UniProtKB - Q8TEW6 (DOK4_HUMAN)
Protein
Docking protein 4
Gene
DOK4
Organism
Homo sapiens (Human)
Status
Functioni
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.By similarity
GO - Biological processi
- axon guidance Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q8TEW6 |
Reactomei | R-HSA-8853659, RET signaling |
SignaLinki | Q8TEW6 |
SIGNORi | Q8TEW6 |
Names & Taxonomyi
Protein namesi | Recommended name: Docking protein 4Alternative name(s): Downstream of tyrosine kinase 4 Insulin receptor substrate 5 Short name: IRS-5 Short name: IRS5 |
Gene namesi | Name:DOK4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19868, DOK4 |
MIMi | 608333, gene |
neXtProti | NX_Q8TEW6 |
VEuPathDBi | HostDB:ENSG00000125170.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55715 |
OpenTargetsi | ENSG00000125170 |
PharmGKBi | PA134892921 |
Miscellaneous databases
Pharosi | Q8TEW6, Tbio |
Genetic variation databases
BioMutai | DOK4 |
DMDMi | 84029600 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187274 | 1 – 326 | Docking protein 4Add BLAST | 326 |
Post-translational modificationi
Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q8TEW6 |
PaxDbi | Q8TEW6 |
PeptideAtlasi | Q8TEW6 |
PRIDEi | Q8TEW6 |
ProteomicsDBi | 74516 |
PTM databases
iPTMneti | Q8TEW6 |
PhosphoSitePlusi | Q8TEW6 |
SwissPalmi | Q8TEW6 |
Expressioni
Tissue specificityi
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.2 Publications
Gene expression databases
Bgeei | ENSG00000125170, Expressed in vagina and 221 other tissues |
ExpressionAtlasi | Q8TEW6, baseline and differential |
Genevisiblei | Q8TEW6, HS |
Organism-specific databases
HPAi | ENSG00000125170, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity).
By similarityBinary interactionsi
Hide detailsQ8TEW6
Protein-protein interaction databases
BioGRIDi | 120837, 44 interactors |
IntActi | Q8TEW6, 34 interactors |
MINTi | Q8TEW6 |
STRINGi | 9606.ENSP00000344277 |
Miscellaneous databases
RNActi | Q8TEW6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 112 | PHAdd BLAST | 106 | |
Domaini | 132 – 237 | IRS-type PTBPROSITE-ProRule annotationAdd BLAST | 106 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 265 – 275 | DKFBH motifAdd BLAST | 11 |
Domaini
PTB domain mediates receptor interaction.By similarity
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4047, Eukaryota |
GeneTreei | ENSGT00940000160143 |
HOGENOMi | CLU_057256_1_0_1 |
InParanoidi | Q8TEW6 |
OMAi | AGRMCDS |
PhylomeDBi | Q8TEW6 |
TreeFami | TF324994 |
Family and domain databases
CDDi | cd14678, PH_DOK4_DOK5_DOK6, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR037816, DOK4/5/6_PH IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF02174, IRS, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00310, PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
Q8TEW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATNFSDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS
60 70 80 90 100
VCLRGCPKVT EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA
110 120 130 140 150
EEWYKTLSVE CLGSRLNDIS LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD
160 170 180 190 200
VYGECKLQIT HENIYLWDIH NPRVKLVSWP LCSLRRYGRD ATRFTFEAGR
210 220 230 240 250
MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE MEKNVRLLNK
260 270 280 290 300
GTEHYSYPCT PTTMLPRSAY WHHITGSQNI AEASSYAGEG YGAAQASSET
310 320
DLLNRFILLK PKPSQGDSSE AKTPSQ
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BQ19 | H3BQ19_HUMAN | Docking protein 4 | DOK4 | 365 | Annotation score: | ||
H3BV67 | H3BV67_HUMAN | Docking protein 4 | DOK4 | 246 | Annotation score: | ||
H3BS85 | H3BS85_HUMAN | Docking protein 4 | DOK4 | 122 | Annotation score: | ||
H3BVB4 | H3BVB4_HUMAN | Docking protein 4 | DOK4 | 116 | Annotation score: | ||
H3BTI7 | H3BTI7_HUMAN | Docking protein 4 | DOK4 | 113 | Annotation score: | ||
H3BSK0 | H3BSK0_HUMAN | Docking protein 4 | DOK4 | 100 | Annotation score: | ||
