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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11

Gene

AGAP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 366C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11
Short name:
AGAP-11
Alternative name(s):
Centaurin-gamma-like protein KIAA1975
Gene namesi
Name:AGAP11
Synonyms:KIAA1975
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29421 AGAP11
neXtProtiNX_Q8TF27

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715011

Polymorphism and mutation databases

BioMutaiAGAP11
DMDMi182641995

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287581 – 550Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11Add BLAST550

Proteomic databases

EPDiQ8TF27
MaxQBiQ8TF27
PeptideAtlasiQ8TF27
PRIDEiQ8TF27
ProteomicsDBi74544

PTM databases

iPTMnetiQ8TF27
PhosphoSitePlusiQ8TF27

Expressioni

Gene expression databases

CleanExiHS_AGAP11

Interactioni

Protein-protein interaction databases

BioGridi125637, 2 interactors
IntActiQ8TF27, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8TF27
SMRiQ8TF27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 307PHPROSITE-ProRule annotationAdd BLAST187
Domaini328 – 448Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Repeati487 – 516ANK 1Add BLAST30
Repeati520 – 549ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 366C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000007233
HOVERGENiHBG054045
InParanoidiQ8TF27
PhylomeDBiQ8TF27

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.30.29.30, 2 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TF27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIISVTLEI HHHITERDAD RSLTILDEQL YSFAFSTVHI TKKRNGGGSL
60 70 80 90 100
NNYSSSIPLT PSTSQEDLYF SVPPTANTPT PICKQSMGWS NLFTSEKGSD
110 120 130 140 150
PDKGRKALES HADTIGSGRA IPIKQGMLLK RSGKWLKTWK KKYVTLCSNG
160 170 180 190 200
VLTYYSSLGD YMKNIHKKEI DLRTSTIKVP GKWPSLATSA CAPISSSKSN
210 220 230 240 250
GLSKDMEALH MSANSDIGLG DSICFSPSIS STTSPKLNLP PSPHANKKKH
260 270 280 290 300
LKKKSTNNLK DDGLSSTAEE EEEKFMIVSV TGQTCHFKAT TYEERDAWVQ
310 320 330 340 350
AIQSQILASL QSCESSKSKS QLTSQSEAMA LQSIQNMRGN SHCVDCETQN
360 370 380 390 400
PKWASLNLGV LMCIECSGIH RSLGTRLSRV RSLELDDWPV ELRKVMSSIG
410 420 430 440 450
NDLANSIWEG SSQGQTKPSI ESTREEKERW IRSKYEHKLF LAPLPCTELS
460 470 480 490 500
LGQHLLRATA DEDLRTAILL LAHGSREEVN ETCGEGDGCT ALHLACRKGN
510 520 530 540 550
VVLAQLLIWY GVDVMARDAH GNTALTYARQ ASSQECINVL LQYGCPDECV
Length:550
Mass (Da):60,549
Last modified:April 8, 2008 - v2
Checksum:iA3A6A204B3ACC967
GO

Sequence cautioni

The sequence BAB85561 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04251882I → V2 PublicationsCorresponds to variant dbSNP:rs2641563Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136982 Genomic DNA No translation available.
AB075855 mRNA Translation: BAB85561.1 Different initiation.
CH471142 Genomic DNA Translation: EAW80308.1
CH471142 Genomic DNA Translation: EAW80307.1
CH471142 Genomic DNA Translation: EAW80310.1
CH471142 Genomic DNA Translation: EAW80311.1
BC140762 mRNA Translation: AAI40763.1
RefSeqiNP_597704.1, NM_133447.1
UniGeneiHs.511787

Genome annotation databases

GeneIDi119385
KEGGihsa:119385

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAGA11_HUMAN
AccessioniPrimary (citable) accession number: Q8TF27
Secondary accession number(s): B9EIP7, D3DWE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 20, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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