UniProtKB - Q8TF39 (ZN483_HUMAN)
Protein
Zinc finger protein 483
Gene
ZNF483
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 439 – 461 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 663 – 685 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 691 – 713 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 719 – 741 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TF39 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 483Alternative name(s): Zinc finger protein with KRAB and SCAN domains 16 |
Gene namesi | Name:ZNF483 Synonyms:KIAA1962, ZKSCAN16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000173258.12 |
HGNCi | HGNC:23384, ZNF483 |
neXtProti | NX_Q8TF39 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 158399 |
OpenTargetsi | ENSG00000173258 |
PharmGKBi | PA134897404 |
Miscellaneous databases
Pharosi | Q8TF39, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF483 |
DMDMi | 205641226 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047610 | 1 – 744 | Zinc finger protein 483Add BLAST | 744 |
Proteomic databases
EPDi | Q8TF39 |
jPOSTi | Q8TF39 |
MassIVEi | Q8TF39 |
PaxDbi | Q8TF39 |
PeptideAtlasi | Q8TF39 |
PRIDEi | Q8TF39 |
ProteomicsDBi | 74547 [Q8TF39-1] 74548 [Q8TF39-2] |
PTM databases
iPTMneti | Q8TF39 |
PhosphoSitePlusi | Q8TF39 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173258, Expressed in corpus callosum and 164 other tissues |
ExpressionAtlasi | Q8TF39, baseline and differential |
Genevisiblei | Q8TF39, HS |
Organism-specific databases
HPAi | ENSG00000173258, Tissue enhanced (brain, pituitary gland) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127677, 32 interactors |
IntActi | Q8TF39, 26 interactors |
STRINGi | 9606.ENSP00000311679 |
Miscellaneous databases
RNActi | Q8TF39, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8TF39 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TF39 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 134 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 170 – 241 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 439 – 461 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 663 – 685 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 691 – 713 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 719 – 741 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162615 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q8TF39 |
OMAi | TEHQKHQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TF39 |
TreeFami | TF350807 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TF39-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQAVVPLNKM TAISPEPQTL ASTEQNEVPR VVTSGEQEAI LRGNAADAES
60 70 80 90 100
FRQRFRWFCY SEVAGPRKAL SQLWELCNQW LRPDIHTKEQ ILELLVFEQF
110 120 130 140 150
LTILPGEIRI WVKSQHPESS EEVVTLIEDL TQMLEEKDPV SQDSTVSQEE
160 170 180 190 200
NSKEDKMVTV CPNTESCESI TLKDVAVNFS RGEWKKLEPF QKELYKEVLL
210 220 230 240 250
ENLRNLEFLD FPVSKLELIS QLKWVELPWL LEEVSKSSRL DESALDKIIE
260 270 280 290 300
RCLRDDDHGL MEESQQYCGS SEEDHGNQGN SKGRVAQNKT LGSGSRGKKF
310 320 330 340 350
DPDKSPFGHN FKETSDLIKH LRVYLRKKSR RYNESKKPFS FHSDLVLNRK
360 370 380 390 400
EKTAGEKSRK SNDGGKVLSH SSALTEHQKR QKIHLGDRSQ KCSKCGIIFI
410 420 430 440 450
RRSTLSRRKT PMCEKCRKDS CQEAALNKDE GNESGEKTHK CSKCGKAFGY
460 470 480 490 500
SASLTKHRRI HTGEKPYMCN ECGKAFSDSS SLTPHHRTHS GEKPFKCDDC
510 520 530 540 550
GKGFTLSAHL IKHQRIHTGE KPYKCKDCGR PFSDSSSLIQ HQRIHTGEKP
560 570 580 590 600
YTCSNCGKSF SHSSSLSKHQ RIHTGEKPYK CGECGKAFRQ NSCLTRHQRI
610 620 630 640 650
HTGEKPYLCN DCGMTFSHFT SVIYHQRLHS GEKPYKCNQC EKAFPTHSLL
660 670 680 690 700
SRHQRIHTGV KPYKCKECGK SFSQSSSLNE HHRIHTGEKP YECNYCGATF
710 720 730 740
SRSSILVEHL KIHTGRREYE CNECEKTFKS NSGLIRHRGF HSAE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6P088 | Q6P088_HUMAN | ZNF483 protein | ZNF483 | 244 | Annotation score: | ||
Q5VZN3 | Q5VZN3_HUMAN | Zinc finger protein 483 | ZNF483 | 178 | Annotation score: |
Sequence cautioni
The sequence BAB85548 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 436 | E → K in BAB85548 (PubMed:11853319).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043023 | 242 – 256 | ESALD…CLRDD → IHGAVKKMQMFSEAE in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_043024 | 257 – 744 | Missing in isoform 2. 1 PublicationAdd BLAST | 488 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075842 mRNA Translation: BAB85548.1 Different initiation. AK092811 mRNA Translation: BAC03981.1 AK291267 mRNA Translation: BAF83956.1 AL159168 Genomic DNA No translation available. AL135787 Genomic DNA No translation available. CH471105 Genomic DNA Translation: EAW59073.1 BC136695 mRNA Translation: AAI36696.1 BC136696 mRNA Translation: AAI36697.1 |
CCDSi | CCDS35105.1 [Q8TF39-2] CCDS35106.1 [Q8TF39-1] |
RefSeqi | NP_001007170.1, NM_001007169.3 [Q8TF39-2] NP_597721.2, NM_133464.3 [Q8TF39-1] XP_011516602.1, XM_011518300.2 [Q8TF39-1] XP_016869826.1, XM_017014337.1 [Q8TF39-1] XP_016869827.1, XM_017014338.1 [Q8TF39-1] |
Genome annotation databases
Ensembli | ENST00000309235; ENSP00000311679; ENSG00000173258 [Q8TF39-1] ENST00000358151; ENSP00000350871; ENSG00000173258 [Q8TF39-2] |
GeneIDi | 158399 |
KEGGi | hsa:158399 |
UCSCi | uc004bff.4, human [Q8TF39-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075842 mRNA Translation: BAB85548.1 Different initiation. AK092811 mRNA Translation: BAC03981.1 AK291267 mRNA Translation: BAF83956.1 AL159168 Genomic DNA No translation available. AL135787 Genomic DNA No translation available. CH471105 Genomic DNA Translation: EAW59073.1 BC136695 mRNA Translation: AAI36696.1 BC136696 mRNA Translation: AAI36697.1 |
CCDSi | CCDS35105.1 [Q8TF39-2] CCDS35106.1 [Q8TF39-1] |
RefSeqi | NP_001007170.1, NM_001007169.3 [Q8TF39-2] NP_597721.2, NM_133464.3 [Q8TF39-1] XP_011516602.1, XM_011518300.2 [Q8TF39-1] XP_016869826.1, XM_017014337.1 [Q8TF39-1] XP_016869827.1, XM_017014338.1 [Q8TF39-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CTU | NMR | - | A | 379-438 | [»] | |
SMRi | Q8TF39 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 127677, 32 interactors |
IntActi | Q8TF39, 26 interactors |
STRINGi | 9606.ENSP00000311679 |
PTM databases
iPTMneti | Q8TF39 |
PhosphoSitePlusi | Q8TF39 |
Polymorphism and mutation databases
BioMutai | ZNF483 |
DMDMi | 205641226 |
Proteomic databases
EPDi | Q8TF39 |
jPOSTi | Q8TF39 |
MassIVEi | Q8TF39 |
PaxDbi | Q8TF39 |
PeptideAtlasi | Q8TF39 |
PRIDEi | Q8TF39 |
ProteomicsDBi | 74547 [Q8TF39-1] 74548 [Q8TF39-2] |
Protocols and materials databases
ABCDi | Q8TF39, 2 sequenced antibodies |
Antibodypediai | 29572, 113 antibodies |
DNASUi | 158399 |
Genome annotation databases
Ensembli | ENST00000309235; ENSP00000311679; ENSG00000173258 [Q8TF39-1] ENST00000358151; ENSP00000350871; ENSG00000173258 [Q8TF39-2] |
GeneIDi | 158399 |
KEGGi | hsa:158399 |
UCSCi | uc004bff.4, human [Q8TF39-1] |
Organism-specific databases
CTDi | 158399 |
DisGeNETi | 158399 |
EuPathDBi | HostDB:ENSG00000173258.12 |
GeneCardsi | ZNF483 |
HGNCi | HGNC:23384, ZNF483 |
HPAi | ENSG00000173258, Tissue enhanced (brain, pituitary gland) |
neXtProti | NX_Q8TF39 |
OpenTargetsi | ENSG00000173258 |
PharmGKBi | PA134897404 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162615 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q8TF39 |
OMAi | TEHQKHQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TF39 |
TreeFami | TF350807 |
Enzyme and pathway databases
PathwayCommonsi | Q8TF39 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 158399, 1 hit in 865 CRISPR screens |
ChiTaRSi | ZNF483, human |
EvolutionaryTracei | Q8TF39 |
GenomeRNAii | 158399 |
Pharosi | Q8TF39, Tdark |
PROi | PR:Q8TF39 |
RNActi | Q8TF39, protein |
Gene expression databases
Bgeei | ENSG00000173258, Expressed in corpus callosum and 164 other tissues |
ExpressionAtlasi | Q8TF39, baseline and differential |
Genevisiblei | Q8TF39, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN483_HUMAN | |
Accessioni | Q8TF39Primary (citable) accession number: Q8TF39 Secondary accession number(s): Q5VZN2, Q8NAE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 11, 2003 |
Last sequence update: | July 22, 2008 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families