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Entry version 125 (17 Jun 2020)
Sequence version 3 (30 Nov 2010)
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Protein

Folliculin-interacting protein 1

Gene

FNIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases (PubMed:24081491). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Required for B-cell development (By similarity).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9639288 Amino acids regulate mTORC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Folliculin-interacting protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNIP11 PublicationImported
Synonyms:KIAA19611 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000217128.11

Human Gene Nomenclature Database

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HGNCi
HGNC:29418 FNIP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610594 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF40

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi938 – 948SSDSALGDSES → EDEALGDEEE: Mimics phosphorylation status; leading to inhibit ATPase activity of HSP90AA1/Hsp90. 1 PublicationAdd BLAST11
Mutagenesisi938S → A: Impaired phosphorylation by CK2 and interaction with HSP90AA1/Hsp90. 1 Publication1
Mutagenesisi982K → R: No effect on ubiquitination and protein stability. 1 Publication1
Mutagenesisi1117K → R: No effect on ubiquitination and protein stability. 1 Publication1
Mutagenesisi1119K → R: Impaired ubiquitination, leading to increased stability. 1 Publication1
Mutagenesisi1134K → R: No effect on ubiquitination and protein stability. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
96459

Open Targets

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OpenTargetsi
ENSG00000217128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142671758

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TF40 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FNIP1

Domain mapping of disease mutations (DMDM)

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DMDMi
313104236

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003084841 – 1166Folliculin-interacting protein 1Add BLAST1166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei220PhosphoserineCombined sources1
Modified residuei294PhosphothreonineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei763PhosphoserineCombined sources1
Modified residuei938Phosphoserine; alternate; by CK21 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi938O-linked (GlcNAc) serine; alternate1 Publication1
Modified residuei939Phosphoserine; by CK21 Publication1
Modified residuei941Phosphoserine; by CK21 Publication1
Modified residuei946Phosphoserine; by CK21 Publication1
Modified residuei948Phosphoserine; by CK21 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sequential phosphorylation by CK2 promotes its gradual interaction with HSP90AA1/Hsp90 (PubMed:30699359). Priming phosphorylation at Ser-938 is followed by relay phosphorylation at Ser-939, Ser-941, Ser-946 and Ser-948, promoting its gradual interaction with HSP90AA1/Hsp90 (PubMed:30699359). This leads to incremental inhibition of HSP90AA1/Hsp90 ATPase activity and gradual activation of both kinase and non-kinase clients (PubMed:30699359). Dephosphorylated by protein phosphatase 5 (PP5), promoting glycosylation by OGT (PubMed:30699359). Phosphorylated by AMPK (PubMed:17028174).2 Publications
GlcNAcylation at Ser-938 by OGT following dephosphorylation by protein phosphatase 5 (PP5) promotes ubiquitination and degradation by the proteasome.1 Publication
Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties at Lys-1119 following glycosylation by OGT, leading to its degradation by the proteasome.1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TF40

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TF40

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8TF40

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TF40

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TF40

PeptideAtlas

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PeptideAtlasi
Q8TF40

PRoteomics IDEntifications database

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PRIDEi
Q8TF40

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
74549 [Q8TF40-1]
74550 [Q8TF40-2]
74551 [Q8TF40-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF40

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TF40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000217128 Expressed in prostate gland and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TF40 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TF40 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000217128 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and homomultimer (PubMed:18403135, PubMed:27353360). Heterodimer and heteromultimer with FNIP2 (PubMed:18403135, PubMed:27353360).

Interacts with FLCN (via C-terminus) (PubMed:17028174, PubMed:27353360).

Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (By similarity).

Interacts with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK) (PubMed:17028174). Phosphorylated FLCN and AMPK are preferentially bound (PubMed:17028174).

Interacts with HSP70, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4 (PubMed:27353360).

Interacts with HSP90AA1; the interaction inhibits HSP90AA1 ATPase activity (PubMed:27353360, PubMed:30699359).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
125175, 26 interactors

Database of interacting proteins

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DIPi
DIP-57169N

Protein interaction database and analysis system

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IntActi
Q8TF40, 11 interactors

Molecular INTeraction database

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MINTi
Q8TF40

STRING: functional protein association networks

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STRINGi
9606.ENSP00000421985

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8TF40 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 478uDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST442
Domaini486 – 1092cDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST607
Domaini1102 – 1157dDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni929 – 1166Interaction with HSP90AA11 PublicationAdd BLAST238

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 99Poly-Ser4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FNIP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3693 Eukaryota
ENOG410ZIEC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000009391

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_026421_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TF40

KEGG Orthology (KO)

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KOi
K20400

Identification of Orthologs from Complete Genome Data

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OMAi
EHAYINH

Database of Orthologous Groups

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OrthoDBi
303571at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TF40

