UniProtKB - Q8TF42 (UBS3B_HUMAN)

>sp|Q8TF42|UBS3B_HUMAN Ubiquitin-associated and SH3 domain-containing protein B OS=Homo sapiens OX=9606 GN=UBASH3B PE=1 SV=2
MAQYGHPSPLGMAAREELYSKVTPRRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALAS
TGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQICGKNKA
HNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKED
SAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEKLAQNIDVKLGC
DWVATIFSRDIRFANHETLQVIYPYTPQNDDELELVPGDFIFMSPMEQTSTSEGWIYGTS
LTTGCSGLLPENYITKADECSTWIFHGSYSILNTSSSNSLTFGDGVLERRPYEDQGLGET
TPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLN
MPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHN
ILKGLQQENHLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPISKL
VVSESYDTYISRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQ
MVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHGPTGGFNWRETLLQE

Entry version 146 (12 Aug 2020)
Sequence version 2 (11 Jul 2006)
Previous versions | rss

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Protein

Ubiquitin-associated and SH3 domain-containing protein B

Gene

UBASH3B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.2 Publications

Catalytic activityⁱ

H₂O
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-tyrosyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
L-tyrosyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
+
phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.9
  "Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases."
  Raguz J., Wagner S., Dikic I., Hoeller D.
  FEBS Lett. 581:4767-4772(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
EC:
3.1.3.48
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.9
  "Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases."
  Raguz J., Wagner S., Dikic I., Hoeller D.
  FEBS Lett. 581:4767-4772(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
H₂O
+
O-phospho-L-tyrosyl-[protein]
L-tyrosine-phosphate residue
zoom
=
L-tyrosyl-[protein]
L-tyrosine residue
zoom
+
phosphate
zoom

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	390	By similarity	1
Active siteⁱ	391	Tele-phosphohistidine intermediateBy similarity	1
Active siteⁱ	576	By similarity	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Enzyme and pathway databases

PathwayCommonsⁱ	Q8TF42
SignaLinkⁱ	Q8TF42
SIGNORⁱ	Q8TF42

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin-associated and SH3 domain-containing protein B (EC:3.1.3.48) Alternative name(s): Cbl-interacting protein p70 Suppressor of T-cell receptor signaling 1 Short name: STS-1 T-cell ubiquitin ligand 2 Short name: TULA-2 Tyrosine-protein phosphatase STS1/TULA2
Gene namesⁱ	Name:UBASH3B Synonyms:KIAA1959, STS1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000154127.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29884, UBASH3B
MIMⁱ	609201, gene
neXtProtⁱ	NX_Q8TF42

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84959
Open Targets More...OpenTargetsⁱ	ENSG00000154127
PharmGKBⁱ	PA162407840

Miscellaneous databases

Pharosⁱ	Q8TF42, Tbio

Pharosⁱ

Q8TF42, Tbio

Polymorphism and mutation databases

BioMutaⁱ	UBASH3B
DMDMⁱ	110287974

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000245508	1 – 649	Ubiquitin-associated and SH3 domain-containing protein BAdd BLAST		649

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	20	PhosphoserineCombined sources		1
Modified residueⁱ	23	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8TF42
jPOSTⁱ	Q8TF42
MassIVEⁱ	Q8TF42
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TF42
PaxDbⁱ	Q8TF42
PeptideAtlas More...PeptideAtlasⁱ	Q8TF42
PRIDEⁱ	Q8TF42
ProteomicsDBⁱ	74552

PTM databases

DEPODⁱ	UBASH3B
iPTMnetⁱ	Q8TF42
PhosphoSitePlusⁱ	Q8TF42

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000154127, Expressed in cerebellum and 174 other tissues
Genevisibleⁱ	Q8TF42, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000154127, Tissue enhanced (brain, lymphoid tissue)

HPAⁱ

ENSG00000154127, Tissue enhanced (brain, lymphoid tissue)

Interactionⁱ

Subunit structureⁱ

Homodimer.

Interacts with JAK2 (in vitro) (By similarity).

Interacts with CBL (PubMed:15159412).

Part of a complex containing CBL and activated EGFR (PubMed:15159412).

