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Protein

Zinc finger protein 483

Gene

ZNF483

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri439 – 461C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 483
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 16
Gene namesi
Name:ZNF483
Synonyms:KIAA1962, ZKSCAN16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000173258.12
HGNCiHGNC:23384 ZNF483
neXtProtiNX_Q8TF39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi158399
OpenTargetsiENSG00000173258
PharmGKBiPA134897404

Polymorphism and mutation databases

DMDMi205641226

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476101 – 744Zinc finger protein 483Add BLAST744

Proteomic databases

EPDiQ8TF39
PaxDbiQ8TF39
PeptideAtlasiQ8TF39
PRIDEiQ8TF39
ProteomicsDBi74547
74548 [Q8TF39-2]

PTM databases

iPTMnetiQ8TF39
PhosphoSitePlusiQ8TF39

Expressioni

Gene expression databases

BgeeiENSG00000173258
CleanExiHS_ZNF483
ExpressionAtlasiQ8TF39 baseline and differential
GenevisibleiQ8TF39 HS

Organism-specific databases

HPAiHPA055041

Interactioni

Protein-protein interaction databases

BioGridi127677, 28 interactors
IntActiQ8TF39, 3 interactors
STRINGi9606.ENSP00000311679

Structurei

Secondary structure

1744
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi388 – 391Combined sources4
Beta strandi393 – 395Combined sources3
Beta strandi398 – 400Combined sources3
Beta strandi408 – 410Combined sources3
Helixi414 – 418Combined sources5

3D structure databases

ProteinModelPortaliQ8TF39
SMRiQ8TF39
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TF39

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini170 – 241KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri439 – 461C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144197
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ8TF39
KOiK09229
OMAiREYECNE
OrthoDBiEOG091G02KC
PhylomeDBiQ8TF39
TreeFamiTF350807

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TF39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAVVPLNKM TAISPEPQTL ASTEQNEVPR VVTSGEQEAI LRGNAADAES
60 70 80 90 100
FRQRFRWFCY SEVAGPRKAL SQLWELCNQW LRPDIHTKEQ ILELLVFEQF
110 120 130 140 150
LTILPGEIRI WVKSQHPESS EEVVTLIEDL TQMLEEKDPV SQDSTVSQEE
160 170 180 190 200
NSKEDKMVTV CPNTESCESI TLKDVAVNFS RGEWKKLEPF QKELYKEVLL
210 220 230 240 250
ENLRNLEFLD FPVSKLELIS QLKWVELPWL LEEVSKSSRL DESALDKIIE
260 270 280 290 300
RCLRDDDHGL MEESQQYCGS SEEDHGNQGN SKGRVAQNKT LGSGSRGKKF
310 320 330 340 350
DPDKSPFGHN FKETSDLIKH LRVYLRKKSR RYNESKKPFS FHSDLVLNRK
360 370 380 390 400
EKTAGEKSRK SNDGGKVLSH SSALTEHQKR QKIHLGDRSQ KCSKCGIIFI
410 420 430 440 450
RRSTLSRRKT PMCEKCRKDS CQEAALNKDE GNESGEKTHK CSKCGKAFGY
460 470 480 490 500
SASLTKHRRI HTGEKPYMCN ECGKAFSDSS SLTPHHRTHS GEKPFKCDDC
510 520 530 540 550
GKGFTLSAHL IKHQRIHTGE KPYKCKDCGR PFSDSSSLIQ HQRIHTGEKP
560 570 580 590 600
YTCSNCGKSF SHSSSLSKHQ RIHTGEKPYK CGECGKAFRQ NSCLTRHQRI
610 620 630 640 650
HTGEKPYLCN DCGMTFSHFT SVIYHQRLHS GEKPYKCNQC EKAFPTHSLL
660 670 680 690 700
SRHQRIHTGV KPYKCKECGK SFSQSSSLNE HHRIHTGEKP YECNYCGATF
710 720 730 740
SRSSILVEHL KIHTGRREYE CNECEKTFKS NSGLIRHRGF HSAE
Length:744
Mass (Da):85,098
Last modified:July 22, 2008 - v3
Checksum:i19B1CCD3BE1C53D0
GO
Isoform 2 (identifier: Q8TF39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-256: ESALDKIIERCLRDD → IHGAVKKMQMFSEAE
     257-744: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):29,568
Checksum:i04E8A0B60A9125C3
GO

Sequence cautioni

The sequence BAB85548 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436E → K in BAB85548 (PubMed:11853319).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043023242 – 256ESALD…CLRDD → IHGAVKKMQMFSEAE in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_043024257 – 744Missing in isoform 2. 1 PublicationAdd BLAST488

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075842 mRNA Translation: BAB85548.1 Different initiation.
AK092811 mRNA Translation: BAC03981.1
AK291267 mRNA Translation: BAF83956.1
AL159168 Genomic DNA No translation available.
AL135787 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59073.1
BC136695 mRNA Translation: AAI36696.1
BC136696 mRNA Translation: AAI36697.1
CCDSiCCDS35105.1 [Q8TF39-2]
CCDS35106.1 [Q8TF39-1]
RefSeqiNP_001007170.1, NM_001007169.3 [Q8TF39-2]
NP_597721.2, NM_133464.3 [Q8TF39-1]
XP_011516602.1, XM_011518300.2 [Q8TF39-1]
XP_016869826.1, XM_017014337.1 [Q8TF39-1]
XP_016869827.1, XM_017014338.1 [Q8TF39-1]
UniGeneiHs.584864
Hs.660784

Genome annotation databases

EnsembliENST00000309235; ENSP00000311679; ENSG00000173258 [Q8TF39-1]
ENST00000358151; ENSP00000350871; ENSG00000173258 [Q8TF39-2]
GeneIDi158399
KEGGihsa:158399
UCSCiuc004bff.4 human [Q8TF39-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN483_HUMAN
AccessioniPrimary (citable) accession number: Q8TF39
Secondary accession number(s): Q5VZN2, Q8NAE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: July 22, 2008
Last modified: June 20, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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