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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 4

Gene

CREB3L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Unfolded protein response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8874211 CREB3 factors activate genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 4
Short name:
cAMP-responsive element-binding protein 3-like protein 4
Alternative name(s):
Androgen-induced basic leucine zipper protein
Short name:
AIbZIP
Attaching to CRE-like 1
Short name:
ATCE1
Cyclic AMP-responsive element-binding protein 4
Short name:
CREB-4
Short name:
cAMP-responsive element-binding protein 4
Transcript induced in spermiogenesis protein 40
Short name:
Tisp40
hJAL
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CREB3L4
Synonyms:AIBZIP, CREB4, JAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143578.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18854 CREB3L4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607138 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TEY5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 295CytoplasmicSequence analysisAdd BLAST295
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei296 – 316Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini317 – 395LumenalSequence analysisAdd BLAST79

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi335R → G: Abolishes cleavage by SP1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
148327

Open Targets

More...
OpenTargetsi
ENSG00000143578

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134922919

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CREB3L4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751463

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002880791 – 395Cyclic AMP-responsive element-binding protein 3-like protein 4Add BLAST395
ChainiPRO_00002962191 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated in the C-terminal region.1 Publication
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei338 – 339Cleavage; by PS1By similarity2

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TEY5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TEY5

PeptideAtlas

More...
PeptideAtlasi
Q8TEY5

PRoteomics IDEntifications database

More...
PRIDEi
Q8TEY5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74525

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TEY5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TEY5

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q8TEY5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By androgens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143578 Expressed in 157 organ(s), highest expression level in prostate gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_CREB3L4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TEY5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TEY5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038122

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a dimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127142, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TEY5, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000271889

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TEY5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TEY5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini217 – 280bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni219 – 248Basic motifPROSITE-ProRule annotationAdd BLAST30
Regioni259 – 280Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0709 Eukaryota
ENOG410ZZQM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160806

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059566

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058316

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TEY5

KEGG Orthology (KO)

More...
KOi
K09048

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIRTVLH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GTJ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TEY5

TreeFam database of animal gene trees

More...
TreeFami
TF316079

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004827 bZIP
IPR029807 CREB4

The PANTHER Classification System

More...
PANTHERi
PTHR22952:SF105 PTHR22952:SF105, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00170 bZIP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338 BRLZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217 BZIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TEY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPVT RLQEQGLQGW
60 70 80 90 100
KSGGDRGCGL QESEPEDFLK LFIDPNEVYC SEASPGSDSG ISEDPCHPDS
110 120 130 140 150
PPAPRATSSP MLYEVVYEAG ALERMQGETG PNVGLISIQL DQWSPAFMVP
160 170 180 190 200
DSCMVSELPF DAHAHILPRA GTVAPVPCTT LLPCQTLFLT DEEKRLLGQE
210 220 230 240 250
GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE YIDGLESRVA
260 270 280 290 300
ACSAQNQELQ KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI
310 320 330 340 350
LLFSLALIIL PSFSPFQSRP EAGSEDYQPH GVTSRNILTH KDVTENLETQ
360 370 380 390
VVESRLREPP GAKDANGSTR TLLEKMGGKP RPSGRIRSVL HADEM
Length:395
Mass (Da):43,432
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3DDF288421AE5F2
GO
Isoform 2 (identifier: Q8TEY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: Missing.

Show »
Length:375
Mass (Da):41,275
Checksum:i69E272BB4E51E127
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4L1Q5T4L1_HUMAN
Cyclic AMP-responsive element-bindi...
CREB3L4
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T4L2Q5T4L2_HUMAN
Cyclic AMP-responsive element-bindi...
CREB3L4
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T4K9Q5T4K9_HUMAN
Cyclic AMP-responsive element-bindi...
CREB3L4
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35P → L in AAO33070 (PubMed:12111373).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04844495P → S. Corresponds to variant dbSNP:rs11264743Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04542639 – 58Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF394167 mRNA Translation: AAL76113.1
AF468007 mRNA Translation: AAO33070.1
AB052778 mRNA Translation: BAC45035.1
AB052781 Genomic DNA Translation: BAC45224.1
AY049977 mRNA Translation: AAL13157.1
AK304665 mRNA Translation: BAG65440.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53251.1
CH471121 Genomic DNA Translation: EAW53253.1
CH471121 Genomic DNA Translation: EAW53254.1
CH471121 Genomic DNA Translation: EAW53256.1
CH471121 Genomic DNA Translation: EAW53257.1
CH471121 Genomic DNA Translation: EAW53258.1
BC038962 mRNA Translation: AAH38962.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1056.1 [Q8TEY5-1]
CCDS58029.1 [Q8TEY5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001242907.1, NM_001255978.1 [Q8TEY5-1]
NP_001242908.1, NM_001255979.1 [Q8TEY5-1]
NP_001242909.1, NM_001255980.1 [Q8TEY5-2]
NP_001242910.1, NM_001255981.1 [Q8TEY5-2]
NP_570968.1, NM_130898.3 [Q8TEY5-1]
XP_006711235.1, XM_006711172.2 [Q8TEY5-2]
XP_016855861.1, XM_017000372.1 [Q8TEY5-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.372924
Hs.745148

