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UniProtKB - Q8TF50 (ZN526_HUMAN)

Entry version 137 (10 Feb 2021)
Sequence version 2 (02 Oct 2007)
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Protein

Zinc finger protein 526

Gene

ZNF526

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri57 – 79C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri108 – 130C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 163C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 409C2H2-type 8PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri442 – 465C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri472 – 494C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TF50

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 526
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF526
Synonyms:KIAA1951
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29415, ZNF526

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614387, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TF50

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000167625.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		116115

Open Targets

More...OpenTargetsi		ENSG00000167625

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134967668

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TF50, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF526

Domain mapping of disease mutations (DMDM)

More...DMDMi		158706495

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068751 – 670Zinc finger protein 526Add BLAST670

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TF50

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TF50

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TF50

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TF50

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TF50

PeptideAtlas

More...PeptideAtlasi		Q8TF50

PRoteomics IDEntifications database

More...PRIDEi		Q8TF50

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74560

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q8TF50

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TF50

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TF50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167625, Expressed in stomach and 147 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TF50, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TF50, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000167625, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TF50
With#Exp.IntAct
BAHD1 [Q8TBE0]3EBI-11035148,EBI-742750
C8orf33 [Q9H7E9]3EBI-11035148,EBI-715389
FAM161A [Q3B820]3EBI-11035148,EBI-719941
FAM90A1 [Q86YD7]3EBI-11035148,EBI-6658203
FARS2 [O95363]3EBI-11035148,EBI-2513774
GPATCH2L - isoform 2 [Q9NWQ4-1]3EBI-11035148,EBI-11959863
hCG_2042749 [A0A024R4Z4]3EBI-11035148,EBI-14231181
HNRNPK - isoform 2 [P61978-2]3EBI-11035148,EBI-7060731
IL16 - isoform 2 [Q14005-2]3EBI-11035148,EBI-17178971
INO80B [Q9C086]3EBI-11035148,EBI-715611
IQUB [Q8NA54]3EBI-11035148,EBI-10220600
KAT5 [Q92993]3EBI-11035148,EBI-399080
LMO1 [P25800]3EBI-11035148,EBI-8639312
LMO3 - isoform 4 [Q8TAP4-4]3EBI-11035148,EBI-11742507
MAPRE3 [Q9UPY8]3EBI-11035148,EBI-726739
MRPL11 [Q9Y3B7]3EBI-11035148,EBI-5453723
NCK2 [O43639]3EBI-11035148,EBI-713635
NME7 [Q9Y5B8]3EBI-11035148,EBI-744782
OVOL2 [Q9BRP0]3EBI-11035148,EBI-13007247
PADI6 [Q6TGC4]3EBI-11035148,EBI-10892722
PBK [Q96KB5]3EBI-11035148,EBI-536853
PHF1 [O43189]3EBI-11035148,EBI-530034
PIN1 [Q13526]3EBI-11035148,EBI-714158
PRKAB2 [O43741]3EBI-11035148,EBI-1053424
PRPF18 [Q99633]3EBI-11035148,EBI-2798416
RBM10 [P98175]3EBI-11035148,EBI-721525
SCNM1 [Q9BWG6]3EBI-11035148,EBI-748391
SEPHS1 [P49903]3EBI-11035148,EBI-714091
SPANXN2 [Q5MJ10]3EBI-11035148,EBI-12023934
TCEA2 [Q15560]3EBI-11035148,EBI-710310
THAP1 [Q9NVV9]3EBI-11035148,EBI-741515
THAP12 [O43422]3EBI-11035148,EBI-2828217
TRIM41 [Q8WV44]3EBI-11035148,EBI-725997
U2AF2 - isoform 2 [P26368-2]3EBI-11035148,EBI-11097439
VCX2 [Q3SXR9]3EBI-11035148,EBI-11983741
YJU2 [Q9BW85]3EBI-11035148,EBI-10300345
ZBTB24 [O43167]3EBI-11035148,EBI-744471
ZNF124 [Q15973]3EBI-11035148,EBI-2555767
ZNF264 [O43296]3EBI-11035148,EBI-4395808
ZNF408 [Q9H9D4]3EBI-11035148,EBI-347633
ZNF438 [Q7Z4V0]3EBI-11035148,EBI-11962468
ZNF497 [Q6ZNH5]3EBI-11035148,EBI-10486136
ZNF524 [Q96C55]3EBI-11035148,EBI-10283126
ZNF575 [Q86XF7]3EBI-11035148,EBI-14069183
ZNF578 [Q96N58]3EBI-11035148,EBI-11955189
ZNF696 [Q9H7X3]3EBI-11035148,EBI-11090299
ZNF76 [P36508]3EBI-11035148,EBI-7254550
ZNF774 [Q6NX45]3EBI-11035148,EBI-10251462
ZNF792 [Q3KQV3]3EBI-11035148,EBI-10240849
ZNF835 [Q9Y2P0]3EBI-11035148,EBI-5667516
ZNF837 [Q96EG3]3EBI-11035148,EBI-11962574

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125475, 73 interactors

Protein interaction database and analysis system

More...IntActi		Q8TF50, 70 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000301215

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TF50, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TF50

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi191 – 256Glu-richAdd BLAST66
Compositional biasi416 – 445Pro-richAdd BLAST30
Compositional biasi605 – 619Pro-richAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 79C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri108 – 130C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 163C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 409C2H2-type 8PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri442 – 465C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri472 – 494C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162624

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_24_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TF50

