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Protein

Arginine/serine-rich protein PNISR

Gene

PNISR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine/serine-rich protein PNISR
Alternative name(s):
PNN-interacting serine/arginine-rich protein
SR-related protein
SR-rich protein
Serine/arginine-rich-splicing regulatory protein 130
Short name:
SRrp130
Splicing factor, arginine/serine-rich 130
Splicing factor, arginine/serine-rich 18
Gene namesi
Name:PNISR
Synonyms:C6orf111, SFRS18, SRRP130
ORF Names:HSPC261, HSPC306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000132424.14
HGNCiHGNC:21222 PNISR
MIMi616653 gene
neXtProtiNX_Q8TF01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25957
OpenTargetsiENSG00000132424
PharmGKBiPA162402984

Polymorphism and mutation databases

BioMutaiPNISR
DMDMi152031686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819471 – 805Arginine/serine-rich protein PNISRAdd BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei290PhosphoserineCombined sources1
Modified residuei304PhosphoserineBy similarity1
Modified residuei313PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei485PhosphothreonineCombined sources1
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki703Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei726PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8TF01
MaxQBiQ8TF01
PaxDbiQ8TF01
PeptideAtlasiQ8TF01
PRIDEiQ8TF01
ProteomicsDBi74530
74531 [Q8TF01-2]

PTM databases

iPTMnetiQ8TF01
PhosphoSitePlusiQ8TF01

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, thymus, spleen, kidney, liver, placenta and leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000132424 Expressed in 236 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SFRS18
GenevisibleiQ8TF01 HS

Organism-specific databases

HPAiHPA038796

Interactioni

Subunit structurei

Interacts with PNN.1 Publication

Protein-protein interaction databases

BioGridi117448, 26 interactors
IntActiQ8TF01, 14 interactors
STRINGi9606.ENSP00000358242

Structurei

3D structure databases

ProteinModelPortaliQ8TF01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili237 – 276Sequence analysisAdd BLAST40
Coiled coili429 – 461Sequence analysisAdd BLAST33
Coiled coili673 – 703Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 56Gln-richAdd BLAST53
Compositional biasi100 – 222Pro-richAdd BLAST123
Compositional biasi508 – 577Ser-richAdd BLAST70
Compositional biasi722 – 804Ser-richAdd BLAST83

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases