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Protein

Zinc finger protein 384

Gene

ZNF384

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 250C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 397C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri403 – 425C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 384
Alternative name(s):
CAG repeat protein 1
CAS-interacting zinc finger protein
Nuclear matrix transcription factor 4
Short name:
Nuclear matrix protein 4
Trinucleotide repeat-containing gene 1 protein
Gene namesi
Name:ZNF384
Synonyms:CAGH1, CIZ, NMP4, TNRC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000126746.17
HGNCiHGNC:11955 ZNF384
MIMi609951 gene
neXtProtiNX_Q8TF68

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi171017
OpenTargetsiENSG00000126746
PharmGKBiPA36644

Polymorphism and mutation databases

BioMutaiZNF384
DMDMi296453052

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475521 – 577Zinc finger protein 384Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TF68
MaxQBiQ8TF68
PaxDbiQ8TF68
PeptideAtlasiQ8TF68
PRIDEiQ8TF68
ProteomicsDBi74568
74569 [Q8TF68-2]
74570 [Q8TF68-3]

PTM databases

iPTMnetiQ8TF68
PhosphoSitePlusiQ8TF68

Expressioni

Gene expression databases

BgeeiENSG00000126746
CleanExiHS_ZNF384
ExpressionAtlasiQ8TF68 baseline and differential
GenevisibleiQ8TF68 HS

Organism-specific databases

HPAiHPA004051

Interactioni

Subunit structurei

Interacts with BCAR1.By similarity

Protein-protein interaction databases

BioGridi128100, 8 interactors
IntActiQ8TF68, 3 interactors
STRINGi9606.ENSP00000354592

Structurei

3D structure databases

ProteinModelPortaliQ8TF68
SMRiQ8TF68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi461 – 521Gln-richAdd BLAST61
Compositional biasi466 – 499Ala-richAdd BLAST34

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 250C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 397C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri403 – 425C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149029
HOGENOMiHOG000233753
HOVERGENiHBG058173
InParanoidiQ8TF68
OMAiSHFNSSP
OrthoDBiEOG091G05IN
PhylomeDBiQ8TF68
TreeFamiTF336115

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q8TF68-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESHFNSNP YFWPSIPTVS GQIENTMFIN KMKDQLLPEK GCGLAPPHYP
60 70 80 90 100
TLLTVPASVS LPSGISMDTE SKSDQLTPHS QASVTQNITV VPVPSTGLMT
110 120 130 140 150
AGVSCSQRWR REGSQSRGPG LVITSPSGSL VTTASSAQTF PISAPMIVSA
160 170 180 190 200
LPPGSQALQV VPDLSKKVAS TLTEEGGGGG GGGGSVAPKP PRGRKKKRML
210 220 230 240 250
ESGLPEMNDP YVLSPEDDDD HQKDGKTYRC RMCSLTFYSK SEMQIHSKSH
260 270 280 290 300
TETKPHKCPH CSKTFANSSY LAQHIRIHSG AKPYSCNFCE KSFRQLSHLQ
310 320 330 340 350
QHTRIHSKMH TETIKPHKCP HCSKTFANTS YLAQHLRIHS GAKPYNCSYC
360 370 380 390 400
QKAFRQLSHL QQHTRIHTGD RPYKCAHPGC EKAFTQLSNL QSHRRQHNKD
410 420 430 440 450
KPFKCHNCHR AYTDAASLEV HLSTHTVKHA KVYTCTICSR AYTSETYLMK
460 470 480 490 500
HMRKHNPPDL QQQVQAAAAA AAVAQAQAQA QAQAQAQAQA QAQAQASQAS
510 520 530 540 550
QQQQQQQQQQ QQQQQQPPPH FQSPGAAPQG GGGGDSNPNP PPQCSFDLTP
560 570
YKTAEHHKDI CLTVTTSTIQ VEHLASS
Length:577
Mass (Da):63,219
Last modified:May 18, 2010 - v2
Checksum:i5899CAB02DBBE0CB
GO
Isoform 2 (identifier: Q8TF68-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-360: Missing.

Show »
Length:516
Mass (Da):56,106
Checksum:iF42612264741B6DD
GO
Isoform 3 (identifier: Q8TF68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-156: Missing.
     293-353: Missing.

Note: No experimental confirmation available.
Show »
Length:461
Mass (Da):50,538
Checksum:i01DFDE11A18418D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti501Missing in BAB85125 (Ref. 1) Curated1
Sequence conflicti501Missing in BAC04618 (PubMed:14702039).Curated1
Sequence conflicti501Missing in EAW88756 (Ref. 4) Curated1
Sequence conflicti501Missing in AAH53361 (PubMed:15489334).Curated1
Sequence conflicti501Missing in AAB91437 (PubMed:9225980).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040314102 – 156Missing in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_040315293 – 353Missing in isoform 3. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_006920300 – 360Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070238 Genomic DNA Translation: BAB85125.1
AK095734 mRNA Translation: BAC04618.1
AC125494 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88756.1
BC053361 mRNA Translation: AAH53361.1
U80738 mRNA Translation: AAB91437.1
CCDSiCCDS31732.1 [Q8TF68-3]
CCDS44817.1 [Q8TF68-1]
CCDS8557.1 [Q8TF68-2]
RefSeqiNP_001035009.1, NM_001039920.2 [Q8TF68-3]
NP_001129206.1, NM_001135734.2 [Q8TF68-1]
NP_597733.2, NM_133476.4 [Q8TF68-2]
XP_016874430.1, XM_017018941.1 [Q8TF68-1]
XP_016874431.1, XM_017018942.1 [Q8TF68-1]
XP_016874432.1, XM_017018943.1 [Q8TF68-1]
XP_016874438.1, XM_017018949.1 [Q8TF68-2]
XP_016874439.1, XM_017018950.1 [Q8TF68-2]
UniGeneiHs.103315

Genome annotation databases

EnsembliENST00000319770; ENSP00000321650; ENSG00000126746 [Q8TF68-2]
ENST00000355772; ENSP00000348018; ENSG00000126746 [Q8TF68-3]
ENST00000361959; ENSP00000354592; ENSG00000126746 [Q8TF68-1]
ENST00000396801; ENSP00000380019; ENSG00000126746 [Q8TF68-1]
GeneIDi171017
KEGGihsa:171017
UCSCiuc001qqa.4 human [Q8TF68-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN384_HUMAN
AccessioniPrimary (citable) accession number: Q8TF68
Secondary accession number(s): O15407, Q7Z722, Q8N938
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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