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Entry version 189 (22 Apr 2020)
Sequence version 2 (16 May 2003)
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Protein

Partitioning defective 3 homolog

Gene

PARD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688).By similarity4 Publications

Miscellaneous

Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Differentiation
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-420029 Tight junction interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8TEW0

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8TEW0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Partitioning defective 3 homolog
Short name:
PAR-3
Short name:
PARD-3
Alternative name(s):
Atypical PKC isotype-specific-interacting protein
Short name:
ASIP
CTCL tumor antigen se2-5
PAR3-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARD3Imported
Synonyms:PAR3, PAR3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16051 PARD3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606745 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TEW0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neural tube defects (NTD)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionCongenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079846349R → H in NTD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199923448EnsemblClinVar.1
Natural variantiVAR_079847783D → G in NTD; reduces interaction with PRKCA, disrupts tight junction formation in epithelial cells. 1 PublicationCorresponds to variant dbSNP:rs1114167354Ensembl.1
Natural variantiVAR_079848913P → Q in NTD; reduces interaction with PRKCA; increases phosphorylation; disrupts tight junction formation in epithelial cells. 1 PublicationCorresponds to variant dbSNP:rs781461462Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi962S → A: Abolishes phosphorylation by AURKA. 1 Publication1
Mutagenesisi1127Y → F: Delayed epithelial tight junction assembly. 1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
56288

MalaCards human disease database

More...
MalaCardsi
PARD3
MIMi182940 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000148498

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32936

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TEW0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PARD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30913162

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001850691 – 1356Partitioning defective 3 homologAdd BLAST1356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25PhosphoserineCombined sources1
Modified residuei91PhosphothreonineCombined sources1
Modified residuei156PhosphoserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei489PhosphotyrosineCombined sources1
Modified residuei692PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei715PhosphoserineCombined sources1
Modified residuei728PhosphoserineCombined sources1
Modified residuei809PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1
Modified residuei834N6-acetyllysineBy similarity1
Modified residuei837PhosphoserineCombined sources1
Modified residuei851N6-acetyllysineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei885N6-acetyllysineBy similarity1
Modified residuei962Phosphoserine; by AURKACombined sources1 Publication1
Modified residuei971PhosphoserineCombined sources1
Modified residuei973PhosphoserineCombined sources1
Modified residuei1046PhosphoserineCombined sources1
Modified residuei1350N6-acetyllysineBy similarity1
Isoform 5 (identifier: Q8TEW0-5)
Modified residuei792PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination.1 Publication
Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity (PubMed:19812038).By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TEW0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TEW0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8TEW0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TEW0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TEW0

PeptideAtlas

More...
PeptideAtlasi
Q8TEW0

PRoteomics IDEntifications database

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PRIDEi
Q8TEW0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
26974
74506 [Q8TEW0-1]
74507 [Q8TEW0-10]
74508 [Q8TEW0-2]
74509 [Q8TEW0-3]
74510 [Q8TEW0-4]
74511 [Q8TEW0-5]
74512 [Q8TEW0-6]
74513 [Q8TEW0-7]
74514 [Q8TEW0-8]
74515 [Q8TEW0-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8TEW0

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q8TEW0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TEW0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148498 Expressed in cervix squamous epithelium and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TEW0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TEW0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000148498 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ.

Interacts with PRCKI and CDH5.

Interacts (via PDZ 3 domain) with PTEN (via C-terminus) (By similarity).

Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1.

Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3.

Interacts with LIMK2, AURKA and AURKB.

Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Directly interacts with TIAM1 and TIAM2.

Interacts with ECT2, FBF1 and SIRT2.

Interacts (via coiled-coil domain) with FRMD4A (By similarity).

Found in a complex with PARD3, CYTH1 and FRMD4A (By similarity).

Interacts with SAPCD2 (PubMed:26766442).

Interacts with PRKCA (PubMed:27925688).

By similarity13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121134, 76 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8TEW0

Database of interacting proteins

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DIPi
DIP-31315N

Protein interaction database and analysis system

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IntActi
Q8TEW0, 60 interactors

Molecular INTeraction database

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MINTi
Q8TEW0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363921

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TEW0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TEW0

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TEW0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini271 – 359PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini461 – 546PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini590 – 677PDZ 3PROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni712 – 936Interaction with PRKCI and PRKCZBy similarityAdd BLAST225
Regioni935 – 1356Interaction with FRMD4ABy similarityAdd BLAST422

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1049 – 1077Sequence analysisAdd BLAST29
Coiled coili1151 – 1174Sequence analysisAdd BLAST24
Coiled coili1201 – 1224Sequence analysisAdd BLAST24
Coiled coili1280 – 1301Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi984 – 1042Lys-richAdd BLAST59

