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Entry version 138 (07 Oct 2020)
Sequence version 2 (02 Oct 2007)
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Protein

Zinc finger protein 721

Gene

ZNF721

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri69 – 91C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri97 – 119C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri125 – 147C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri181 – 203C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri601 – 623C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 651C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 24; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 791C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri797 – 819C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri825 – 847C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri853 – 875C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri881 – 903C2H2-type 30PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TF20

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 721
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF721
Synonyms:KIAA1982
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000182903.15

Human Gene Nomenclature Database

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HGNCi
HGNC:29425, ZNF721

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000182903

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TF20, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF721

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158706490

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068791 – 911Zinc finger protein 721Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki786Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TF20

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TF20

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TF20

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TF20

PeptideAtlas

More...
PeptideAtlasi
Q8TF20

PRoteomics IDEntifications database

More...
PRIDEi
Q8TF20

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74540 [Q8TF20-1]
74541 [Q8TF20-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF20

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TF20

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000182903, Expressed in epithelial cell of pancreas and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TF20, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TF20, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182903, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128095, 3 interactors

Protein interaction database and analysis system

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IntActi
Q8TF20, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428878

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8TF20, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TF20

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri69 – 91C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri97 – 119C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri125 – 147C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri181 – 203C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri601 – 623C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 651C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 24; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 791C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri797 – 819C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri825 – 847C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri853 – 875C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri881 – 903C2H2-type 30PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT01000000214429

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_17_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TF20

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
WYTDLNQ

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TF20

TreeFam database of animal gene trees

More...
TreeFami
TF343410

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041697, Znf-C2H2_11
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 19 hits
PF16622, zf-C2H2_11, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 25 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 15 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 23 hits
PS50157, ZINC_FINGER_C2H2_2, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCSHFTQDFL PVQGIEDSFH KLILRRYEKC GHDNLQLRKG CKSMNVCKVQ
60 70 80 90 100
KGVYNGINKC LSNTQSKIFQ CNARVKVFSK FANSNKDKTR HTGEKHFKCN
110 120 130 140 150
ECGKSFQKFS DLTQHKGIHA GEKPYTCEER GKDFGWYTDL NQHKKIHTGE
160 170 180 190 200
KPYKCEECGK AFNRSTNLTA HKRIHNREKA YTGEDRDRAF GWSTNLNEYK
210 220 230 240 250
KIHTGDKPYK CKECGKAFMH SSHLNKHEKI HTGEKPYKCK ECGKVISSSS
260 270 280 290 300
SFAKHKRIHT GEKPFKCLEC GKAFNISTTL TKHRRIHTGE KPYTCEVCGK
310 320 330 340 350
AFRQSANLYV HRRIHTGEKP YTCGECGKTF RQSANLYVHR RIHTGEKPYK
360 370 380 390 400
CEDCGKAFGR YTALNQHKKI HTGEKPYKCE ECGKAFNSST NLTAHKRIHT
410 420 430 440 450
REKPYTCEDR GRAFGLSTNL NEYKKIHTGD KPYKCKECGK AFIHSLHLNK
460 470 480 490 500
HEKIHTGKKP YKCKQCGKVI TSSSSFAKHK RIHTGEKPFE CLECGKAFTS
510 520 530 540 550
STTLTKHRRI HTGEKPYTCE VCGKAFRQSA ILYVHRRIHT GEKPYTCEEC
560 570 580 590 600
GKTFRQSANL YVHRRIHTGE KPYKCEECGK AFGRYTDLNQ HKKIHTGEKL
610 620 630 640 650
YKCEECGKDF VWYTDLNQQK KIYTGEKPYK CEECGKAFAP STDLNQHTKI
660 670 680 690 700
LTGEQSYKCE ECGKAFGWSI ALNQHKKIHT GEKPYKCEEC GKAFSRSRNL
710 720 730 740 750
TTHRRVHTRE KPYKCEDRGR SFGWSTNLNE YKKIHTGDKL YKCKECGKVF
760 770 780 790 800
KQSSHLNRHE KIHTGKKPYK CKECGKVITS SSSFAKHKRI HTGEKPFKCL
810 820 830 840 850
ECGKAFTSST TLTKHRRIHT GEKPYTCEEC GKAFRQSAIL YVHRRIHTGE
860 870 880 890 900
KPYTCGECGK TFRQSANLYA HKKIHTGEKP YTCGDCGKTF RQSANLYAHK
910
KIHTGDKTIQ V
Length:911
Mass (Da):105,084
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA0D3FBAC9C789AA
GO
Isoform 2 (identifier: Q8TF20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLENYRNLVSLAM