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000271889; ENSP00000271889; ENSG00000143578 [Q8TEY5-1]
ENST00000368600; ENSP00000357589; ENSG00000143578 [Q8TEY5-2]
ENST00000368603; ENSP00000357592; ENSG00000143578 [Q8TEY5-1]
ENST00000368607; ENSP00000357596; ENSG00000143578 [Q8TEY5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
148327

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:148327

UCSC genome browser

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UCSCi
uc001fdm.3 human [Q8TEY5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394167 mRNA Translation: AAL76113.1
AF468007 mRNA Translation: AAO33070.1
AB052778 mRNA Translation: BAC45035.1
AB052781 Genomic DNA Translation: BAC45224.1
AY049977 mRNA Translation: AAL13157.1
AK304665 mRNA Translation: BAG65440.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53251.1
CH471121 Genomic DNA Translation: EAW53253.1
CH471121 Genomic DNA Translation: EAW53254.1
CH471121 Genomic DNA Translation: EAW53256.1
CH471121 Genomic DNA Translation: EAW53257.1
CH471121 Genomic DNA Translation: EAW53258.1
BC038962 mRNA Translation: AAH38962.1
CCDSiCCDS1056.1 [Q8TEY5-1]
CCDS58029.1 [Q8TEY5-2]
RefSeqiNP_001242907.1, NM_001255978.1 [Q8TEY5-1]
NP_001242908.1, NM_001255979.1 [Q8TEY5-1]
NP_001242909.1, NM_001255980.1 [Q8TEY5-2]
NP_001242910.1, NM_001255981.1 [Q8TEY5-2]
NP_570968.1, NM_130898.3 [Q8TEY5-1]
XP_006711235.1, XM_006711172.2 [Q8TEY5-2]
XP_016855861.1, XM_017000372.1 [Q8TEY5-2]
UniGeneiHs.372924
Hs.745148

3D structure databases

ProteinModelPortaliQ8TEY5
SMRiQ8TEY5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127142, 8 interactors
IntActiQ8TEY5, 5 interactors
STRINGi9606.ENSP00000271889

PTM databases

iPTMnetiQ8TEY5
PhosphoSitePlusiQ8TEY5

Polymorphism and mutation databases

BioMutaiCREB3L4
DMDMi74751463

Proteomic databases

MaxQBiQ8TEY5
PaxDbiQ8TEY5
PeptideAtlasiQ8TEY5
PRIDEiQ8TEY5
ProteomicsDBi74525

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
148327
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271889; ENSP00000271889; ENSG00000143578 [Q8TEY5-1]
ENST00000368600; ENSP00000357589; ENSG00000143578 [Q8TEY5-2]
ENST00000368603; ENSP00000357592; ENSG00000143578 [Q8TEY5-1]
ENST00000368607; ENSP00000357596; ENSG00000143578 [Q8TEY5-1]
GeneIDi148327
KEGGihsa:148327
UCSCiuc001fdm.3 human [Q8TEY5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
148327
DisGeNETi148327
EuPathDBiHostDB:ENSG00000143578.15

GeneCards: human genes, protein and diseases

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GeneCardsi
CREB3L4
HGNCiHGNC:18854 CREB3L4
HPAiHPA038122
MIMi607138 gene
neXtProtiNX_Q8TEY5
OpenTargetsiENSG00000143578
PharmGKBiPA134922919

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0709 Eukaryota
ENOG410ZZQM LUCA
GeneTreeiENSGT00940000160806
HOGENOMiHOG000059566
HOVERGENiHBG058316
InParanoidiQ8TEY5
KOiK09048
OMAiHIRTVLH
OrthoDBiEOG091G0GTJ
PhylomeDBiQ8TEY5
TreeFamiTF316079

Enzyme and pathway databases

ReactomeiR-HSA-8874211 CREB3 factors activate genes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CREB3L4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
148327
PMAP-CutDBiQ8TEY5

Protein Ontology

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PROi
PR:Q8TEY5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143578 Expressed in 157 organ(s), highest expression level in prostate gland
CleanExiHS_CREB3L4
ExpressionAtlasiQ8TEY5 baseline and differential
GenevisibleiQ8TEY5 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029807 CREB4
PANTHERiPTHR22952:SF105 PTHR22952:SF105, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCR3L4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEY5
Secondary accession number(s): D3DV62, Q5T4L0, Q86YW6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2002
Last modified: December 5, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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