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Entry version 154 (17 Jun 2020)
Sequence version 2 (19 Sep 2002)
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Protein

Zinc finger protein 418

Gene

ZNF418

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri82 – 105C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri230 – 252C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri619 – 641C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri647 – 669C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 418
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF418
Synonyms:KIAA1956
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196724.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20647 ZNF418

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF45

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
147686

Open Targets

More...
OpenTargetsi
ENSG00000196724

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134912102

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TF45 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF418

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23396985

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475731 – 676Zinc finger protein 418Add BLAST676

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TF45

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TF45

PeptideAtlas

More...
PeptideAtlasi
Q8TF45

PRoteomics IDEntifications database

More...
PRIDEi
Q8TF45

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74554

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TF45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196724 Expressed in corpus callosum and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TF45 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TF45 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196724 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127074, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TF45, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379451

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TF45 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TF45

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 91KRABPROSITE-ProRule annotationAdd BLAST87

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri82 – 105C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri230 – 252C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri619 – 641C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri647 – 669C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164269

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_55_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TF45

KEGG Orthology (KO)

More...
KOi
K09228

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TF45

TreeFam database of animal gene trees

More...
TreeFami
TF339848

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q8TF45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS
60 70 80 90 100
EDEEAPSKKS ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH
110 120 130 140 150
QGTHHKQKLH RCEAWGNKLY DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC
160 170 180 190 200
KFHVSEESSI FIQSGKDFLP SSGLLLQEAT HTGEKSNSKP ECESPFQWGD
210 220 230 240 250
THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS KYDSVSNHQR
260 270 280 290 300
VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS
310 320 330 340 350
LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC
360 370 380 390 400
FTQKGNLIQH QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC
410 420 430 440 450
GECGKSFSRK GHLRNHQRGH TGERPYECGE CGKSFSRKGN LIQHQRSHTG
460 470 480 490 500
ERPYECRECR KLFRGKSHLI EHQRVHTGER PYECNECGKS FQDSSGFRVH
510 520 530 540 550
QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC GECGKSFHQS
560 570 580 590 600
SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF
610 620 630 640 650
TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS
660 670
ECGKSFHRSS SLLRHQRVHT ERSPYK
Length:676
Mass (Da):77,858
Last modified:September 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BB0F0064B8F3BD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQR4J3KQR4_HUMAN
Zinc finger protein 418
ZNF418
697Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXB3M0QXB3_HUMAN
Zinc finger protein 418
ZNF418
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYW9M0QYW9_HUMAN
Zinc finger protein 418
ZNF418
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1R2M0R1R2_HUMAN
Zinc finger protein 418
ZNF418
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX21M0QX21_HUMAN
Zinc finger protein 418
ZNF418
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX82M0QX82_HUMAN
Zinc finger protein 418
ZNF418
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85542 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti290E → G in BAB71096 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY695825 mRNA Translation: AAU05132.1
AB075836 mRNA Translation: BAB85542.1 Different initiation.
AK056113 mRNA Translation: BAB71096.1
BC112244 mRNA Translation: AAI12245.1
BC113707 mRNA Translation: AAI13708.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42642.1

NCBI Reference Sequences

More...
RefSeqi
NP_001303956.1, NM_001317027.1
NP_001303957.1, NM_001317028.1
NP_001303958.1, NM_001317029.1
NP_001303959.1, NM_001317030.1
NP_597717.1, NM_133460.2
XP_016881801.1, XM_017026312.1
XP_016881802.1, XM_017026313.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396147; ENSP00000379451; ENSG00000196724
ENST00000595830; ENSP00000471652; ENSG00000196724
ENST00000616958; ENSP00000483763; ENSG00000196724

Database of genes from NCBI RefSeq genomes

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GeneIDi
147686

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:147686

UCSC genome browser

More...
UCSCi
uc002qqs.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY695825 mRNA Translation: AAU05132.1
AB075836 mRNA Translation: BAB85542.1 Different initiation.
AK056113 mRNA Translation: BAB71096.1
BC112244 mRNA Translation: AAI12245.1
BC113707 mRNA Translation: AAI13708.1
CCDSiCCDS42642.1
RefSeqiNP_001303956.1, NM_001317027.1
NP_001303957.1, NM_001317028.1
NP_001303958.1, NM_001317029.1
NP_001303959.1, NM_001317030.1
NP_597717.1, NM_133460.2
XP_016881801.1, XM_017026312.1
XP_016881802.1, XM_017026313.1

3D structure databases

SMRiQ8TF45
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127074, 2 interactors
IntActiQ8TF45, 3 interactors
STRINGi9606.ENSP00000379451

PTM databases

iPTMnetiQ8TF45
PhosphoSitePlusiQ8TF45

Polymorphism and mutation databases

BioMutaiZNF418
DMDMi23396985

Proteomic databases

MassIVEiQ8TF45
PaxDbiQ8TF45
PeptideAtlasiQ8TF45
PRIDEiQ8TF45
ProteomicsDBi74554

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33292 53 antibodies

The DNASU plasmid repository

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DNASUi
147686

Genome annotation databases

EnsembliENST00000396147; ENSP00000379451; ENSG00000196724
ENST00000595830; ENSP00000471652; ENSG00000196724
ENST00000616958; ENSP00000483763; ENSG00000196724
GeneIDi147686
KEGGihsa:147686
UCSCiuc002qqs.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
147686
DisGeNETi147686
EuPathDBiHostDB:ENSG00000196724.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF418
HGNCiHGNC:20647 ZNF418
HPAiENSG00000196724 Low tissue specificity
neXtProtiNX_Q8TF45
OpenTargetsiENSG00000196724
PharmGKBiPA134912102

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164269
HOGENOMiCLU_002678_55_2_1
InParanoidiQ8TF45
KOiK09228
PhylomeDBiQ8TF45
TreeFamiTF339848

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
147686 1 hit in 810 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF418 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
147686
PharosiQ8TF45 Tdark

Protein Ontology

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PROi
PR:Q8TF45
RNActiQ8TF45 protein

Gene expression databases

BgeeiENSG00000196724 Expressed in corpus callosum and 125 other tissues
ExpressionAtlasiQ8TF45 baseline and differential
GenevisibleiQ8TF45 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN418_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF45
Secondary accession number(s): Q2M1S2, Q670L5, Q96N18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: June 17, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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