Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Importin-4

Gene

IPO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.By similarity1 Publication

GO - Molecular functioni

  • nuclear localization sequence binding Source: GO_Central
  • Ran GTPase binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-4
Short name:
Imp4
Alternative name(s):
Importin-4b
Short name:
Imp4b
Ran-binding protein 4
Short name:
RanBP4
Gene namesi
Name:IPO4
Synonyms:IMP4B, RANBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000196497.15
HGNCiHGNC:19426 IPO4
neXtProtiNX_Q8TEX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196497
PharmGKBiPA134968932

Polymorphism and mutation databases

BioMutaiIPO4
DMDMi126302558

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207481 – 1081Importin-4Add BLAST1081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TEX9
MaxQBiQ8TEX9
PaxDbiQ8TEX9
PeptideAtlasiQ8TEX9
PRIDEiQ8TEX9
ProteomicsDBi74523
74524 [Q8TEX9-2]

PTM databases

CarbonylDBiQ8TEX9
iPTMnetiQ8TEX9
PhosphoSitePlusiQ8TEX9

Expressioni

Gene expression databases

BgeeiENSG00000196497 Expressed in 91 organ(s), highest expression level in testis
CleanExiHS_IPO4
ExpressionAtlasiQ8TEX9 baseline and differential
GenevisibleiQ8TEX9 HS

Organism-specific databases

HPAiHPA039043
HPA064572

Interactioni

Subunit structurei

Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Binds to human cytomegalovirus UL84. Found in a cytosolic complex with ASF1A, ASF1B, CDAN1 and histones H3.1 and H4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEBPDP497165EBI-395967,EBI-7962058

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122828, 75 interactors
CORUMiQ8TEX9
DIPiDIP-32944N
IntActiQ8TEX9, 36 interactors
MINTiQ8TEX9
STRINGi9606.ENSP00000346453

Structurei

Secondary structure

11081
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TEX9
SMRiQ8TEX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 90Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
Repeati348 – 385HEAT 1Add BLAST38
Repeati390 – 427HEAT 2Add BLAST38
Repeati431 – 471HEAT 3Add BLAST41
Repeati475 – 513HEAT 4Add BLAST39
Repeati895 – 932HEAT 5Add BLAST38
Repeati936 – 974HEAT 6Add BLAST39

Sequence similaritiesi

Belongs to the importin beta family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQKY Eukaryota
ENOG410XP2Z LUCA
GeneTreeiENSGT00550000075074
HOVERGENiHBG049052
InParanoidiQ8TEX9
KOiK20221
OMAiLCKTKQG
OrthoDBiEOG091G012W
PhylomeDBiQ8TEX9
TreeFamiTF323157

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR021133 HEAT_type_2
IPR001494 Importin-beta_N
IPR034085 TOG
PfamiView protein in Pfam
PF02985 HEAT, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SM01349 TOG, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 2 hits
PS50166 IMPORTIN_B_NT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TEX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESAGLEQLL RELLLPDTER IRRATEQLQI VLRAPAALPA LCDLLASAAD
60 70 80 90 100
PQIRQFAAVL TRRRLNTRWR RLAAEQRESL KSLILTALQR ETEHCVSLSL
110 120 130 140 150
AQLSATIFRK EGLEAWPQLL QLLQHSTHSP HSPEREMGLL LLSVVVTSRP
160 170 180 190 200
EAFQPHHREL LRLLNETLGE VGSPGLLFYS LRTLTTMAPY LSTEDVPLAR
210 220 230 240 250
MLVPKLIMAM QTLIPIDEAK ACEALEALDE LLESEVPVIT PYLSEVLTFC
260 270 280 290 300
LEVARNVALG NAIRIRILCC LTFLVKVKSK ALLKNRLLPP LLHTLFPIVA
310 320 330 340 350
AEPPPGQLDP EDQDSEEEEL EIELMGETPK HFAVQVVDML ALHLPPEKLC
360 370 380 390 400
PQLMPMLEEA LRSESPYQRK AGLLVLAVLS DGAGDHIRQR LLPPLLQIVC
410 420 430 440 450
KGLEDPSQVV RNAALFALGQ FSENLQPHIS SYSREVMPLL LAYLKSVPLG
460 470 480 490 500
HTHHLAKACY ALENFVENLG PKVQPYLPEL MECMLQLLRN PSSPRAKELA
510 520 530 540 550
VSALGAIATA AQASLLPYFP AIMEHLREFL LTGREDLQPV QIQSLETLGV
560 570 580 590 600
LARAVGEPMR PLAEECCQLG LGLCDQVDDP DLRRCTYSLF AALSGLMGEG
610 620 630 640 650
LAPHLEQITT LMLLSLRSTE GIVPQYDGSS SFLLFDDESD GEEEEELMDE
660 670 680 690 700
DVEEEDDSEI SGYSVENAFF DEKEDTCAAV GEISVNTSVA FLPYMESVFE
710 720 730 740 750
EVFKLLECPH LNVRKAAHEA LGQFCCALHK ACQSCPSEPN TAALQAALAR
760 770 780 790 800
VVPSYMQAVN RERERQVVMA VLEALTGVLR SCGTLTLKPP GRLAELCGVL
810 820 830 840 850
KAVLQRKTAC QDTDEEEEEE DDDQAEYDAM LLEHAGEAIP ALAAAAGGDS
860 870 880 890 900
FAPFFAGFLP LLVCKTKQGC TVAEKSFAVG TLAETIQGLG AASAQFVSRL
910 920 930 940 950
LPVLLSTAQE ADPEVRSNAI FGMGVLAEHG GHPAQEHFPK LLGLLFPLLA
960 970 980 990 1000
RERHDRVRDN ICGALARLLM ASPTRKPEPQ VLAALLHALP LKEDLEEWVT
1010 1020 1030 1040 1050
IGRLFSFLYQ SSPDQVIDVA PELLRICSLI LADNKIPPDT KAALLLLLTF
1060 1070 1080
LAKQHTDSFQ AALGSLPVDK AQELQAVLGL S
Length:1,081
Mass (Da):118,715
Last modified:February 20, 2007 - v2
Checksum:i36D11AF0D6DA8B1E
GO
Isoform 2 (identifier: Q8TEX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: P → PGE

Note: No experimental confirmation available.
Show »
Length:1,083
Mass (Da):118,901
Checksum:iBBB539F050812D96
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN14H0YN14_HUMAN
Importin-4
IPO4
911Annotation score:
H0YL92H0YL92_HUMAN
Importin-4
IPO4
101Annotation score:
H0YLV0H0YLV0_HUMAN
Importin-4
IPO4
98Annotation score:
H0YN07H0YN07_HUMAN
Importin-4
IPO4
312Annotation score:
H0YMR4H0YMR4_HUMAN
Importin-4
IPO4
547Annotation score:
H0YKG5H0YKG5_HUMAN
Importin-4
IPO4
154Annotation score:
H0YK93H0YK93_HUMAN
Importin-4
IPO4
48Annotation score:

Sequence cautioni

The sequence BAB15616 differs from that shown. Reason: Frameshift at position 234.Curated
The sequence BAB55421 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11174 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD62595 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti865K → R in BAB15616 (PubMed:14702039).Curated1
Sequence conflicti943G → E in BAB55421 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030758513A → V2 PublicationsCorresponds to variant dbSNP:rs7146310Ensembl.1
Natural variantiVAR_030759580P → A2 PublicationsCorresponds to variant dbSNP:rs11550452Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0093391038P → PGE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411122 mRNA Translation: AAL78660.1
BX248267 mRNA Translation: CAD62595.1 Different initiation.
AL136295 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66078.1
BC003690 mRNA Translation: AAH03690.2
BC110804 mRNA Translation: AAI10805.1
BC136759 mRNA Translation: AAI36760.1
AK026991 mRNA Translation: BAB15616.1 Frameshift.
AK027871 mRNA Translation: BAB55421.1 Different initiation.
AK074743 mRNA Translation: BAC11174.1 Different initiation.
CCDSiCCDS9616.1 [Q8TEX9-1]
RefSeqiNP_078934.3, NM_024658.3 [Q8TEX9-1]
UniGeneiHs.411865

