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Protein

Dynein light chain roadblock-type 2

Gene

DYNLRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Miscellaneous

Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.

GO - Molecular functioni

  • dynein intermediate chain binding Source: GO_Central
  • microtubule motor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain roadblock-type 2
Alternative name(s):
Dynein light chain 2B, cytoplasmic
Roadblock domain-containing protein 2
Gene namesi
Name:DYNLRB2
Synonyms:DNCL2B, DNLC2B, ROBLD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168589.14
HGNCiHGNC:15467 DYNLRB2
MIMi607168 gene
neXtProtiNX_Q8TF09

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi83657
OpenTargetsiENSG00000168589
PharmGKBiPA27437

Polymorphism and mutation databases

BioMutaiDYNLRB2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002209582 – 96Dynein light chain roadblock-type 2Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TF09
MaxQBiQ8TF09
PaxDbiQ8TF09
PeptideAtlasiQ8TF09
PRIDEiQ8TF09
ProteomicsDBi74535
TopDownProteomicsiQ8TF09

PTM databases

iPTMnetiQ8TF09
PhosphoSitePlusiQ8TF09

Expressioni

Tissue specificityi

High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte.

Gene expression databases

BgeeiENSG00000168589 Expressed in 127 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_DYNLRB2
ExpressionAtlasiQ8TF09 baseline and differential
GenevisibleiQ8TF09 HS

Interactioni

Subunit structurei

Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1.Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123714, 9 interactors
CORUMiQ8TF09
IntActiQ8TF09, 7 interactors
STRINGi9606.ENSP00000302936

Structurei

3D structure databases

ProteinModelPortaliQ8TF09
SMRiQ8TF09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4115 Eukaryota
ENOG4111NDV LUCA
GeneTreeiENSGT00390000011067
HOGENOMiHOG000232033
HOVERGENiHBG058598
InParanoidiQ8TF09
KOiK10419
PhylomeDBiQ8TF09
TreeFamiTF315165

Family and domain databases

InterProiView protein in InterPro
IPR016561 DYNLRB1/2
IPR004942 Roadblock/LAMTOR2_dom
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
PIRSFiPIRSF009998 DLC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8TF09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVEETLKR IQSHKGVIGT MVVNAEGIPI RTTLDNSTTV QYAGLLHHLT
60 70 80 90
MKAKSTVRDI DPQNDLTFLR IRSKKHEIMV APDKEYLLIV IQNPCE
Length:96
Mass (Da):10,855
Last modified:June 1, 2002 - v1
Checksum:i526F073855F14330
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQI1H3BQI1_HUMAN
Dynein light chain roadblock-type 2
DYNLRB2
125Annotation score:
H3BPA0H3BPA0_HUMAN
Dynein light chain roadblock-type 2
DYNLRB2
44Annotation score:
H3BNG9H3BNG9_HUMAN
Dynein light chain roadblock-type 2
DYNLRB2
40Annotation score:
Q7Z4M1Q7Z4M1_HUMAN
DYNLRB2 protein
DYNLRB2
54Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04912614H → R. Corresponds to variant dbSNP:rs13332289Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125108 mRNA Translation: AAL75945.1
CCDSiCCDS10929.1
RefSeqiNP_570967.1, NM_130897.2
XP_006721358.1, XM_006721295.3
UniGeneiHs.98849

Genome annotation databases

EnsembliENST00000305904; ENSP00000302936; ENSG00000168589
GeneIDi83657
KEGGihsa:83657
UCSCiuc002ffo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125108 mRNA Translation: AAL75945.1
CCDSiCCDS10929.1
RefSeqiNP_570967.1, NM_130897.2
XP_006721358.1, XM_006721295.3
UniGeneiHs.98849

3D structure databases

ProteinModelPortaliQ8TF09
SMRiQ8TF09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123714, 9 interactors
CORUMiQ8TF09
IntActiQ8TF09, 7 interactors
STRINGi9606.ENSP00000302936

PTM databases

iPTMnetiQ8TF09
PhosphoSitePlusiQ8TF09

Polymorphism and mutation databases

BioMutaiDYNLRB2

Proteomic databases

EPDiQ8TF09
MaxQBiQ8TF09
PaxDbiQ8TF09
PeptideAtlasiQ8TF09
PRIDEiQ8TF09
ProteomicsDBi74535
TopDownProteomicsiQ8TF09

Protocols and materials databases

DNASUi83657
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305904; ENSP00000302936; ENSG00000168589
GeneIDi83657
KEGGihsa:83657
UCSCiuc002ffo.3 human

Organism-specific databases

CTDi83657
DisGeNETi83657
EuPathDBiHostDB:ENSG00000168589.14
GeneCardsiDYNLRB2
HGNCiHGNC:15467 DYNLRB2
MIMi607168 gene
neXtProtiNX_Q8TF09
OpenTargetsiENSG00000168589
PharmGKBiPA27437
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4115 Eukaryota
ENOG4111NDV LUCA
GeneTreeiENSGT00390000011067
HOGENOMiHOG000232033
HOVERGENiHBG058598
InParanoidiQ8TF09
KOiK10419
PhylomeDBiQ8TF09
TreeFamiTF315165

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRSiDYNLRB2 human
GenomeRNAii83657
PROiPR:Q8TF09
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168589 Expressed in 127 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_DYNLRB2
ExpressionAtlasiQ8TF09 baseline and differential
GenevisibleiQ8TF09 HS

Family and domain databases

InterProiView protein in InterPro
IPR016561 DYNLRB1/2
IPR004942 Roadblock/LAMTOR2_dom
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
PIRSFiPIRSF009998 DLC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLRB2_HUMAN
AccessioniPrimary (citable) accession number: Q8TF09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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