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization.By similarity
The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAR3 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITAJ Eukaryota
ENOG410ZDVK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_006629_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TEW0

KEGG Orthology (KO)

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KOi
K04237

Identification of Orthologs from Complete Genome Data

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OMAi
CNASSAN

Database of Orthologous Groups

More...
OrthoDBi
908238at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TEW0

TreeFam database of animal gene trees

More...
TreeFami
TF323729

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021922 Par3/HAL_N
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12053 Par3_HAL_N_term, 1 hit
PF00595 PDZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 11 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TEW0-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR
60 70 80 90 100
LEHGDGGILD LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS
110 120 130 140 150
PEIFGSELGT NNVSAFQPYQ ATSEIEVTPS VLRANMPLHV RRSSDPALIG
160 170 180 190 200
LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL KQNTAGSPKT CDRKKDENYR
210 220 230 240 250
SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE DGTEEDNSRV
260 270 280 290 300
EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG
310 320 330 340 350
LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT
360 370 380 390 400
PIIWFHVVPA ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH
410 420 430 440 450
TVQRAPRLNH PPEQIDSHSR LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG
460 470 480 490 500
YNTKKIGKRL NIQLKKGTEG LGFSITSRDV TIGGSAPIYV KNILPRGAAI
510 520 530 540 550
QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV SLLVFRQEDA
560 570 580 590 600
FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG
610 620 630 640 650
LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL
660 670 680 690 700
LGKTNQDAME TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE
710 720 730 740 750
LPIETALDDR ERRISHSLYS GIEGLDESPS RNAALSRIMG ESGKYQLSPT
760 770 780 790 800
VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS SHDDVGFVTA DAGTWAKAAI
810 820 830 840 850
SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS QLDFVKTRKS
860 870 880 890 900
KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV
910 920 930 940 950
TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE
960 970 980 990 1000
DTEESSRSGR ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK
1010 1020 1030 1040 1050
KDRDKEKDKM KAKKGMLKGL GDMFRFGKHR KDDKIEKTGK IKIQESFTSE
1060 1070 1080 1090 1100
EERIRMKQEQ ERIQAKTREF RERQARERDY AEIQDFHRTF GCDDELMYGG
1110 1120 1130 1140 1150
VSSYEGSMAL NARPQSPREG HMMDALYAQV KKPRNSKPSP VDSNRSTPSN
1160 1170 1180 1190 1200
HDRIQRLRQE FQQAKQDEDV EDRRRTYSFE QPWPNARPAT QSGRHSVSVE
1210 1220 1230 1240 1250
VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK NASSVSQDSW EQNYSPGEGF
1260 1270 1280 1290 1300
QSAKENPRYS SYQGSRNGYL GGHGFNARVM LETQELLRQE QRRKEQQMKK
1310 1320 1330 1340 1350
QPPSEGPSNY DSYKKVQDPS YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK

GRPFYS
Length:1,356
Mass (Da):151,423
Last modified:May 16, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4FD3F4F9AD8B92A
GO
Isoform 2 (identifier: Q8TEW0-2) [UniParc]FASTAAdd to basket
Also known as: B, La

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.

Show »
Length:1,353
Mass (Da):151,150
Checksum:iBC531577B9C31AE3
GO
Isoform 3 (identifier: Q8TEW0-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Show »
Length:1,266
Mass (Da):141,072
Checksum:i92DF51B68081A4A2
GO
Isoform 4 (identifier: Q8TEW0-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1061: Missing.

Show »
Length:1,319
Mass (Da):146,877
Checksum:iF5FBF3CE4E67163B
GO
Isoform 5 (identifier: Q8TEW0-5) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     195-238: Missing.
     557-569: Missing.
     740-742: Missing.
     857-857: I → S
     858-872: Missing.
     1025-1061: Missing.

Show »
Length:1,244
Mass (Da):138,332
Checksum:iC3C156C8811D49C2
GO
Isoform 6 (identifier: Q8TEW0-6) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.

Show »
Length:1,310
Mass (Da):146,276
Checksum:i57361092A273AC60
GO
Isoform 7 (identifier: Q8TEW0-7) [UniParc]FASTAAdd to basket
Also known as: Lb

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1061: Missing.

