Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8TF61 (FBX41_HUMAN)

Entry version 141 (10 Feb 2021)
Sequence version 5 (16 May 2012)
Previous versions | rss
Add a publicationFeedback
Protein

F-box only protein 41

Gene

FBXO41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TF61

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 41
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO41
Synonyms:FBX41, KIAA1940
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29409, FBXO41

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609108, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TF61

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163013.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		150726

Open Targets

More...OpenTargetsi		ENSG00000163013

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134946052

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TF61, Tdark

Chemistry databases

Drug and drug target database

More...DrugBanki		DB12695, Phenethyl Isothiocyanate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FBXO41

Domain mapping of disease mutations (DMDM)

More...DMDMi		387912926

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001199401 – 875F-box only protein 41Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei360Omega-N-methylarginineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei479PhosphothreonineBy similarity1
Modified residuei762PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TF61

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TF61

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TF61

PeptideAtlas

More...PeptideAtlasi		Q8TF61

PRoteomics IDEntifications database

More...PRIDEi		Q8TF61

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74561

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TF61

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TF61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163013, Expressed in cerebellar vermis and 208 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TF61, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163013, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with SKP1 and CUL1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127320, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q8TF61, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000428646

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TF61, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini496 – 540F-boxAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili209 – 351Sequence analysisAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 61Poly-AlaAdd BLAST11
Compositional biasi107 – 112Poly-His6
Compositional biasi140 – 143Poly-Ala4
Compositional biasi359 – 368Poly-Gly10

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4341, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018140_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TF61

Identification of Orthologs from Complete Genome Data

More...OMAi		QNWHRRP

Database of Orthologous Groups

More...OrthoDBi		236860at2759

TreeFam database of animal gene trees

More...TreeFami		TF329439

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12937, F-box-like, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81383, SSF81383, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TF61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG 
        60         70         80         90        100
AAAAAAAAAA ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQAAGPSP 
       110        120        130        140        150
AAPHLLHHHH HHAPLAHFPG DLVPASLPCE ELAEPGLVPA AAARYALREI 
       160        170        180        190        200
EIPLGELFAR KSVASSACST PPPGPGPGPC PGPASASPAS PSPADVAYEE 
       210        220        230        240        250
GLARLKIRAL EKLEVDRRLE RLSEEVEQKI AGQVGRLQAE LERKAAELET 
       260        270        280        290        300
ARQESARLGR EKEELEERAS ELSRQVDVSV ELLASLKQDL VHKEQELSRK 
       310        320        330        340        350
QQEVVQIDQF LKETAAREAS AKLRLQQFIE ELLERADRAE RQLQVISSSC 
       360        370        380        390        400
GSTPSASLGR GGGGGGAGPN ARGPGRMREH HVGPAVPNTY AVSRHGSSPS 
       410        420        430        440        450
TGASSRVPAA SQSSGCYDSD SLELPRPEEG APEDSGPGGL GTRAQAANGG 
       460        470        480        490        500
SERSQPPRSS GLRRQAIQNW QRRPRRHSTE GEEGDVSDVG SRTTESEAEG 
       510        520        530        540        550
PLDAPRPGPA MAGPLSSCRL SARPEGGSGR GRRAERVSPS RSNEVISPEI 
       560        570        580        590        600
LKMRAALFCI FTYLDTRTLL HAAEVCRDWR FVARHPAVWT RVLLENARVC 
       610        620        630        640        650
SKFLAMLAQW CTQAHSLTLQ NLKPRQRGKK ESKEEYARST RGCLEAGLES 
       660        670        680        690        700
LLKAAGGNLL ILRISHCPNI LTDRSLWLAS CYCRALQAVT YRSATDPVGH 
       710        720        730        740        750
EVIWALGAGC REIVSLQVAP LHPCQQPTRF SNRCLQMIGR CWPHLRALGV 
       760        770        780        790        800
GGAGCGVQGL ASLARNCMRL QVLELDHVSE ITQEVAAEVC REGLKGLEML 
       810        820        830        840        850
VLTATPVTPK ALLHFNSICR NLKSIVVQIG IADYFKEPSS PEAQKLFEDM 
       860        870 
VTKLQALRRR PGFSKILHIK VEGGC
Length:875
Mass (Da):94,496
Last modified:May 16, 2012 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1491A923068389C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti454S → T in BAB85526 (PubMed:11853319).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC010913 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99736.1
AB075820 mRNA Translation: BAB85526.1
BC112202 mRNA Translation: AAI12203.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46337.2