H3BTK2 | H3BTK2_HUMAN | Docking protein 4 | DOK4 | 103 | Annotation score: | ||
H3BPY9 | H3BPY9_HUMAN | Docking protein 4 | DOK4 | 53 | Annotation score: | ||
H3BN90 | H3BN90_HUMAN | Docking protein 4 | DOK4 | 78 | Annotation score: | ||
H3BTI4 | H3BTI4_HUMAN | Docking protein 4 | DOK4 | 77 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence AAC24310 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 64 | N → S no nucleotide entry (PubMed:12730241).Curated | 1 | |
Sequence conflicti | 64 | N → S in BAA91642 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 75 | T → A in AAL74195 (PubMed:12595900).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF466369 mRNA Translation: AAL74195.1 AK001350 mRNA Translation: BAA91642.1 AC004382 Genomic DNA Translation: AAC24310.1 Sequence problems. BC001540 mRNA Translation: AAH01540.1 BC003541 mRNA Translation: AAH03541.1 |
CCDSi | CCDS10783.1 |
RefSeqi | NP_060580.2, NM_018110.3 XP_005256100.1, XM_005256043.2 |
Genome annotation databases
Ensembli | ENST00000340099; ENSP00000344277; ENSG00000125170 ENST00000569548; ENSP00000455128; ENSG00000125170 |
GeneIDi | 55715 |
KEGGi | hsa:55715 |
UCSCi | uc002elv.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF466369 mRNA Translation: AAL74195.1 AK001350 mRNA Translation: BAA91642.1 AC004382 Genomic DNA Translation: AAC24310.1 Sequence problems. BC001540 mRNA Translation: AAH01540.1 BC003541 mRNA Translation: AAH03541.1 |
CCDSi | CCDS10783.1 |
RefSeqi | NP_060580.2, NM_018110.3 XP_005256100.1, XM_005256043.2 |
3D structure databases
SMRi | Q8TEW6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120837, 44 interactors |
IntActi | Q8TEW6, 34 interactors |
MINTi | Q8TEW6 |
STRINGi | 9606.ENSP00000344277 |
PTM databases
iPTMneti | Q8TEW6 |
PhosphoSitePlusi | Q8TEW6 |
SwissPalmi | Q8TEW6 |
Genetic variation databases
BioMutai | DOK4 |
DMDMi | 84029600 |
Proteomic databases
MassIVEi | Q8TEW6 |
PaxDbi | Q8TEW6 |
PeptideAtlasi | Q8TEW6 |
PRIDEi | Q8TEW6 |
ProteomicsDBi | 74516 |
Protocols and materials databases
Antibodypediai | 28881, 238 antibodies |
DNASUi | 55715 |
Genome annotation databases
Ensembli | ENST00000340099; ENSP00000344277; ENSG00000125170 ENST00000569548; ENSP00000455128; ENSG00000125170 |
GeneIDi | 55715 |
KEGGi | hsa:55715 |
UCSCi | uc002elv.5, human |
Organism-specific databases
CTDi | 55715 |
DisGeNETi | 55715 |
GeneCardsi | DOK4 |
HGNCi | HGNC:19868, DOK4 |
HPAi | ENSG00000125170, Low tissue specificity |
MIMi | 608333, gene |
neXtProti | NX_Q8TEW6 |
OpenTargetsi | ENSG00000125170 |
PharmGKBi | PA134892921 |
VEuPathDBi | HostDB:ENSG00000125170.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4047, Eukaryota |
GeneTreei | ENSGT00940000160143 |
HOGENOMi | CLU_057256_1_0_1 |
InParanoidi | Q8TEW6 |
OMAi | AGRMCDS |
PhylomeDBi | Q8TEW6 |
TreeFami | TF324994 |
Enzyme and pathway databases
PathwayCommonsi | Q8TEW6 |
Reactomei | R-HSA-8853659, RET signaling |
SignaLinki | Q8TEW6 |
SIGNORi | Q8TEW6 |
Miscellaneous databases
BioGRID-ORCSi | 55715, 3 hits in 993 CRISPR screens |
ChiTaRSi | DOK4, human |
GeneWikii | DOK4 |
GenomeRNAii | 55715 |
Pharosi | Q8TEW6, Tbio |
PROi | PR:Q8TEW6 |
RNActi | Q8TEW6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125170, Expressed in vagina and 221 other tissues |
ExpressionAtlasi | Q8TEW6, baseline and differential |
Genevisiblei | Q8TEW6, HS |
Family and domain databases
CDDi | cd14678, PH_DOK4_DOK5_DOK6, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR037816, DOK4/5/6_PH IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF02174, IRS, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00310, PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DOK4_HUMAN | |
Accessioni | Q8TEW6Primary (citable) accession number: Q8TEW6 Secondary accession number(s): O75209, Q9BTP2, Q9NVV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families