UniProtKB - Q8TEU7 (RPGF6_HUMAN)
Protein
Rap guanine nucleotide exchange factor 6
Gene
RAPGEF6
Organism
Homo sapiens (Human)
Status
Functioni
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 280 – 399 | cNMPAdd BLAST | 120 |
GO - Molecular functioni
- GTP-dependent protein binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: UniProtKB
- phosphatidic acid binding Source: UniProtKB
- small GTPase binding Source: UniProtKB
GO - Biological processi
- microvillus assembly Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- protein localization to plasma membrane Source: UniProtKB
- Ras protein signal transduction Source: UniProtKB
- regulation of GTPase activity Source: UniProtKB
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
PathwayCommonsi | Q8TEU7 |
SIGNORi | Q8TEU7 |
Names & Taxonomyi
Protein namesi | Recommended name: Rap guanine nucleotide exchange factor 6Alternative name(s): PDZ domain-containing guanine nucleotide exchange factor 2 Short name: PDZ-GEF2 RA-GEF-2 |
Gene namesi | Name:RAPGEF6 Synonyms:PDZGEF2 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20655, RAPGEF6 |
MIMi | 610499, gene |
neXtProti | NX_Q8TEU7 |
VEuPathDBi | HostDB:ENSG00000158987.20 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Upon binding to M-Ras, it translocates to the plasma membrane.
Cytoskeleton
- centrosome Source: HPA
Cytosol
- cytosol Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- endocytic vesicle Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51735 |
OpenTargetsi | ENSG00000158987 |
PharmGKBi | PA134885793 |
Miscellaneous databases
Pharosi | Q8TEU7, Tbio |
Genetic variation databases
BioMutai | RAPGEF6 |
DMDMi | 313104174 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068876 | 1 – 1601 | Rap guanine nucleotide exchange factor 6Add BLAST | 1601 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8TEU7 |
jPOSTi | Q8TEU7 |
MassIVEi | Q8TEU7 |
MaxQBi | Q8TEU7 |
PaxDbi | Q8TEU7 |
PeptideAtlasi | Q8TEU7 |
PRIDEi | Q8TEU7 |
ProteomicsDBi | 19757 74497 [Q8TEU7-1] 74498 [Q8TEU7-2] 74499 [Q8TEU7-3] 74500 [Q8TEU7-4] 74501 [Q8TEU7-5] |
PTM databases
iPTMneti | Q8TEU7 |
PhosphoSitePlusi | Q8TEU7 |
Expressioni
Tissue specificityi
Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000158987, Expressed in corpus callosum and 218 other tissues |
ExpressionAtlasi | Q8TEU7, baseline and differential |
Genevisiblei | Q8TEU7, HS |
Organism-specific databases
HPAi | ENSG00000158987, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the second PDZ domain of human PTP1e.
Curated1 PublicationBinary interactionsi
Q8TEU7
With | #Exp. | IntAct |
---|---|---|
PTPN13 [Q12923] | 4 | EBI-2693017,EBI-355227 |
GO - Molecular functioni
- GTP-dependent protein binding Source: UniProtKB
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119705, 34 interactors |
ELMi | Q8TEU7 |
IntActi | Q8TEU7, 19 interactors |
MINTi | Q8TEU7 |
STRINGi | 9606.ENSP00000296859 |
Miscellaneous databases
RNActi | Q8TEU7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8TEU7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TEU7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 412 – 526 | N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 530 – 615 | PDZPROSITE-ProRule annotationCuratedAdd BLAST | 86 | |
Domaini | 749 – 835 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 860 – 1088 | Ras-GEFPROSITE-ProRule annotationAdd BLAST | 229 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1229 – 1440 | Ser-richAdd BLAST | 212 |
Phylogenomic databases
eggNOGi | KOG3542, Eukaryota |
GeneTreei | ENSGT00940000158124 |
InParanoidi | Q8TEU7 |
OMAi | EVCSEHN |
PhylomeDBi | Q8TEU7 |
TreeFami | TF313184 |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit cd00155, RasGEF, 1 hit cd06224, REM, 1 hit |
Gene3Di | 2.30.42.10, 1 hit 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR014710, RmlC-like_jellyroll |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit |
SUPFAMi | SSF48366, SSF48366, 1 hit SSF50156, SSF50156, 1 hit SSF51206, SSF51206, 2 hits |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TEU7-1) [UniParc]FASTAAdd to basket
Also known as: PDZ-GEF2A1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS
60 70 80 90 100
ARARYERYSG NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG
110 120 130 140 150
GKRGCDCLVL EPSEMIVVEN AKDNEDSILQ REIPARQSRR RFRKINYKGE
160 170 180 190 200
RQTITDDVEV NSYLSLPADL TKMHLTENPH PQVTHVSSSQ SGCSIASDSG
210 220 230 240 250
SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI DRTDPLQGRD
260 270 280 290 300
LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
310 320 330 340 350
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL
360 370 380 390 400
DKQYMHGIVR TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH
410 420 430 440 450
EHRELDRSGT RKGHIVIKAT PERLIMHLIE EHSIVDPTYI EDFLLTYRTF
460 470 480 490 500
LESPLDVGIK LLEWFKIDSL RDKVTRIVLL WVNNHFNDFE GDPAMTRFLE
510 520 530 540 550
EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES PLQFSLNGGS
560 570 580 590 600
EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
610 620 630 640 650
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG
660 670 680 690 700
DIEQTSQEKG SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ
710 720 730 740 750
SQDDSIVGTR HCRHSLAIMP IPGTLSSSSP DLLQPTTSML DFSNPSDIPD
760 770 780 790 800
QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA VHEFGLTGAS DTYSLCEVSV
810 820 830 840 850
TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC SDEDAQELVK
860 870 880 890 900
ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
910 920 930 940 950
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM
960 970 980 990 1000
FAIISGLNLA SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL
1010 1020 1030 1040 1050
SSQSMQPPII PLFPVVKKDM TFLHEGNDSK VDGLVNFEKL RMISKEIRQV
1060 1070 1080 1090 1100
VRMTSANMDP AMMFRQRSLS QGSTNSNMLD VQGGAHKKRA RRSSLLNAKK
1110 1120 1130 1140 1150
LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT LTKNLSEKRS
1160 1170 1180 1190 1200
AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
1210 1220 1230 1240 1250
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY
1260 1270 1280 1290 1300
TLIPSAKSDN LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV
1310 1320 1330 1340 1350
PESTGALEKT EHASGIGDHS QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ
1360 1370 1380 1390 1400
EHIIIEAADS GRGSWTSCSS SSHDNFQSLP NPKSWDFLNS YRHTHLDDPI
1410 1420 1430 1440 1450
AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS DTYEPNYGTV
1460 1470 1480 1490 1500
KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
1510 1520 1530 1540 1550
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP
1560 1570 1580 1590 1600
PASLSSNLVA CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA
V
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RE77 | D6RE77_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEF6 | 1,114 | Annotation score: | ||
B7Z7Y1 | B7Z7Y1_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEF6 | 1,204 | Annotation score: | ||
D6RB02 | D6RB02_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEF6 | 155 | Annotation score: | ||
D6RD23 | D6RD23_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEF6 | 149 | Annotation score: | ||
D6RIH0 | D6RIH0_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEF6 | 155 | Annotation score: | ||
A0A5F9ZHG7 | A0A5F9ZHG7_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEF6 | 1,267 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 566 | K → E in AAL79915 (PubMed:12581858).Curated | 1 | |
Sequence conflicti | 566 | K → E in AAL79916 (PubMed:12581858).Curated | 1 | |
Sequence conflicti | 619 | L → P in AAL79915 (PubMed:12581858).Curated | 1 | |
Sequence conflicti | 619 | L → P in AAL79916 (PubMed:12581858).Curated | 1 | |
Sequence conflicti | 637 | E → K in AAL79915 (PubMed:12581858).Curated | 1 | |
Sequence conflicti | 637 | E → K in AAL79916 (PubMed:12581858).Curated | 1 | |
Sequence conflicti | 669 | V → A in AAL79915 (PubMed:12581858).Curated | 1 | |
Sequence conflicti | 669 | V → A in AAL79916 (PubMed:12581858).Curated | 1 | |
Sequence conflicti | 749 | P → A in AAI42965 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057168 | 570 | S → A. Corresponds to variant dbSNP:rs3756293Ensembl. | 1 | |
Natural variantiVAR_057169 | 594 | A → P. Corresponds to variant dbSNP:rs34112735Ensembl. | 1 | |
Natural variantiVAR_057170 | 1353 | I → V. Corresponds to variant dbSNP:rs7717835Ensembl. | 1 | |
Natural variantiVAR_059793 | 1452 | Q → R3 PublicationsCorresponds to variant dbSNP:rs1291602Ensembl. | 1 | |
Natural variantiVAR_057171 | 1559 | V → E. Corresponds to variant dbSNP:rs1064539EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050607 | 747 | D → AVGFYY in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_045027 | 828 – 1601 | Missing in isoform 6. 1 PublicationAdd BLAST | 774 | |
Alternative sequenceiVSP_050608 | 1067 | R → RKKRWRSLG in isoform 3, isoform 4 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_050610 | 1249 – 1391 | GYTLI…FLNSY → VGSIISDHSSKISGQSCPGI GGAYLQKKILQITRSTAKRT DSTEKATEENRDRTSCENTT RKRMTSPFRRLRERMLSRER LVNSQKEDTDHNQATESCEK VKDVGSNIKDEKGSAIFNSN SQGNSNTLNCFYTRFKSKRR KTL in isoform 2. 1 PublicationAdd BLAST | 143 | |
Alternative sequenceiVSP_050611 | 1392 – 1601 | Missing in isoform 2. 1 PublicationAdd BLAST | 210 | |
Alternative sequenceiVSP_050609 | 1489 – 1593 | Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 105 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF478468 mRNA Translation: AAL79915.1 AF478469 mRNA Translation: AAL79916.1 AF478567 mRNA Translation: AAM21637.1 AF394782 mRNA Translation: AAK83368.1 AC004227 Genomic DNA No translation available. AC004622 Genomic DNA No translation available. AC008497 Genomic DNA No translation available. AC008695 Genomic DNA No translation available. AC026754 Genomic DNA No translation available. BC133703 mRNA Translation: AAI33704.1 BC142964 mRNA Translation: AAI42965.1 BC144627 mRNA Translation: AAI44628.1 |
CCDSi | CCDS34225.1 [Q8TEU7-1] CCDS54897.1 [Q8TEU7-6] CCDS54898.1 [Q8TEU7-2] CCDS54899.1 [Q8TEU7-5] CCDS54900.1 [Q8TEU7-4] CCDS54901.1 [Q8TEU7-3] |
RefSeqi | NP_001157858.1, NM_001164386.1 [Q8TEU7-4] NP_001157859.1, NM_001164387.1 [Q8TEU7-3] NP_001157860.1, NM_001164388.1 [Q8TEU7-5] NP_001157861.1, NM_001164389.1 [Q8TEU7-2] NP_001157862.1, NM_001164390.1 [Q8TEU7-6] NP_057424.3, NM_016340.5 [Q8TEU7-1] |
Genome annotation databases
Ensembli | ENST00000296859; ENSP00000296859; ENSG00000158987 [Q8TEU7-4] ENST00000308008; ENSP00000311419; ENSG00000158987 [Q8TEU7-2] ENST00000507093; ENSP00000426081; ENSG00000158987 [Q8TEU7-3] ENST00000509018; ENSP00000421684; ENSG00000158987 [Q8TEU7-1] ENST00000510071; ENSP00000425389; ENSG00000158987 [Q8TEU7-6] ENST00000627212; ENSP00000487439; ENSG00000158987 [Q8TEU7-5] |
GeneIDi | 51735 |
KEGGi | hsa:51735 |
UCSCi | uc003kvn.2, human [Q8TEU7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF478468 mRNA Translation: AAL79915.1 AF478469 mRNA Translation: AAL79916.1 AF478567 mRNA Translation: AAM21637.1 AF394782 mRNA Translation: AAK83368.1 AC004227 Genomic DNA No translation available. AC004622 Genomic DNA No translation available. AC008497 Genomic DNA No translation available. AC008695 Genomic DNA No translation available. AC026754 Genomic DNA No translation available. BC133703 mRNA Translation: AAI33704.1 BC142964 mRNA Translation: AAI42965.1 BC144627 mRNA Translation: AAI44628.1 |
CCDSi | CCDS34225.1 [Q8TEU7-1] CCDS54897.1 [Q8TEU7-6] CCDS54898.1 [Q8TEU7-2] CCDS54899.1 [Q8TEU7-5] CCDS54900.1 [Q8TEU7-4] CCDS54901.1 [Q8TEU7-3] |
RefSeqi | NP_001157858.1, NM_001164386.1 [Q8TEU7-4] NP_001157859.1, NM_001164387.1 [Q8TEU7-3] NP_001157860.1, NM_001164388.1 [Q8TEU7-5] NP_001157861.1, NM_001164389.1 [Q8TEU7-2] NP_001157862.1, NM_001164390.1 [Q8TEU7-6] NP_057424.3, NM_016340.5 [Q8TEU7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2D93 | NMR | - | A | 265-385 | [»] | |
3LNY | X-ray | 1.30 | B | 1596-1601 | [»] | |
SMRi | Q8TEU7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119705, 34 interactors |
ELMi | Q8TEU7 |
IntActi | Q8TEU7, 19 interactors |
MINTi | Q8TEU7 |
STRINGi | 9606.ENSP00000296859 |
PTM databases
iPTMneti | Q8TEU7 |
PhosphoSitePlusi | Q8TEU7 |
Genetic variation databases
BioMutai | RAPGEF6 |
DMDMi | 313104174 |
Proteomic databases
EPDi | Q8TEU7 |
jPOSTi | Q8TEU7 |
MassIVEi | Q8TEU7 |
MaxQBi | Q8TEU7 |
PaxDbi | Q8TEU7 |
PeptideAtlasi | Q8TEU7 |
PRIDEi | Q8TEU7 |
ProteomicsDBi | 19757 74497 [Q8TEU7-1] 74498 [Q8TEU7-2] 74499 [Q8TEU7-3] 74500 [Q8TEU7-4] 74501 [Q8TEU7-5] |
Protocols and materials databases
Antibodypediai | 25867, 121 antibodies |
Genome annotation databases
Ensembli | ENST00000296859; ENSP00000296859; ENSG00000158987 [Q8TEU7-4] ENST00000308008; ENSP00000311419; ENSG00000158987 [Q8TEU7-2] ENST00000507093; ENSP00000426081; ENSG00000158987 [Q8TEU7-3] ENST00000509018; ENSP00000421684; ENSG00000158987 [Q8TEU7-1] ENST00000510071; ENSP00000425389; ENSG00000158987 [Q8TEU7-6] ENST00000627212; ENSP00000487439; ENSG00000158987 [Q8TEU7-5] |
GeneIDi | 51735 |
KEGGi | hsa:51735 |
UCSCi | uc003kvn.2, human [Q8TEU7-1] |
Organism-specific databases
CTDi | 51735 |
DisGeNETi | 51735 |
GeneCardsi | RAPGEF6 |
HGNCi | HGNC:20655, RAPGEF6 |
HPAi | ENSG00000158987, Low tissue specificity |
MIMi | 610499, gene |
neXtProti | NX_Q8TEU7 |
OpenTargetsi | ENSG00000158987 |
PharmGKBi | PA134885793 |
VEuPathDBi | HostDB:ENSG00000158987.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3542, Eukaryota |
GeneTreei | ENSGT00940000158124 |
InParanoidi | Q8TEU7 |
OMAi | EVCSEHN |
PhylomeDBi | Q8TEU7 |
TreeFami | TF313184 |
Enzyme and pathway databases
PathwayCommonsi | Q8TEU7 |
SIGNORi | Q8TEU7 |
Miscellaneous databases
BioGRID-ORCSi | 51735, 13 hits in 996 CRISPR screens |
ChiTaRSi | RAPGEF6, human |
EvolutionaryTracei | Q8TEU7 |
GeneWikii | RAPGEF6 |
GenomeRNAii | 51735 |
Pharosi | Q8TEU7, Tbio |
PROi | PR:Q8TEU7 |
RNActi | Q8TEU7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158987, Expressed in corpus callosum and 218 other tissues |
ExpressionAtlasi | Q8TEU7, baseline and differential |
Genevisiblei | Q8TEU7, HS |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit cd00155, RasGEF, 1 hit cd06224, REM, 1 hit |
Gene3Di | 2.30.42.10, 1 hit 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR014710, RmlC-like_jellyroll |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit |
SUPFAMi | SSF48366, SSF48366, 1 hit SSF50156, SSF50156, 1 hit SSF51206, SSF51206, 2 hits |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPGF6_HUMAN | |
Accessioni | Q8TEU7Primary (citable) accession number: Q8TEU7 Secondary accession number(s): A3KN82 Q96PC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2003 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references