Interacts with ubiquitin and with mono-ubiquitinated proteins (PubMed:15159412).

Interacts with ZAP70 (ubiquitinated form) (PubMed:26903241).

By similarity2 Publications

Binary interactionsⁱ

Hide details

Q8TF42

With	#Exp.	IntAct
BBC3 [Q96PG8]	3	EBI-1380492,EBI-17289784
CBLB [Q13191]	6	EBI-1380492,EBI-744027
CCDC74B - isoform 2 [Q96LY2-2]	3	EBI-1380492,EBI-17967022
DAZAP2 [Q15038]	6	EBI-1380492,EBI-724310
DISC1 - isoform 2 [Q9NRI5-2]	3	EBI-1380492,EBI-11988027
DLGAP2 - isoform 3 [Q9P1A6-3]	3	EBI-1380492,EBI-12019838
DMRT3 [Q9NQL9]	3	EBI-1380492,EBI-9679045
DOC2A [Q14183]	5	EBI-1380492,EBI-20861623
DTX3 [Q8N9I9]	3	EBI-1380492,EBI-2340258
EFS - isoform Efs2 [O43281-2]	3	EBI-1380492,EBI-11525448
FAM168A [Q92567]	4	EBI-1380492,EBI-7957930
HOXB2 [P14652]	3	EBI-1380492,EBI-5329558
INCA1 [Q0VD86]	3	EBI-1380492,EBI-6509505
KAT5 [Q92993]	3	EBI-1380492,EBI-399080
KDM1A [O60341]	3	EBI-1380492,EBI-710124
KPRP [Q5T749]	5	EBI-1380492,EBI-10981970
LMO2 - isoform 3 [P25791-3]	3	EBI-1380492,EBI-11959475
LZTS2 [Q9BRK4]	3	EBI-1380492,EBI-741037
PIAS2 - isoform PIAS2-alpha [O75928-2]	3	EBI-1380492,EBI-348567
PRR35 [P0CG20]	3	EBI-1380492,EBI-11986293
PSMB1 [P20618]	3	EBI-1380492,EBI-372273
PTPN21 [Q16825]	3	EBI-1380492,EBI-2860264
RCHY1 [Q96PM5]	6	EBI-1380492,EBI-947779
REL - isoform 2 [Q04864-2]	3	EBI-1380492,EBI-10829018
RNF216 [Q9NWF9]	3	EBI-1380492,EBI-723313
SLC25A48 [Q6ZT89]	3	EBI-1380492,EBI-10255185
SPRY2 [O43597]	3	EBI-1380492,EBI-742487
SYK [P43405]	2	EBI-1380492,EBI-78302
TCF4 - isoform SEF2-1D [P15884-3]	3	EBI-1380492,EBI-13636688
TEPSIN [Q96N21]	3	EBI-1380492,EBI-11139477
TNKS [O95271]	3	EBI-1380492,EBI-1105254
TP53BP2 [Q05BL1]	3	EBI-1380492,EBI-11952721
itself	4	EBI-1380492,EBI-1380492
VPS37B [Q9H9H4]	6	EBI-1380492,EBI-4400866
WASL [O00401]	3	EBI-1380492,EBI-957615

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	124390, 115 interactors
IntActⁱ	Q8TF42, 65 interactors
Molecular INTeraction database More...MINTⁱ	Q8TF42
STRINGⁱ	9606.ENSP00000284273

