PAQR8

Functionⁱ

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).1 PublicationBy similarity1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).1 Publication

GO - Molecular functionⁱ

signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW
oogenesis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Receptor
Biological process	Differentiation, Oogenesis
Ligand	Lipid-binding, Steroid-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Membrane progestin receptor beta1 Publication Short name: mPR beta1 Publication Alternative name(s): Lysosomal membrane protein in brain 11 Publication Membrane progesterone P4 receptor beta1 Publication Membrane progesterone receptor beta1 Publication Progesterone and adipoQ receptor family member 8 Progestin and adipoQ receptor family member 81 Publication Progestin and adipoQ receptor family member VIII
Gene namesⁱ	Name:PAQR8Imported Synonyms:C6orf33Imported, LMPB1, MPRB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170915.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15708 PAQR8
MIMⁱ	607780 gene
neXtProtⁱ	NX_Q8TEZ7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 75	CytoplasmicSequence analysisAdd BLAST	75
Transmembraneⁱ	76 – 96	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	97 – 111	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	112 – 132	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	133 – 174	CytoplasmicSequence analysisAdd BLAST	42
Transmembraneⁱ	175 – 195	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	196 – 213	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	214 – 234	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	235 – 243	CytoplasmicSequence analysis	9
Transmembraneⁱ	244 – 264	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	265 – 283	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	284 – 304	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	305 – 319	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	320 – 340	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	341 – 354	ExtracellularSequence analysisAdd BLAST	14

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000170915
PharmGKBⁱ	PA25934

Polymorphism and mutation databases

BioMutaⁱ	PAQR8
DMDMⁱ	51316493

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218840	1 – 354	Membrane progestin receptor betaAdd BLAST		354

Proteomic databases

EPDⁱ	Q8TEZ7
PaxDbⁱ	Q8TEZ7
PeptideAtlas More...PeptideAtlasⁱ	Q8TEZ7
PRIDEⁱ	Q8TEZ7
ProteomicsDBⁱ	74529

PTM databases

iPTMnetⁱ	Q8TEZ7
PhosphoSitePlusⁱ	Q8TEZ7

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the hypothalamus (PubMed:23161870). Also expressed in spinal cord, kidney and testis.4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000170915 Expressed in 186 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_PAQR8
ExpressionAtlasⁱ	Q8TEZ7 baseline and differential
Genevisibleⁱ	Q8TEZ7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064625

HPAⁱ

HPA064625

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q8TEZ7, 3 interactors
STRINGⁱ	9606.ENSP00000353953

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TEZ7
SMRⁱ	Q8TEZ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ADIPOR family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0748 Eukaryota COG1272 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062965
HOGENOMⁱ	HOG000230872
HOVERGENⁱ	HBG052504
InParanoidⁱ	Q8TEZ7
OMAⁱ	REPYIHA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QDA
PhylomeDBⁱ	Q8TEZ7
TreeFamⁱ	TF319738

Family and domain databases

InterProⁱ	View protein in InterPro IPR004254 AdipoR/HlyIII-related
PANTHERⁱ	PTHR20855 PTHR20855, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03006 HlyIII, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8TEZ7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY 
        60         70         80         90        100
IRTGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE 
       110        120        130        140        150
ALPWASTHSL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG 
       160        170        180        190        200
VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL PAAAFCGWLS CAGCCYAKYR 
       210        220        230        240        250
YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC QEQAAWYHTL 
       260        270        280        290        300
QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI 
       310        320        330        340        350
LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT 

KKDS

Length:354

Mass (Da):40,464

Last modified:June 1, 2002 - v1

Checksum:ⁱB0ECCD9C54C0CA24

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RCM7	D6RCM7_HUMAN		Membrane progestin receptor beta Membrane progestin receptor beta	PAQR8	112	Annotation score:

Sequence cautionⁱ

The sequence AAR08374 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF347029 mRNA Translation: AAL79777.2 AY424286 mRNA Translation: AAR08374.1 Different initiation. AK315088 mRNA Translation: BAG37553.1 AL136125 Genomic DNA No translation available. BC030664 mRNA Translation: AAH30664.2 AF313619 mRNA Translation: AAO47232.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4941.1
NCBI Reference Sequences More...RefSeqⁱ	NP_588608.1, NM_133367.4
UniGeneⁱ	Hs.239388

