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Entry version 145 (12 Aug 2020)
Sequence version 2 (10 Jul 2007)
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Protein

Arginine/serine-rich protein PNISR

Gene

PNISR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TF01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginine/serine-rich protein PNISR
Alternative name(s):
PNN-interacting serine/arginine-rich protein
SR-related protein
SR-rich protein
Serine/arginine-rich-splicing regulatory protein 130
Short name:
SRrp130
Splicing factor, arginine/serine-rich 130
Splicing factor, arginine/serine-rich 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNISR
Synonyms:C6orf111, SFRS18, SRRP130
ORF Names:HSPC261, HSPC306
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000132424.14

Human Gene Nomenclature Database

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HGNCi
HGNC:21222, PNISR

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616653, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8TF01

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25957

Open Targets

More...
OpenTargetsi
ENSG00000132424

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402984

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TF01, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PNISR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152031686

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819471 – 805Arginine/serine-rich protein PNISRAdd BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei204PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei290PhosphoserineCombined sources1
Modified residuei304PhosphoserineBy similarity1
Modified residuei313PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei485PhosphothreonineCombined sources1
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki703Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei726PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TF01

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TF01

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8TF01

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TF01

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TF01

PeptideAtlas

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PeptideAtlasi
Q8TF01

PRoteomics IDEntifications database

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PRIDEi
Q8TF01

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74530 [Q8TF01-1]
74531 [Q8TF01-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8TF01

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TF01

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, skeletal muscle, thymus, spleen, kidney, liver, placenta and leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132424, Expressed in left lobe of thyroid gland and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TF01, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TF01, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132424, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PNN.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117448, 35 interactors

Protein interaction database and analysis system

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IntActi
Q8TF01, 19 interactors

Molecular INTeraction database

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MINTi
Q8TF01

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358242

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TF01, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili237 – 276Sequence analysisAdd BLAST40
Coiled coili429 – 461Sequence analysisAdd BLAST33
Coiled coili673 – 703Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 56Gln-richAdd BLAST53
Compositional biasi100 – 222Pro-richAdd BLAST123
Compositional biasi508 – 577Ser-richAdd BLAST70
Compositional biasi722 – 804Ser-richAdd BLAST83

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QUV0, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00730000111138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_372518_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TF01

KEGG Orthology (KO)

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KOi
K13170

Identification of Orthologs from Complete Genome Data

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OMAi
QFNGKRP

Database of Orthologous Groups

More...
OrthoDBi
928665at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TF01

TreeFam database of animal gene trees

More...
TreeFami
TF332904

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031937, PNISR

The PANTHER Classification System

More...
PANTHERi
PTHR31518, PTHR31518, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15996, PNISR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWDQGGQPWQ QWPLNQQQWM QSFQHQQDPS QIDWAALAQA WIAQREASGQ
60 70 80 90 100
QSMVEQPPGM MPNGQDMSTM ESGPNNHGNF QGDSNFNRMW QPEWGMHQQP
110 120 130 140 150
PHPPPDQPWM PPTPGPMDIV PPSEDSNSQD SGEFAPDNRH IFNQNNHNFG
160 170 180 190 200
GPPDNFAVGP VNQFDYQHGA AFGPPQGGFH PPYWQPGPPG PPAPPQNRRE
210 220 230 240 250
RPSSFRDRQR SPIALPVKQE PPQIDAVKRR TLPAWIREGL EKMEREKQKK
260 270 280 290 300
LEKERMEQQR SQLSKKEKKA TEDAEGGDGP RLPQRSKFDS DEEEEDTENV
310 320 330 340 350
EAASSGKVTR SPSPVPQEEH SDPEMTEEEK EYQMMLLTKM LLTEILLDVT
360 370 380 390 400
DEEIYYVAKD AHRKATKAPA KQLAQSSALA SLTGLGGLGG YGSGDSEDER
410 420 430 440 450
SDRGSESSDT DDEELRHRIR QKQEAFWRKE KEQQLLHDKQ MEEEKQQTER
460 470 480 490 500
VTKEMNEFIH KEQNSLSLLE AREADGDVVN EKKRTPNETT SVLEPKKEHK
510 520 530 540 550
EKEKQGRSRS GSSSSGSSSS NSRTSSTSST VSSSSYSSSS GSSRTSSRSS
560 570 580 590 600
SPKRKKRHSR SRSPTIKARR SRSRSYSRRI KIESNRARVK IRDRRRSNRN
610 620 630 640 650
SIERERRRNR SPSRERRRSR SRSRDRRTNR ASRSRSRDRR KIDDQRGNLS
660 670 680 690 700
GNSHKHKGEA KEQERKKERS RSIDKDRKKK DKEREREQDK RKEKQKREEK
710 720 730 740 750
DFKFSSQDDR LKRKRESERT FSRSGSISVK IIRHDSRQDS KKSTTKDSKK
760 770 780 790 800
HSGSDSSGRS SSESPGSSKE KKAKKPKHSR SRSVEKSQRS GKKASRKHKS