Miscellaneous databases

RNActⁱ	Q8TF42, protein

RNActⁱ

Q8TF42, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	34 – 36	Combined sources	3
Helixⁱ	40 – 47	Combined sources	8
Helixⁱ	51 – 60	Combined sources	10
Turnⁱ	61 – 63	Combined sources	3
Helixⁱ	66 – 74	Combined sources	9
Beta strandⁱ	252 – 254	Combined sources	3
Beta strandⁱ	257 – 261	Combined sources	5
Beta strandⁱ	268 – 272	Combined sources	5
Beta strandⁱ	280 – 283	Combined sources	4
Helixⁱ	285 – 287	Combined sources	3
Turnⁱ	291 – 294	Combined sources	4
Beta strandⁱ	295 – 303	Combined sources	9
Beta strandⁱ	306 – 310	Combined sources	5
Helixⁱ	311 – 313	Combined sources	3
Beta strandⁱ	314 – 316	Combined sources	3
Beta strandⁱ	385 – 390	Combined sources	6
Helixⁱ	395 – 399	Combined sources	5
Helixⁱ	403 – 407	Combined sources	5
Helixⁱ	432 – 437	Combined sources	6
Helixⁱ	443 – 458	Combined sources	16
Beta strandⁱ	465 – 468	Combined sources	4
Helixⁱ	472 – 485	Combined sources	14
Turnⁱ	488 – 490	Combined sources	3
Beta strandⁱ	493 – 495	Combined sources	3
Helixⁱ	497 – 499	Combined sources	3
Helixⁱ	503 – 505	Combined sources	3
Beta strandⁱ	508 – 510	Combined sources	3
Helixⁱ	517 – 522	Combined sources	6
Helixⁱ	537 – 539	Combined sources	3
Helixⁱ	546 – 564	Combined sources	19
Beta strandⁱ	565 – 567	Combined sources	3
Beta strandⁱ	569 – 575	Combined sources	7
Helixⁱ	579 – 582	Combined sources	4
Turnⁱ	583 – 585	Combined sources	3
Helixⁱ	586 – 588	Combined sources	3
Helixⁱ	595 – 602	Combined sources	8
Beta strandⁱ	610 – 615	Combined sources	6
Turnⁱ	617 – 619	Combined sources	3
Beta strandⁱ	622 – 625	Combined sources	4
Helixⁱ	642 – 645	Combined sources	4

Show more details

3D structure databases

SMRⁱ	Q8TF42
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8TF42

EvolutionaryTraceⁱ

Q8TF42

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 76	UBAPROSITE-ProRule annotationAdd BLAST		50
Domainⁱ	254 – 319	SH3PROSITE-ProRule annotationAdd BLAST		66

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	380 – 649	Protein tyrosine phosphataseBy similarityAdd BLAST		270

Keywords - Domainⁱ

SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG3734, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156097
HOGENOMⁱ	CLU_016516_1_0_1
InParanoidⁱ	Q8TF42
KEGG Orthology (KO) More...KOⁱ	K18993
OMAⁱ	DECGTWV
Database of Orthologous Groups More...OrthoDBⁱ	243749at2759
PhylomeDBⁱ	Q8TF42
TreeFamⁱ	TF313334

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07067, HP_PGM_like, 1 hit cd11936, SH3_UBASH3B, 1 hit
Gene3Dⁱ	3.40.50.1240, 1 hit
InterProⁱ	View protein in InterPro IPR013078, His_Pase_superF_clade-1 IPR029033, His_PPase_superfam IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR015940, UBA IPR009060, UBA-like_sf IPR035632, UBASH3B_SH3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00300, His_Phos_1, 1 hit PF14604, SH3_9, 1 hit PF00627, UBA, 1 hit
SMARTⁱ	View protein in SMART SM00326, SH3, 1 hit SM00165, UBA, 1 hit
SUPFAMⁱ	SSF46934, SSF46934, 1 hit SSF50044, SSF50044, 1 hit SSF53254, SSF53254, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002, SH3, 1 hit PS50030, UBA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8TF42-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQYGHPSPL GMAAREELYS KVTPRRNRQQ RPGTIKHGSA LDVLLSMGFP 
        60         70         80         90        100
RARAQKALAS TGGRSVQAAC DWLFSHVGDP FLDDPLPREY VLYLRPTGPL 
       110        120        130        140        150
AQKLSDFWQQ SKQICGKNKA HNIFPHITLC QFFMCEDSKV DALGEALQTT 
       160        170        180        190        200
VSRWKCKFSA PLPLELYTSS NFIGLFVKED SAEVLKKFAA DFAAEAASKT 
       210        220        230        240        250
EVHVEPHKKQ LHVTLAYHFQ ASHLPTLEKL AQNIDVKLGC DWVATIFSRD 
       260        270        280        290        300
IRFANHETLQ VIYPYTPQND DELELVPGDF IFMSPMEQTS TSEGWIYGTS 
       310        320        330        340        350
LTTGCSGLLP ENYITKADEC STWIFHGSYS ILNTSSSNSL TFGDGVLERR 
       360        370        380        390        400
PYEDQGLGET TPLTIICQPM QPLRVNSQPG PQKRCLFVCR HGERMDVVFG 
       410        420        430        440        450
KYWLSQCFDA KGRYIRTNLN MPHSLPQRSG GFRDYEKDAP ITVFGCMQAR 
       460        470        480        490        500
LVGEALLESN TIIDHVYCSP SLRCVQTAHN ILKGLQQENH LKIRVEPGLF 
       510        520        530        540        550
EWTKWVAGST LPAWIPPSEL AAANLSVDTT YRPHIPISKL VVSESYDTYI 
       560        570        580        590        600
SRSFQVTKEI ISECKSKGNN ILIVAHASSL EACTCQLQGL SPQNSKDFVQ 
       610        620        630        640 
MVRKIPYLGF CSCEELGETG IWQLTDPPIL PLTHGPTGGF NWRETLLQE

