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UniProtKB - Q8TF39 (ZN483_HUMAN)

Entry version 163 (02 Dec 2020)
Sequence version 3 (22 Jul 2008)
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Protein

Zinc finger protein 483

Gene

ZNF483

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri439 – 461C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TF39

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 483
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF483
Synonyms:KIAA1962, ZKSCAN16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000173258.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:23384, ZNF483

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TF39

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		158399

Open Targets

More...OpenTargetsi		ENSG00000173258

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134897404

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TF39, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF483

Domain mapping of disease mutations (DMDM)

More...DMDMi		205641226

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476101 – 744Zinc finger protein 483Add BLAST744

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TF39

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TF39

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TF39

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TF39

PeptideAtlas

More...PeptideAtlasi		Q8TF39

PRoteomics IDEntifications database

More...PRIDEi		Q8TF39

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74547 [Q8TF39-1]
74548 [Q8TF39-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TF39

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TF39

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173258, Expressed in corpus callosum and 164 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TF39, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TF39, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173258, Tissue enhanced (brain, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127677, 32 interactors

Protein interaction database and analysis system

More...IntActi		Q8TF39, 26 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000311679

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TF39, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1744
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TF39

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8TF39

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini170 – 241KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri439 – 461C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162615

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_49_8_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TF39

Identification of Orthologs from Complete Genome Data

More...OMAi		TEHQKHQ

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TF39

TreeFam database of animal gene trees

More...TreeFami		TF350807

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQAVVPLNKM TAISPEPQTL ASTEQNEVPR VVTSGEQEAI LRGNAADAES 
        60         70         80         90        100
FRQRFRWFCY SEVAGPRKAL SQLWELCNQW LRPDIHTKEQ ILELLVFEQF 
       110        120        130        140        150
LTILPGEIRI WVKSQHPESS EEVVTLIEDL TQMLEEKDPV SQDSTVSQEE 
       160        170        180        190        200
NSKEDKMVTV CPNTESCESI TLKDVAVNFS RGEWKKLEPF QKELYKEVLL 
       210        220        230        240        250
ENLRNLEFLD FPVSKLELIS QLKWVELPWL LEEVSKSSRL DESALDKIIE 
       260        270        280        290        300
RCLRDDDHGL MEESQQYCGS SEEDHGNQGN SKGRVAQNKT LGSGSRGKKF 
       310        320        330        340        350
DPDKSPFGHN FKETSDLIKH LRVYLRKKSR RYNESKKPFS FHSDLVLNRK 
       360        370        380        390        400
EKTAGEKSRK SNDGGKVLSH SSALTEHQKR QKIHLGDRSQ KCSKCGIIFI 
       410        420        430        440        450
RRSTLSRRKT PMCEKCRKDS CQEAALNKDE GNESGEKTHK CSKCGKAFGY 
       460        470        480        490        500
SASLTKHRRI HTGEKPYMCN ECGKAFSDSS SLTPHHRTHS GEKPFKCDDC 
       510        520        530        540        550
GKGFTLSAHL IKHQRIHTGE KPYKCKDCGR PFSDSSSLIQ HQRIHTGEKP 
       560        570        580        590        600
YTCSNCGKSF SHSSSLSKHQ RIHTGEKPYK CGECGKAFRQ NSCLTRHQRI 
       610        620        630        640        650
HTGEKPYLCN DCGMTFSHFT SVIYHQRLHS GEKPYKCNQC EKAFPTHSLL 
       660        670        680        690        700
SRHQRIHTGV KPYKCKECGK SFSQSSSLNE HHRIHTGEKP YECNYCGATF 
       710        720        730        740 
SRSSILVEHL KIHTGRREYE CNECEKTFKS NSGLIRHRGF HSAE
Length:744
Mass (Da):85,098
Last modified:July 22, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19B1CCD3BE1C53D0
GO
Isoform 2 (identifier: Q8TF39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-256: ESALDKIIERCLRDD → IHGAVKKMQMFSEAE
     257-744: Missing.

