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UniProtKB - Q8TF21 (ANR24_HUMAN)

Entry version 129 (02 Dec 2020)
Sequence version 2 (08 Apr 2008)
Previous versions | rss
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Protein

Ankyrin repeat domain-containing protein 24

Gene

ANKRD24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TF21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 24
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD24
Synonyms:KIAA1981
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000089847.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:29424, ANKRD24

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TF21

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		170961

Open Targets

More...OpenTargetsi		ENSG00000089847

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134937612

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TF21, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANKRD24

Domain mapping of disease mutations (DMDM)

More...DMDMi		182627626

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003288361 – 1146Ankyrin repeat domain-containing protein 24Add BLAST1146

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TF21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TF21

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TF21

PeptideAtlas

More...PeptideAtlasi		Q8TF21

PRoteomics IDEntifications database

More...PRIDEi		Q8TF21

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74542 [Q8TF21-1]
74543 [Q8TF21-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TF21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TF21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000089847, Expressed in frontal cortex and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TF21, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TF21, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000089847, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128096, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q8TF21, 6 interactors

Molecular INTeraction database

More...MINTi		Q8TF21

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000471252

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TF21, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TF21

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati81 – 110ANK 1Add BLAST30
Repeati114 – 143ANK 2Add BLAST30
Repeati147 – 176ANK 3Add BLAST30
Repeati180 – 209ANK 4Add BLAST30
Repeati213 – 242ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili320 – 517Sequence analysisAdd BLAST198
Coiled coili714 – 1110Sequence analysisAdd BLAST397

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi308 – 311Poly-Pro4

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQ0K, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159237

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005323_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TF21

Identification of Orthologs from Complete Genome Data

More...OMAi		TLWDFKA

Database of Orthologous Groups

More...OrthoDBi		876605at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TF21

TreeFam database of animal gene trees

More...TreeFami		TF331274

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTLRARFKK TELRLSPTDL GSCPPCGPCP IPKPAARGRR QSQDWGKSDE 
        60         70         80         90        100
RLLQAVENND APRVAALIAR KGLVPTKLDP EGKSAFHLAA MRGAASCLEV 
       110        120        130        140        150
MIAHGSNVMS ADGAGYNALH LAAKYGHPQC LKQLLQASCV VDVVDSSGWT 
       160        170        180        190        200
ALHHAAAGGC LSCSEVLCSF KAHLNPQDRS GATPLIIAAQ MCHTDLCRLL 
       210        220        230        240        250
LQQGAAANDQ DLQGRTALML ACEGASPETV EVLLQGGAQP GITDALGQDA 
       260        270        280        290        300
AHYGALAGDK LILHLLQEAA QRPSPPSALT EDDSGEASSQ NSMSSHGKQG 
       310        320        330        340        350
APKKRKAPPP PASIPMPDDR DAYEEIVRLR QERGRLLQKI RGLEQHKERR 
       360        370        380        390        400
QQESPEASSL HILERQVQEL QQLLVERQEE KESLGREVES LQSRLSLLEN 
       410        420        430        440        450
ERENTSYDVT TLQDEEGELP DLPGAEVLLS RQLSPSAQEH LASLQEQVAV 
       460        470        480        490        500
LTRQNQELME KVQILENFEK DETQMEVEAL AEVIPLALYD SLRAEFDQLR 
       510        520        530        540        550
RQHAEALQAL RQQETREVPR EEGAACGESE VAGATATKNG PTHMELNGSV 
       560        570        580        590        600
APETKVNGAE TIDEEAAGDE TMEARTMEAE ATGAEATGAE ATGAKVTETK 
       610        620        630        640        650
PTGAEVREME TTEEEANMET KPTGAQATDT ETTGVEAMGV EATKTKAEEA 
       660        670        680        690        700
EMQAYGVGAG QAEPPVTGTT NMEATGSRAT GMESTGVSAT GVENPGVEAT 
       710        720        730        740        750
VPGISAGPIL HPGAAEASEK LQVELETRIR GLEEALRQRE REAAAELEAA 
       760        770        780        790        800
LGKCEAAEAE AGRLRERVRE AEGSGASGGG GGDTTQLRAA LEQAREDLRD 
       810        820        830        840        850
RDSRLRELEA ASACLDEARA SRLLAEEEAR GLRAELAQRE EARLEQSREL 
       860        870        880        890        900
EVLREQLATA RATGEQQRTA AAELGRARDA AEARVAELPA ACEEARQGLA 
       910        920        930        940        950
ELREASEALR QSVVPASEHR RLQEEALELR GRAASLEQEV VATGKEAARL 
       960        970        980        990       1000
RAELERERVC SVALSEHERI VGTLQANVAQ LEGQLEELGR RHEKTSAEVF 
      1010       1020       1030       1040       1050
QVQREALFMK SERHAAEAQL ATAEQQLRGL RTEAERARQA QSRAQEALDK 
      1060       1070       1080       1090       1100
AKEKDKKITE LSKEVFNLKE ALKEQPAALA TPEVEALRDQ VKDLQQQLQE 
      1110       1120       1130       1140 
AARDHSSVVA LYRSHLLYAI QGQMDEDVQR ILSQILQMQR LQAQGR
Length:1,146
Mass (Da):124,187
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89E82EAD9056DCCB
GO
Isoform 2 (identifier: Q8TF21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MKTLRARFKK...PKPAARGRRQ → MQPAACAGEG...LCLCAAASFA