NCBI Reference Sequences

More...RefSeqi		NP_001073879.2, NM_001080410.2
XP_006712013.1, XM_006711950.2
XP_011530864.1, XM_011532562.1
XP_016858910.1, XM_017003421.1
XP_016858911.1, XM_017003422.1
XP_016858912.1, XM_017003423.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295133; ENSP00000295133; ENSG00000163013
ENST00000520530; ENSP00000430968; ENSG00000163013
ENST00000521871; ENSP00000428646; ENSG00000163013

Database of genes from NCBI RefSeq genomes

More...GeneIDi		150726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:150726

UCSC genome browser

More...UCSCi		uc021vjh.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010913 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99736.1
AB075820 mRNA Translation: BAB85526.1
BC112202 mRNA Translation: AAI12203.1
CCDSiCCDS46337.2
RefSeqiNP_001073879.2, NM_001080410.2
XP_006712013.1, XM_006711950.2
XP_011530864.1, XM_011532562.1
XP_016858910.1, XM_017003421.1
XP_016858911.1, XM_017003422.1
XP_016858912.1, XM_017003423.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127320, 1 interactor
IntActiQ8TF61, 2 interactors
STRINGi9606.ENSP00000428646

Chemistry databases

DrugBankiDB12695, Phenethyl Isothiocyanate

PTM databases

iPTMnetiQ8TF61
PhosphoSitePlusiQ8TF61

Genetic variation databases

BioMutaiFBXO41
DMDMi387912926

Proteomic databases

jPOSTiQ8TF61
MassIVEiQ8TF61
PaxDbiQ8TF61
PeptideAtlasiQ8TF61
PRIDEiQ8TF61
ProteomicsDBi74561

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		65168, 56 antibodies

Genome annotation databases

EnsembliENST00000295133; ENSP00000295133; ENSG00000163013
ENST00000520530; ENSP00000430968; ENSG00000163013
ENST00000521871; ENSP00000428646; ENSG00000163013
GeneIDi150726
KEGGihsa:150726
UCSCiuc021vjh.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		150726
DisGeNETi150726

GeneCards: human genes, protein and diseases

More...GeneCardsi		FBXO41
HGNCiHGNC:29409, FBXO41
HPAiENSG00000163013, Tissue enhanced (brain)
MIMi609108, gene
neXtProtiNX_Q8TF61
OpenTargetsiENSG00000163013
PharmGKBiPA134946052
VEuPathDBiHostDB:ENSG00000163013.11

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4341, Eukaryota
GeneTreeiENSGT00530000063713
HOGENOMiCLU_018140_0_0_1
InParanoidiQ8TF61
OMAiQNWHRRP
OrthoDBi236860at2759
TreeFamiTF329439

Enzyme and pathway databases

PathwayCommonsiQ8TF61
ReactomeiR-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		150726, 26 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FBXO41, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		150726
PharosiQ8TF61, Tdark

Protein Ontology

More...PROi		PR:Q8TF61
RNActiQ8TF61, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163013, Expressed in cerebellar vermis and 208 other tissues
GenevisibleiQ8TF61, HS

Family and domain databases

InterProiView protein in InterPro
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
PfamiView protein in Pfam
PF12937, F-box-like, 1 hit
SUPFAMiSSF81383, SSF81383, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX41_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF61
Secondary accession number(s): G3V0Z7, Q2M1V8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 16, 2012
Last modified: February 10, 2021
This is version 141 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again