Genome annotation databases

EnsembliENST00000354464; ENSP00000346453; ENSG00000196497 [Q8TEX9-1]
ENST00000644546; ENSP00000494795; ENSG00000285248 [Q8TEX9-1]
GeneIDi79711
KEGGihsa:79711
UCSCiuc001wmv.2 human [Q8TEX9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411122 mRNA Translation: AAL78660.1
BX248267 mRNA Translation: CAD62595.1 Different initiation.
AL136295 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66078.1
BC003690 mRNA Translation: AAH03690.2
BC110804 mRNA Translation: AAI10805.1
BC136759 mRNA Translation: AAI36760.1
AK026991 mRNA Translation: BAB15616.1 Frameshift.
AK027871 mRNA Translation: BAB55421.1 Different initiation.
AK074743 mRNA Translation: BAC11174.1 Different initiation.
CCDSiCCDS9616.1 [Q8TEX9-1]
RefSeqiNP_078934.3, NM_024658.3 [Q8TEX9-1]
UniGeneiHs.411865

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XAHX-ray3.00A/B/C/D668-1081[»]
5XBKX-ray3.22A/B/C/D668-1081[»]
ProteinModelPortaliQ8TEX9
SMRiQ8TEX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122828, 75 interactors
CORUMiQ8TEX9
DIPiDIP-32944N
IntActiQ8TEX9, 36 interactors
MINTiQ8TEX9
STRINGi9606.ENSP00000346453

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

CarbonylDBiQ8TEX9
iPTMnetiQ8TEX9
PhosphoSitePlusiQ8TEX9

Polymorphism and mutation databases

BioMutaiIPO4
DMDMi126302558

Proteomic databases

EPDiQ8TEX9
MaxQBiQ8TEX9
PaxDbiQ8TEX9
PeptideAtlasiQ8TEX9
PRIDEiQ8TEX9
ProteomicsDBi74523
74524 [Q8TEX9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354464; ENSP00000346453; ENSG00000196497 [Q8TEX9-1]
ENST00000644546; ENSP00000494795; ENSG00000285248 [Q8TEX9-1]
GeneIDi79711
KEGGihsa:79711
UCSCiuc001wmv.2 human [Q8TEX9-1]

Organism-specific databases

CTDi79711
EuPathDBiHostDB:ENSG00000196497.15
GeneCardsiIPO4
HGNCiHGNC:19426 IPO4
HPAiHPA039043
HPA064572
neXtProtiNX_Q8TEX9
OpenTargetsiENSG00000196497
PharmGKBiPA134968932
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQKY Eukaryota
ENOG410XP2Z LUCA
GeneTreeiENSGT00550000075074
HOVERGENiHBG049052
InParanoidiQ8TEX9
KOiK20221
OMAiLCKTKQG
OrthoDBiEOG091G012W
PhylomeDBiQ8TEX9
TreeFamiTF323157

Miscellaneous databases

ChiTaRSiIPO4 human
GeneWikiiIPO4
GenomeRNAii79711
PROiPR:Q8TEX9

Gene expression databases

BgeeiENSG00000196497 Expressed in 91 organ(s), highest expression level in testis
CleanExiHS_IPO4
ExpressionAtlasiQ8TEX9 baseline and differential
GenevisibleiQ8TEX9 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR021133 HEAT_type_2
IPR001494 Importin-beta_N
IPR034085 TOG
PfamiView protein in Pfam
PF02985 HEAT, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SM01349 TOG, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 2 hits
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPO4_HUMAN
AccessioniPrimary (citable) accession number: Q8TEX9
Secondary accession number(s): B2RN95
, Q2NL96, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again