UniProtKB - Q8TF50 (ZN526_HUMAN)
Protein
Zinc finger protein 526
Gene
ZNF526
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 57 – 79 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 108 – 130 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 140 – 163 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 197 – 219 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 332 – 354 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 360 – 382 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 388 – 409 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 442 – 465 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 472 – 494 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 500 – 522 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 528 – 550 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 573 – 595 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TF50 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 526 |
Gene namesi | Name:ZNF526 Synonyms:KIAA1951 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29415, ZNF526 |
MIMi | 614387, gene |
neXtProti | NX_Q8TF50 |
VEuPathDBi | HostDB:ENSG00000167625.10 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 116115 |
OpenTargetsi | ENSG00000167625 |
PharmGKBi | PA134967668 |
Miscellaneous databases
Pharosi | Q8TF50, Tdark |
Genetic variation databases
BioMutai | ZNF526 |
DMDMi | 158706495 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306875 | 1 – 670 | Zinc finger protein 526Add BLAST | 670 |
Proteomic databases
EPDi | Q8TF50 |
jPOSTi | Q8TF50 |
MassIVEi | Q8TF50 |
MaxQBi | Q8TF50 |
PaxDbi | Q8TF50 |
PeptideAtlasi | Q8TF50 |
PRIDEi | Q8TF50 |
ProteomicsDBi | 74560 |
PTM databases
CarbonylDBi | Q8TF50 |
iPTMneti | Q8TF50 |
PhosphoSitePlusi | Q8TF50 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167625, Expressed in stomach and 147 other tissues |
ExpressionAtlasi | Q8TF50, baseline and differential |
Genevisiblei | Q8TF50, HS |
Organism-specific databases
HPAi | ENSG00000167625, Low tissue specificity |
Interactioni
Binary interactionsi
Q8TF50
Protein-protein interaction databases
BioGRIDi | 125475, 73 interactors |
IntActi | Q8TF50, 70 interactors |
STRINGi | 9606.ENSP00000301215 |
Miscellaneous databases
RNActi | Q8TF50, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 191 – 256 | Glu-richAdd BLAST | 66 | |
Compositional biasi | 416 – 445 | Pro-richAdd BLAST | 30 | |
Compositional biasi | 605 – 619 | Pro-richAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 57 – 79 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 108 – 130 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 140 – 163 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 197 – 219 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 332 – 354 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 360 – 382 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 388 – 409 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 442 – 465 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 472 – 494 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 500 – 522 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 528 – 550 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 573 – 595 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162624 |
HOGENOMi | CLU_002678_24_3_1 |
InParanoidi | Q8TF50 |
OMAi | ELWVAHR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TF50 |
TreeFami | TF350791 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8TF50-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEVVAEVAE MPTQMSPGAV EMSTPMSAEM MEMSTEVTEM TPGEALASSL
60 70 80 90 100
FFQHHQFMCS ECGSLYNTLE EVLSHQEQHM LAVSEEEALT TQNVGLEPEL
110 120 130 140 150
VPGAEGPFQC GECSQLILSP GELLAHQDAH LRESANQIQY QCWDCQELFP
160 170 180 190 200
SPELWVAHRK AQHLSATVAE PPVPPPLPPP TPLPPPSPPS EVKMEPYECP
210 220 230 240 250
ECSTLCATPE EFLEHQGTHF DSLEKEERNG LEEEEEDDEE DEEDDEEMED