Length:649

Mass (Da):72,696

Last modified:July 11, 2006 - v2

Checksum:ⁱ70ED9F50EA20BF43

Sequence cautionⁱ

The sequence AAL16953 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB85545 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	465	H → R in BAD96563 (Ref. 3) Curated		1
Sequence conflictⁱ	465	H → R in BAD96566 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052676	68	A → T1 PublicationCorresponds to variant dbSNP:rs12790613Ensembl.		1
Natural variantⁱVAR_061923	569	N → S. Corresponds to variant dbSNP:rs35343548Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB075839 mRNA Translation: BAB85545.1 Different initiation. AK075203 mRNA Translation: BAC11468.1 AK222843 mRNA Translation: BAD96563.1 AK222846 mRNA Translation: BAD96566.1 BC007541 mRNA Translation: AAH07541.2 AF425252 mRNA Translation: AAL16953.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31694.1
NCBI Reference Sequences More...RefSeqⁱ	NP_116262.2, NM_032873.4

Genome annotation databases

Ensemblⁱ	ENST00000284273; ENSP00000284273; ENSG00000154127
GeneIDⁱ	84959
KEGGⁱ	hsa:84959
UCSC genome browser More...UCSCⁱ	uc001pyi.5, human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8TF42	Ubiquitin-associated and SH3 domain-containing protein B (Fragment)		MACMU		305	UniRef100_Q8TF42

Protein	Similar proteins		Species	Score	Length	Source
Q8TF42	Ubiquitin-associated and SH3 domain-containing protein B (Fragment)		MACMU		305	UniRef90_Q8TF42
ubiquitin-associated and SH3 domain-containing protein B		TARSY		653
ubiquitin-associated and SH3 domain-containing protein B isoform X1		Ursus arctos horribilis		649
Uncharacterized protein		RHIRO		649
Uncharacterized protein		COLAP		649
+206

Protein	Similar proteins		Species	Score	Length	Source
Q8TF42	Ubiquitin-associated and SH3 domain-containing protein B (Fragment)		MACMU		305	UniRef50_Q8TF42
ubiquitin-associated and SH3 domain-containing protein B		TARSY		653
Uncharacterized protein		PAPAN		649
Uncharacterized protein		CERAT		649
Uncharacterized protein		MANLE		649
+559

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB075839 mRNA Translation: BAB85545.1 Different initiation. AK075203 mRNA Translation: BAC11468.1 AK222843 mRNA Translation: BAD96563.1 AK222846 mRNA Translation: BAD96566.1 BC007541 mRNA Translation: AAH07541.2 AF425252 mRNA Translation: AAL16953.1 Different initiation.
CCDSⁱ	CCDS31694.1
RefSeqⁱ	NP_116262.2, NM_032873.4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CPW	NMR	-	A	26-76	[»]
	2E5K	NMR	-	A	248-328	[»]
	5VR6	X-ray	1.87	A/B	384-649	[»]
	5W5G	X-ray	2.48	A/B/C	383-644	[»]
SMRⁱ	Q8TF42
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	124390, 115 interactors
IntActⁱ	Q8TF42, 65 interactors
MINTⁱ	Q8TF42
STRINGⁱ	9606.ENSP00000284273

