Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 184 (07 Apr 2021)
Sequence version 2 (20 Feb 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Importin-4

Gene

IPO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TEX9

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Importin-4
Short name:
Imp4
Alternative name(s):
Importin-4b
Short name:
Imp4b
Ran-binding protein 4
Short name:
RanBP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IPO4
Synonyms:IMP4B, RANBP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19426, IPO4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TEX9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000196497.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79711

Open Targets

More...
OpenTargetsi
ENSG00000196497

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134968932

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TEX9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IPO4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126302558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207481 – 1081Importin-4Add BLAST1081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TEX9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TEX9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TEX9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TEX9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TEX9

PeptideAtlas

More...
PeptideAtlasi
Q8TEX9

PRoteomics IDEntifications database

More...
PRIDEi
Q8TEX9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74523 [Q8TEX9-1]
74524 [Q8TEX9-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8TEX9

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TEX9

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q8TEX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TEX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196497, Expressed in testis and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TEX9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TEX9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196497, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Binds to human cytomegalovirus UL84.

Found in a cytosolic complex with ASF1A, ASF1B, CDAN1 and histones H3.1 and H4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122828, 115 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8TEX9

Database of interacting proteins

More...
DIPi
DIP-32944N

Protein interaction database and analysis system

More...
IntActi
Q8TEX9, 54 interactors

Molecular INTeraction database

More...
MINTi
Q8TEX9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346453

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TEX9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11081
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TEX9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 90Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati348 – 385HEAT 1Add BLAST38
Repeati390 – 427HEAT 2Add BLAST38
Repeati431 – 471HEAT 3Add BLAST41
Repeati475 – 513HEAT 4Add BLAST39
Repeati895 – 932HEAT 5Add BLAST38
Repeati936 – 974HEAT 6Add BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the importin beta family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2171, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075074

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003794_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TEX9

Identification of Orthologs from Complete Genome Data

More...
OMAi
FENISTM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TEX9

TreeFam database of animal gene trees

More...
TreeFami
TF323157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR021133, HEAT_type_2
IPR001494, Importin-beta_N
IPR040122, Importin_beta
IPR034085, TOG

The PANTHER Classification System

More...
PANTHERi
PTHR10527, PTHR10527, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985, HEAT, 1 hit
PF03810, IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00913, IBN_N, 1 hit
SM01349, TOG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077, HEAT_REPEAT, 2 hits
PS50166, IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TEX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESAGLEQLL RELLLPDTER IRRATEQLQI VLRAPAALPA LCDLLASAAD
60 70 80 90 100
PQIRQFAAVL TRRRLNTRWR RLAAEQRESL KSLILTALQR ETEHCVSLSL
110 120 130 140 150
AQLSATIFRK EGLEAWPQLL QLLQHSTHSP HSPEREMGLL LLSVVVTSRP
160 170 180 190 200
EAFQPHHREL LRLLNETLGE VGSPGLLFYS LRTLTTMAPY LSTEDVPLAR
210 220 230 240 250
MLVPKLIMAM QTLIPIDEAK ACEALEALDE LLESEVPVIT PYLSEVLTFC
260 270 280 290 300
LEVARNVALG NAIRIRILCC LTFLVKVKSK ALLKNRLLPP LLHTLFPIVA
310 320 330 340 350
AEPPPGQLDP EDQDSEEEEL EIELMGETPK HFAVQVVDML ALHLPPEKLC
360 370 380 390 400
PQLMPMLEEA LRSESPYQRK AGLLVLAVLS DGAGDHIRQR LLPPLLQIVC
410 420 430 440 450
KGLEDPSQVV RNAALFALGQ FSENLQPHIS SYSREVMPLL LAYLKSVPLG
460 470 480 490 500
HTHHLAKACY ALENFVENLG PKVQPYLPEL MECMLQLLRN PSSPRAKELA
510 520 530 540 550
VSALGAIATA AQASLLPYFP AIMEHLREFL LTGREDLQPV QIQSLETLGV
560 570 580 590 600
LARAVGEPMR PLAEECCQLG LGLCDQVDDP DLRRCTYSLF AALSGLMGEG
610 620 630 640 650
LAPHLEQITT LMLLSLRSTE GIVPQYDGSS SFLLFDDESD GEEEEELMDE
660 670 680 690 700
DVEEEDDSEI SGYSVENAFF DEKEDTCAAV GEISVNTSVA FLPYMESVFE
710 720 730 740 750
EVFKLLECPH LNVRKAAHEA LGQFCCALHK ACQSCPSEPN TAALQAALAR
760 770 780 790 800
VVPSYMQAVN RERERQVVMA VLEALTGVLR SCGTLTLKPP GRLAELCGVL
810 820 830 840 850
KAVLQRKTAC QDTDEEEEEE DDDQAEYDAM LLEHAGEAIP ALAAAAGGDS
860 870 880 890 900
FAPFFAGFLP LLVCKTKQGC TVAEKSFAVG TLAETIQGLG AASAQFVSRL
910 920 930 940 950
LPVLLSTAQE ADPEVRSNAI FGMGVLAEHG GHPAQEHFPK LLGLLFPLLA
960 970 980 990 1000
RERHDRVRDN ICGALARLLM ASPTRKPEPQ VLAALLHALP LKEDLEEWVT
1010 1020 1030 1040 1050
IGRLFSFLYQ SSPDQVIDVA PELLRICSLI LADNKIPPDT KAALLLLLTF
1060 1070 1080
LAKQHTDSFQ AALGSLPVDK AQELQAVLGL S
Length:1,081
Mass (Da):118,715
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36D11AF0D6DA8B1E
GO
Isoform 2 (identifier: Q8TEX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: P → PGE