Show »
Length:1,273
Mass (Da):141,730
Checksum:i53C1A94D8CB7341E
GO
Isoform 8 (identifier: Q8TEW0-8) [UniParc]FASTAAdd to basket
Also known as: Sa

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Show »
Length:1,031
Mass (Da):113,419
Checksum:i40DD593636EAE999
GO
Isoform 9 (identifier: Q8TEW0-9) [UniParc]FASTAAdd to basket
Also known as: Sb

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.
     827-856: Missing.
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Show »
Length:988
Mass (Da):108,545
Checksum:i89F2139B096F7F7F
GO
Isoform 10 (identifier: Q8TEW0-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     740-742: Missing.
     827-856: Missing.
     857-858: IA → T
     1025-1034: RFGKHRKDDK → SLAKLKPEKR
     1035-1356: Missing.

Show »
Length:1,000
Mass (Da):109,917
Checksum:i135A54F80C144606
GO
Isoform 11 (identifier: Q8TEW0-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-569: Missing.
     740-742: Missing.

Show »
Length:1,340
Mass (Da):149,695
Checksum:i3DAB16557C6BBA86
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VWV2Q5VWV2_HUMAN
Partitioning defective 3 homolog
PARD3
1,296Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZI3F5GZI3_HUMAN
Partitioning defective 3 homolog
PARD3
747Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VWU8Q5VWU8_HUMAN
Partitioning defective 3 homolog
PARD3
1,001Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AP52B1AP52_HUMAN
Partitioning defective 3 homolog
PARD3
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG33676 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91366 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55330 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti190T → A in BAB55330 (PubMed:14702039).Curated1
Sequence conflicti233L → Q in BAB55330 (PubMed:14702039).Curated1
Sequence conflicti594N → S in BAB55330 (PubMed:14702039).Curated1
Sequence conflicti764D → N in AAH71566 (PubMed:15489334).Curated1
Sequence conflicti996 – 1000GKEKK → VELHE in BAA91366 (PubMed:14702039).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015663107E → D. Corresponds to variant dbSNP:rs1436731Ensembl.1
Natural variantiVAR_079846349R → H in NTD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199923448EnsemblClinVar.1
Natural variantiVAR_050453575D → N. Corresponds to variant dbSNP:rs3758459Ensembl.1
Natural variantiVAR_079847783D → G in NTD; reduces interaction with PRKCA, disrupts tight junction formation in epithelial cells. 1 PublicationCorresponds to variant dbSNP:rs1114167354Ensembl.1
Natural variantiVAR_079848913P → Q in NTD; reduces interaction with PRKCA; increases phosphorylation; disrupts tight junction formation in epithelial cells. 1 PublicationCorresponds to variant dbSNP:rs781461462Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007462195 – 238Missing in isoform 3 and isoform 5. 4 PublicationsAdd BLAST44
Alternative sequenceiVSP_007463557 – 569Missing in isoform 3, isoform 5, isoform 6, isoform 7, isoform 9 and isoform 11. 6 PublicationsAdd BLAST13
Alternative sequenceiVSP_007464740 – 742Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 6 Publications3
Alternative sequenceiVSP_007465827 – 856Missing in isoform 3, isoform 6, isoform 7, isoform 9 and isoform 10. 4 PublicationsAdd BLAST30
Alternative sequenceiVSP_007467857 – 858IA → T in isoform 10. 1 Publication2
Alternative sequenceiVSP_007466857I → S in isoform 5. 2 Publications1
Alternative sequenceiVSP_007468858 – 872Missing in isoform 5. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0074691025 – 1061Missing in isoform 4, isoform 5 and isoform 7. 3 PublicationsAdd BLAST37
Alternative sequenceiVSP_0074701025 – 1034RFGKHRKDDK → SLAKLKPEKR in isoform 8, isoform 9 and isoform 10. 2 Publications10
Alternative sequenceiVSP_0074711035 – 1356Missing in isoform 8, isoform 9 and isoform 10. 2 PublicationsAdd BLAST322

