Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 171 (26 Feb 2020)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Rap guanine nucleotide exchange factor 6

Gene

RAPGEF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi280 – 399cNMPAdd BLAST120

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8TEU7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 6
Alternative name(s):
PDZ domain-containing guanine nucleotide exchange factor 2
Short name:
PDZ-GEF2
RA-GEF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAPGEF6
Synonyms:PDZGEF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20655 RAPGEF6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610499 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TEU7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51735

Open Targets

More...
OpenTargetsi
ENSG00000158987

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134885793

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TEU7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAPGEF6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104174

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688761 – 1601Rap guanine nucleotide exchange factor 6Add BLAST1601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TEU7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TEU7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TEU7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TEU7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TEU7

PeptideAtlas

More...
PeptideAtlasi
Q8TEU7

PRoteomics IDEntifications database

More...
PRIDEi
Q8TEU7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19757
74497 [Q8TEU7-1]
74498 [Q8TEU7-2]
74499 [Q8TEU7-3]
74500 [Q8TEU7-4]
74501 [Q8TEU7-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TEU7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TEU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158987 Expressed in corpus callosum and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TEU7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TEU7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037982
HPA037983

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the second PDZ domain of human PTP1e.

Curated1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q129234EBI-2693017,EBI-355227

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119705, 28 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8TEU7

Protein interaction database and analysis system

More...
IntActi
Q8TEU7, 19 interactors

Molecular INTeraction database

More...
MINTi
Q8TEU7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296859

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TEU7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11601
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TEU7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TEU7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini412 – 526N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST115
Domaini530 – 615PDZPROSITE-ProRule annotationCuratedAdd BLAST86
Domaini749 – 835Ras-associatingPROSITE-ProRule annotationAdd BLAST87
Domaini860 – 1088Ras-GEFPROSITE-ProRule annotationAdd BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1229 – 1440Ser-richAdd BLAST212

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3542 Eukaryota
ENOG410XS6B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158124

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TEU7

KEGG Orthology (KO)

More...
KOi
K08020

Identification of Orthologs from Complete Genome Data

More...
OMAi
PAYGTCE

Database of Orthologous Groups

More...
OrthoDBi
31139at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TEU7

TreeFam database of animal gene trees

More...
TreeFami
TF313184

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll

The PANTHER Classification System

More...
PANTHERi
PTHR23113 PTHR23113, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48366 SSF48366, 1 hit
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TEU7-1) [UniParc]FASTAAdd to basket
Also known as: PDZ-GEF2A1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS
60 70 80 90 100
ARARYERYSG NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG
110 120 130 140 150
GKRGCDCLVL EPSEMIVVEN AKDNEDSILQ REIPARQSRR RFRKINYKGE
160 170 180 190 200
RQTITDDVEV NSYLSLPADL TKMHLTENPH PQVTHVSSSQ SGCSIASDSG
210 220 230 240 250
SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI DRTDPLQGRD
260 270 280 290 300
LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
310 320 330 340 350
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL
360 370 380 390 400
DKQYMHGIVR TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH
410 420 430 440 450
EHRELDRSGT RKGHIVIKAT PERLIMHLIE EHSIVDPTYI EDFLLTYRTF
460 470 480 490 500
LESPLDVGIK LLEWFKIDSL RDKVTRIVLL WVNNHFNDFE GDPAMTRFLE
510 520 530 540 550
EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES PLQFSLNGGS
560 570 580 590 600
EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
610 620 630 640 650
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG
660 670 680 690 700
DIEQTSQEKG SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ
710 720 730 740 750
SQDDSIVGTR HCRHSLAIMP IPGTLSSSSP DLLQPTTSML DFSNPSDIPD
760 770 780 790 800
QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA VHEFGLTGAS DTYSLCEVSV
810 820 830 840 850
TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC SDEDAQELVK
860 870 880 890 900
ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
910 920 930 940 950
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM
960 970 980 990 1000
FAIISGLNLA SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL
1010 1020 1030 1040 1050
SSQSMQPPII PLFPVVKKDM TFLHEGNDSK VDGLVNFEKL RMISKEIRQV
1060 1070 1080 1090 1100
VRMTSANMDP AMMFRQRSLS QGSTNSNMLD VQGGAHKKRA RRSSLLNAKK
1110 1120 1130 1140 1150
LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT LTKNLSEKRS
1160 1170 1180 1190 1200
AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
1210 1220 1230 1240 1250
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY
1260 1270 1280 1290 1300
TLIPSAKSDN LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV
1310 1320 1330 1340 1350
PESTGALEKT EHASGIGDHS QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ
1360 1370 1380 1390 1400
EHIIIEAADS GRGSWTSCSS SSHDNFQSLP NPKSWDFLNS YRHTHLDDPI
1410 1420 1430 1440 1450
AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS DTYEPNYGTV
1460 1470 1480 1490 1500
KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
1510 1520 1530 1540 1550
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP
1560 1570 1580 1590 1600
PASLSSNLVA CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA

