UniProtKB - Q8TF61 (FBX41_HUMAN)
Protein
F-box only protein 41
Gene
FBXO41
Organism
Homo sapiens (Human)
Status
Functioni
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity
GO - Biological processi
- post-translational protein modification Source: Reactome
- protein polyubiquitination Source: Reactome
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q8TF61 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 41 |
Gene namesi | Name:FBXO41 Synonyms:FBX41, KIAA1940 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29409, FBXO41 |
MIMi | 609108, gene |
neXtProti | NX_Q8TF61 |
VEuPathDBi | HostDB:ENSG00000163013.11 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 150726 |
OpenTargetsi | ENSG00000163013 |
PharmGKBi | PA134946052 |
Miscellaneous databases
Pharosi | Q8TF61, Tdark |
Chemistry databases
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Genetic variation databases
BioMutai | FBXO41 |
DMDMi | 387912926 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119940 | 1 – 875 | F-box only protein 41Add BLAST | 875 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 360 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 478 | PhosphoserineBy similarity | 1 | |
Modified residuei | 479 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 762 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
jPOSTi | Q8TF61 |
MassIVEi | Q8TF61 |
PaxDbi | Q8TF61 |
PeptideAtlasi | Q8TF61 |
PRIDEi | Q8TF61 |
ProteomicsDBi | 74561 |
PTM databases
iPTMneti | Q8TF61 |
PhosphoSitePlusi | Q8TF61 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163013, Expressed in cerebellar vermis and 208 other tissues |
Genevisiblei | Q8TF61, HS |
Organism-specific databases
HPAi | ENSG00000163013, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Directly interacts with SKP1 and CUL1.
By similarityProtein-protein interaction databases
BioGRIDi | 127320, 1 interactor |
IntActi | Q8TF61, 2 interactors |
STRINGi | 9606.ENSP00000428646 |
Miscellaneous databases
RNActi | Q8TF61, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 496 – 540 | F-boxAdd BLAST | 45 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 209 – 351 | Sequence analysisAdd BLAST | 143 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 51 – 61 | Poly-AlaAdd BLAST | 11 | |
Compositional biasi | 107 – 112 | Poly-His | 6 | |
Compositional biasi | 140 – 143 | Poly-Ala | 4 | |
Compositional biasi | 359 – 368 | Poly-Gly | 10 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4341, Eukaryota |
GeneTreei | ENSGT00530000063713 |
HOGENOMi | CLU_018140_0_0_1 |
InParanoidi | Q8TF61 |
OMAi | QNWHRRP |
OrthoDBi | 236860at2759 |
TreeFami | TF329439 |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8TF61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG
60 70 80 90 100
AAAAAAAAAA ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQAAGPSP
110 120 130 140 150
AAPHLLHHHH HHAPLAHFPG DLVPASLPCE ELAEPGLVPA AAARYALREI
160 170 180 190 200
EIPLGELFAR KSVASSACST PPPGPGPGPC PGPASASPAS PSPADVAYEE
210 220 230 240 250
GLARLKIRAL EKLEVDRRLE RLSEEVEQKI AGQVGRLQAE LERKAAELET
260 270 280 290 300
ARQESARLGR EKEELEERAS ELSRQVDVSV ELLASLKQDL VHKEQELSRK
310 320 330 340 350
QQEVVQIDQF LKETAAREAS AKLRLQQFIE ELLERADRAE RQLQVISSSC
360 370 380 390 400
GSTPSASLGR GGGGGGAGPN ARGPGRMREH HVGPAVPNTY AVSRHGSSPS
410 420 430 440 450
TGASSRVPAA SQSSGCYDSD SLELPRPEEG APEDSGPGGL GTRAQAANGG
460 470 480 490 500
SERSQPPRSS GLRRQAIQNW QRRPRRHSTE GEEGDVSDVG SRTTESEAEG
510 520 530 540 550
PLDAPRPGPA MAGPLSSCRL SARPEGGSGR GRRAERVSPS RSNEVISPEI
560 570 580 590 600
LKMRAALFCI FTYLDTRTLL HAAEVCRDWR FVARHPAVWT RVLLENARVC
610 620 630 640 650
