UniProtKB - Q8TEW6 (DOK4_HUMAN)

BLAST

>sp|Q8TEW6|DOK4_HUMAN Docking protein 4 OS=Homo sapiens OX=9606 GN=DOK4 PE=1 SV=2
MATNFSDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEKYPDEKSVCLRGCPKVT
EISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEEWYKTLSVECLGSRLNDIS
LGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQITHENIYLWDIHNPRVKLVSWP
LCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQIYQRVHSATLAIAEQHKRVLLE
MEKNVRLLNKGTEHYSYPCTPTTMLPRSAYWHHITGSQNIAEASSYAGEGYGAAQASSET
DLLNRFILLKPKPSQGDSSEAKTPSQ

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History
Entry version 124 (12 Sep 2018)
Sequence version 2 (10 May 2005)
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Protein

Docking protein 4

Gene

DOK4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.By similarity

GO - Biological processⁱ

axon guidance Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8853659 RET signaling
SignaLinkⁱ	Q8TEW6
SIGNORⁱ	Q8TEW6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Docking protein 4 Alternative name(s): Downstream of tyrosine kinase 4 Insulin receptor substrate 5 Short name: IRS-5 Short name: IRS5
Gene namesⁱ	Name:DOK4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125170.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19868 DOK4
MIMⁱ	608333 gene
neXtProtⁱ	NX_Q8TEW6

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55715
Open Targets More...OpenTargetsⁱ	ENSG00000125170
PharmGKBⁱ	PA134892921

Polymorphism and mutation databases

BioMutaⁱ	DOK4
DMDMⁱ	84029600

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000187274	1 – 326	Docking protein 4Add BLAST		326

Post-translational modificationⁱ

Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8TEW6
PeptideAtlas More...PeptideAtlasⁱ	Q8TEW6
PRIDEⁱ	Q8TEW6
ProteomicsDBⁱ	74516

PTM databases

iPTMnetⁱ	Q8TEW6
PhosphoSitePlusⁱ	Q8TEW6

Expressionⁱ

Tissue specificityⁱ

Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000125170 Expressed in 208 organ(s), highest expression level in vagina
CleanExⁱ	HS_DOK4
ExpressionAtlasⁱ	Q8TEW6 baseline and differential
Genevisibleⁱ	Q8TEW6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055849

HPAⁱ

HPA055849

Interactionⁱ

Subunit structureⁱ

Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCM2	Q9BSQ5	3	EBI-6918542,EBI-1573056
DOK3	Q7L591-3	3	EBI-6918542,EBI-10694655
ERBB2	P04626	2	EBI-6918542,EBI-641062
OPRM1	P35372	4	EBI-6918542,EBI-2624570

Protein-protein interaction databases

BioGridⁱ	120837, 39 interactors
IntActⁱ	Q8TEW6, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q8TEW6
STRINGⁱ	9606.ENSP00000344277

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TEW6
SMRⁱ	Q8TEW6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	7 – 112	PHAdd BLAST		106
Domainⁱ	132 – 237	IRS-type PTBPROSITE-ProRule annotationAdd BLAST		106

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	265 – 275	DKFBH motifAdd BLAST		11

Domainⁱ

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesⁱ

Belongs to the DOK family. Type B subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG4047 Eukaryota ENOG410XS2S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110348
HOGENOMⁱ	HOG000247025
HOVERGENⁱ	HBG002356
InParanoidⁱ	Q8TEW6
PhylomeDBⁱ	Q8TEW6
TreeFamⁱ	TF324994

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR037816 DOK4/5/6_PH IPR002404 IRS_PTB IPR011993 PH-like_dom_sf IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02174 IRS, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00310 PTBI, 1 hit
PROSITEⁱ	View protein in PROSITE PS51064 IRS_PTB, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show all Align All

Q8TEW6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATNFSDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS 
        60         70         80         90        100
VCLRGCPKVT EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA 
       110        120        130        140        150
EEWYKTLSVE CLGSRLNDIS LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD 
       160        170        180        190        200
VYGECKLQIT HENIYLWDIH NPRVKLVSWP LCSLRRYGRD ATRFTFEAGR 
       210        220        230        240        250
MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE MEKNVRLLNK 
       260        270        280        290        300
GTEHYSYPCT PTTMLPRSAY WHHITGSQNI AEASSYAGEG YGAAQASSET 
       310        320 
DLLNRFILLK PKPSQGDSSE AKTPSQ

Length:326

Mass (Da):37,028

Last modified:May 10, 2005 - v2

Checksum:ⁱ1595B0CEC5584816

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	H3BQ19	H3BQ19_HUMAN	Docking protein 4 Docking protein 4	DOK4	365	Annotation score:
	H3BV67	H3BV67_HUMAN	Docking protein 4 Docking protein 4	DOK4	246	Annotation score:
	H3BS85	H3BS85_HUMAN	Docking protein 4 Docking protein 4	DOK4	122	Annotation score:
	H3BVB4	H3BVB4_HUMAN	Docking protein 4 Docking protein 4	DOK4	116	Annotation score:
	H3BSK0	H3BSK0_HUMAN	Docking protein 4 Docking protein 4	DOK4	100	Annotation score:
	H3BTK2	H3BTK2_HUMAN	Docking protein 4 Docking protein 4	DOK4	103	Annotation score:
	H3BTI7	H3BTI7_HUMAN	Docking protein 4 Docking protein 4	DOK4	113	Annotation score:
	H3BTI4	H3BTI4_HUMAN	Docking protein 4 Docking protein 4	DOK4	77	Annotation score:
	H3BN90	H3BN90_HUMAN	Docking protein 4 Docking protein 4	DOK4	78	Annotation score:
	H3BST9	H3BST9_HUMAN	Docking protein 4 Docking protein 4	DOK4	59	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAC24310 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	64	N → S no nucleotide entry (PubMed:12730241).Curated	1
Sequence conflictⁱ	64	N → S in BAA91642 (PubMed:14702039).Curated	1
Sequence conflictⁱ	75	T → A in AAL74195 (PubMed:12595900).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF466369 mRNA Translation: AAL74195.1 AK001350 mRNA Translation: BAA91642.1 AC004382 Genomic DNA Translation: AAC24310.1 Sequence problems. BC001540 mRNA Translation: AAH01540.1 BC003541 mRNA Translation: AAH03541.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10783.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060580.2, NM_018110.3 XP_005256100.1, XM_005256043.2
UniGeneⁱ	Hs.279832

