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Protein

Membrane progestin receptor beta

Gene

PAQR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).1 PublicationBy similarity1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).1 Publication

GO - Molecular functioni

  • signaling receptor activity Source: GO_Central
  • steroid binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Oogenesis
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor beta1 Publication
Short name:
mPR beta1 Publication
Alternative name(s):
Lysosomal membrane protein in brain 11 Publication
Membrane progesterone P4 receptor beta1 Publication
Membrane progesterone receptor beta1 Publication
Progesterone and adipoQ receptor family member 8
Progestin and adipoQ receptor family member 81 Publication
Progestin and adipoQ receptor family member VIII
Gene namesi
Name:PAQR8Imported
Synonyms:C6orf33Imported, LMPB1, MPRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000170915.8
HGNCiHGNC:15708 PAQR8
MIMi607780 gene
neXtProtiNX_Q8TEZ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
Transmembranei76 – 96Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 132Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini133 – 174CytoplasmicSequence analysisAdd BLAST42
Transmembranei175 – 195Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini196 – 213ExtracellularSequence analysisAdd BLAST18
Transmembranei214 – 234Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini235 – 243CytoplasmicSequence analysis9
Transmembranei244 – 264Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini265 – 283ExtracellularSequence analysisAdd BLAST19
Transmembranei284 – 304Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini305 – 319CytoplasmicSequence analysisAdd BLAST15
Transmembranei320 – 340Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini341 – 354ExtracellularSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170915
PharmGKBiPA25934

Polymorphism and mutation databases

BioMutaiPAQR8
DMDMi51316493

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188401 – 354Membrane progestin receptor betaAdd BLAST354

Proteomic databases

EPDiQ8TEZ7
PaxDbiQ8TEZ7
PeptideAtlasiQ8TEZ7
PRIDEiQ8TEZ7
ProteomicsDBi74529

PTM databases

iPTMnetiQ8TEZ7
PhosphoSitePlusiQ8TEZ7

Expressioni

Tissue specificityi

Highly expressed in the hypothalamus (PubMed:23161870). Also expressed in spinal cord, kidney and testis.4 Publications

Gene expression databases

BgeeiENSG00000170915 Expressed in 186 organ(s), highest expression level in globus pallidus
CleanExiHS_PAQR8
ExpressionAtlasiQ8TEZ7 baseline and differential
GenevisibleiQ8TEZ7 HS

Organism-specific databases

HPAiHPA064625

Interactioni

Protein-protein interaction databases

IntActiQ8TEZ7, 3 interactors
STRINGi9606.ENSP00000353953

Structurei

3D structure databases

ProteinModelPortaliQ8TEZ7
SMRiQ8TEZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000230872
HOVERGENiHBG052504
InParanoidiQ8TEZ7
OMAiREPYIHA
OrthoDBiEOG091G0QDA
PhylomeDBiQ8TEZ7
TreeFamiTF319738

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8TEZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY
60 70 80 90 100
IRTGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE
110 120 130 140 150
ALPWASTHSL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG
160 170 180 190 200
VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL PAAAFCGWLS CAGCCYAKYR
210 220 230 240 250
YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC QEQAAWYHTL
260 270 280 290 300
QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI
310 320 330 340 350
LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT

KKDS
Length:354
Mass (Da):40,464
Last modified:June 1, 2002 - v1
Checksum:iB0ECCD9C54C0CA24
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCM7D6RCM7_HUMAN
Membrane progestin receptor beta
PAQR8
112Annotation score:

Sequence cautioni

The sequence AAR08374 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347029 mRNA Translation: AAL79777.2
AY424286 mRNA Translation: AAR08374.1 Different initiation.
AK315088 mRNA Translation: BAG37553.1
AL136125 Genomic DNA No translation available.
BC030664 mRNA Translation: AAH30664.2
AF313619 mRNA Translation: AAO47232.1
CCDSiCCDS4941.1
RefSeqiNP_588608.1, NM_133367.4
UniGeneiHs.239388

Genome annotation databases

EnsembliENST00000360726; ENSP00000353953; ENSG00000170915
ENST00000442253; ENSP00000406197; ENSG00000170915
GeneIDi85315
KEGGihsa:85315
UCSCiuc003pao.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347029 mRNA Translation: AAL79777.2
AY424286 mRNA Translation: AAR08374.1 Different initiation.
AK315088 mRNA Translation: BAG37553.1
AL136125 Genomic DNA No translation available.
BC030664 mRNA Translation: AAH30664.2
AF313619 mRNA Translation: AAO47232.1
CCDSiCCDS4941.1
RefSeqiNP_588608.1, NM_133367.4
UniGeneiHs.239388

3D structure databases

ProteinModelPortaliQ8TEZ7
SMRiQ8TEZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TEZ7, 3 interactors
STRINGi9606.ENSP00000353953

PTM databases

iPTMnetiQ8TEZ7
PhosphoSitePlusiQ8TEZ7

Polymorphism and mutation databases

BioMutaiPAQR8
DMDMi51316493

Proteomic databases

EPDiQ8TEZ7
PaxDbiQ8TEZ7
PeptideAtlasiQ8TEZ7
PRIDEiQ8TEZ7
ProteomicsDBi74529

Protocols and materials databases

DNASUi85315
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360726; ENSP00000353953; ENSG00000170915
ENST00000442253; ENSP00000406197; ENSG00000170915
GeneIDi85315
KEGGihsa:85315
UCSCiuc003pao.4 human

Organism-specific databases

CTDi85315
EuPathDBiHostDB:ENSG00000170915.8
GeneCardsiPAQR8
HGNCiHGNC:15708 PAQR8
HPAiHPA064625
MIMi607780 gene
neXtProtiNX_Q8TEZ7
OpenTargetsiENSG00000170915
PharmGKBiPA25934
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000230872
HOVERGENiHBG052504
InParanoidiQ8TEZ7
OMAiREPYIHA
OrthoDBiEOG091G0QDA
PhylomeDBiQ8TEZ7
TreeFamiTF319738

Miscellaneous databases

GeneWikiiPAQR8
GenomeRNAii85315
PROiPR:Q8TEZ7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170915 Expressed in 186 organ(s), highest expression level in globus pallidus
CleanExiHS_PAQR8
ExpressionAtlasiQ8TEZ7 baseline and differential
GenevisibleiQ8TEZ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAQR8_HUMAN
AccessioniPrimary (citable) accession number: Q8TEZ7
Secondary accession number(s): B2RCF6
, Q86WL0, Q8N6D3, Q9HD02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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