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Protein

Monocarboxylate transporter 10

Gene

SLC16A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: Reactome
  • aromatic amino acid transport Source: HGNC

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.1.13.8 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 10
Short name:
MCT 10
Alternative name(s):
Aromatic amino acid transporter 1
Solute carrier family 16 member 10
T-type amino acid transporter 1
Gene namesi
Name:SLC16A10
Synonyms:MCT10, TAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112394.16
HGNCiHGNC:17027 SLC16A10
MIMi607550 gene
neXtProtiNX_Q8TF71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66CytoplasmicSequence analysisAdd BLAST66
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 515CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi117247
OpenTargetsiENSG00000112394
PharmGKBiPA38197

Chemistry databases

DrugBankiDB02952 Alpha-Aminoisobutyric Acid
DB03107 Beta-Alanine
DB01786 D-Alanine
DB01746 D-Leucine
DB02556 D-Phenylalanine
DB03929 D-Serine
DB03225 D-Tryptophan
DB03839 D-Tyrosine
DB06262 Droxidopa
DB00145 Glycine
DB00160 L-Alanine
DB00125 L-Arginine
DB00174 L-Asparagine
DB00128 L-Aspartic Acid
DB00151 L-Cysteine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00130 L-Glutamine
DB00117 L-Histidine
DB00167 L-Isoleucine
DB00149 L-Leucine
DB00123 L-Lysine
DB00134 L-Methionine
DB00120 L-Phenylalanine
DB00172 L-Proline
DB00133 L-Serine
DB00156 L-Threonine
DB00150 L-Tryptophan
DB00135 L-Tyrosine
DB00161 L-Valine
DB04398 Lactic Acid
DB01235 Levodopa
DB00279 Liothyronine
DB01583 Liotrix
DB00119 Pyruvic acid

Polymorphism and mutation databases

BioMutaiSLC16A10
DMDMi74751472

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003142531 – 515Monocarboxylate transporter 10Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei503PhosphoserineBy similarity1
Modified residuei504PhosphoserineBy similarity1

Post-translational modificationi

Not N-glycosylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TF71
MaxQBiQ8TF71
PaxDbiQ8TF71
PeptideAtlasiQ8TF71
PRIDEiQ8TF71
ProteomicsDBi74571

PTM databases

iPTMnetiQ8TF71
PhosphoSitePlusiQ8TF71

Expressioni

Tissue specificityi

Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.1 Publication

Gene expression databases

BgeeiENSG00000112394 Expressed in 147 organ(s), highest expression level in gastrocnemius
CleanExiHS_SLC16A10
ExpressionAtlasiQ8TF71 baseline and differential
GenevisibleiQ8TF71 HS

Organism-specific databases

HPAiHPA016860

Interactioni

Protein-protein interaction databases

BioGridi125582, 18 interactors
IntActiQ8TF71, 4 interactors
STRINGi9606.ENSP00000357844

Structurei

3D structure databases

ProteinModelPortaliQ8TF71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00910000144077
HOGENOMiHOG000046644
HOVERGENiHBG006387
InParanoidiQ8TF71
KOiK08187
OMAiHLMKHVN
OrthoDBiEOG091G0449
PhylomeDBiQ8TF71
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030762 MCT10
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF119 PTHR11360:SF119, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8TF71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSQEEPDS ARGTSEAQPL GPAPTGAAPP PGPGPSDSPE AAVEKVEVEL
60 70 80 90 100
AGPATAEPHE PPEPPEGGWG WLVMLAAMWC NGSVFGIQNA CGVLFVSMLE
110 120 130 140 150
TFGSKDDDKM VFKTAWVGSL SMGMIFFCCP IVSVFTDLFG CRKTAVVGAA
160 170 180 190 200
VGFVGLMSSS FVSSIEPLYL TYGIIFACGC SFAYQPSLVI LGHYFKKRLG
210 220 230 240 250
LVNGIVTAGS SVFTILLPLL LRVLIDSVGL FYTLRVLCIF MFVLFLAGFT
260 270 280 290 300
YRPLATSTKD KESGGSGSSL FSRKKFSPPK KIFNFAIFKV TAYAVWAVGI
310 320 330 340 350
PLALFGYFVP YVHLMKHVNE RFQDEKNKEV VLMCIGVTSG VGRLLFGRIA
360 370 380 390 400
DYVPGVKKVY LQVLSFFFIG LMSMMIPLCS IFGALIAVCL IMGLFDGCFI
410 420 430 440 450
SIMAPIAFEL VGAQDVSQAI GFLLGFMSIP MTVGPPIAGL LRDKLGSYDV
460 470 480 490 500
AFYLAGVPPL IGGAVLCFIP WIHSKKQREI SKTTGKEKME KMLENQNSLL
510
SSSSGMFKKE SDSII
Length:515
Mass (Da):55,493
Last modified:June 1, 2002 - v1
Checksum:iA870E4DDC26B918E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9P1I2Q9P1I2_HUMAN
Monocarboxylate transporter 10
SLC16A10
201Annotation score:
H0Y3W8H0Y3W8_HUMAN
Monocarboxylate transporter 10
SLC16A10
206Annotation score:
H0Y5M8H0Y5M8_HUMAN
Monocarboxylate transporter 10
SLC16A10
211Annotation score:
A0A087X138A0A087X138_HUMAN
Monocarboxylate transporter 10
SLC16A10
326Annotation score:

