Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 159 (26 Feb 2020)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 1

Gene

PPP4R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP4R1
Synonyms:MEG1, PP4R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9320 PPP4R1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604908 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9989

Open Targets

More...
OpenTargetsi
ENSG00000154845

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33684

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TF05 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP4R1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
44888283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000715271 – 950Serine/threonine-protein phosphatase 4 regulatory subunit 1Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei935PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TF05

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TF05

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TF05

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TF05

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TF05

PeptideAtlas

More...
PeptideAtlasi
Q8TF05

PRoteomics IDEntifications database

More...
PRIDEi
Q8TF05

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74532 [Q8TF05-1]
74533 [Q8TF05-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF05

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TF05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154845 Expressed in sperm and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TF05 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TF05 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040905
HPA041089

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

Component of the PP4 complex PPP4C-PPP4R1.

Interacts with HDAC3.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P605107EBI-1056262,EBI-1046072

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115310, 40 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1842 PPP4C-PPP4R1 protein phosphatase 4 complex

Protein interaction database and analysis system

More...
IntActi
Q8TF05, 25 interactors

Molecular INTeraction database

More...
MINTi
Q8TF05

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383402

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TF05 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TF05

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 25HEAT 1Add BLAST25
Repeati26 – 63HEAT 2Add BLAST38
Repeati65 – 81HEAT 3Add BLAST17
Repeati82 – 119HEAT 4Add BLAST38
Repeati127 – 164HEAT 5Add BLAST38
Repeati168 – 206HEAT 6Add BLAST39
Repeati208 – 246HEAT 7Add BLAST39
Repeati248 – 285HEAT 8Add BLAST38
Repeati287 – 324HEAT 9Add BLAST38
Repeati505 – 542HEAT 10Add BLAST38
Repeati568 – 606HEAT 11Add BLAST39
Repeati698 – 734HEAT 12Add BLAST37
Repeati799 – 837HEAT 13Add BLAST39
Repeati861 – 898HEAT 14Add BLAST38

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUDJ Eukaryota
ENOG410XQII LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183066

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009128_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TF05

KEGG Orthology (KO)

More...
KOi
K15424

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDSSLHY

Database of Orthologous Groups

More...
OrthoDBi
249499at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TF05

TreeFam database of animal gene trees

More...
TreeFami
TF105560

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR021133 HEAT_type_2
IPR031087 PP4R1
IPR033461 WRNPLPNID

The PANTHER Classification System

More...
PANTHERi
PTHR10648:SF8 PTHR10648:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985 HEAT, 2 hits
PF15017 WRNPLPNID, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF05-1) [UniParc]FASTAAdd to basket
Also known as: PP4Rmeg

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADLSLLQED LQEDADGFGV DDYSSESDVI IIPSALDFVS QDEMLTPLGR
60 70 80 90 100
LDKYAASENI FNRQMVARSL LDTLREVCDD ERDCIAVLER ISRLADDSEP
110 120 130 140 150
TVRAELMEQV PHIALFCQEN RPSIPYAFSK FLLPIVVRYL ADQNNQVRKT
160 170 180 190 200
SQAALLALLE QELIERFDVE TKVCPVLIEL TAPDSNDDVK TEAVAIMCKM
210 220 230 240 250
APMVGKDITE RLILPRFCEM CCDCRMFHVR KVCAANFGDI CSVVGQQATE
260 270 280 290 300
EMLLPRFFQL CSDNVWGVRK ACAECFMAVS CATCQEIRRT KLSALFINLI
310 320 330 340 350
SDPSRWVRQA AFQSLGPFIS TFANPSSSGQ YFKEESKSSE EMSVENKNRT
360 370 380 390 400
RDQEAPEDVQ VRPEDTPSDL SVSNSSVILE NTMEDHAAEA SGKPLGEISV
410 420 430 440 450
PLDSSLLCTL SSESHQEAAS NENDKKPGNY KSMLRPEVGT TSQDSALLDQ
460 470 480 490 500
ELYNSFHFWR TPLPEIDLDI ELEQNSGGKP SPEGPEEESE GPVPSSPNIT
510 520 530 540 550
MATRKELEEM IENLEPHIDD PDVKAQVEVL SAALRASSLD AHEETISIEK
560 570 580 590 600
RSDLQDELDI NELPNCKINQ EDSVPLISDA VENMDSTLHY IHSDSDLSNN
610 620 630 640 650
SSFSPDEERR TKVQDVVPQA LLDQYLSMTD PSRAQTVDTE IAKHCAYSLP
660 670 680 690 700
GVALTLGRQN WHCLRETYET LASDMQWKVR RTLAFSIHEL AVILGDQLTA
710 720 730 740 750
ADLVPIFNGF LKDLDEVRIG VLKHLHDFLK LLHIDKRREY LYQLQEFLVT
760 770 780 790 800
DNSRNWRFRA ELAEQLILLL ELYSPRDVYD YLRPIALNLC ADKVSSVRWI
810 820 830 840 850
SYKLVSEMVK KLHAATPPTF GVDLINELVE NFGRCPKWSG RQAFVFVCQT
860 870 880 890 900
VIEDDCLPMD QFAVHLMPHL LTLANDRVPN VRVLLAKTLR QTLLEKDYFL
910 920 930 940 950
ASASCHQEAV EQTIMALQMD RDSDVKYFAS IHPASTKISE DAMSTASSTY
Length:950
Mass (Da):107,004
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1392E6BAD3B58CB
GO
Isoform 2 (identifier: Q8TF05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-35: FGVDDYSSESDVIIIPSA → S