Genome annotation databases

Ensemblⁱ	ENST00000340099; ENSP00000344277; ENSG00000125170 ENST00000569548; ENSP00000455128; ENSG00000125170
GeneIDⁱ	55715
KEGGⁱ	hsa:55715
UCSC genome browser More...UCSCⁱ	uc002elv.5 human

Protein	Similar proteins		Species	Score	Length	Source
Q8TEW6	Docking protein 4, isoform CRA_a		HUMAN		326	UniRef100_Q8TEW6
DOK4 isoform 12		PANTR		326
Docking protein 4		MACMU		326
Docking protein 4		CALJA		326
Docking protein 4		RHIBE		326
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8TEW6	Docking protein 4		MOUSE		325	UniRef90_Q8TEW6
Docking protein 4, isoform CRA_a		HUMAN		326
DOK4 isoform 12		PANTR		326
Docking protein 4		MACMU		326
Docking protein 4		CALJA		326
+87

Protein	Similar proteins		Species	Score	Length	Source
Q8TEW6	Docking protein 4		MOUSE		325	UniRef50_Q8TEW6
Docking protein 4		PONAB		339
Docking protein 4, isoform CRA_a		HUMAN		326
DOK4 isoform 12		PANTR		326
Docking protein 4		MACMU		326
+324

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF466369 mRNA Translation: AAL74195.1 AK001350 mRNA Translation: BAA91642.1 AC004382 Genomic DNA Translation: AAC24310.1 Sequence problems. BC001540 mRNA Translation: AAH01540.1 BC003541 mRNA Translation: AAH03541.1
CCDSⁱ	CCDS10783.1
RefSeqⁱ	NP_060580.2, NM_018110.3 XP_005256100.1, XM_005256043.2
UniGeneⁱ	Hs.279832

3D structure databases

ProteinModelPortalⁱ	Q8TEW6
SMRⁱ	Q8TEW6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120837, 39 interactors
IntActⁱ	Q8TEW6, 14 interactors
MINTⁱ	Q8TEW6
STRINGⁱ	9606.ENSP00000344277

PTM databases

iPTMnetⁱ	Q8TEW6
PhosphoSitePlusⁱ	Q8TEW6

Polymorphism and mutation databases

BioMutaⁱ	DOK4
DMDMⁱ	84029600

Proteomic databases

PaxDbⁱ	Q8TEW6
PeptideAtlasⁱ	Q8TEW6
PRIDEⁱ	Q8TEW6
ProteomicsDBⁱ	74516

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55715
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340099; ENSP00000344277; ENSG00000125170 ENST00000569548; ENSP00000455128; ENSG00000125170
GeneIDⁱ	55715
KEGGⁱ	hsa:55715
UCSCⁱ	uc002elv.5 human

Organism-specific databases

CTDⁱ	55715
DisGeNETⁱ	55715
EuPathDBⁱ	HostDB:ENSG00000125170.10
GeneCardsⁱ	DOK4
HGNCⁱ	HGNC:19868 DOK4
HPAⁱ	HPA055849
MIMⁱ	608333 gene
neXtProtⁱ	NX_Q8TEW6
OpenTargetsⁱ	ENSG00000125170
PharmGKBⁱ	PA134892921
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4047 Eukaryota ENOG410XS2S LUCA
GeneTreeⁱ	ENSGT00730000110348
HOGENOMⁱ	HOG000247025
HOVERGENⁱ	HBG002356
InParanoidⁱ	Q8TEW6
PhylomeDBⁱ	Q8TEW6
TreeFamⁱ	TF324994

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8853659 RET signaling
SignaLinkⁱ	Q8TEW6
SIGNORⁱ	Q8TEW6

Miscellaneous databases

ChiTaRSⁱ	DOK4 human
GeneWikiⁱ	DOK4
GenomeRNAiⁱ	55715
Protein Ontology More...PROⁱ	PR:Q8TEW6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125170 Expressed in 208 organ(s), highest expression level in vagina
CleanExⁱ	HS_DOK4
ExpressionAtlasⁱ	Q8TEW6 baseline and differential
Genevisibleⁱ	Q8TEW6 HS

Family and domain databases

CDDⁱ	cd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR037816 DOK4/5/6_PH IPR002404 IRS_PTB IPR011993 PH-like_dom_sf IPR001849 PH_domain
Pfamⁱ	View protein in Pfam PF02174 IRS, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00310 PTBI, 1 hit
PROSITEⁱ	View protein in PROSITE PS51064 IRS_PTB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DOK4_HUMAN
Accessionⁱ	Q8TEW6Primary (citable) accession number: Q8TEW6 Secondary accession number(s): O75209, Q9BTP2, Q9NVV3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	September 12, 2018
	This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q8TEW6 (DOK4_HUMAN)

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Docking protein 4

DOK4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