TreeFam database of animal gene trees

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TreeFami
TF324090

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR037545 DENN_FNIP1/2
IPR028086 FNIP_C_dom
IPR026156 FNIP_fam
IPR028085 FNIP_mid_dom
IPR028084 FNIP_N_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF14638 FNIP_C, 1 hit
PF14637 FNIP_M, 1 hit
PF14636 FNIP_N, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02073 FOLLICULNIP1

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51836 DENN_FNIP12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPTLFQKLF SKRTGLGAPG RDARDPDCGF SWPLPEFDPS QIRLIVYQDC
60 70 80 90 100
ERRGRNVLFD SSVKRRNEDI SVSKLGSDAQ VKVFGKCCQL KPGGDSSSSL
110 120 130 140 150
DSSVTSSSDI KDQCLKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ
160 170 180 190 200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDNN TLKADNNTVI
210 220 230 240 250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE
260 270 280 290 300
DRDSGIARSA SLSSLLITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG
310 320 330 340 350
VFPRWSIEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE
360 370 380 390 400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRIVDALNEF
410 420 430 440 450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNH LCYRFMKEFT FLMENASKNQ
460 470 480 490 500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV DMLAKTHPYN
510 520 530 540 550
PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD MVQRLLYFLT YFIRCSELQE
560 570 580 590 600
THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLVTMHR NKSSLLFKES
610 620 630 640 650
EEIRTPNCNC KYCSHPLLGQ NVENISQQER EDIQNSSKEL LGISDECQMI
660 670 680 690 700
SPSDCQEENA VDVKQYRDKL RTCFDAKLET VVCTGSVPVD KCALSESGLE
710 720 730 740 750
STEETWQSEK LLDSDSHTGK AMRSTGMVVE KKPPDKIVPA SFSCEAAQTK
760 770 780 790 800
VTFLIGDSMS PDSDTELRSQ AVVDQITRHH TKPLKEERGA IDQHQETKQT
810 820 830 840 850
TKDQSGESDT QNMVSEEPCE LPCWNHSDPE SMSLFDEYFN DDSIETRTID
860 870 880 890 900
DVPFKTSTDS KDHCCMLEFS KILCTKNNKQ NNEFCKCIET VPQDSCKTCF
910 920 930 940 950
PQQDQRDTLS ILVPHGDKES SDKKIAVGTE WDIPRNESSD SALGDSESED
960 970 980 990 1000
TGHDMTRQVS SYYGGEQEDW AEEDEIPFPG SKLIEVSAVQ PNIANFGRSL
1010 1020 1030 1040 1050
LGGYCSSYVP DFVLQGIGSD ERFRQCLMSD LSHAVQHPVL DEPIAEAVCI
1060 1070 1080 1090 1100
IADMDKWTVQ VASSQRRVTD NKLGKEVLVS SLVSNLLHST LQLYKHNLSP
1110 1120 1130 1140 1150
NFCVMHLEDR LQELYFKSKM LSEYLRGQMR VHVKELGVVL GIESSDLPLL
1160
AAVASTHSPY VAQILL
Length:1,166
Mass (Da):130,555
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B99DBA98E7169C5
GO
Isoform 2 (identifier: Q8TF40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-508: D → M
     509-1166: Missing.

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Length:508
Mass (Da):56,802
Checksum:i59A0719AD6A85CF9
GO
Isoform 3 (identifier: Q8TF40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-235: Missing.

Show »
Length:1,138
Mass (Da):127,444
Checksum:i3CA14555745B9C37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNG8J3KNG8_HUMAN
Folliculin-interacting protein 1
FNIP1
1,121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX11A0A087WX11_HUMAN
Folliculin-interacting protein 1
FNIP1
918Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03682476G → C2 PublicationsCorresponds to variant dbSNP:rs7730228Ensembl.1
Natural variantiVAR_036825354S → L. Corresponds to variant dbSNP:rs13177318Ensembl.1
Natural variantiVAR_036826648Q → R3 PublicationsCorresponds to variant dbSNP:rs26008Ensembl.1
Natural variantiVAR_036827738V → L. Corresponds to variant dbSNP:rs12109782Ensembl.1
Natural variantiVAR_036828844I → V. Corresponds to variant dbSNP:rs7717874Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028984208 – 235Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_028982508D → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_028983509 – 1166Missing in isoform 2. 1 PublicationAdd BLAST658

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ145719 mRNA Translation: AAZ65854.1
AC004227 Genomic DNA No translation available.
AC004622 Genomic DNA No translation available.
AC005593 Genomic DNA No translation available.
AC008695 Genomic DNA No translation available.
AC008497 Genomic DNA No translation available.
AC026754 Genomic DNA No translation available.
BC001956 mRNA Translation: AAH01956.1
AB075841 mRNA Translation: BAB85547.1
AL832008 mRNA Translation: CAD91145.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34226.1 [Q8TF40-3]
CCDS34227.1 [Q8TF40-1]
CCDS87321.1 [Q8TF40-2]

