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Entry version 113 (13 Feb 2019)
Sequence version 1 (01 Jun 2002)
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Protein

PDZ domain-containing protein GIPC3

Gene

GIPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PDZ domain-containing protein GIPC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GIPC3
Synonyms:C19orf64
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000179855.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18183 GIPC3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608792 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF64

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 15 (DFNB15)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss with prelingual onset. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:601869
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06596746G → R in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs946085339Ensembl.1
Natural variantiVAR_06596888M → I in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs1214652710Ensembl.1
Natural variantiVAR_06596994G → D in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs763523474Ensembl.1
Natural variantiVAR_065970189R → C in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs387907002EnsemblClinVar.1
Natural variantiVAR_065971221T → I in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs761543680Ensembl.1
Natural variantiVAR_065972256G → D in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs387907001EnsemblClinVar.1
Natural variantiVAR_065973262L → R in DFNB15. 2 PublicationsCorresponds to variant dbSNP:rs387906999EnsemblClinVar.1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
126326

MalaCards human disease database

More...
MalaCardsi
GIPC3
MIMi601869 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000179855

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671736

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GIPC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74716119

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002471911 – 312PDZ domain-containing protein GIPC3Add BLAST312

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TF64

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TF64

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TF64

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TF64

PeptideAtlas

More...
PeptideAtlasi
Q8TF64

PRoteomics IDEntifications database

More...
PRIDEi
Q8TF64

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74564

2D gel databases

USC-OGP 2-DE database

More...
OGPi
O75227

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF64

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TF64

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult and fetal tissues. Highest levels are found in jejunum, lymph node, parietal lobe, fetal spleen and fetal thymus. Expressed in cervical, melanoma, chronic myelogenous and gastric cancer cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179855 Expressed in 102 organ(s), highest expression level in lower esophagus muscularis layer

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TF64 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TF64 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA061258
HPA067765

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125980, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TF64, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319254

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TF64

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TF64

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 192PDZPROSITE-ProRule annotationAdd BLAST81

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3938 Eukaryota
ENOG410XQ87 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003420

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293347

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000898

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TF64

KEGG Orthology (KO)

More...
KOi
K20056

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSIVGCR

Database of Orthologous Groups

More...
OrthoDBi
1442796at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TF64

TreeFam database of animal gene trees

More...
TreeFami
TF313878

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12259 PTHR12259, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038083 UCP038083_GIPC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8TF64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGAAAREAR GTETPRASAP PPAPSEPPAA PRARPRLVFR TQLAHGSPTG
60 70 80 90 100
KIEGFTNVRE LYAKIAEAFG IAPTEILFCT LNSHKVDMQK LLGGQIGLED
110 120 130 140 150
FIFAHVRGET KEVEVTKTED ALGLTITDNG AGYAFIKRIK EGSIINRIEA
160 170 180 190 200
VCVGDSIEAI NDHSIVGCRH YEVAKMLREL PKSQPFTLRL VQPKRAFDMI
210 220 230 240 250
GQRSRSSKCP VEAKVTSGRE TLRLRSGGAA TVEEAPSEFE EEASRKVDDL
260 270 280 290 300
LESYMGIRDP ELASTMVETS KKTASAQEFA RCLDSVLGEF AFPDEFVVEV
310
WAAIGEAREA CG
Length:312
Mass (Da):33,982
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i854F1C8CAAF5AF1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y651A0A2R8Y651_HUMAN
PDZ domain-containing protein GIPC3
GIPC3
1,349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC24304 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06596746G → R in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs946085339Ensembl.1
Natural variantiVAR_06596888M → I in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs1214652710Ensembl.1
Natural variantiVAR_06596994G → D in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs763523474Ensembl.1
Natural variantiVAR_065970189R → C in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs387907002EnsemblClinVar.1
Natural variantiVAR_065971221T → I in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs761543680Ensembl.1
Natural variantiVAR_065972256G → D in DFNB15. 1 PublicationCorresponds to variant dbSNP:rs387907001EnsemblClinVar.1
Natural variantiVAR_065973262L → R in DFNB15. 2 PublicationsCorresponds to variant dbSNP:rs387906999EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB073738 mRNA Translation: BAB84712.1
AC005175 Genomic DNA Translation: AAC24304.1 Sequence problems.
BC117312 mRNA Translation: AAI17313.1
BC117314 mRNA Translation: AAI17315.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32871.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T02669

NCBI Reference Sequences

More...
RefSeqi
NP_573568.1, NM_133261.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.266873

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322315; ENSP00000319254; ENSG00000179855
ENST00000644452; ENSP00000493901; ENSG00000179855

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
126326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126326

UCSC genome browser

More...
UCSCi
uc002lyd.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073738 mRNA Translation: BAB84712.1
AC005175 Genomic DNA Translation: AAC24304.1 Sequence problems.
BC117312 mRNA Translation: AAI17313.1
BC117314 mRNA Translation: AAI17315.1
CCDSiCCDS32871.1
PIRiT02669
RefSeqiNP_573568.1, NM_133261.2
UniGeneiHs.266873

3D structure databases

ProteinModelPortaliQ8TF64
SMRiQ8TF64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125980, 3 interactors
IntActiQ8TF64, 2 interactors
STRINGi9606.ENSP00000319254

PTM databases

iPTMnetiQ8TF64
PhosphoSitePlusiQ8TF64

Polymorphism and mutation databases

BioMutaiGIPC3
DMDMi74716119

2D gel databases

OGPiO75227

Proteomic databases

EPDiQ8TF64
jPOSTiQ8TF64
MaxQBiQ8TF64
PaxDbiQ8TF64
PeptideAtlasiQ8TF64
PRIDEiQ8TF64
ProteomicsDBi74564

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322315; ENSP00000319254; ENSG00000179855
ENST00000644452; ENSP00000493901; ENSG00000179855
GeneIDi126326
KEGGihsa:126326
UCSCiuc002lyd.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126326
DisGeNETi126326
EuPathDBiHostDB:ENSG00000179855.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GIPC3
HGNCiHGNC:18183 GIPC3
HPAiHPA061258
HPA067765
MalaCardsiGIPC3
MIMi601869 phenotype
608792 gene
neXtProtiNX_Q8TF64
OpenTargetsiENSG00000179855
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA142671736

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
HOVERGENiHBG000898
InParanoidiQ8TF64
KOiK20056
OMAiQSIVGCR
OrthoDBi1442796at2759
PhylomeDBiQ8TF64
TreeFamiTF313878

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GIPC3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GIPC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
126326

Protein Ontology

More...
PROi
PR:Q8TF64

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179855 Expressed in 102 organ(s), highest expression level in lower esophagus muscularis layer
ExpressionAtlasiQ8TF64 baseline and differential
GenevisibleiQ8TF64 HS

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGIPC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF64
Secondary accession number(s): O75227
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: February 13, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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