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Protein

DIS3-like exonuclease 1

Gene

DIS3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.2 Publications

Cofactori

Mg2+2 Publications

GO - Molecular functioni

  • 3'-5'-exoribonuclease activity Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
DIS3-like exonuclease 1 (EC:3.1.13.-)
Gene namesi
Name:DIS3L
Synonyms:DIS3L1, KIAA1955
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166938.12
HGNCiHGNC:28698 DIS3L
MIMi614183 gene
neXtProtiNX_Q8TF46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Exosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi62D → N: No change of exonuclease activity. 1 Publication1
Mutagenesisi166D → N: No change of exonuclease activity. 1 Publication1
Mutagenesisi486D → N: Complete loss of exonuclease activity. 2 Publications1

Organism-specific databases

DisGeNETi115752
OpenTargetsiENSG00000166938
PharmGKBiPA162383675

Polymorphism and mutation databases

BioMutaiDIS3L
DMDMi166201903

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148101 – 1054DIS3-like exonuclease 1Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei989PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TF46
MaxQBiQ8TF46
PaxDbiQ8TF46
PeptideAtlasiQ8TF46
PRIDEiQ8TF46
ProteomicsDBi74555
74556 [Q8TF46-2]
74557 [Q8TF46-3]
74558 [Q8TF46-4]

PTM databases

iPTMnetiQ8TF46
PhosphoSitePlusiQ8TF46

Expressioni

Gene expression databases

BgeeiENSG00000166938 Expressed in 207 organ(s), highest expression level in corpus callosum
CleanExiHS_DIS3L
ExpressionAtlasiQ8TF46 baseline and differential
GenevisibleiQ8TF46 HS

Organism-specific databases

HPAiHPA041805

Interactioni

Subunit structurei

Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125453, 29 interactors
ComplexPortaliCPX-592 Cytoplasmic exosome complex, DIS3L variant
CPX-600 Cytoplasmic exosome complex, DIS3L-EXOSC10 variant
IntActiQ8TF46, 20 interactors
MINTiQ8TF46
STRINGi9606.ENSP00000321711

Structurei

3D structure databases

ProteinModelPortaliQ8TF46
SMRiQ8TF46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNR ribonuclease family.Curated

Phylogenomic databases

eggNOGiKOG2102 Eukaryota
COG0557 LUCA
GeneTreeiENSGT00530000063106
HOGENOMiHOG000191945
HOVERGENiHBG059397
InParanoidiQ8TF46
KOiK18681
OMAiIPRFGIK
OrthoDBiEOG091G06EJ
PhylomeDBiQ8TF46
TreeFamiTF105755

Family and domain databases

InterProiView protein in InterPro
IPR031192 DIS3L
IPR012340 NA-bd_OB-fold
IPR022966 RNase_II/R_CS
IPR033771 Rrp44_CSD1
IPR033770 RRP44_S1
PANTHERiPTHR23355:SF30 PTHR23355:SF30, 1 hit
PfamiView protein in Pfam
PF17216 Rrp44_CSD1, 1 hit
PF17215 Rrp44_S1, 1 hit
SUPFAMiSSF50249 SSF50249, 4 hits
PROSITEiView protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQKREKVLL LRTFQGRTLR IVREHYLRPC VPCHSPLCPQ PAACSHDGKL
60 70 80 90 100
LSSDVTHYVI PDWKVVQDYL EILEFPELKG IIFMQTACQA VQHQRGRRQY
110 120 130 140 150
NKLRNLLKDA RHDCILFANE FQQCCYLPRE RGESMEKWQT RSIYNAAVWY
160 170 180 190 200
YHHCQDRMPI VMVTEDEEAI QQYGSETEGV FVITFKNYLD NFWPDLKAAH
210 220 230 240 250
ELCDSILQSR RERENESQES HGKEYPEHLP LEVLEAGIKS GRYIQGILNV
260 270 280 290 300
NKHRAQIEAF VRLQGASSKD SDLVSDILIH GMKARNRSIH GDVVVVELLP
310 320 330 340 350
KNEWKGRTVA LCENDCDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP
360 370 380 390 400
SKEEVQSQGK NAQKILVTPW DYRIPKIRIS TQQAETLQDF RVVVRIDSWE
410 420 430 440 450
STSVYPNGHF VRVLGRIGDL EGEIATILVE NSISVIPFSE AQMCEMPVNT
460 470 480 490 500
PESPWKVSPE EEQKRKDLRK SHLVFSIDPK GCEDVDDTLS VRTLNNGNLE
510 520 530 540 550
LGVHIADVTH FVAPNSYIDI EARTRATTYY LADRRYDMLP SVLSADLCSL
560 570 580 590 600
LGGVDRYAVS IMWELDKASY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN
610 620 630 640 650
LSVVDDIPEF KDLDEKSRQA KLEELVWAIG KLTDIARHVR AKRDGCGALE
660 670 680 690 700
LEGVEVCVQL DDKKNIHDLI PKQPLEVHET VAECMILANH WVAKKIWESF
710 720 730 740 750
PHQALLRQHP PPHQEFFSEL RECAKAKGFF IDTRSNKTLA DSLDNANDPH
760 770 780 790 800
DPIVNRLLRS MATQAMSNAL YFSTGSCAEE EFHHYGLALD KYTHFTSPIR
810 820 830 840 850
RYSDIVVHRL LMAAISKDKK MEIKGNLFSN KDLEELCRHI NNRNQAAQHS
860 870 880 890 900
QKQSTELFQC MYFKDKDPAT EERCISDGVI YSIRTNGVLL FIPRFGIKGA
910 920 930 940 950
AYLKNKDGLV ISCGPDSCSE WKPGSLQRFQ NKITSTTTDG ESVTFHLFDH
960 970 980 990 1000
VTVRISIQAS RCHSDTIRLE IISNKPYKIP NTELIHQSSP LLKSELVKEV
1010 1020 1030 1040 1050
TKSVEEAQLA QEVKVNIIQE EYQEYRQTKG RSLYTLLEEI RDLALLDVSN