Show »
Length:1,236
Mass (Da):132,379
Checksum:i47CB3FA05D3CB79F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZ18M0QZ18_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD24
839Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0N9M0R0N9_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD24
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC33490 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAD15479 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042536111A → T1 PublicationCorresponds to variant dbSNP:rs2052191Ensembl.1
Natural variantiVAR_042537349R → Q1 PublicationCorresponds to variant dbSNP:rs12978469Ensembl.1
Natural variantiVAR_042538585E → K1 PublicationCorresponds to variant dbSNP:rs10413818Ensembl.1
Natural variantiVAR_042539684S → A1 PublicationCorresponds to variant dbSNP:rs353693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0328111 – 41MKTLR…RGRRQ → MQPAACAGEGAGPPAPRPPH PPGDKVRRGRGGAPSLSPQP PAPYLGLPIPSRGGGGWRGG QGGGGGTREGGTGRAGGAGS SGSAQPRPPAAPRGPSRPSG RRLLLEPRAPPAPRAPDAMK QLCLCAAASFA in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC006930 Genomic DNA Translation: AAD15479.1 Sequence problems.
AC005578 Genomic DNA Translation: AAC33490.1 Sequence problems.
AB075861 mRNA Translation: BAB85567.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45925.1 [Q8TF21-1]

NCBI Reference Sequences

More...RefSeqi		NP_597732.1, NM_133475.1 [Q8TF21-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262970; ENSP00000262970; ENSG00000089847 [Q8TF21-2]
ENST00000318934; ENSP00000321731; ENSG00000089847 [Q8TF21-1]
ENST00000600132; ENSP00000471252; ENSG00000089847 [Q8TF21-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		170961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:170961

UCSC genome browser

More...UCSCi		uc002lzt.3, human [Q8TF21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006930 Genomic DNA Translation: AAD15479.1 Sequence problems.
AC005578 Genomic DNA Translation: AAC33490.1 Sequence problems.
AB075861 mRNA Translation: BAB85567.1
CCDSiCCDS45925.1 [Q8TF21-1]
RefSeqiNP_597732.1, NM_133475.1 [Q8TF21-1]

3D structure databases

SMRiQ8TF21
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128096, 5 interactors
IntActiQ8TF21, 6 interactors
MINTiQ8TF21
STRINGi9606.ENSP00000471252

PTM databases

iPTMnetiQ8TF21
PhosphoSitePlusiQ8TF21

Polymorphism and mutation databases

BioMutaiANKRD24
DMDMi182627626

Proteomic databases

EPDiQ8TF21
MassIVEiQ8TF21
PaxDbiQ8TF21
PeptideAtlasiQ8TF21
PRIDEiQ8TF21
ProteomicsDBi74542 [Q8TF21-1]
74543 [Q8TF21-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53380, 16 antibodies

Genome annotation databases

EnsembliENST00000262970; ENSP00000262970; ENSG00000089847 [Q8TF21-2]
ENST00000318934; ENSP00000321731; ENSG00000089847 [Q8TF21-1]
ENST00000600132; ENSP00000471252; ENSG00000089847 [Q8TF21-1]
GeneIDi170961
KEGGihsa:170961
UCSCiuc002lzt.3, human [Q8TF21-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		170961
DisGeNETi170961
EuPathDBiHostDB:ENSG00000089847.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANKRD24
HGNCiHGNC:29424, ANKRD24
HPAiENSG00000089847, Tissue enhanced (brain)
neXtProtiNX_Q8TF21
OpenTargetsiENSG00000089847
PharmGKBiPA134937612

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQ0K, Eukaryota
GeneTreeiENSGT00940000159237
HOGENOMiCLU_005323_0_0_1
InParanoidiQ8TF21
OMAiTLWDFKA
OrthoDBi876605at2759
PhylomeDBiQ8TF21
TreeFamiTF331274

Enzyme and pathway databases

PathwayCommonsiQ8TF21

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		170961, 6 hits in 840 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANKRD24, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		170961
PharosiQ8TF21, Tdark

Protein Ontology

More...PROi		PR:Q8TF21
RNActiQ8TF21, protein

Gene expression databases

BgeeiENSG00000089847, Expressed in frontal cortex and 118 other tissues
ExpressionAtlasiQ8TF21, baseline and differential
GenevisibleiQ8TF21, HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR24_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF21
Secondary accession number(s): O75268, O95781
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: December 2, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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