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF252293 mRNA Translation: AAF71530.1
AF196185 mRNA Translation: AAK27891.1
AF196186 mRNA Translation: AAK27892.1
AF332592 mRNA Translation: AAK69192.1
AF332593 mRNA Translation: AAK69193.1
AB073671 mRNA Translation: BAC54037.1
AF467002 mRNA Translation: AAL76042.1
AF467003 mRNA Translation: AAL76043.1
AF467004 mRNA Translation: AAL76044.1
AF467005 mRNA Translation: AAL76045.1
AF467006 mRNA Translation: AAL76046.1
AL138768 Genomic DNA No translation available.
AL160409 Genomic DNA No translation available.
AL360233 Genomic DNA No translation available.
AL390766 Genomic DNA No translation available.
AL392123 Genomic DNA No translation available.
AL450337 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85932.1
CH471072 Genomic DNA Translation: EAW85934.1
BC011711 mRNA Translation: AAH11711.2
BC071566 mRNA Translation: AAH71566.1
AK000761 mRNA Translation: BAA91366.1 Different initiation.
AK027735 mRNA Translation: BAB55330.1 Different initiation.
AF177228 mRNA Translation: AAG33676.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53509.1 [Q8TEW0-5]
CCDS53510.1 [Q8TEW0-3]
CCDS53511.1 [Q8TEW0-11]
CCDS53512.1 [Q8TEW0-6]
CCDS53513.1 [Q8TEW0-9]
CCDS53514.1 [Q8TEW0-4]
CCDS53515.1 [Q8TEW0-2]
CCDS53516.1 [Q8TEW0-8]
CCDS7178.1 [Q8TEW0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001171714.1, NM_001184785.1 [Q8TEW0-2]
NP_001171715.1, NM_001184786.1 [Q8TEW0-11]
NP_001171716.1, NM_001184787.1 [Q8TEW0-4]
NP_001171717.1, NM_001184788.1 [Q8TEW0-6]
NP_001171718.1, NM_001184789.1 [Q8TEW0-7]
NP_001171719.1, NM_001184790.1 [Q8TEW0-3]
NP_001171720.1, NM_001184791.1 [Q8TEW0-5]
NP_001171721.1, NM_001184792.1 [Q8TEW0-8]
NP_001171722.1, NM_001184793.1 [Q8TEW0-10]
NP_001171723.1, NM_001184794.1 [Q8TEW0-9]
NP_062565.2, NM_019619.3 [Q8TEW0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340077; ENSP00000341844; ENSG00000148498 [Q8TEW0-8]
ENST00000346874; ENSP00000340591; ENSG00000148498 [Q8TEW0-4]
ENST00000350537; ENSP00000311986; ENSG00000148498 [Q8TEW0-6]
ENST00000374776; ENSP00000363908; ENSG00000148498 [Q8TEW0-9]
ENST00000374788; ENSP00000363920; ENSG00000148498 [Q8TEW0-2]
ENST00000374789; ENSP00000363921; ENSG00000148498 [Q8TEW0-1]
ENST00000374794; ENSP00000363926; ENSG00000148498 [Q8TEW0-5]
ENST00000545260; ENSP00000440857; ENSG00000148498 [Q8TEW0-3]
ENST00000545693; ENSP00000443147; ENSG00000148498 [Q8TEW0-11]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56288

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56288

UCSC genome browser

More...
UCSCi
uc001ixq.3 human [Q8TEW0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252293 mRNA Translation: AAF71530.1
AF196185 mRNA Translation: AAK27891.1
AF196186 mRNA Translation: AAK27892.1
AF332592 mRNA Translation: AAK69192.1
AF332593 mRNA Translation: AAK69193.1
AB073671 mRNA Translation: BAC54037.1
AF467002 mRNA Translation: AAL76042.1
AF467003 mRNA Translation: AAL76043.1
AF467004 mRNA Translation: AAL76044.1
AF467005 mRNA Translation: AAL76045.1
AF467006 mRNA Translation: AAL76046.1
AL138768 Genomic DNA No translation available.
AL160409 Genomic DNA No translation available.
AL360233 Genomic DNA No translation available.
AL390766 Genomic DNA No translation available.
AL392123 Genomic DNA No translation available.
AL450337 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85932.1
CH471072 Genomic DNA Translation: EAW85934.1
BC011711 mRNA Translation: AAH11711.2
BC071566 mRNA Translation: AAH71566.1
AK000761 mRNA Translation: BAA91366.1 Different initiation.
AK027735 mRNA Translation: BAB55330.1 Different initiation.
AF177228 mRNA Translation: AAG33676.1 Sequence problems.
CCDSiCCDS53509.1 [Q8TEW0-5]
CCDS53510.1 [Q8TEW0-3]
CCDS53511.1 [Q8TEW0-11]
CCDS53512.1 [Q8TEW0-6]
CCDS53513.1 [Q8TEW0-9]
CCDS53514.1 [Q8TEW0-4]
CCDS53515.1 [Q8TEW0-2]
CCDS53516.1 [Q8TEW0-8]
CCDS7178.1 [Q8TEW0-1]
RefSeqiNP_001171714.1, NM_001184785.1 [Q8TEW0-2]
NP_001171715.1, NM_001184786.1 [Q8TEW0-11]
NP_001171716.1, NM_001184787.1 [Q8TEW0-4]
NP_001171717.1, NM_001184788.1 [Q8TEW0-6]
NP_001171718.1, NM_001184789.1 [Q8TEW0-7]
NP_001171719.1, NM_001184790.1 [Q8TEW0-3]
NP_001171720.1, NM_001184791.1 [Q8TEW0-5]
NP_001171721.1, NM_001184792.1 [Q8TEW0-8]
NP_001171722.1, NM_001184793.1 [Q8TEW0-10]
NP_001171723.1, NM_001184794.1 [Q8TEW0-9]
NP_062565.2, NM_019619.3 [Q8TEW0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KOMNMR-A451-549[»]
SMRiQ8TEW0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121134, 76 interactors
CORUMiQ8TEW0
DIPiDIP-31315N
IntActiQ8TEW0, 60 interactors
MINTiQ8TEW0
STRINGi9606.ENSP00000363921

