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Protein

Docking protein 4

Gene

DOK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8853659 RET signaling
SignaLinkiQ8TEW6
SIGNORiQ8TEW6

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 4
Alternative name(s):
Downstream of tyrosine kinase 4
Insulin receptor substrate 5
Short name:
IRS-5
Short name:
IRS5
Gene namesi
Name:DOK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000125170.10
HGNCiHGNC:19868 DOK4
MIMi608333 gene
neXtProtiNX_Q8TEW6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55715
OpenTargetsiENSG00000125170
PharmGKBiPA134892921

Polymorphism and mutation databases

BioMutaiDOK4
DMDMi84029600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872741 – 326Docking protein 4Add BLAST326

Post-translational modificationi

Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TEW6
PeptideAtlasiQ8TEW6
PRIDEiQ8TEW6
ProteomicsDBi74516

PTM databases

iPTMnetiQ8TEW6
PhosphoSitePlusiQ8TEW6

Expressioni

Tissue specificityi

Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.2 Publications

Gene expression databases

BgeeiENSG00000125170 Expressed in 208 organ(s), highest expression level in vagina
CleanExiHS_DOK4
ExpressionAtlasiQ8TEW6 baseline and differential
GenevisibleiQ8TEW6 HS

Organism-specific databases

HPAiHPA055849

Interactioni

Subunit structurei

Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi120837, 39 interactors
IntActiQ8TEW6, 14 interactors
MINTiQ8TEW6
STRINGi9606.ENSP00000344277

Structurei

3D structure databases

ProteinModelPortaliQ8TEW6
SMRiQ8TEW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 112PHAdd BLAST106
Domaini132 – 237IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi265 – 275DKFBH motifAdd BLAST11

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOGENOMiHOG000247025
HOVERGENiHBG002356
InParanoidiQ8TEW6
PhylomeDBiQ8TEW6
TreeFamiTF324994

Family and domain databases

CDDicd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037816 DOK4/5/6_PH
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

Q8TEW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATNFSDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS
60 70 80 90 100
VCLRGCPKVT EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA
110 120 130 140 150
EEWYKTLSVE CLGSRLNDIS LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD
160 170 180 190 200
VYGECKLQIT HENIYLWDIH NPRVKLVSWP LCSLRRYGRD ATRFTFEAGR
210 220 230 240 250
MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE MEKNVRLLNK
260 270 280 290 300
GTEHYSYPCT PTTMLPRSAY WHHITGSQNI AEASSYAGEG YGAAQASSET
310 320
DLLNRFILLK PKPSQGDSSE AKTPSQ
Length:326
Mass (Da):37,028
Last modified:May 10, 2005 - v2
Checksum:i1595B0CEC5584816
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQ19H3BQ19_HUMAN
Docking protein 4
DOK4
365Annotation score:
H3BV67H3BV67_HUMAN
Docking protein 4
DOK4
246Annotation score:
H3BS85H3BS85_HUMAN
Docking protein 4
DOK4
122Annotation score:
H3BVB4H3BVB4_HUMAN
Docking protein 4
DOK4
116Annotation score:
H3BSK0H3BSK0_HUMAN
Docking protein 4
DOK4
100Annotation score:
H3BTK2H3BTK2_HUMAN
Docking protein 4
DOK4
103Annotation score:
H3BTI7H3BTI7_HUMAN
Docking protein 4
DOK4
113Annotation score:
H3BTI4H3BTI4_HUMAN
Docking protein 4
DOK4
77Annotation score:
H3BN90H3BN90_HUMAN
Docking protein 4
DOK4
78Annotation score:
H3BST9H3BST9_HUMAN
Docking protein 4
DOK4
59Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAC24310 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64N → S no nucleotide entry (PubMed:12730241).Curated1
Sequence conflicti64N → S in BAA91642 (PubMed:14702039).Curated1
Sequence conflicti75T → A in AAL74195 (PubMed:12595900).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466369 mRNA Translation: AAL74195.1
AK001350 mRNA Translation: BAA91642.1
AC004382 Genomic DNA Translation: AAC24310.1 Sequence problems.
BC001540 mRNA Translation: AAH01540.1
BC003541 mRNA Translation: AAH03541.1
CCDSiCCDS10783.1
RefSeqiNP_060580.2, NM_018110.3
XP_005256100.1, XM_005256043.2
UniGeneiHs.279832

Genome annotation databases

EnsembliENST00000340099; ENSP00000344277; ENSG00000125170
ENST00000569548; ENSP00000455128; ENSG00000125170
GeneIDi55715
KEGGihsa:55715
UCSCiuc002elv.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466369 mRNA Translation: AAL74195.1
AK001350 mRNA Translation: BAA91642.1
AC004382 Genomic DNA Translation: AAC24310.1 Sequence problems.
BC001540 mRNA Translation: AAH01540.1
BC003541 mRNA Translation: AAH03541.1
CCDSiCCDS10783.1
RefSeqiNP_060580.2, NM_018110.3
XP_005256100.1, XM_005256043.2
UniGeneiHs.279832

3D structure databases

ProteinModelPortaliQ8TEW6
SMRiQ8TEW6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120837, 39 interactors
IntActiQ8TEW6, 14 interactors
MINTiQ8TEW6
STRINGi9606.ENSP00000344277

PTM databases

iPTMnetiQ8TEW6
PhosphoSitePlusiQ8TEW6

Polymorphism and mutation databases

BioMutaiDOK4
DMDMi84029600

Proteomic databases

PaxDbiQ8TEW6
PeptideAtlasiQ8TEW6
PRIDEiQ8TEW6
ProteomicsDBi74516

Protocols and materials databases

DNASUi55715
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340099; ENSP00000344277; ENSG00000125170
ENST00000569548; ENSP00000455128; ENSG00000125170
GeneIDi55715
KEGGihsa:55715
UCSCiuc002elv.5 human

Organism-specific databases

CTDi55715
DisGeNETi55715
EuPathDBiHostDB:ENSG00000125170.10
GeneCardsiDOK4
HGNCiHGNC:19868 DOK4
HPAiHPA055849
MIMi608333 gene
neXtProtiNX_Q8TEW6
OpenTargetsiENSG00000125170
PharmGKBiPA134892921
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOGENOMiHOG000247025
HOVERGENiHBG002356
InParanoidiQ8TEW6
PhylomeDBiQ8TEW6
TreeFamiTF324994

Enzyme and pathway databases

ReactomeiR-HSA-8853659 RET signaling
SignaLinkiQ8TEW6
SIGNORiQ8TEW6

Miscellaneous databases

ChiTaRSiDOK4 human
GeneWikiiDOK4
GenomeRNAii55715
PROiPR:Q8TEW6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125170 Expressed in 208 organ(s), highest expression level in vagina
CleanExiHS_DOK4
ExpressionAtlasiQ8TEW6 baseline and differential
GenevisibleiQ8TEW6 HS

Family and domain databases

CDDicd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037816 DOK4/5/6_PH
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDOK4_HUMAN
AccessioniPrimary (citable) accession number: Q8TEW6
Secondary accession number(s): O75209, Q9BTP2, Q9NVV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 12, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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