V
Length:1,601
Mass (Da):179,423
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF4C5407EB61EEE2
GO
Isoform 2 (identifier: Q8TEU7-2) [UniParc]FASTAAdd to basket
Also known as: PDZ-GEF2B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1391: GYTLIPSAKS...PKSWDFLNSY → VGSIISDHSS...RFKSKRRKTL
     1392-1601: Missing.

Show »
Length:1,391
Mass (Da):157,540
Checksum:i479E95ACE48D3938
GO
Isoform 3 (identifier: Q8TEU7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     747-747: D → AVGFYY
     1067-1067: R → RKKRWRSLG
     1489-1593: Missing.

Show »
Length:1,509
Mass (Da):169,500
Checksum:i726CDBA718C65649
GO
Isoform 4 (identifier: Q8TEU7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1067: R → RKKRWRSLG

Show »
Length:1,609
Mass (Da):180,435
Checksum:i2674B9180DEB7FCC
GO
Isoform 5 (identifier: Q8TEU7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1067: R → RKKRWRSLG
     1489-1593: Missing.

Show »
Length:1,504
Mass (Da):168,914
Checksum:i52E76A090032E29F
GO
Isoform 6 (identifier: Q8TEU7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     828-1601: Missing.

Show »
Length:827
Mass (Da):93,442
Checksum:i2EF5931EDE350449
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RE77D6RE77_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
1,114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z7Y1B7Z7Y1_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
1,204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB02D6RB02_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD23D6RD23_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIH0D6RIH0_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHG7A0A5F9ZHG7_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
1,267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti566K → E in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti566K → E in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti619L → P in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti619L → P in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti637E → K in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti637E → K in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti669V → A in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti669V → A in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti749P → A in AAI42965 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057168570S → A. Corresponds to variant dbSNP:rs3756293Ensembl.1
Natural variantiVAR_057169594A → P. Corresponds to variant dbSNP:rs34112735Ensembl.1
Natural variantiVAR_0571701353I → V. Corresponds to variant dbSNP:rs7717835Ensembl.1
Natural variantiVAR_0597931452Q → R3 PublicationsCorresponds to variant dbSNP:rs1291602Ensembl.1
Natural variantiVAR_0571711559V → E. Corresponds to variant dbSNP:rs1064539Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050607747D → AVGFYY in isoform 3. 1 Publication1
Alternative sequenceiVSP_045027828 – 1601Missing in isoform 6. 1 PublicationAdd BLAST774
Alternative sequenceiVSP_0506081067R → RKKRWRSLG in isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_0506101249 – 1391GYTLI…FLNSY → VGSIISDHSSKISGQSCPGI GGAYLQKKILQITRSTAKRT DSTEKATEENRDRTSCENTT RKRMTSPFRRLRERMLSRER LVNSQKEDTDHNQATESCEK VKDVGSNIKDEKGSAIFNSN SQGNSNTLNCFYTRFKSKRR KTL in isoform 2. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_0506111392 – 1601Missing in isoform 2. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_0506091489 – 1593Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF478468 mRNA Translation: AAL79915.1
AF478469 mRNA Translation: AAL79916.1
AF478567 mRNA Translation: AAM21637.1
AF394782 mRNA Translation: AAK83368.1
AC004227 Genomic DNA No translation available.
AC004622 Genomic DNA No translation available.
AC008497 Genomic DNA No translation available.
AC008695 Genomic DNA No translation available.
AC026754 Genomic DNA No translation available.
BC133703 mRNA Translation: AAI33704.1
BC142964 mRNA Translation: AAI42965.1
BC144627 mRNA Translation: AAI44628.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34225.1 [Q8TEU7-1]
CCDS54897.1 [Q8TEU7-6]
CCDS54898.1 [Q8TEU7-2]
CCDS54899.1 [Q8TEU7-5]
CCDS54900.1 [Q8TEU7-4]
CCDS54901.1 [Q8TEU7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001157858.1, NM_001164386.1 [Q8TEU7-4]
NP_001157859.1, NM_001164387.1 [Q8TEU7-3]
NP_001157860.1, NM_001164388.1 [Q8TEU7-5]
NP_001157861.1, NM_001164389.1 [Q8TEU7-2]
NP_001157862.1, NM_001164390.1 [Q8TEU7-6]
NP_057424.3, NM_016340.5 [Q8TEU7-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51735