PTM databases

DEPODⁱ	UBASH3B
iPTMnetⁱ	Q8TF42
PhosphoSitePlusⁱ	Q8TF42

Polymorphism and mutation databases

BioMutaⁱ	UBASH3B
DMDMⁱ	110287974

Proteomic databases

EPDⁱ	Q8TF42
jPOSTⁱ	Q8TF42
MassIVEⁱ	Q8TF42
MaxQBⁱ	Q8TF42
PaxDbⁱ	Q8TF42
PeptideAtlasⁱ	Q8TF42
PRIDEⁱ	Q8TF42
ProteomicsDBⁱ	74552

Protocols and materials databases

Antibodypediaⁱ	32801, 136 antibodies

Antibodypediaⁱ

32801, 136 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000284273; ENSP00000284273; ENSG00000154127
GeneIDⁱ	84959
KEGGⁱ	hsa:84959
UCSCⁱ	uc001pyi.5, human

Organism-specific databases

CTDⁱ	84959
DisGeNETⁱ	84959
EuPathDBⁱ	HostDB:ENSG00000154127.9
GeneCardsⁱ	UBASH3B
HGNCⁱ	HGNC:29884, UBASH3B
HPAⁱ	ENSG00000154127, Tissue enhanced (brain, lymphoid tissue)
MIMⁱ	609201, gene
neXtProtⁱ	NX_Q8TF42
OpenTargetsⁱ	ENSG00000154127
PharmGKBⁱ	PA162407840
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3734, Eukaryota
GeneTreeⁱ	ENSGT00940000156097
HOGENOMⁱ	CLU_016516_1_0_1
InParanoidⁱ	Q8TF42
KOⁱ	K18993
OMAⁱ	DECGTWV
OrthoDBⁱ	243749at2759
PhylomeDBⁱ	Q8TF42
TreeFamⁱ	TF313334

Enzyme and pathway databases

PathwayCommonsⁱ	Q8TF42
SignaLinkⁱ	Q8TF42
SIGNORⁱ	Q8TF42

Miscellaneous databases

BioGRID-ORCSⁱ	84959, 5 hits in 878 CRISPR screens
ChiTaRSⁱ	UBASH3B, human
EvolutionaryTraceⁱ	Q8TF42
GeneWikiⁱ	STS-1_(gene)
GenomeRNAiⁱ	84959
Pharosⁱ	Q8TF42, Tbio
Protein Ontology More...PROⁱ	PR:Q8TF42
RNActⁱ	Q8TF42, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154127, Expressed in cerebellum and 174 other tissues
Genevisibleⁱ	Q8TF42, HS

Family and domain databases

CDDⁱ	cd07067, HP_PGM_like, 1 hit cd11936, SH3_UBASH3B, 1 hit
Gene3Dⁱ	3.40.50.1240, 1 hit
InterProⁱ	View protein in InterPro IPR013078, His_Pase_superF_clade-1 IPR029033, His_PPase_superfam IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR015940, UBA IPR009060, UBA-like_sf IPR035632, UBASH3B_SH3
Pfamⁱ	View protein in Pfam PF00300, His_Phos_1, 1 hit PF14604, SH3_9, 1 hit PF00627, UBA, 1 hit
SMARTⁱ	View protein in SMART SM00326, SH3, 1 hit SM00165, UBA, 1 hit
SUPFAMⁱ	SSF46934, SSF46934, 1 hit SSF50044, SSF50044, 1 hit SSF53254, SSF53254, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002, SH3, 1 hit PS50030, UBA, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBS3B_HUMAN
Accessionⁱ	Q8TF42Primary (citable) accession number: Q8TF42 Secondary accession number(s): Q53GT5 , Q53GT8, Q8NBV7, Q96IG9, Q96NZ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
	Last sequence update:	July 11, 2006
	Last modified:	August 12, 2020
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TF42 (UBS3B_HUMAN)

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Ubiquitin-associated and SH3 domain-containing protein B

UBASH3B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q8TF42

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