Show »
Length:1,083
Mass (Da):118,901
Checksum:iBBB539F050812D96
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN14H0YN14_HUMAN
Importin-4
IPO4
911Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN07H0YN07_HUMAN
Importin-4
IPO4
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMR4H0YMR4_HUMAN
Importin-4
IPO4
547Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLV0H0YLV0_HUMAN
Importin-4
IPO4
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL92H0YL92_HUMAN
Importin-4
IPO4
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKG5H0YKG5_HUMAN
Importin-4
IPO4
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK93H0YK93_HUMAN
Importin-4
IPO4
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15616 differs from that shown. Reason: Frameshift.Curated
The sequence BAB55421 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC11174 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD62595 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti865K → R in BAB15616 (PubMed:14702039).Curated1
Sequence conflicti943G → E in BAB55421 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030758513A → V2 PublicationsCorresponds to variant dbSNP:rs7146310Ensembl.1
Natural variantiVAR_030759580P → A2 PublicationsCorresponds to variant dbSNP:rs11550452Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0093391038P → PGE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF411122 mRNA Translation: AAL78660.1
BX248267 mRNA Translation: CAD62595.1 Different initiation.
AL136295 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66078.1
BC003690 mRNA Translation: AAH03690.2
BC110804 mRNA Translation: AAI10805.1
BC136759 mRNA Translation: AAI36760.1
AK026991 mRNA Translation: BAB15616.1 Frameshift.
AK027871 mRNA Translation: BAB55421.1 Different initiation.
AK074743 mRNA Translation: BAC11174.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9616.1 [Q8TEX9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_078934.3, NM_024658.3 [Q8TEX9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354464; ENSP00000346453; ENSG00000196497 [Q8TEX9-1]
ENST00000644546; ENSP00000494795; ENSG00000285248 [Q8TEX9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79711

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79711

UCSC genome browser

More...
UCSCi
uc001wmv.2, human [Q8TEX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411122 mRNA Translation: AAL78660.1
BX248267 mRNA Translation: CAD62595.1 Different initiation.
AL136295 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66078.1
BC003690 mRNA Translation: AAH03690.2
BC110804 mRNA Translation: AAI10805.1
BC136759 mRNA Translation: AAI36760.1
AK026991 mRNA Translation: BAB15616.1 Frameshift.
AK027871 mRNA Translation: BAB55421.1 Different initiation.
AK074743 mRNA Translation: BAC11174.1 Different initiation.
CCDSiCCDS9616.1 [Q8TEX9-1]
RefSeqiNP_078934.3, NM_024658.3 [Q8TEX9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XAHX-ray3.00A/B/C/D668-1081[»]
5XBKX-ray3.22A/B/C/D668-1081[»]
SMRiQ8TEX9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122828, 115 interactors
CORUMiQ8TEX9
DIPiDIP-32944N
IntActiQ8TEX9, 54 interactors
MINTiQ8TEX9
STRINGi9606.ENSP00000346453

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

CarbonylDBiQ8TEX9
iPTMnetiQ8TEX9
MetOSiteiQ8TEX9
PhosphoSitePlusiQ8TEX9

Genetic variation databases

BioMutaiIPO4
DMDMi126302558

Proteomic databases

EPDiQ8TEX9
jPOSTiQ8TEX9
MassIVEiQ8TEX9
MaxQBiQ8TEX9
PaxDbiQ8TEX9
PeptideAtlasiQ8TEX9
PRIDEiQ8TEX9
ProteomicsDBi74523 [Q8TEX9-1]
74524 [Q8TEX9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
47245, 101 antibodies

Genome annotation databases

EnsembliENST00000354464; ENSP00000346453; ENSG00000196497 [Q8TEX9-1]
ENST00000644546; ENSP00000494795; ENSG00000285248 [Q8TEX9-1]
GeneIDi79711
KEGGihsa:79711
UCSCiuc001wmv.2, human [Q8TEX9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79711
DisGeNETi79711

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IPO4
HGNCiHGNC:19426, IPO4
HPAiENSG00000196497, Tissue enhanced (testis)
neXtProtiNX_Q8TEX9
OpenTargetsiENSG00000196497
PharmGKBiPA134968932
VEuPathDBiHostDB:ENSG00000196497.15

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2171, Eukaryota
GeneTreeiENSGT00550000075074
HOGENOMiCLU_003794_1_2_1
InParanoidiQ8TEX9
OMAiFENISTM
PhylomeDBiQ8TEX9
TreeFamiTF323157

Enzyme and pathway databases

PathwayCommonsiQ8TEX9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79711, 24 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IPO4, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IPO4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79711
PharosiQ8TEX9, Tbio

Protein Ontology

More...
PROi
PR:Q8TEX9
RNActiQ8TEX9, protein

Gene expression databases

BgeeiENSG00000196497, Expressed in testis and 113 other tissues
ExpressionAtlasiQ8TEX9, baseline and differential
GenevisibleiQ8TEX9, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR021133, HEAT_type_2
IPR001494, Importin-beta_N
IPR040122, Importin_beta
IPR034085, TOG
PANTHERiPTHR10527, PTHR10527, 1 hit
PfamiView protein in Pfam
PF02985, HEAT, 1 hit
PF03810, IBN_N, 1 hit
SMARTiView protein in SMART
SM00913, IBN_N, 1 hit
SM01349, TOG, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077, HEAT_REPEAT, 2 hits
PS50166, IMPORTIN_B_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPO4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEX9
Secondary accession number(s): B2RN95
, Q2NL96, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 20, 2007
Last modified: April 7, 2021
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again