SKFLAMLAQW CTQAHSLTLQ NLKPRQRGKK ESKEEYARST RGCLEAGLES
660 670 680 690 700
LLKAAGGNLL ILRISHCPNI LTDRSLWLAS CYCRALQAVT YRSATDPVGH
710 720 730 740 750
EVIWALGAGC REIVSLQVAP LHPCQQPTRF SNRCLQMIGR CWPHLRALGV
760 770 780 790 800
GGAGCGVQGL ASLARNCMRL QVLELDHVSE ITQEVAAEVC REGLKGLEML
810 820 830 840 850
VLTATPVTPK ALLHFNSICR NLKSIVVQIG IADYFKEPSS PEAQKLFEDM
860 870
VTKLQALRRR PGFSKILHIK VEGGC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 454 | S → T in BAB85526 (PubMed:11853319).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010913 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAW99736.1 AB075820 mRNA Translation: BAB85526.1 BC112202 mRNA Translation: AAI12203.1 |
CCDSi | CCDS46337.2 |
RefSeqi | NP_001073879.2, NM_001080410.2 XP_006712013.1, XM_006711950.2 XP_011530864.1, XM_011532562.1 XP_016858910.1, XM_017003421.1 XP_016858911.1, XM_017003422.1 XP_016858912.1, XM_017003423.1 |
Genome annotation databases
Ensembli | ENST00000295133; ENSP00000295133; ENSG00000163013 ENST00000520530; ENSP00000430968; ENSG00000163013 ENST00000521871; ENSP00000428646; ENSG00000163013 |
GeneIDi | 150726 |
KEGGi | hsa:150726 |
UCSCi | uc021vjh.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010913 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAW99736.1 AB075820 mRNA Translation: BAB85526.1 BC112202 mRNA Translation: AAI12203.1 |
CCDSi | CCDS46337.2 |
RefSeqi | NP_001073879.2, NM_001080410.2 XP_006712013.1, XM_006711950.2 XP_011530864.1, XM_011532562.1 XP_016858910.1, XM_017003421.1 XP_016858911.1, XM_017003422.1 XP_016858912.1, XM_017003423.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127320, 1 interactor |
IntActi | Q8TF61, 2 interactors |
STRINGi | 9606.ENSP00000428646 |
Chemistry databases
DrugBanki | DB12695, Phenethyl Isothiocyanate |
PTM databases
iPTMneti | Q8TF61 |
PhosphoSitePlusi | Q8TF61 |
Genetic variation databases
BioMutai | FBXO41 |
DMDMi | 387912926 |
Proteomic databases
jPOSTi | Q8TF61 |
MassIVEi | Q8TF61 |
PaxDbi | Q8TF61 |
PeptideAtlasi | Q8TF61 |
PRIDEi | Q8TF61 |
ProteomicsDBi | 74561 |
Protocols and materials databases
Antibodypediai | 65168, 56 antibodies |
Genome annotation databases
Ensembli | ENST00000295133; ENSP00000295133; ENSG00000163013 ENST00000520530; ENSP00000430968; ENSG00000163013 ENST00000521871; ENSP00000428646; ENSG00000163013 |
GeneIDi | 150726 |
KEGGi | hsa:150726 |
UCSCi | uc021vjh.2, human |
Organism-specific databases
CTDi | 150726 |
DisGeNETi | 150726 |
GeneCardsi | FBXO41 |
HGNCi | HGNC:29409, FBXO41 |
HPAi | ENSG00000163013, Tissue enhanced (brain) |
MIMi | 609108, gene |
neXtProti | NX_Q8TF61 |
OpenTargetsi | ENSG00000163013 |
PharmGKBi | PA134946052 |
VEuPathDBi | HostDB:ENSG00000163013.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4341, Eukaryota |
GeneTreei | ENSGT00530000063713 |
HOGENOMi | CLU_018140_0_0_1 |
InParanoidi | Q8TF61 |
OMAi | QNWHRRP |
OrthoDBi | 236860at2759 |
TreeFami | TF329439 |
Enzyme and pathway databases
PathwayCommonsi | Q8TF61 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 150726, 26 hits in 875 CRISPR screens |
ChiTaRSi | FBXO41, human |
GenomeRNAii | 150726 |
Pharosi | Q8TF61, Tdark |
PROi | PR:Q8TF61 |
RNActi | Q8TF61, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163013, Expressed in cerebellar vermis and 208 other tissues |
Genevisiblei | Q8TF61, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX41_HUMAN | |
Accessioni | Q8TF61Primary (citable) accession number: Q8TF61 Secondary accession number(s): G3V0Z7, Q2M1V8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | May 16, 2012 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot