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Entry version 145 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

Gene

WFIKKN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity).

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei140 – 141Reactive bondPROSITE-ProRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TEU8

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.954

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Alternative name(s):
Growth and differentiation factor-associated serum protein 1
Short name:
GASP-1
Short name:
hGASP-1
WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein
WFIKKN-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WFIKKN2
Synonyms:GASP1, WFIKKNRP
ORF Names:UNQ9235/PRO31996
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30916, WFIKKN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610895, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TEU8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000173714.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
124857

Open Targets

More...
OpenTargetsi
ENSG00000173714

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134864812

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TEU8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WFIKKN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74716081

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34By similarityAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030782035 – 576WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi46 ↔ 79By similarity
Disulfide bondi62 ↔ 83By similarity
Disulfide bondi66 ↔ 78By similarity
Disulfide bondi72 ↔ 88By similarity
Disulfide bondi134 ↔ 164By similarity
Disulfide bondi138 ↔ 157By similarity
Disulfide bondi146 ↔ 175By similarity
Disulfide bondi231 ↔ 287By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi328 ↔ 378By similarity
Disulfide bondi337 ↔ 361By similarity
Disulfide bondi353 ↔ 374By similarity
Disulfide bondi386 ↔ 436By similarity
Disulfide bondi395 ↔ 419By similarity
Disulfide bondi411 ↔ 432By similarity
Disulfide bondi445 ↔ 515By similarity
Disulfide bondi448 ↔ 517By similarity
Disulfide bondi459 ↔ 566By similarity
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TEU8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TEU8

PeptideAtlas

More...
PeptideAtlasi
Q8TEU8

PRoteomics IDEntifications database

More...
PRIDEi
Q8TEU8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74502

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8TEU8, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TEU8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TEU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173714, Expressed in left ovary and 93 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TEU8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TEU8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000173714, Group enriched (brain, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with both mature and propeptide myostatin/MSTN.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8TEU8, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8TEU8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311184

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TEU8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TEU8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 92WAPPROSITE-ProRule annotationAdd BLAST54
Domaini126 – 177Kazal-likePROSITE-ProRule annotationAdd BLAST52
Domaini210 – 303Ig-like C2-typeAdd BLAST94
Domaini328 – 378BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini386 – 436BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini445 – 566NTRPROSITE-ProRule annotationAdd BLAST122

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WFIKKN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4597, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160624

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TEU8

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCKRECE

Database of Orthologous Groups

More...
OrthoDBi
324177at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TEU8

TreeFam database of animal gene trees

More...
TreeFami
TF315349

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109, KU, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.40.10, 1 hit
4.10.410.10, 2 hits
4.10.75.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036645, Elafin-like_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR020901, Prtase_inh_Kunz-CS
IPR008993, TIMP-like_OB-fold
IPR008197, WAP_dom
IPR033638, WFIKKN1/2

The PANTHER Classification System

More...
PANTHERi
PTHR45938:SF6, PTHR45938:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 1 hit
PF00014, Kunitz_BPTI, 2 hits
PF01759, NTR, 1 hit
PF00095, WAP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759, BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00131, KU, 2 hits
SM00217, WAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895, SSF100895, 1 hit
SSF48726, SSF48726, 1 hit
SSF50242, SSF50242, 1 hit
SSF57256, SSF57256, 1 hit
SSF57362, SSF57362, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 2 hits
PS50835, IG_LIKE, 1 hit
PS51465, KAZAL_2, 1 hit
PS50189, NTR, 1 hit
PS51390, WAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8TEU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWAPRCRRFW SRWEQVAALL LLLLLLGVPP RSLALPPIRY SHAGICPNDM
60 70 80 90 100
NPNLWVDAQS TCRRECETDQ ECETYEKCCP NVCGTKSCVA ARYMDVKGKK
110 120 130 140 150
GPVGMPKEAT CDHFMCLQQG SECDIWDGQP VCKCKDRCEK EPSFTCASDG
160 170 180 190 200
LTYYNRCYMD AEACSKGITL AVVTCRYHFT WPNTSPPPPE TTMHPTTASP
210 220 230 240 250
ETPELDMAAP ALLNNPVHQS VTMGETVSFL CDVVGRPRPE ITWEKQLEDR
260 270 280 290 300
ENVVMRPNHV RGNVVVTNIA QLVIYNAQLQ DAGIYTCTAR NVAGVLRADF
310 320 330 340 350
PLSVVRGHQA AATSESSPNG TAFPAAECLK PPDSEDCGEE QTRWHFDAQA
360 370 380 390 400
NNCLTFTFGH CHRNLNHFET YEACMLACMS GPLAACSLPA LQGPCKAYAP
410 420 430 440 450
RWAYNSQTGQ CQSFVYGGCE GNGNNFESRE ACEESCPFPR GNQRCRACKP
460 470 480 490 500
RQKLVTSFCR SDFVILGRVS ELTEEPDSGR ALVTVDEVLK DEKMGLKFLG
510 520 530 540 550
QEPLEVTLLH VDWACPCPNV TVSEMPLIIM GEVDGGMAML RPDSFVGASS
560 570
ARRVRKLREV MHKKTCDVLK EFLGLH
Length:576
Mass (Da):63,941
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08B4F2EDBE121F81
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6G4C9J6G4_HUMAN
WAP, Kazal, immunoglobulin, Kunitz ...
WFIKKN2
483Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06198431R → Q1 PublicationCorresponds to variant dbSNP:rs55700534EnsemblClinVar.1
Natural variantiVAR_03669296V → M. Corresponds to variant dbSNP:rs35300894Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF468657 mRNA Translation: AAL77058.1
AY358142 mRNA Translation: AAQ88509.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11575.1

NCBI Reference Sequences

More...
RefSeqi
NP_001317270.1, NM_001330341.1
NP_783165.1, NM_175575.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311378; ENSP00000311184; ENSG00000173714

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
124857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:124857

UCSC genome browser

More...
UCSCi
uc002isv.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468657 mRNA Translation: AAL77058.1
AY358142 mRNA Translation: AAQ88509.1
CCDSiCCDS11575.1
RefSeqiNP_001317270.1, NM_001330341.1
NP_783165.1, NM_175575.5

3D structure databases

SMRiQ8TEU8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8TEU8, 8 interactors
MINTiQ8TEU8
STRINGi9606.ENSP00000311184

Protein family/group databases

MEROPSiI02.954

PTM databases

GlyGeniQ8TEU8, 2 sites
iPTMnetiQ8TEU8
PhosphoSitePlusiQ8TEU8

Genetic variation databases

BioMutaiWFIKKN2
DMDMi74716081

Proteomic databases

MassIVEiQ8TEU8
PaxDbiQ8TEU8
PeptideAtlasiQ8TEU8
PRIDEiQ8TEU8
ProteomicsDBi74502

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2618, 123 antibodies

The DNASU plasmid repository

More...
DNASUi
124857

Genome annotation databases

EnsembliENST00000311378; ENSP00000311184; ENSG00000173714
GeneIDi124857
KEGGihsa:124857
UCSCiuc002isv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
124857
DisGeNETi124857

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WFIKKN2
HGNCiHGNC:30916, WFIKKN2
HPAiENSG00000173714, Group enriched (brain, ovary)
MIMi610895, gene
neXtProtiNX_Q8TEU8
OpenTargetsiENSG00000173714
PharmGKBiPA134864812
VEuPathDBiHostDB:ENSG00000173714.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4597, Eukaryota
GeneTreeiENSGT00940000160624
InParanoidiQ8TEU8
OMAiTCKRECE
OrthoDBi324177at2759
PhylomeDBiQ8TEU8
TreeFamiTF315349

Enzyme and pathway databases

PathwayCommonsiQ8TEU8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
124857, 6 hits in 981 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
124857
PharosiQ8TEU8, Tbio

Protein Ontology

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PROi
PR:Q8TEU8
RNActiQ8TEU8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000173714, Expressed in left ovary and 93 other tissues
ExpressionAtlasiQ8TEU8, baseline and differential
GenevisibleiQ8TEU8, HS

Family and domain databases

CDDicd00109, KU, 2 hits
Gene3Di2.40.50.120, 1 hit
2.60.40.10, 1 hit
4.10.410.10, 2 hits
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645, Elafin-like_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR020901, Prtase_inh_Kunz-CS
IPR008993, TIMP-like_OB-fold
IPR008197, WAP_dom
IPR033638, WFIKKN1/2
PANTHERiPTHR45938:SF6, PTHR45938:SF6, 1 hit
PfamiView protein in Pfam
PF07679, I-set, 1 hit
PF00014, Kunitz_BPTI, 2 hits
PF01759, NTR, 1 hit
PF00095, WAP, 1 hit
PRINTSiPR00759, BASICPTASE
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00131, KU, 2 hits
SM00217, WAP, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF48726, SSF48726, 1 hit
SSF50242, SSF50242, 1 hit
SSF57256, SSF57256, 1 hit
SSF57362, SSF57362, 2 hits
PROSITEiView protein in PROSITE
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 2 hits
PS50835, IG_LIKE, 1 hit
PS51465, KAZAL_2, 1 hit
PS50189, NTR, 1 hit
PS51390, WAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWFKN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEU8
Secondary accession number(s): Q6UXZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2002
Last modified: June 2, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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