Show »
Length:923
Mass (Da):106,489
Checksum:iA639F47FC62B50CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGC2D6RGC2_HUMAN
Zinc finger protein 721
ZNF721
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGH0E5RGH0_HUMAN
Zinc finger protein 721
ZNF721
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E159B4E159_HUMAN
Zinc finger protein 721
ZNF721
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH10687 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti210K → T in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti247 – 249SSS → LIL in CAH10687 (PubMed:17974005).Curated3
Sequence conflicti307N → I in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti324G → E in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti363A → D in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti387 – 388NS → VC in CAH10687 (PubMed:17974005).Curated2
Sequence conflicti391N → D in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti395H → M in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti410R → C in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti416L → M in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti444H → HS in CAH10687 (PubMed:17974005).Curated1
Sequence conflicti465Q → E in CAH10687 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0408791M → MLENYRNLVSLAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL834155 mRNA Translation: CAH10687.1 Frameshift.
AC092574 Genomic DNA No translation available.
DA309597 mRNA No translation available.
AB075862 mRNA Translation: BAB85568.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46991.1 [Q8TF20-2]

NCBI Reference Sequences

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RefSeqi
NP_597731.2, NM_133474.3 [Q8TF20-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338977; ENSP00000340524; ENSG00000182903 [Q8TF20-1]
ENST00000511833; ENSP00000428878; ENSG00000182903 [Q8TF20-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
170960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:170960

UCSC genome browser

More...
UCSCi
uc003gag.5, human [Q8TF20-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834155 mRNA Translation: CAH10687.1 Frameshift.
AC092574 Genomic DNA No translation available.
DA309597 mRNA No translation available.
AB075862 mRNA Translation: BAB85568.1
CCDSiCCDS46991.1 [Q8TF20-2]
RefSeqiNP_597731.2, NM_133474.3 [Q8TF20-2]

3D structure databases

SMRiQ8TF20
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128095, 3 interactors
IntActiQ8TF20, 3 interactors
STRINGi9606.ENSP00000428878

PTM databases

iPTMnetiQ8TF20
PhosphoSitePlusiQ8TF20

Polymorphism and mutation databases

BioMutaiZNF721
DMDMi158706490

Proteomic databases

EPDiQ8TF20
jPOSTiQ8TF20
MassIVEiQ8TF20
PaxDbiQ8TF20
PeptideAtlasiQ8TF20
PRIDEiQ8TF20
ProteomicsDBi74540 [Q8TF20-1]
74541 [Q8TF20-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
77821, 4 antibodies

Genome annotation databases

EnsembliENST00000338977; ENSP00000340524; ENSG00000182903 [Q8TF20-1]
ENST00000511833; ENSP00000428878; ENSG00000182903 [Q8TF20-2]
GeneIDi170960
KEGGihsa:170960
UCSCiuc003gag.5, human [Q8TF20-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
170960
EuPathDBiHostDB:ENSG00000182903.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF721
HGNCiHGNC:29425, ZNF721
HPAiENSG00000182903, Low tissue specificity
neXtProtiNX_Q8TF20
OpenTargetsiENSG00000182903

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT01000000214429
HOGENOMiCLU_002678_17_4_1
InParanoidiQ8TF20
KOiK09228
OMAiWYTDLNQ
OrthoDBi1318335at2759
PhylomeDBiQ8TF20
TreeFamiTF343410

Enzyme and pathway databases

PathwayCommonsiQ8TF20
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
170960, 36 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF721, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
170960
PharosiQ8TF20, Tdark

Protein Ontology

More...
PROi
PR:Q8TF20
RNActiQ8TF20, protein

Gene expression databases

BgeeiENSG00000182903, Expressed in epithelial cell of pancreas and 215 other tissues
ExpressionAtlasiQ8TF20, baseline and differential
GenevisibleiQ8TF20, HS

Family and domain databases

InterProiView protein in InterPro
IPR041697, Znf-C2H2_11
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 19 hits
PF16622, zf-C2H2_11, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 25 hits
SUPFAMiSSF57667, SSF57667, 15 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 23 hits
PS50157, ZINC_FINGER_C2H2_2, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN721_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF20
Secondary accession number(s): Q69YG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 7, 2020
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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