260 270 280 290 300
EEAMAEVGDD AVGGDESTAG WAQGCGDCPQ HQPSAGARRQ HRRTAHSPAS
310 320 330 340 350
ATHPFHCSQC QRSFSSANRL QAHGRAHVGG THECTTCSKV FKKAASLEQH
360 370 380 390 400
LRLHRGEARY LCVDCGRGFG TELTLVAHRR AHTANPLHRC RCGKTFSNMT
410 420 430 440 450
KFLYHRRTHA GKSGAPPTGA TAPPAPAEPT PPPPPPAPPA QLPCPQCSKS
460 470 480 490 500
FASASRLSRH RRAVHGPPER RHRCGVCGKG FKKLIHVRNH LRTHTGERPF
510 520 530 540 550
QCHSCGKTFA SLANLSRHQL THTGARPYQC LDCGKRFTQS SNLQQHRRLH
560 570 580 590 600
LRPVAFARAP RLPITGLYNK SPYYCGTCGR WFRAMAGLRL HQRVHARART
610 620 630 640 650
LTLQPPRSPS PAPPPPPEPQ QTIMCTELGE TIAIIETSQP LALEDTLQLC
660 670
QAALGASEAG GLLQLDTAFV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R395 | M0R395_HUMAN | Zinc finger protein 526 | ZNF526 | 68 | Annotation score: |
Sequence cautioni
The sequence BAB85537 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035331 | 94 | V → A. Corresponds to variant dbSNP:rs3810151Ensembl. | 1 | |
Natural variantiVAR_035332 | 511 | S → F1 PublicationCorresponds to variant dbSNP:rs17850994Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075831 mRNA Translation: BAB85537.1 Different initiation. AK122649 mRNA Translation: BAG53641.1 CH471126 Genomic DNA Translation: EAW57113.1 BC013013 mRNA Translation: AAH13013.1 AL833399 mRNA Translation: CAH10586.1 |
CCDSi | CCDS12598.1 |
RefSeqi | NP_001300962.1, NM_001314033.2 NP_597701.1, NM_133444.2 |
Genome annotation databases
Ensembli | ENST00000301215; ENSP00000301215; ENSG00000167625 |
GeneIDi | 116115 |
KEGGi | hsa:116115 |
UCSCi | uc002osz.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075831 mRNA Translation: BAB85537.1 Different initiation. AK122649 mRNA Translation: BAG53641.1 CH471126 Genomic DNA Translation: EAW57113.1 BC013013 mRNA Translation: AAH13013.1 AL833399 mRNA Translation: CAH10586.1 |
CCDSi | CCDS12598.1 |
RefSeqi | NP_001300962.1, NM_001314033.2 NP_597701.1, NM_133444.2 |
3D structure databases
SMRi | Q8TF50 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125475, 73 interactors |
IntActi | Q8TF50, 70 interactors |
STRINGi | 9606.ENSP00000301215 |
PTM databases
CarbonylDBi | Q8TF50 |
iPTMneti | Q8TF50 |
PhosphoSitePlusi | Q8TF50 |
Genetic variation databases
BioMutai | ZNF526 |
DMDMi | 158706495 |
Proteomic databases
EPDi | Q8TF50 |
jPOSTi | Q8TF50 |
MassIVEi | Q8TF50 |
MaxQBi | Q8TF50 |
PaxDbi | Q8TF50 |
PeptideAtlasi | Q8TF50 |
PRIDEi | Q8TF50 |
ProteomicsDBi | 74560 |
Protocols and materials databases
Antibodypediai | 30899, 65 antibodies |
Genome annotation databases
Ensembli | ENST00000301215; ENSP00000301215; ENSG00000167625 |
GeneIDi | 116115 |
KEGGi | hsa:116115 |
UCSCi | uc002osz.2, human |
Organism-specific databases
CTDi | 116115 |
DisGeNETi | 116115 |
GeneCardsi | ZNF526 |
HGNCi | HGNC:29415, ZNF526 |
HPAi | ENSG00000167625, Low tissue specificity |
MIMi | 614387, gene |
neXtProti | NX_Q8TF50 |
OpenTargetsi | ENSG00000167625 |
PharmGKBi | PA134967668 |
VEuPathDBi | HostDB:ENSG00000167625.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162624 |
HOGENOMi | CLU_002678_24_3_1 |
InParanoidi | Q8TF50 |
OMAi | ELWVAHR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TF50 |
TreeFami | TF350791 |
Enzyme and pathway databases
PathwayCommonsi | Q8TF50 |
Miscellaneous databases
BioGRID-ORCSi | 116115, 5 hits in 896 CRISPR screens |
ChiTaRSi | ZNF526, human |
GenomeRNAii | 116115 |
Pharosi | Q8TF50, Tdark |
PROi | PR:Q8TF50 |
RNActi | Q8TF50, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167625, Expressed in stomach and 147 other tissues |
ExpressionAtlasi | Q8TF50, baseline and differential |
Genevisiblei | Q8TF50, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN526_HUMAN | |
Accessioni | Q8TF50Primary (citable) accession number: Q8TF50 Secondary accession number(s): B3KV29, Q69YI2, Q96E24 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 10, 2021 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families