KSRSR
Length:805
Mass (Da):92,577
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7738BC276B6E80B2
GO
Isoform 2 (identifier: Q8TF01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-413: APAKQLAQSS...GSESSDTDDE → GIFWCFWFCF...ILLHVLTLKD
     414-805: Missing.

Show »
Length:413
Mass (Da):47,436
Checksum:i35B426FBABBB3F2E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y2Y1A0A2R8Y2Y1_HUMAN
Arginine/serine-rich protein PNISR
PNISR
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07791 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH19074 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH52638 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64413 differs from that shown. Reason: Frameshift.Curated
The sequence AAH64640 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34W → R in BAB55350 (PubMed:14702039).Curated1
Sequence conflicti249K → R in BAB55440 (PubMed:14702039).Curated1
Sequence conflicti327E → G in BAB55273 (PubMed:14702039).Curated1
Sequence conflicti507R → G in CAB45767 (PubMed:17974005).Curated1
Sequence conflicti518S → P in AAL76163 (PubMed:14578391).Curated1
Sequence conflicti663Q → R in CAB45767 (PubMed:17974005).Curated1
Sequence conflicti784V → A in AAL76163 (PubMed:14578391).Curated1
Sequence conflicti784V → A in AAL76164 (PubMed:14578391).Curated1
Sequence conflicti805R → KSSILFKVFCLIFKKN in AAF28939 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014458368 – 413APAKQ…DTDDE → GIFWCFWFCFSWGILVLMTI LAFFCCPCWISTRYLNILLH VLTLKD in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_014459414 – 805Missing in isoform 2. 1 PublicationAdd BLAST392

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF314184 mRNA Translation: AAL76163.1
AF314185 mRNA Translation: AAL76164.1
AK027658 mRNA Translation: BAB55273.1
AK027759 mRNA Translation: BAB55350.1
AK027898 mRNA Translation: BAB55440.1
AK074628 mRNA Translation: BAC11098.1 Different termination.
AK291155 mRNA Translation: BAF83844.1
AL513550 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48476.1
CH471051 Genomic DNA Translation: EAW48477.1
CH471051 Genomic DNA Translation: EAW48479.1
CH471051 Genomic DNA Translation: EAW48481.1
BC007791 mRNA Translation: AAH07791.1 Sequence problems.
BC019074 mRNA Translation: AAH19074.1 Sequence problems.
BC052638 mRNA Translation: AAH52638.1 Sequence problems.
BC064413 mRNA Translation: AAH64413.1 Frameshift.
BC064640 mRNA Translation: AAH64640.1 Sequence problems.
AF161379 mRNA Translation: AAF28939.1
AF161424 mRNA Translation: AAF28984.1
AL080186 mRNA Translation: CAB45767.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5043.1 [Q8TF01-1]

Protein sequence database of the Protein Information Resource

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PIRi
T12483

NCBI Reference Sequences

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RefSeqi
NP_001309334.1, NM_001322405.1 [Q8TF01-1]
NP_001309335.1, NM_001322406.1 [Q8TF01-1]
NP_001309337.1, NM_001322408.1 [Q8TF01-1]
NP_001309341.1, NM_001322412.1
NP_001309342.1, NM_001322413.1
NP_001309344.1, NM_001322415.1
NP_056306.1, NM_015491.2 [Q8TF01-1]
NP_116259.2, NM_032870.3 [Q8TF01-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369239; ENSP00000358242; ENSG00000132424 [Q8TF01-1]
ENST00000438806; ENSP00000387997; ENSG00000132424 [Q8TF01-1]
ENST00000478777; ENSP00000435246; ENSG00000132424 [Q8TF01-2]
ENST00000647811; ENSP00000496842; ENSG00000132424 [Q8TF01-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25957