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51735

UCSC genome browser

More...
UCSCi
uc003kvn.2 human [Q8TEU7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478468 mRNA Translation: AAL79915.1
AF478469 mRNA Translation: AAL79916.1
AF478567 mRNA Translation: AAM21637.1
AF394782 mRNA Translation: AAK83368.1
AC004227 Genomic DNA No translation available.
AC004622 Genomic DNA No translation available.
AC008497 Genomic DNA No translation available.
AC008695 Genomic DNA No translation available.
AC026754 Genomic DNA No translation available.
BC133703 mRNA Translation: AAI33704.1
BC142964 mRNA Translation: AAI42965.1
BC144627 mRNA Translation: AAI44628.1
CCDSiCCDS34225.1 [Q8TEU7-1]
CCDS54897.1 [Q8TEU7-6]
CCDS54898.1 [Q8TEU7-2]
CCDS54899.1 [Q8TEU7-5]
CCDS54900.1 [Q8TEU7-4]
CCDS54901.1 [Q8TEU7-3]
RefSeqiNP_001157858.1, NM_001164386.1 [Q8TEU7-4]
NP_001157859.1, NM_001164387.1 [Q8TEU7-3]
NP_001157860.1, NM_001164388.1 [Q8TEU7-5]
NP_001157861.1, NM_001164389.1 [Q8TEU7-2]
NP_001157862.1, NM_001164390.1 [Q8TEU7-6]
NP_057424.3, NM_016340.5 [Q8TEU7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D93NMR-A265-385[»]
3LNYX-ray1.30B1596-1601[»]
SMRiQ8TEU7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119705, 28 interactors
ELMiQ8TEU7
IntActiQ8TEU7, 19 interactors
MINTiQ8TEU7
STRINGi9606.ENSP00000296859

PTM databases

iPTMnetiQ8TEU7
PhosphoSitePlusiQ8TEU7

Polymorphism and mutation databases

BioMutaiRAPGEF6
DMDMi313104174

Proteomic databases

EPDiQ8TEU7
jPOSTiQ8TEU7
MassIVEiQ8TEU7
MaxQBiQ8TEU7
PaxDbiQ8TEU7
PeptideAtlasiQ8TEU7
PRIDEiQ8TEU7
ProteomicsDBi19757
74497 [Q8TEU7-1]
74498 [Q8TEU7-2]
74499 [Q8TEU7-3]
74500 [Q8TEU7-4]
74501 [Q8TEU7-5]

Genome annotation databases

GeneIDi51735
KEGGihsa:51735
UCSCiuc003kvn.2 human [Q8TEU7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51735
DisGeNETi51735

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RAPGEF6
HGNCiHGNC:20655 RAPGEF6
HPAiHPA037982
HPA037983
MIMi610499 gene
neXtProtiNX_Q8TEU7
OpenTargetsiENSG00000158987
PharmGKBiPA134885793

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
GeneTreeiENSGT00940000158124
InParanoidiQ8TEU7
KOiK08020
OMAiPAYGTCE
OrthoDBi31139at2759
PhylomeDBiQ8TEU7
TreeFamiTF313184

Enzyme and pathway databases

SIGNORiQ8TEU7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAPGEF6 human
EvolutionaryTraceiQ8TEU7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAPGEF6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51735
PharosiQ8TEU7 Tbio

Protein Ontology

More...
PROi
PR:Q8TEU7
RNActiQ8TEU7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158987 Expressed in corpus callosum and 204 other tissues
ExpressionAtlasiQ8TEU7 baseline and differential
GenevisibleiQ8TEU7 HS

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPGF6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEU7
Secondary accession number(s): A3KN82
, A5PLL6, B7ZML2, E9PDV7, Q8NI21, Q8TEU6, Q96PC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 30, 2010
Last modified: February 26, 2020
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again