Sequence cautioni

The sequence AAH17968 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti422F → L in AAH17968 (PubMed:15489334).Curated1
Sequence conflicti431M → T in BAD18768 (PubMed:14702039).Curated1
Sequence conflicti443D → G in BAD18768 (PubMed:14702039).Curated1
Sequence conflicti508K → E in AAH17968 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037874508K → Q. Corresponds to variant dbSNP:rs17072442Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057445 mRNA Translation: BAB84670.1
AK126183 mRNA Translation: BAG54292.1
AK172789 mRNA Translation: BAD18768.1
AL360227 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48298.1
BC017968 mRNA Translation: AAH17968.1 Different initiation.
BC066985 mRNA Translation: AAH66985.1
CCDSiCCDS5089.1
RefSeqiNP_061063.2, NM_018593.4
UniGeneiHs.591327

Genome annotation databases

EnsembliENST00000368851; ENSP00000357844; ENSG00000112394
GeneIDi117247
KEGGihsa:117247
UCSCiuc003pus.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057445 mRNA Translation: BAB84670.1
AK126183 mRNA Translation: BAG54292.1
AK172789 mRNA Translation: BAD18768.1
AL360227 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48298.1
BC017968 mRNA Translation: AAH17968.1 Different initiation.
BC066985 mRNA Translation: AAH66985.1
CCDSiCCDS5089.1
RefSeqiNP_061063.2, NM_018593.4
UniGeneiHs.591327

3D structure databases

ProteinModelPortaliQ8TF71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125582, 18 interactors
IntActiQ8TF71, 4 interactors
STRINGi9606.ENSP00000357844

Chemistry databases

DrugBankiDB02952 Alpha-Aminoisobutyric Acid
DB03107 Beta-Alanine
DB01786 D-Alanine
DB01746 D-Leucine
DB02556 D-Phenylalanine
DB03929 D-Serine
DB03225 D-Tryptophan
DB03839 D-Tyrosine
DB06262 Droxidopa
DB00145 Glycine
DB00160 L-Alanine
DB00125 L-Arginine
DB00174 L-Asparagine
DB00128 L-Aspartic Acid
DB00151 L-Cysteine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00130 L-Glutamine
DB00117 L-Histidine
DB00167 L-Isoleucine
DB00149 L-Leucine
DB00123 L-Lysine
DB00134 L-Methionine
DB00120 L-Phenylalanine
DB00172 L-Proline
DB00133 L-Serine
DB00156 L-Threonine
DB00150 L-Tryptophan
DB00135 L-Tyrosine
DB00161 L-Valine
DB04398 Lactic Acid
DB01235 Levodopa
DB00279 Liothyronine
DB01583 Liotrix
DB00119 Pyruvic acid

Protein family/group databases

TCDBi2.A.1.13.8 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8TF71
PhosphoSitePlusiQ8TF71

Polymorphism and mutation databases

BioMutaiSLC16A10
DMDMi74751472

Proteomic databases

EPDiQ8TF71
MaxQBiQ8TF71
PaxDbiQ8TF71
PeptideAtlasiQ8TF71
PRIDEiQ8TF71
ProteomicsDBi74571

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368851; ENSP00000357844; ENSG00000112394
GeneIDi117247
KEGGihsa:117247
UCSCiuc003pus.4 human

Organism-specific databases

CTDi117247
DisGeNETi117247
EuPathDBiHostDB:ENSG00000112394.16
GeneCardsiSLC16A10
HGNCiHGNC:17027 SLC16A10
HPAiHPA016860
MIMi607550 gene
neXtProtiNX_Q8TF71
OpenTargetsiENSG00000112394
PharmGKBiPA38197
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00910000144077
HOGENOMiHOG000046644
HOVERGENiHBG006387
InParanoidiQ8TF71
KOiK08187
OMAiHLMKHVN
OrthoDBiEOG091G0449
PhylomeDBiQ8TF71
TreeFamiTF313792

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

ChiTaRSiSLC16A10 human
GeneWikiiSLC16A10
GenomeRNAii117247
PROiPR:Q8TF71
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112394 Expressed in 147 organ(s), highest expression level in gastrocnemius
CleanExiHS_SLC16A10
ExpressionAtlasiQ8TF71 baseline and differential
GenevisibleiQ8TF71 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030762 MCT10
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF119 PTHR11360:SF119, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT10_HUMAN
AccessioniPrimary (citable) accession number: Q8TF71
Secondary accession number(s): B3KWY0, Q6ZMG0, Q8WVI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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