UCSC genome browser

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UCSCi
uc003ppo.5, human [Q8TF01-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314184 mRNA Translation: AAL76163.1
AF314185 mRNA Translation: AAL76164.1
AK027658 mRNA Translation: BAB55273.1
AK027759 mRNA Translation: BAB55350.1
AK027898 mRNA Translation: BAB55440.1
AK074628 mRNA Translation: BAC11098.1 Different termination.
AK291155 mRNA Translation: BAF83844.1
AL513550 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48476.1
CH471051 Genomic DNA Translation: EAW48477.1
CH471051 Genomic DNA Translation: EAW48479.1
CH471051 Genomic DNA Translation: EAW48481.1
BC007791 mRNA Translation: AAH07791.1 Sequence problems.
BC019074 mRNA Translation: AAH19074.1 Sequence problems.
BC052638 mRNA Translation: AAH52638.1 Sequence problems.
BC064413 mRNA Translation: AAH64413.1 Frameshift.
BC064640 mRNA Translation: AAH64640.1 Sequence problems.
AF161379 mRNA Translation: AAF28939.1
AF161424 mRNA Translation: AAF28984.1
AL080186 mRNA Translation: CAB45767.1
CCDSiCCDS5043.1 [Q8TF01-1]
PIRiT12483
RefSeqiNP_001309334.1, NM_001322405.1 [Q8TF01-1]
NP_001309335.1, NM_001322406.1 [Q8TF01-1]
NP_001309337.1, NM_001322408.1 [Q8TF01-1]
NP_001309341.1, NM_001322412.1
NP_001309342.1, NM_001322413.1
NP_001309344.1, NM_001322415.1
NP_056306.1, NM_015491.2 [Q8TF01-1]
NP_116259.2, NM_032870.3 [Q8TF01-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117448, 35 interactors
IntActiQ8TF01, 19 interactors
MINTiQ8TF01
STRINGi9606.ENSP00000358242

PTM databases

iPTMnetiQ8TF01
PhosphoSitePlusiQ8TF01

Polymorphism and mutation databases

BioMutaiPNISR
DMDMi152031686

Proteomic databases

EPDiQ8TF01
jPOSTiQ8TF01
MassIVEiQ8TF01
MaxQBiQ8TF01
PaxDbiQ8TF01
PeptideAtlasiQ8TF01
PRIDEiQ8TF01
ProteomicsDBi74530 [Q8TF01-1]
74531 [Q8TF01-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32003, 27 antibodies

Genome annotation databases

EnsembliENST00000369239; ENSP00000358242; ENSG00000132424 [Q8TF01-1]
ENST00000438806; ENSP00000387997; ENSG00000132424 [Q8TF01-1]
ENST00000478777; ENSP00000435246; ENSG00000132424 [Q8TF01-2]
ENST00000647811; ENSP00000496842; ENSG00000132424 [Q8TF01-1]
GeneIDi25957
KEGGihsa:25957
UCSCiuc003ppo.5, human [Q8TF01-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25957
DisGeNETi25957
EuPathDBiHostDB:ENSG00000132424.14

GeneCards: human genes, protein and diseases

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GeneCardsi
PNISR
HGNCiHGNC:21222, PNISR
HPAiENSG00000132424, Low tissue specificity
MIMi616653, gene
neXtProtiNX_Q8TF01
OpenTargetsiENSG00000132424
PharmGKBiPA162402984

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QUV0, Eukaryota
GeneTreeiENSGT00730000111138
HOGENOMiCLU_372518_0_0_1
InParanoidiQ8TF01
KOiK13170
OMAiQFNGKRP
OrthoDBi928665at2759
PhylomeDBiQ8TF01
TreeFamiTF332904

Enzyme and pathway databases

PathwayCommonsiQ8TF01

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
25957, 322 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PNISR, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PNISR_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25957
PharosiQ8TF01, Tdark

Protein Ontology

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PROi
PR:Q8TF01
RNActiQ8TF01, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132424, Expressed in left lobe of thyroid gland and 247 other tissues
ExpressionAtlasiQ8TF01, baseline and differential
GenevisibleiQ8TF01, HS

Family and domain databases

InterProiView protein in InterPro
IPR031937, PNISR
PANTHERiPTHR31518, PTHR31518, 2 hits
PfamiView protein in Pfam
PF15996, PNISR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNISR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF01
Secondary accession number(s): A8K540
, E1P5D2, Q5T064, Q5T065, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8N2L1, Q8TF00, Q96K10, Q96SI3, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 10, 2007
Last modified: August 12, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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