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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 4

Gene

CREB3L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Unfolded protein response

Enzyme and pathway databases

ReactomeiR-HSA-8874211 CREB3 factors activate genes

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 4
Short name:
cAMP-responsive element-binding protein 3-like protein 4
Alternative name(s):
Androgen-induced basic leucine zipper protein
Short name:
AIbZIP
Attaching to CRE-like 1
Short name:
ATCE1
Cyclic AMP-responsive element-binding protein 4
Short name:
CREB-4
Short name:
cAMP-responsive element-binding protein 4
Transcript induced in spermiogenesis protein 40
Short name:
Tisp40
hJAL
Cleaved into the following chain:
Gene namesi
Name:CREB3L4
Synonyms:AIBZIP, CREB4, JAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143578.15
HGNCiHGNC:18854 CREB3L4
MIMi607138 gene
neXtProtiNX_Q8TEY5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 295CytoplasmicSequence analysisAdd BLAST295
Transmembranei296 – 316Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini317 – 395LumenalSequence analysisAdd BLAST79

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi335R → G: Abolishes cleavage by SP1. 1 Publication1

Organism-specific databases

DisGeNETi148327
OpenTargetsiENSG00000143578
PharmGKBiPA134922919

Polymorphism and mutation databases

BioMutaiCREB3L4
DMDMi74751463

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880791 – 395Cyclic AMP-responsive element-binding protein 3-like protein 4Add BLAST395
ChainiPRO_00002962191 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated in the C-terminal region.1 Publication
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei338 – 339Cleavage; by PS1By similarity2

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8TEY5
PaxDbiQ8TEY5
PeptideAtlasiQ8TEY5
PRIDEiQ8TEY5
ProteomicsDBi74525

PTM databases

iPTMnetiQ8TEY5
PhosphoSitePlusiQ8TEY5

Miscellaneous databases

PMAP-CutDBiQ8TEY5

Expressioni

Tissue specificityi

According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.3 Publications

Inductioni

By androgens.

Gene expression databases

BgeeiENSG00000143578 Expressed in 157 organ(s), highest expression level in prostate gland
CleanExiHS_CREB3L4
ExpressionAtlasiQ8TEY5 baseline and differential
GenevisibleiQ8TEY5 HS

Organism-specific databases

HPAiHPA038122

Interactioni

Subunit structurei

Binds DNA as a dimer.By similarity

Protein-protein interaction databases

BioGridi127142, 8 interactors
IntActiQ8TEY5, 5 interactors
STRINGi9606.ENSP00000271889

Structurei

3D structure databases

ProteinModelPortaliQ8TEY5
SMRiQ8TEY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 280bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 248Basic motifPROSITE-ProRule annotationAdd BLAST30
Regioni259 – 280Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0709 Eukaryota
ENOG410ZZQM LUCA
GeneTreeiENSGT00520000055538
HOGENOMiHOG000059566
HOVERGENiHBG058316
InParanoidiQ8TEY5
KOiK09048
OMAiEDYQPHG
OrthoDBiEOG091G0GTJ
PhylomeDBiQ8TEY5
TreeFamiTF316079

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029807 CREB4
PANTHERiPTHR22952:SF105 PTHR22952:SF105, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TEY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPVT RLQEQGLQGW
60 70 80 90 100
KSGGDRGCGL QESEPEDFLK LFIDPNEVYC SEASPGSDSG ISEDPCHPDS
110 120 130 140 150
PPAPRATSSP MLYEVVYEAG ALERMQGETG PNVGLISIQL DQWSPAFMVP
160 170 180 190 200
DSCMVSELPF DAHAHILPRA GTVAPVPCTT LLPCQTLFLT DEEKRLLGQE
210 220 230 240 250
GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE YIDGLESRVA
260 270 280 290 300
ACSAQNQELQ KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI
310 320 330 340 350
LLFSLALIIL PSFSPFQSRP EAGSEDYQPH GVTSRNILTH KDVTENLETQ
360 370 380 390
VVESRLREPP GAKDANGSTR TLLEKMGGKP RPSGRIRSVL HADEM
Length:395
Mass (Da):43,432
Last modified:June 1, 2002 - v1
Checksum:iF3DDF288421AE5F2
GO
Isoform 2 (identifier: Q8TEY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: Missing.

Show »
Length:375
Mass (Da):41,275
Checksum:i69E272BB4E51E127
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4L1Q5T4L1_HUMAN
Cyclic AMP-responsive element-bindi...
CREB3L4
228Annotation score:
Q5T4K9Q5T4K9_HUMAN
Cyclic AMP-responsive element-bindi...
CREB3L4
217Annotation score:
Q5T4L2Q5T4L2_HUMAN
Cyclic AMP-responsive element-bindi...
CREB3L4
182Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35P → L in AAO33070 (PubMed:12111373).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04844495P → S. Corresponds to variant dbSNP:rs11264743Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04542639 – 58Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394167 mRNA Translation: AAL76113.1
AF468007 mRNA Translation: AAO33070.1
AB052778 mRNA Translation: BAC45035.1
AB052781 Genomic DNA Translation: BAC45224.1
AY049977 mRNA Translation: AAL13157.1
AK304665 mRNA Translation: BAG65440.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53251.1
CH471121 Genomic DNA Translation: EAW53253.1
CH471121 Genomic DNA Translation: EAW53254.1
CH471121 Genomic DNA Translation: EAW53256.1
CH471121 Genomic DNA Translation: EAW53257.1
CH471121 Genomic DNA Translation: EAW53258.1
BC038962 mRNA Translation: AAH38962.1
CCDSiCCDS1056.1 [Q8TEY5-1]
CCDS58029.1 [Q8TEY5-2]
RefSeqiNP_001242907.1, NM_001255978.1 [Q8TEY5-1]
NP_001242908.1, NM_001255979.1 [Q8TEY5-1]
NP_001242909.1, NM_001255980.1 [Q8TEY5-2]
NP_001242910.1, NM_001255981.1 [Q8TEY5-2]
NP_570968.1, NM_130898.3 [Q8TEY5-1]
XP_006711235.1, XM_006711172.2 [Q8TEY5-2]
XP_016855861.1, XM_017000372.1 [Q8TEY5-2]
UniGeneiHs.372924
Hs.745148