NYGI
Length:1,054
Mass (Da):120,787
Last modified:January 15, 2008 - v2
Checksum:iB57B691CC25F65B8
GO
Isoform 2 (identifier: Q8TF46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Note: No experimental confirmation available.
Show »
Length:920
Mass (Da):105,012
Checksum:i2F7FB46F906C79A0
GO
Isoform 3 (identifier: Q8TF46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     735-750: SNKTLADSLDNANDPH → YSSFEGAEEWSGMLYI
     751-1054: Missing.

Note: No experimental confirmation available.
Show »
Length:750
Mass (Da):86,260
Checksum:iDBACF862A569703A
GO
Isoform 4 (identifier: Q8TF46-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Note: No experimental confirmation available.
Show »
Length:971
Mass (Da):111,119
Checksum:iA3145DE249DF5279
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PI20E9PI20_HUMAN
DIS3-like exonuclease 1
DIS3L
103Annotation score:
E9PI27E9PI27_HUMAN
DIS3-like exonuclease 1
DIS3L
97Annotation score:
E9PIL0E9PIL0_HUMAN
DIS3-like exonuclease 1
DIS3L
57Annotation score:
E9PS35E9PS35_HUMAN
DIS3-like exonuclease 1
DIS3L
150Annotation score:
E9PKI7E9PKI7_HUMAN
DIS3-like exonuclease 1
DIS3L
55Annotation score:

Sequence cautioni

The sequence BAB85541 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038056518I → V. Corresponds to variant dbSNP:rs34668776Ensembl.1
Natural variantiVAR_038057614D → G2 PublicationsCorresponds to variant dbSNP:rs3803412Ensembl.1
Natural variantiVAR_038058747N → S. Corresponds to variant dbSNP:rs17258507Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0303661 – 134Missing in isoform 2. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_0303671 – 83Missing in isoform 4. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_030368735 – 750SNKTL…ANDPH → YSSFEGAEEWSGMLYI in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_030369751 – 1054Missing in isoform 3. 1 PublicationAdd BLAST304

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075835 mRNA Translation: BAB85541.1 Different initiation.
AK095407 mRNA Translation: BAC04542.1
AC055855 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77759.1
BC014124 mRNA Translation: AAH14124.2
BC022089 mRNA Translation: AAH22089.1
CCDSiCCDS10214.1 [Q8TF46-4]
CCDS45286.1 [Q8TF46-1]
RefSeqiNP_001137160.1, NM_001143688.2 [Q8TF46-1]
NP_001310865.1, NM_001323936.1 [Q8TF46-4]
NP_001310867.1, NM_001323938.1 [Q8TF46-2]
NP_001310868.1, NM_001323939.1 [Q8TF46-2]
NP_001310870.1, NM_001323941.1 [Q8TF46-2]
NP_001310874.1, NM_001323945.1 [Q8TF46-4]
NP_001310875.1, NM_001323946.1 [Q8TF46-2]
NP_588616.1, NM_133375.4 [Q8TF46-4]
UniGeneiHs.446251
Hs.658492