NCBI Reference Sequences

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RefSeqi
NP_001008738.2, NM_001008738.2 [Q8TF40-3]
NP_001333042.1, NM_001346113.1 [Q8TF40-2]
NP_588613.2, NM_133372.2 [Q8TF40-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307968; ENSP00000309266; ENSG00000217128 [Q8TF40-3]
ENST00000510461; ENSP00000421985; ENSG00000217128 [Q8TF40-1]
ENST00000511848; ENSP00000425619; ENSG00000217128 [Q8TF40-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
96459

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:96459

UCSC genome browser

More...
UCSCi
uc003kvs.2 human [Q8TF40-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ145719 mRNA Translation: AAZ65854.1
AC004227 Genomic DNA No translation available.
AC004622 Genomic DNA No translation available.
AC005593 Genomic DNA No translation available.
AC008695 Genomic DNA No translation available.
AC008497 Genomic DNA No translation available.
AC026754 Genomic DNA No translation available.
BC001956 mRNA Translation: AAH01956.1
AB075841 mRNA Translation: BAB85547.1
AL832008 mRNA Translation: CAD91145.1
CCDSiCCDS34226.1 [Q8TF40-3]
CCDS34227.1 [Q8TF40-1]
CCDS87321.1 [Q8TF40-2]
RefSeqiNP_001008738.2, NM_001008738.2 [Q8TF40-3]
NP_001333042.1, NM_001346113.1 [Q8TF40-2]
NP_588613.2, NM_133372.2 [Q8TF40-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125175, 26 interactors
DIPiDIP-57169N
IntActiQ8TF40, 11 interactors
MINTiQ8TF40
STRINGi9606.ENSP00000421985

PTM databases

iPTMnetiQ8TF40
PhosphoSitePlusiQ8TF40

Polymorphism and mutation databases

BioMutaiFNIP1
DMDMi313104236

Proteomic databases

EPDiQ8TF40
jPOSTiQ8TF40
MassIVEiQ8TF40
MaxQBiQ8TF40
PaxDbiQ8TF40
PeptideAtlasiQ8TF40
PRIDEiQ8TF40
ProteomicsDBi74549 [Q8TF40-1]
74550 [Q8TF40-2]
74551 [Q8TF40-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25902 125 antibodies

Genome annotation databases

EnsembliENST00000307968; ENSP00000309266; ENSG00000217128 [Q8TF40-3]
ENST00000510461; ENSP00000421985; ENSG00000217128 [Q8TF40-1]
ENST00000511848; ENSP00000425619; ENSG00000217128 [Q8TF40-2]
GeneIDi96459
KEGGihsa:96459
UCSCiuc003kvs.2 human [Q8TF40-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
96459
DisGeNETi96459
EuPathDBiHostDB:ENSG00000217128.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FNIP1
HGNCiHGNC:29418 FNIP1
HPAiENSG00000217128 Low tissue specificity
MIMi610594 gene
neXtProtiNX_Q8TF40
OpenTargetsiENSG00000217128
PharmGKBiPA142671758

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3693 Eukaryota
ENOG410ZIEC LUCA
GeneTreeiENSGT00390000009391
HOGENOMiCLU_026421_0_0_1
InParanoidiQ8TF40
KOiK20400
OMAiEHAYINH
OrthoDBi303571at2759
PhylomeDBiQ8TF40
TreeFamiTF324090

Enzyme and pathway databases

ReactomeiR-HSA-9639288 Amino acids regulate mTORC1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
96459 7 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FNIP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
96459
PharosiQ8TF40 Tbio

Protein Ontology

More...
PROi
PR:Q8TF40
RNActiQ8TF40 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000217128 Expressed in prostate gland and 215 other tissues
ExpressionAtlasiQ8TF40 baseline and differential
GenevisibleiQ8TF40 HS

Family and domain databases

InterProiView protein in InterPro
IPR037545 DENN_FNIP1/2
IPR028086 FNIP_C_dom
IPR026156 FNIP_fam
IPR028085 FNIP_mid_dom
IPR028084 FNIP_N_dom
PfamiView protein in Pfam
PF14638 FNIP_C, 1 hit
PF14637 FNIP_M, 1 hit
PF14636 FNIP_N, 1 hit
PRINTSiPR02073 FOLLICULNIP1
PROSITEiView protein in PROSITE
PS51836 DENN_FNIP12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFNIP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF40
Secondary accession number(s): D6RJH5, Q86T47, Q9BUT0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 30, 2010
Last modified: June 17, 2020
This is version 125 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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