Genome annotation databases

EnsembliENST00000271889; ENSP00000271889; ENSG00000143578 [Q8TEY5-1]
ENST00000368600; ENSP00000357589; ENSG00000143578 [Q8TEY5-2]
ENST00000368603; ENSP00000357592; ENSG00000143578 [Q8TEY5-1]
ENST00000368607; ENSP00000357596; ENSG00000143578 [Q8TEY5-1]
GeneIDi148327
KEGGihsa:148327
UCSCiuc001fdm.3 human [Q8TEY5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394167 mRNA Translation: AAL76113.1
AF468007 mRNA Translation: AAO33070.1
AB052778 mRNA Translation: BAC45035.1
AB052781 Genomic DNA Translation: BAC45224.1
AY049977 mRNA Translation: AAL13157.1
AK304665 mRNA Translation: BAG65440.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53251.1
CH471121 Genomic DNA Translation: EAW53253.1
CH471121 Genomic DNA Translation: EAW53254.1
CH471121 Genomic DNA Translation: EAW53256.1
CH471121 Genomic DNA Translation: EAW53257.1
CH471121 Genomic DNA Translation: EAW53258.1
BC038962 mRNA Translation: AAH38962.1
CCDSiCCDS1056.1 [Q8TEY5-1]
CCDS58029.1 [Q8TEY5-2]
RefSeqiNP_001242907.1, NM_001255978.1 [Q8TEY5-1]
NP_001242908.1, NM_001255979.1 [Q8TEY5-1]
NP_001242909.1, NM_001255980.1 [Q8TEY5-2]
NP_001242910.1, NM_001255981.1 [Q8TEY5-2]
NP_570968.1, NM_130898.3 [Q8TEY5-1]
XP_006711235.1, XM_006711172.2 [Q8TEY5-2]
XP_016855861.1, XM_017000372.1 [Q8TEY5-2]
UniGeneiHs.372924
Hs.745148

3D structure databases

ProteinModelPortaliQ8TEY5
SMRiQ8TEY5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127142, 8 interactors
IntActiQ8TEY5, 5 interactors
STRINGi9606.ENSP00000271889

PTM databases

iPTMnetiQ8TEY5
PhosphoSitePlusiQ8TEY5

Polymorphism and mutation databases

BioMutaiCREB3L4
DMDMi74751463

Proteomic databases

MaxQBiQ8TEY5
PaxDbiQ8TEY5
PeptideAtlasiQ8TEY5
PRIDEiQ8TEY5
ProteomicsDBi74525

Protocols and materials databases

DNASUi148327
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271889; ENSP00000271889; ENSG00000143578 [Q8TEY5-1]
ENST00000368600; ENSP00000357589; ENSG00000143578 [Q8TEY5-2]
ENST00000368603; ENSP00000357592; ENSG00000143578 [Q8TEY5-1]
ENST00000368607; ENSP00000357596; ENSG00000143578 [Q8TEY5-1]
GeneIDi148327
KEGGihsa:148327
UCSCiuc001fdm.3 human [Q8TEY5-1]

Organism-specific databases

CTDi148327
DisGeNETi148327
EuPathDBiHostDB:ENSG00000143578.15
GeneCardsiCREB3L4
HGNCiHGNC:18854 CREB3L4
HPAiHPA038122
MIMi607138 gene
neXtProtiNX_Q8TEY5
OpenTargetsiENSG00000143578
PharmGKBiPA134922919
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0709 Eukaryota
ENOG410ZZQM LUCA
GeneTreeiENSGT00520000055538
HOGENOMiHOG000059566
HOVERGENiHBG058316
InParanoidiQ8TEY5
KOiK09048
OMAiEDYQPHG
OrthoDBiEOG091G0GTJ
PhylomeDBiQ8TEY5
TreeFamiTF316079

Enzyme and pathway databases

ReactomeiR-HSA-8874211 CREB3 factors activate genes

Miscellaneous databases

ChiTaRSiCREB3L4 human
GenomeRNAii148327
PMAP-CutDBiQ8TEY5
PROiPR:Q8TEY5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143578 Expressed in 157 organ(s), highest expression level in prostate gland
CleanExiHS_CREB3L4
ExpressionAtlasiQ8TEY5 baseline and differential
GenevisibleiQ8TEY5 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029807 CREB4
PANTHERiPTHR22952:SF105 PTHR22952:SF105, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCR3L4_HUMAN
AccessioniPrimary (citable) accession number: Q8TEY5
Secondary accession number(s): D3DV62, Q5T4L0, Q86YW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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