Genome annotation databases

Ensemblⁱ	ENST00000360726; ENSP00000353953; ENSG00000170915 ENST00000442253; ENSP00000406197; ENSG00000170915
GeneIDⁱ	85315
KEGGⁱ	hsa:85315
UCSC genome browser More...UCSCⁱ	uc003pao.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TEZ7	Progestin and adipoQ receptor family member VIII, isoform CRA_a		HUMAN		359	UniRef100_Q8TEZ7
PAQR8 isoform 2		PANTR		354
Uncharacterized protein		PANPA		354
Progestin and adipoQ receptor family member 8		GORGO		354

Protein	Similar proteins		Species	Score	Length	Source
Q8TEZ7	Membrane progestin receptor beta		MOUSE		354	UniRef90_Q8TEZ7
Progestin and adipoQ receptor family member VIII, isoform CRA_a		HUMAN		359
PAQR8 isoform 2		PANTR		354
Uncharacterized protein		PANPA		354
Progestin and adipoQ receptor family member 8		GORGO		354
+15

Protein	Similar proteins		Species	Score	Length	Source
Q8TEZ7	Membrane progestin receptor alpha-B		DANRE		354	UniRef50_Q801G2
Membrane progestin receptor alpha		CYNNE		352
Membrane progestin receptor beta		PIG		354
Membrane progestin receptor beta		MOUSE		354
Uncharacterized protein		ASTMX		379
+278

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF347029 mRNA Translation: AAL79777.2 AY424286 mRNA Translation: AAR08374.1 Different initiation. AK315088 mRNA Translation: BAG37553.1 AL136125 Genomic DNA No translation available. BC030664 mRNA Translation: AAH30664.2 AF313619 mRNA Translation: AAO47232.1
CCDSⁱ	CCDS4941.1
RefSeqⁱ	NP_588608.1, NM_133367.4
UniGeneⁱ	Hs.239388

3D structure databases

ProteinModelPortalⁱ	Q8TEZ7
SMRⁱ	Q8TEZ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8TEZ7, 3 interactors
STRINGⁱ	9606.ENSP00000353953

PTM databases

iPTMnetⁱ	Q8TEZ7
PhosphoSitePlusⁱ	Q8TEZ7

Polymorphism and mutation databases

BioMutaⁱ	PAQR8
DMDMⁱ	51316493

Proteomic databases

EPDⁱ	Q8TEZ7
PaxDbⁱ	Q8TEZ7
PeptideAtlasⁱ	Q8TEZ7
PRIDEⁱ	Q8TEZ7
ProteomicsDBⁱ	74529

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	85315
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000360726; ENSP00000353953; ENSG00000170915 ENST00000442253; ENSP00000406197; ENSG00000170915
GeneIDⁱ	85315
KEGGⁱ	hsa:85315
UCSCⁱ	uc003pao.4 human

Organism-specific databases

CTDⁱ	85315
EuPathDBⁱ	HostDB:ENSG00000170915.8
GeneCardsⁱ	PAQR8
HGNCⁱ	HGNC:15708 PAQR8
HPAⁱ	HPA064625
MIMⁱ	607780 gene
neXtProtⁱ	NX_Q8TEZ7
OpenTargetsⁱ	ENSG00000170915
PharmGKBⁱ	PA25934
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0748 Eukaryota COG1272 LUCA
GeneTreeⁱ	ENSGT00530000062965
HOGENOMⁱ	HOG000230872
HOVERGENⁱ	HBG052504
InParanoidⁱ	Q8TEZ7
OMAⁱ	REPYIHA
OrthoDBⁱ	EOG091G0QDA
PhylomeDBⁱ	Q8TEZ7
TreeFamⁱ	TF319738

Miscellaneous databases

GeneWikiⁱ	PAQR8
GenomeRNAiⁱ	85315
Protein Ontology More...PROⁱ	PR:Q8TEZ7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170915 Expressed in 186 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_PAQR8
ExpressionAtlasⁱ	Q8TEZ7 baseline and differential
Genevisibleⁱ	Q8TEZ7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004254 AdipoR/HlyIII-related
PANTHERⁱ	PTHR20855 PTHR20855, 1 hit
Pfamⁱ	View protein in Pfam PF03006 HlyIII, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PAQR8_HUMAN
Accessionⁱ	Q8TEZ7Primary (citable) accession number: Q8TEZ7 Secondary accession number(s): B2RCF6 , Q86WL0, Q8N6D3, Q9HD02
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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Supporting data

UniProtKB - Q8TEZ7 (PAQR8_HUMAN)

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Membrane progestin receptor beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