Show »
Length:933
Mass (Da):105,195
Checksum:i3AD23605BB2A371A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQV0J3QQV0_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLA6J3QLA6_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSB0J3KSB0_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL26J3QL26_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRU1J3KRU1_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSS1J3KSS1_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRV2J3QRV2_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAJ9F8WAJ9_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSH2J3KSH2_HUMAN
Serine/threonine-protein phosphatas...
PPP4R1
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD43008 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01780743E → K. Corresponds to variant dbSNP:rs1056191Ensembl.1
Natural variantiVAR_017808470I → V. Corresponds to variant dbSNP:rs329003Ensembl.1
Natural variantiVAR_051748593S → N. Corresponds to variant dbSNP:rs2306134Ensembl.1
Natural variantiVAR_017809595S → N. Corresponds to variant dbSNP:rs2306134Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00946918 – 35FGVDD…IIPSA → S in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF111106 mRNA Translation: AAD09818.1
AF200478 mRNA Translation: AAL78298.1
AP000902 Genomic DNA No translation available.
AP001381 Genomic DNA No translation available.
BC060829 mRNA Translation: AAH60829.1
AF100744 mRNA Translation: AAD43008.1 Different initiation.
U79267 mRNA Translation: AAB50211.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42412.1 [Q8TF05-1]
CCDS42413.1 [Q8TF05-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001035847.1, NM_001042388.2 [Q8TF05-1]
NP_005125.1, NM_005134.3 [Q8TF05-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400556; ENSP00000383402; ENSG00000154845 [Q8TF05-1]
ENST00000400555; ENSP00000383401; ENSG00000154845 [Q8TF05-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9989

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9989

UCSC genome browser

More...
UCSCi
uc002kod.3 human [Q8TF05-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111106 mRNA Translation: AAD09818.1
AF200478 mRNA Translation: AAL78298.1
AP000902 Genomic DNA No translation available.
AP001381 Genomic DNA No translation available.
BC060829 mRNA Translation: AAH60829.1
AF100744 mRNA Translation: AAD43008.1 Different initiation.
U79267 mRNA Translation: AAB50211.1
CCDSiCCDS42412.1 [Q8TF05-1]
CCDS42413.1 [Q8TF05-2]
RefSeqiNP_001035847.1, NM_001042388.2 [Q8TF05-1]
NP_005125.1, NM_005134.3 [Q8TF05-2]

3D structure databases

SMRiQ8TF05
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115310, 40 interactors
ComplexPortaliCPX-1842 PPP4C-PPP4R1 protein phosphatase 4 complex
IntActiQ8TF05, 25 interactors
MINTiQ8TF05
STRINGi9606.ENSP00000383402

PTM databases

iPTMnetiQ8TF05
PhosphoSitePlusiQ8TF05

Polymorphism and mutation databases

BioMutaiPPP4R1
DMDMi44888283

Proteomic databases

EPDiQ8TF05
jPOSTiQ8TF05
MassIVEiQ8TF05
MaxQBiQ8TF05
PaxDbiQ8TF05
PeptideAtlasiQ8TF05
PRIDEiQ8TF05
ProteomicsDBi74532 [Q8TF05-1]
74533 [Q8TF05-2]

Genome annotation databases

EnsembliENST00000400556; ENSP00000383402; ENSG00000154845 [Q8TF05-1]
ENST00000400555; ENSP00000383401; ENSG00000154845 [Q8TF05-2]
GeneIDi9989
KEGGihsa:9989
UCSCiuc002kod.3 human [Q8TF05-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9989
DisGeNETi9989

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP4R1
HGNCiHGNC:9320 PPP4R1
HPAiHPA040905
HPA041089
MIMi604908 gene
neXtProtiNX_Q8TF05
OpenTargetsiENSG00000154845
PharmGKBiPA33684

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUDJ Eukaryota
ENOG410XQII LUCA
GeneTreeiENSGT00950000183066
HOGENOMiCLU_009128_1_1_1
InParanoidiQ8TF05
KOiK15424
OMAiMDSSLHY
OrthoDBi249499at2759
PhylomeDBiQ8TF05
TreeFamiTF105560

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP4R1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPP4R1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9989
PharosiQ8TF05 Tbio

Protein Ontology

More...
PROi
PR:Q8TF05
RNActiQ8TF05 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154845 Expressed in sperm and 224 other tissues
ExpressionAtlasiQ8TF05 baseline and differential
GenevisibleiQ8TF05 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR021133 HEAT_type_2
IPR031087 PP4R1
IPR033461 WRNPLPNID
PANTHERiPTHR10648:SF8 PTHR10648:SF8, 1 hit
PfamiView protein in Pfam
PF02985 HEAT, 2 hits
PF15017 WRNPLPNID, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP4R1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF05
Secondary accession number(s): Q99774, Q9UNQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2002
Last modified: February 26, 2020
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again