Identification of Orthologs from Complete Genome Data

More...OMAi		ELWVAHR

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TF50

TreeFam database of animal gene trees

More...TreeFami		TF350791

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8TF50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVVAEVAE MPTQMSPGAV EMSTPMSAEM MEMSTEVTEM TPGEALASSL 
        60         70         80         90        100
FFQHHQFMCS ECGSLYNTLE EVLSHQEQHM LAVSEEEALT TQNVGLEPEL 
       110        120        130        140        150
VPGAEGPFQC GECSQLILSP GELLAHQDAH LRESANQIQY QCWDCQELFP 
       160        170        180        190        200
SPELWVAHRK AQHLSATVAE PPVPPPLPPP TPLPPPSPPS EVKMEPYECP 
       210        220        230        240        250
ECSTLCATPE EFLEHQGTHF DSLEKEERNG LEEEEEDDEE DEEDDEEMED 
       260        270        280        290        300
EEAMAEVGDD AVGGDESTAG WAQGCGDCPQ HQPSAGARRQ HRRTAHSPAS 
       310        320        330        340        350
ATHPFHCSQC QRSFSSANRL QAHGRAHVGG THECTTCSKV FKKAASLEQH 
       360        370        380        390        400
LRLHRGEARY LCVDCGRGFG TELTLVAHRR AHTANPLHRC RCGKTFSNMT 
       410        420        430        440        450
KFLYHRRTHA GKSGAPPTGA TAPPAPAEPT PPPPPPAPPA QLPCPQCSKS 
       460        470        480        490        500
FASASRLSRH RRAVHGPPER RHRCGVCGKG FKKLIHVRNH LRTHTGERPF 
       510        520        530        540        550
QCHSCGKTFA SLANLSRHQL THTGARPYQC LDCGKRFTQS SNLQQHRRLH 
       560        570        580        590        600
LRPVAFARAP RLPITGLYNK SPYYCGTCGR WFRAMAGLRL HQRVHARART 
       610        620        630        640        650
LTLQPPRSPS PAPPPPPEPQ QTIMCTELGE TIAIIETSQP LALEDTLQLC 
       660        670
QAALGASEAG GLLQLDTAFV
Length:670
Mass (Da):73,622
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83C09EB3961765E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R395M0R395_HUMAN
Zinc finger protein 526
ZNF526
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85537 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03533194V → A. Corresponds to variant dbSNP:rs3810151Ensembl.1
Natural variantiVAR_035332511S → F1 PublicationCorresponds to variant dbSNP:rs17850994Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB075831 mRNA Translation: BAB85537.1 Different initiation.
AK122649 mRNA Translation: BAG53641.1
CH471126 Genomic DNA Translation: EAW57113.1
BC013013 mRNA Translation: AAH13013.1
AL833399 mRNA Translation: CAH10586.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12598.1

NCBI Reference Sequences

More...RefSeqi		NP_001300962.1, NM_001314033.2
NP_597701.1, NM_133444.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000301215; ENSP00000301215; ENSG00000167625

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116115

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:116115

UCSC genome browser

More...UCSCi		uc002osz.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075831 mRNA Translation: BAB85537.1 Different initiation.
AK122649 mRNA Translation: BAG53641.1
CH471126 Genomic DNA Translation: EAW57113.1
BC013013 mRNA Translation: AAH13013.1
AL833399 mRNA Translation: CAH10586.1
CCDSiCCDS12598.1
RefSeqiNP_001300962.1, NM_001314033.2
NP_597701.1, NM_133444.2

3D structure databases

SMRiQ8TF50
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125475, 73 interactors
IntActiQ8TF50, 70 interactors
STRINGi9606.ENSP00000301215

PTM databases

CarbonylDBiQ8TF50
iPTMnetiQ8TF50
PhosphoSitePlusiQ8TF50

Genetic variation databases

BioMutaiZNF526
DMDMi158706495

Proteomic databases

EPDiQ8TF50
jPOSTiQ8TF50
MassIVEiQ8TF50
MaxQBiQ8TF50
PaxDbiQ8TF50
PeptideAtlasiQ8TF50
PRIDEiQ8TF50
ProteomicsDBi74560

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30899, 65 antibodies

Genome annotation databases

EnsembliENST00000301215; ENSP00000301215; ENSG00000167625
GeneIDi116115
KEGGihsa:116115
UCSCiuc002osz.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		116115
DisGeNETi116115

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF526
HGNCiHGNC:29415, ZNF526
HPAiENSG00000167625, Low tissue specificity
MIMi614387, gene
neXtProtiNX_Q8TF50
OpenTargetsiENSG00000167625
PharmGKBiPA134967668
VEuPathDBiHostDB:ENSG00000167625.10

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162624
HOGENOMiCLU_002678_24_3_1
InParanoidiQ8TF50
OMAiELWVAHR
OrthoDBi1318335at2759
PhylomeDBiQ8TF50
TreeFamiTF350791

Enzyme and pathway databases

PathwayCommonsiQ8TF50

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		116115, 5 hits in 896 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF526, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		116115
PharosiQ8TF50, Tdark

Protein Ontology

More...PROi		PR:Q8TF50
RNActiQ8TF50, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167625, Expressed in stomach and 147 other tissues
ExpressionAtlasiQ8TF50, baseline and differential
GenevisibleiQ8TF50, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 14 hits
SUPFAMiSSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN526_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF50
Secondary accession number(s): B3KV29, Q69YI2, Q96E24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: February 10, 2021
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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