PTM databases

iPTMnetiQ8TEW0
MetOSiteiQ8TEW0
PhosphoSitePlusiQ8TEW0

Polymorphism and mutation databases

BioMutaiPARD3
DMDMi30913162

Proteomic databases

EPDiQ8TEW0
jPOSTiQ8TEW0
MassIVEiQ8TEW0
MaxQBiQ8TEW0
PaxDbiQ8TEW0
PeptideAtlasiQ8TEW0
PRIDEiQ8TEW0
ProteomicsDBi26974
74506 [Q8TEW0-1]
74507 [Q8TEW0-10]
74508 [Q8TEW0-2]
74509 [Q8TEW0-3]
74510 [Q8TEW0-4]
74511 [Q8TEW0-5]
74512 [Q8TEW0-6]
74513 [Q8TEW0-7]
74514 [Q8TEW0-8]
74515 [Q8TEW0-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26597 242 antibodies

Genome annotation databases

EnsembliENST00000340077; ENSP00000341844; ENSG00000148498 [Q8TEW0-8]
ENST00000346874; ENSP00000340591; ENSG00000148498 [Q8TEW0-4]
ENST00000350537; ENSP00000311986; ENSG00000148498 [Q8TEW0-6]
ENST00000374776; ENSP00000363908; ENSG00000148498 [Q8TEW0-9]
ENST00000374788; ENSP00000363920; ENSG00000148498 [Q8TEW0-2]
ENST00000374789; ENSP00000363921; ENSG00000148498 [Q8TEW0-1]
ENST00000374794; ENSP00000363926; ENSG00000148498 [Q8TEW0-5]
ENST00000545260; ENSP00000440857; ENSG00000148498 [Q8TEW0-3]
ENST00000545693; ENSP00000443147; ENSG00000148498 [Q8TEW0-11]
GeneIDi56288
KEGGihsa:56288
UCSCiuc001ixq.3 human [Q8TEW0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56288
DisGeNETi56288

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PARD3
HGNCiHGNC:16051 PARD3
HPAiENSG00000148498 Low tissue specificity
MalaCardsiPARD3
MIMi182940 phenotype
606745 gene
neXtProtiNX_Q8TEW0
OpenTargetsiENSG00000148498
PharmGKBiPA32936

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITAJ Eukaryota
ENOG410ZDVK LUCA
GeneTreeiENSGT00950000183214
HOGENOMiCLU_006629_0_0_1
InParanoidiQ8TEW0
KOiK04237
OMAiCNASSAN
OrthoDBi908238at2759
PhylomeDBiQ8TEW0
TreeFamiTF323729

Enzyme and pathway databases

ReactomeiR-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-420029 Tight junction interactions
SignaLinkiQ8TEW0
SIGNORiQ8TEW0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PARD3 human
EvolutionaryTraceiQ8TEW0

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PARD3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56288
PharosiQ8TEW0 Tbio

Protein Ontology

More...
PROi
PR:Q8TEW0
RNActiQ8TEW0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148498 Expressed in cervix squamous epithelium and 220 other tissues
ExpressionAtlasiQ8TEW0 baseline and differential
GenevisibleiQ8TEW0 HS

Family and domain databases

InterProiView protein in InterPro
IPR021922 Par3/HAL_N
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF12053 Par3_HAL_N_term, 1 hit
PF00595 PDZ, 2 hits
SMARTiView protein in SMART
SM00228 PDZ, 3 hits
SUPFAMiSSF50156 SSF50156, 3 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEW0
Secondary accession number(s): F5H5T0
, Q5T2U1, Q5VUA2, Q5VUA3, Q5VWV0, Q5VWV1, Q5VWV3, Q5VWV4, Q5VWV5, Q6IQ47, Q8TCZ9, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 16, 2003
Last modified: April 22, 2020
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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