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Protein

Leucine-rich repeat-containing protein 15

Gene

LRRC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 15
Alternative name(s):
Leucine-rich repeat protein induced by beta-amyloid homolog
Short name:
hLib
Gene namesi
Name:LRRC15
Synonyms:LIB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172061.8
HGNCiHGNC:20818 LRRC15
neXtProtiNX_Q8TF66

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 538ExtracellularSequence analysisAdd BLAST517
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 581CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi131578
OpenTargetsiENSG00000172061
PharmGKBiPA134956867

Polymorphism and mutation databases

BioMutaiLRRC15
DMDMi334302830

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002160522 – 581Leucine-rich repeat-containing protein 15Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi369N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TF66
MaxQBiQ8TF66
PaxDbiQ8TF66
PeptideAtlasiQ8TF66
PRIDEiQ8TF66
ProteomicsDBi74566
74567 [Q8TF66-2]

PTM databases

GlyConnecti1451
iPTMnetiQ8TF66
PhosphoSitePlusiQ8TF66

Expressioni

Tissue specificityi

Brain and placenta.

Gene expression databases

BgeeiENSG00000172061 Expressed in 97 organ(s), highest expression level in periodontal ligament
CleanExiHS_LRRC15
GenevisibleiQ8TF66 HS

Organism-specific databases

HPAiHPA035503

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126287, 65 interactors
IntActiQ8TF66, 3 interactors
STRINGi9606.ENSP00000389128

Structurei

3D structure databases

ProteinModelPortaliQ8TF66
SMRiQ8TF66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 53LRRNTAdd BLAST32
Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Repeati222 – 243LRR 8Add BLAST22
Repeati246 – 267LRR 9Add BLAST22
Repeati270 – 291LRR 10Add BLAST22
Repeati294 – 315LRR 11Add BLAST22
Repeati318 – 339LRR 12Add BLAST22
Repeati342 – 363LRR 13Add BLAST22
Repeati366 – 387LRR 14Add BLAST22
Repeati390 – 411LRR 15Add BLAST22
Domaini423 – 475LRRCTAdd BLAST53

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000040004
HOVERGENiHBG052343
InParanoidiQ8TF66
OMAiMTIQLQN
OrthoDBiEOG091G057B
TreeFamiTF351124

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 2 hits
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 14 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TF66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLKHYLLLL VGCQAWGAGL AYHGCPSECT CSRASQVECT GARIVAVPTP
60 70 80 90 100
LPWNAMSLQI LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL
110 120 130 140 150
GSLRYLSLAN NKLQVLPIGL FQGLDSLESL LLSSNQLLQI QPAHFSQCSN
160 170 180 190 200
LKELQLHGNH LEYIPDGAFD HLVGLTKLNL GKNSLTHISP RVFQHLGNLQ
210 220 230 240 250
VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL FHNNHNLQRL
260 270 280 290 300
YLSNNHISQL PPSVFMQLPQ LNRLTLFGNS LKELSPGIFG PMPNLRELWL
310 320 330 340 350
YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT
360 370 380 390 400
NALQDLDGNV FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ
410 420 430 440 450
LENLPLGIFD HLGKLCELRL YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV
460 470 480 490 500
PVCFSPANVR GQSLIIINVN VAVPSVHVPE VPSYPETPWY PDTPSYPDTT
510 520 530 540 550
SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA IAAIVIGIVA
560 570 580
LACSLAACVG CCCCKKRSQA VLMQMKAPNE C
Length:581
Mass (Da):64,366
Last modified:May 31, 2011 - v2
Checksum:i1CA7B1752C7FE5B3
GO
Isoform 2 (identifier: Q8TF66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPLDKAM

Show »
Length:587
Mass (Da):65,022
Checksum:i3B047531FCF9EF9F
GO

Sequence cautioni

The sequence AAI01065 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence DAA01740 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051101264V → I2 PublicationsCorresponds to variant dbSNP:rs13060627Ensembl.1
Natural variantiVAR_051102286P → L2 PublicationsCorresponds to variant dbSNP:rs13070515Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0411301M → MPLDKAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071037 mRNA Translation: BAB84587.1
AC125362 Genomic DNA No translation available.
AC174158 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78054.1
BC101064 mRNA Translation: AAI01065.1 Different initiation.
BC101065 mRNA Translation: AAI01066.1
BK001325 mRNA Translation: DAA01740.1 Different initiation.
CCDSiCCDS3306.1 [Q8TF66-1]
CCDS46984.1 [Q8TF66-2]
RefSeqiNP_001128529.2, NM_001135057.2 [Q8TF66-2]
NP_570843.2, NM_130830.4 [Q8TF66-1]
UniGeneiHs.288467

Genome annotation databases

EnsembliENST00000347624; ENSP00000306276; ENSG00000172061 [Q8TF66-1]
ENST00000428839; ENSP00000413707; ENSG00000172061 [Q8TF66-2]
GeneIDi131578
KEGGihsa:131578
UCSCiuc003ftt.4 human [Q8TF66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071037 mRNA Translation: BAB84587.1
AC125362 Genomic DNA No translation available.
AC174158 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78054.1
BC101064 mRNA Translation: AAI01065.1 Different initiation.
BC101065 mRNA Translation: AAI01066.1
BK001325 mRNA Translation: DAA01740.1 Different initiation.
CCDSiCCDS3306.1 [Q8TF66-1]
CCDS46984.1 [Q8TF66-2]
RefSeqiNP_001128529.2, NM_001135057.2 [Q8TF66-2]
NP_570843.2, NM_130830.4 [Q8TF66-1]
UniGeneiHs.288467

3D structure databases

ProteinModelPortaliQ8TF66
SMRiQ8TF66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126287, 65 interactors
IntActiQ8TF66, 3 interactors
STRINGi9606.ENSP00000389128

PTM databases

GlyConnecti1451
iPTMnetiQ8TF66
PhosphoSitePlusiQ8TF66

Polymorphism and mutation databases

BioMutaiLRRC15
DMDMi334302830

Proteomic databases

EPDiQ8TF66
MaxQBiQ8TF66
PaxDbiQ8TF66
PeptideAtlasiQ8TF66
PRIDEiQ8TF66
ProteomicsDBi74566
74567 [Q8TF66-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347624; ENSP00000306276; ENSG00000172061 [Q8TF66-1]
ENST00000428839; ENSP00000413707; ENSG00000172061 [Q8TF66-2]
GeneIDi131578
KEGGihsa:131578
UCSCiuc003ftt.4 human [Q8TF66-1]

Organism-specific databases

CTDi131578
DisGeNETi131578
EuPathDBiHostDB:ENSG00000172061.8
GeneCardsiLRRC15
H-InvDBiHIX0003982
HGNCiHGNC:20818 LRRC15
HPAiHPA035503
neXtProtiNX_Q8TF66
OpenTargetsiENSG00000172061
PharmGKBiPA134956867
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000040004
HOVERGENiHBG052343
InParanoidiQ8TF66
OMAiMTIQLQN
OrthoDBiEOG091G057B
TreeFamiTF351124

Miscellaneous databases

ChiTaRSiLRRC15 human
GenomeRNAii131578
PROiPR:Q8TF66

Gene expression databases

BgeeiENSG00000172061 Expressed in 97 organ(s), highest expression level in periodontal ligament
CleanExiHS_LRRC15
GenevisibleiQ8TF66 HS

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 2 hits
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 14 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC15_HUMAN
AccessioniPrimary (citable) accession number: Q8TF66
Secondary accession number(s): Q495Q6, Q7RTN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 31, 2011
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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