UniProtKB - Q8TEZ7 (PAQR8_HUMAN)
Protein
Membrane progestin receptor beta
Gene
PAQR8
Organism
Homo sapiens (Human)
Status
Functioni
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).1 PublicationBy similarity1 Publication
Miscellaneous
Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).1 Publication
GO - Molecular functioni
- signaling receptor activity Source: GO_Central
- steroid binding Source: GO_Central
- steroid hormone receptor activity Source: GO_Central
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- oogenesis Source: UniProtKB-KW
- response to steroid hormone Source: GO_Central
Keywordsi
Molecular function | Developmental protein, Receptor |
Biological process | Differentiation, Oogenesis |
Ligand | Lipid-binding, Steroid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8TEZ7 |
Protein family/group databases
TCDBi | 1.C.113.1.12, the hly iii (hly iii) family |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane progestin receptor beta1 PublicationShort name: mPR beta1 Publication Alternative name(s): Lysosomal membrane protein in brain 11 Publication Membrane progesterone P4 receptor beta1 Publication Membrane progesterone receptor beta1 Publication Progesterone and adipoQ receptor family member 8 Progestin and adipoQ receptor family member 81 Publication Progestin and adipoQ receptor family member VIII |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15708, PAQR8 |
MIMi | 607780, gene |
neXtProti | NX_Q8TEZ7 |
VEuPathDBi | HostDB:ENSG00000170915.8 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication1 Publication; Multi-pass membrane protein Sequence analysis
Note: Colocalizes with a lysosomal protein CTSD/cathepsin D.1 Publication
Golgi apparatus
- Golgi apparatus Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 75 | CytoplasmicSequence analysisAdd BLAST | 75 | |
Transmembranei | 76 – 96 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 111 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 112 – 132 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 133 – 174 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 175 – 195 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 196 – 213 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 214 – 234 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 235 – 243 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 244 – 264 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 265 – 283 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 284 – 304 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 305 – 319 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 320 – 340 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 341 – 354 | ExtracellularSequence analysisAdd BLAST | 14 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 85315 |
OpenTargetsi | ENSG00000170915 |
PharmGKBi | PA25934 |
Miscellaneous databases
Pharosi | Q8TEZ7, Tbio |
Genetic variation databases
BioMutai | PAQR8 |
DMDMi | 51316493 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218840 | 1 – 354 | Membrane progestin receptor betaAdd BLAST | 354 |
Proteomic databases
MassIVEi | Q8TEZ7 |
PaxDbi | Q8TEZ7 |
PeptideAtlasi | Q8TEZ7 |
PRIDEi | Q8TEZ7 |
ProteomicsDBi | 74529 |
PTM databases
iPTMneti | Q8TEZ7 |
PhosphoSitePlusi | Q8TEZ7 |
Expressioni
Tissue specificityi
Highly expressed in the hypothalamus (PubMed:23161870). Also expressed in spinal cord, kidney and testis.4 Publications
Gene expression databases
Bgeei | ENSG00000170915, Expressed in globus pallidus and 205 other tissues |
ExpressionAtlasi | Q8TEZ7, baseline and differential |
Genevisiblei | Q8TEZ7, HS |
Organism-specific databases
HPAi | ENSG00000170915, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Hide detailsQ8TEZ7
With | #Exp. | IntAct |
---|---|---|
EHHADH [Q08426] | 3 | EBI-12847818,EBI-2339219 |
LEPROTL1 [O95214] | 3 | EBI-12847818,EBI-750776 |
MPP1 [Q00013] | 3 | EBI-12847818,EBI-711788 |
Protein-protein interaction databases
BioGRIDi | 124469, 3 interactors |
IntActi | Q8TEZ7, 3 interactors |
STRINGi | 9606.ENSP00000406197 |
Miscellaneous databases
RNActi | Q8TEZ7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ADIPOR family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0748, Eukaryota |
GeneTreei | ENSGT00940000159860 |