Show »
Length:256
Mass (Da):29,568
Checksum:i04E8A0B60A9125C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P088Q6P088_HUMAN
ZNF483 protein
ZNF483
244Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VZN3Q5VZN3_HUMAN
Zinc finger protein 483
ZNF483
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85548 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti436E → K in BAB85548 (PubMed:11853319).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043023242 – 256ESALD…CLRDD → IHGAVKKMQMFSEAE in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_043024257 – 744Missing in isoform 2. 1 PublicationAdd BLAST488

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB075842 mRNA Translation: BAB85548.1 Different initiation.
AK092811 mRNA Translation: BAC03981.1
AK291267 mRNA Translation: BAF83956.1
AL159168 Genomic DNA No translation available.
AL135787 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59073.1
BC136695 mRNA Translation: AAI36696.1
BC136696 mRNA Translation: AAI36697.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35105.1 [Q8TF39-2]
CCDS35106.1 [Q8TF39-1]

NCBI Reference Sequences

More...RefSeqi		NP_001007170.1, NM_001007169.3 [Q8TF39-2]
NP_597721.2, NM_133464.3 [Q8TF39-1]
XP_011516602.1, XM_011518300.2 [Q8TF39-1]
XP_016869826.1, XM_017014337.1 [Q8TF39-1]
XP_016869827.1, XM_017014338.1 [Q8TF39-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309235; ENSP00000311679; ENSG00000173258 [Q8TF39-1]
ENST00000358151; ENSP00000350871; ENSG00000173258 [Q8TF39-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		158399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:158399

UCSC genome browser

More...UCSCi		uc004bff.4, human [Q8TF39-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075842 mRNA Translation: BAB85548.1 Different initiation.
AK092811 mRNA Translation: BAC03981.1
AK291267 mRNA Translation: BAF83956.1
AL159168 Genomic DNA No translation available.
AL135787 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59073.1
BC136695 mRNA Translation: AAI36696.1
BC136696 mRNA Translation: AAI36697.1
CCDSiCCDS35105.1 [Q8TF39-2]
CCDS35106.1 [Q8TF39-1]
RefSeqiNP_001007170.1, NM_001007169.3 [Q8TF39-2]
NP_597721.2, NM_133464.3 [Q8TF39-1]
XP_011516602.1, XM_011518300.2 [Q8TF39-1]
XP_016869826.1, XM_017014337.1 [Q8TF39-1]
XP_016869827.1, XM_017014338.1 [Q8TF39-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CTUNMR-A379-438[»]
SMRiQ8TF39
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127677, 32 interactors
IntActiQ8TF39, 26 interactors
STRINGi9606.ENSP00000311679

PTM databases

iPTMnetiQ8TF39
PhosphoSitePlusiQ8TF39

Polymorphism and mutation databases

BioMutaiZNF483
DMDMi205641226

Proteomic databases

EPDiQ8TF39
jPOSTiQ8TF39
MassIVEiQ8TF39
PaxDbiQ8TF39
PeptideAtlasiQ8TF39
PRIDEiQ8TF39
ProteomicsDBi74547 [Q8TF39-1]
74548 [Q8TF39-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q8TF39, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29572, 113 antibodies

The DNASU plasmid repository

More...DNASUi		158399

Genome annotation databases

EnsembliENST00000309235; ENSP00000311679; ENSG00000173258 [Q8TF39-1]
ENST00000358151; ENSP00000350871; ENSG00000173258 [Q8TF39-2]
GeneIDi158399
KEGGihsa:158399
UCSCiuc004bff.4, human [Q8TF39-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		158399
DisGeNETi158399
EuPathDBiHostDB:ENSG00000173258.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF483
HGNCiHGNC:23384, ZNF483
HPAiENSG00000173258, Tissue enhanced (brain, pituitary gland)
neXtProtiNX_Q8TF39
OpenTargetsiENSG00000173258
PharmGKBiPA134897404

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162615
HOGENOMiCLU_002678_49_8_1
InParanoidiQ8TF39
OMAiTEHQKHQ
OrthoDBi1318335at2759
PhylomeDBiQ8TF39
TreeFamiTF350807

Enzyme and pathway databases

PathwayCommonsiQ8TF39
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		158399, 1 hit in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF483, human
EvolutionaryTraceiQ8TF39

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		158399
PharosiQ8TF39, Tdark

Protein Ontology

More...PROi		PR:Q8TF39
RNActiQ8TF39, protein

Gene expression databases

BgeeiENSG00000173258, Expressed in corpus callosum and 164 other tissues
ExpressionAtlasiQ8TF39, baseline and differential
GenevisibleiQ8TF39, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 11 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN483_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF39
Secondary accession number(s): Q5VZN2, Q8NAE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: July 22, 2008
Last modified: December 2, 2020
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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