Genome annotation databases

EnsembliENST00000319194; ENSP00000321583; ENSG00000166938 [Q8TF46-4]
ENST00000319212; ENSP00000321711; ENSG00000166938 [Q8TF46-1]
GeneIDi115752
KEGGihsa:115752
UCSCiuc002app.4 human [Q8TF46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075835 mRNA Translation: BAB85541.1 Different initiation.
AK095407 mRNA Translation: BAC04542.1
AC055855 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77759.1
BC014124 mRNA Translation: AAH14124.2
BC022089 mRNA Translation: AAH22089.1
CCDSiCCDS10214.1 [Q8TF46-4]
CCDS45286.1 [Q8TF46-1]
RefSeqiNP_001137160.1, NM_001143688.2 [Q8TF46-1]
NP_001310865.1, NM_001323936.1 [Q8TF46-4]
NP_001310867.1, NM_001323938.1 [Q8TF46-2]
NP_001310868.1, NM_001323939.1 [Q8TF46-2]
NP_001310870.1, NM_001323941.1 [Q8TF46-2]
NP_001310874.1, NM_001323945.1 [Q8TF46-4]
NP_001310875.1, NM_001323946.1 [Q8TF46-2]
NP_588616.1, NM_133375.4 [Q8TF46-4]
UniGeneiHs.446251
Hs.658492

3D structure databases

ProteinModelPortaliQ8TF46
SMRiQ8TF46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125453, 29 interactors
ComplexPortaliCPX-592 Cytoplasmic exosome complex, DIS3L variant
CPX-600 Cytoplasmic exosome complex, DIS3L-EXOSC10 variant
IntActiQ8TF46, 20 interactors
MINTiQ8TF46
STRINGi9606.ENSP00000321711

PTM databases

iPTMnetiQ8TF46
PhosphoSitePlusiQ8TF46

Polymorphism and mutation databases

BioMutaiDIS3L
DMDMi166201903

Proteomic databases

EPDiQ8TF46
MaxQBiQ8TF46
PaxDbiQ8TF46
PeptideAtlasiQ8TF46
PRIDEiQ8TF46
ProteomicsDBi74555
74556 [Q8TF46-2]
74557 [Q8TF46-3]
74558 [Q8TF46-4]

Protocols and materials databases

DNASUi115752
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319194; ENSP00000321583; ENSG00000166938 [Q8TF46-4]
ENST00000319212; ENSP00000321711; ENSG00000166938 [Q8TF46-1]
GeneIDi115752
KEGGihsa:115752
UCSCiuc002app.4 human [Q8TF46-1]

Organism-specific databases

CTDi115752
DisGeNETi115752
EuPathDBiHostDB:ENSG00000166938.12
GeneCardsiDIS3L
HGNCiHGNC:28698 DIS3L
HPAiHPA041805
MIMi614183 gene
neXtProtiNX_Q8TF46
OpenTargetsiENSG00000166938
PharmGKBiPA162383675
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2102 Eukaryota
COG0557 LUCA
GeneTreeiENSGT00530000063106
HOGENOMiHOG000191945
HOVERGENiHBG059397
InParanoidiQ8TF46
KOiK18681
OMAiIPRFGIK
OrthoDBiEOG091G06EJ
PhylomeDBiQ8TF46
TreeFamiTF105755

Miscellaneous databases

ChiTaRSiDIS3L human
GeneWikiiDIS3L
GenomeRNAii115752
PROiPR:Q8TF46
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166938 Expressed in 207 organ(s), highest expression level in corpus callosum
CleanExiHS_DIS3L
ExpressionAtlasiQ8TF46 baseline and differential
GenevisibleiQ8TF46 HS

Family and domain databases

InterProiView protein in InterPro
IPR031192 DIS3L
IPR012340 NA-bd_OB-fold
IPR022966 RNase_II/R_CS
IPR033771 Rrp44_CSD1
IPR033770 RRP44_S1
PANTHERiPTHR23355:SF30 PTHR23355:SF30, 1 hit
PfamiView protein in Pfam
PF17216 Rrp44_CSD1, 1 hit
PF17215 Rrp44_S1, 1 hit
SUPFAMiSSF50249 SSF50249, 4 hits
PROSITEiView protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDI3L1_HUMAN
AccessioniPrimary (citable) accession number: Q8TF46
Secondary accession number(s): Q8N1N8, Q8WTU9, Q96CM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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