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Protein Shroom3

SHROOM3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

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GO - Biological processi

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Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Phylogenomic databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