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Entry version 155 (16 Oct 2019)
Sequence version 2 (31 May 2011)
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Protein

Leucine-rich repeat-containing protein 15

Gene

LRRC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.43.1.13 the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 15
Alternative name(s):
Leucine-rich repeat protein induced by beta-amyloid homolog
Short name:
hLib
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC15
Synonyms:LIB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20818 LRRC15

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 538ExtracellularSequence analysisAdd BLAST517
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 581CytoplasmicSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
131578

Open Targets

More...
OpenTargetsi
ENSG00000172061

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956867

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TF66

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
334302830

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002160522 – 581Leucine-rich repeat-containing protein 15Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi369N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TF66

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TF66

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TF66

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TF66

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TF66

PeptideAtlas

More...
PeptideAtlasi
Q8TF66

PRoteomics IDEntifications database

More...
PRIDEi
Q8TF66

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74566 [Q8TF66-1]
74567 [Q8TF66-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1451

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TF66

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TF66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172061 Expressed in 97 organ(s), highest expression level in periodontal ligament

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TF66 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035503

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126287, 69 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TF66, 47 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000413707

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 53LRRNTAdd BLAST32
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Repeati222 – 243LRR 8Add BLAST22
Repeati246 – 267LRR 9Add BLAST22
Repeati270 – 291LRR 10Add BLAST22
Repeati294 – 315LRR 11Add BLAST22
Repeati318 – 339LRR 12Add BLAST22
Repeati342 – 363LRR 13Add BLAST22
Repeati366 – 387LRR 14Add BLAST22
Repeati390 – 411LRR 15Add BLAST22
Domaini423 – 475LRRCTAdd BLAST53

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161771

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000040004

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TF66

Identification of Orthologs from Complete Genome Data

More...
OMAi
WGMTRAQ

Database of Orthologous Groups

More...
OrthoDBi
826997at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351124

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00560 LRR_1, 2 hits
PF13855 LRR_8, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TF66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLKHYLLLL VGCQAWGAGL AYHGCPSECT CSRASQVECT GARIVAVPTP
60 70 80 90 100
LPWNAMSLQI LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL
110 120 130 140 150
GSLRYLSLAN NKLQVLPIGL FQGLDSLESL LLSSNQLLQI QPAHFSQCSN
160 170 180 190 200
LKELQLHGNH LEYIPDGAFD HLVGLTKLNL GKNSLTHISP RVFQHLGNLQ
210 220 230 240 250
VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL FHNNHNLQRL
260 270 280 290 300
YLSNNHISQL PPSVFMQLPQ LNRLTLFGNS LKELSPGIFG PMPNLRELWL
310 320 330 340 350
YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT
360 370 380 390 400
NALQDLDGNV FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ
410 420 430 440 450
LENLPLGIFD HLGKLCELRL YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV
460 470 480 490 500
PVCFSPANVR GQSLIIINVN VAVPSVHVPE VPSYPETPWY PDTPSYPDTT
510 520 530 540 550
SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA IAAIVIGIVA
560 570 580
LACSLAACVG CCCCKKRSQA VLMQMKAPNE C
Length:581
Mass (Da):64,366
Last modified:May 31, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CA7B1752C7FE5B3
GO
Isoform 2 (identifier: Q8TF66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPLDKAM

Show »
Length:587
Mass (Da):65,022
Checksum:i3B047531FCF9EF9F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI01065 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence DAA01740 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051101264V → I2 PublicationsCorresponds to variant dbSNP:rs13060627Ensembl.1
Natural variantiVAR_051102286P → L2 PublicationsCorresponds to variant dbSNP:rs13070515Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0411301M → MPLDKAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB071037 mRNA Translation: BAB84587.1
AC125362 Genomic DNA No translation available.
AC174158 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78054.1
BC101064 mRNA Translation: AAI01065.1 Different initiation.
BC101065 mRNA Translation: AAI01066.1
BK001325 mRNA Translation: DAA01740.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3306.1 [Q8TF66-1]
CCDS46984.1 [Q8TF66-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001128529.2, NM_001135057.2 [Q8TF66-2]
NP_570843.2, NM_130830.4 [Q8TF66-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000347624; ENSP00000306276; ENSG00000172061 [Q8TF66-1]
ENST00000428839; ENSP00000413707; ENSG00000172061 [Q8TF66-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
131578

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:131578

UCSC genome browser

More...
UCSCi
uc003ftt.4 human [Q8TF66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071037 mRNA Translation: BAB84587.1
AC125362 Genomic DNA No translation available.
AC174158 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78054.1
BC101064 mRNA Translation: AAI01065.1 Different initiation.
BC101065 mRNA Translation: AAI01066.1
BK001325 mRNA Translation: DAA01740.1 Different initiation.
CCDSiCCDS3306.1 [Q8TF66-1]
CCDS46984.1 [Q8TF66-2]
RefSeqiNP_001128529.2, NM_001135057.2 [Q8TF66-2]
NP_570843.2, NM_130830.4 [Q8TF66-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126287, 69 interactors
IntActiQ8TF66, 47 interactors
STRINGi9606.ENSP00000413707

Protein family/group databases

TCDBi8.A.43.1.13 the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

PTM databases

GlyConnecti1451
iPTMnetiQ8TF66
PhosphoSitePlusiQ8TF66
SwissPalmiQ8TF66

Polymorphism and mutation databases

BioMutaiLRRC15
DMDMi334302830

Proteomic databases

EPDiQ8TF66
jPOSTiQ8TF66
MassIVEiQ8TF66
MaxQBiQ8TF66
PaxDbiQ8TF66
PeptideAtlasiQ8TF66
PRIDEiQ8TF66
ProteomicsDBi74566 [Q8TF66-1]
74567 [Q8TF66-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q8TF66

Genome annotation databases

EnsembliENST00000347624; ENSP00000306276; ENSG00000172061 [Q8TF66-1]
ENST00000428839; ENSP00000413707; ENSG00000172061 [Q8TF66-2]
GeneIDi131578
KEGGihsa:131578
UCSCiuc003ftt.4 human [Q8TF66-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
131578
DisGeNETi131578

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC15
HGNCiHGNC:20818 LRRC15
HPAiHPA035503
neXtProtiNX_Q8TF66
OpenTargetsiENSG00000172061
PharmGKBiPA134956867

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000161771
HOGENOMiHOG000040004
InParanoidiQ8TF66
OMAiWGMTRAQ
OrthoDBi826997at2759
TreeFamiTF351124

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRC15 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
131578
PharosiQ8TF66

Protein Ontology

More...
PROi
PR:Q8TF66

Gene expression databases

BgeeiENSG00000172061 Expressed in 97 organ(s), highest expression level in periodontal ligament
GenevisibleiQ8TF66 HS

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 2 hits
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF66
Secondary accession number(s): Q495Q6, Q7RTN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 31, 2011
Last modified: October 16, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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