HOGENOMi | CLU_052356_0_0_1 |
InParanoidi | Q8TEZ7 |
OMAi | REPYIHA |
OrthoDBi | 1524940at2759 |
PhylomeDBi | Q8TEZ7 |
TreeFami | TF319738 |
Family and domain databases
InterProi | View protein in InterPro IPR004254, AdipoR/HlyIII-related |
PANTHERi | PTHR20855, PTHR20855, 1 hit |
Pfami | View protein in Pfam PF03006, HlyIII, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8TEZ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY
60 70 80 90 100
IRTGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE
110 120 130 140 150
ALPWASTHSL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG
160 170 180 190 200
VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL PAAAFCGWLS CAGCCYAKYR
210 220 230 240 250
YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC QEQAAWYHTL
260 270 280 290 300
QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI
310 320 330 340 350
LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT
KKDS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RCM7 | D6RCM7_HUMAN | Membrane progestin receptor beta | PAQR8 | 112 | Annotation score: |
Sequence cautioni
The sequence AAR08374 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF347029 mRNA Translation: AAL79777.2 AY424286 mRNA Translation: AAR08374.1 Different initiation. AK315088 mRNA Translation: BAG37553.1 AL136125 Genomic DNA No translation available. BC030664 mRNA Translation: AAH30664.2 AF313619 mRNA Translation: AAO47232.1 |
CCDSi | CCDS4941.1 |
RefSeqi | NP_588608.1, NM_133367.4 |
Genome annotation databases
Ensembli | ENST00000360726; ENSP00000353953; ENSG00000170915 ENST00000442253; ENSP00000406197; ENSG00000170915 |
GeneIDi | 85315 |
KEGGi | hsa:85315 |
UCSCi | uc003pao.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF347029 mRNA Translation: AAL79777.2 AY424286 mRNA Translation: AAR08374.1 Different initiation. AK315088 mRNA Translation: BAG37553.1 AL136125 Genomic DNA No translation available. BC030664 mRNA Translation: AAH30664.2 AF313619 mRNA Translation: AAO47232.1 |
CCDSi | CCDS4941.1 |
RefSeqi | NP_588608.1, NM_133367.4 |
3D structure databases
SMRi | Q8TEZ7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124469, 3 interactors |
IntActi | Q8TEZ7, 3 interactors |
STRINGi | 9606.ENSP00000406197 |
Protein family/group databases
TCDBi | 1.C.113.1.12, the hly iii (hly iii) family |
PTM databases
iPTMneti | Q8TEZ7 |
PhosphoSitePlusi | Q8TEZ7 |
Genetic variation databases
BioMutai | PAQR8 |
DMDMi | 51316493 |
Proteomic databases
MassIVEi | Q8TEZ7 |
PaxDbi | Q8TEZ7 |
PeptideAtlasi | Q8TEZ7 |
PRIDEi | Q8TEZ7 |
ProteomicsDBi | 74529 |
Protocols and materials databases
Antibodypediai | 30905, 113 antibodies |
DNASUi | 85315 |
Genome annotation databases
Ensembli | ENST00000360726; ENSP00000353953; ENSG00000170915 ENST00000442253; ENSP00000406197; ENSG00000170915 |
GeneIDi | 85315 |
KEGGi | hsa:85315 |
UCSCi | uc003pao.4, human |
Organism-specific databases
CTDi | 85315 |
DisGeNETi | 85315 |
GeneCardsi | PAQR8 |
HGNCi | HGNC:15708, PAQR8 |
HPAi | ENSG00000170915, Tissue enhanced (brain) |
MIMi | 607780, gene |
neXtProti | NX_Q8TEZ7 |
OpenTargetsi | ENSG00000170915 |
PharmGKBi | PA25934 |
VEuPathDBi | HostDB:ENSG00000170915.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0748, Eukaryota |
GeneTreei | ENSGT00940000159860 |
HOGENOMi | CLU_052356_0_0_1 |
InParanoidi | Q8TEZ7 |
OMAi | REPYIHA |
OrthoDBi | 1524940at2759 |
PhylomeDBi | Q8TEZ7 |
TreeFami | TF319738 |
Enzyme and pathway databases
PathwayCommonsi | Q8TEZ7 |
Miscellaneous databases
BioGRID-ORCSi | 85315, 10 hits in 872 CRISPR screens |
ChiTaRSi | PAQR8, human |
GeneWikii | PAQR8 |
GenomeRNAii | 85315 |
Pharosi | Q8TEZ7, Tbio |
PROi | PR:Q8TEZ7 |
RNActi | Q8TEZ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170915, Expressed in globus pallidus and 205 other tissues |
ExpressionAtlasi | Q8TEZ7, baseline and differential |
Genevisiblei | Q8TEZ7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004254, AdipoR/HlyIII-related |
PANTHERi | PTHR20855, PTHR20855, 1 hit |
Pfami | View protein in Pfam PF03006, HlyIII, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAQR8_HUMAN | |
Accessioni | Q8TEZ7Primary (citable) accession number: Q8TEZ7 Secondary accession number(s): B2RCF6 Q9HD02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM