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Protein

Rap guanine nucleotide exchange factor 6

Gene

RAPGEF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi280 – 399cNMPAdd BLAST120

GO - Molecular functioni

GO - Biological processi

  • microvillus assembly Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • Ras protein signal transduction Source: UniProtKB
  • regulation of GTPase activity Source: UniProtKB

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

SIGNORiQ8TEU7

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 6
Alternative name(s):
PDZ domain-containing guanine nucleotide exchange factor 2
Short name:
PDZ-GEF2
RA-GEF-2
Gene namesi
Name:RAPGEF6
Synonyms:PDZGEF2
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000158987.20
HGNCiHGNC:20655 RAPGEF6
MIMi610499 gene
neXtProtiNX_Q8TEU7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51735
OpenTargetsiENSG00000158987
PharmGKBiPA134885793

Polymorphism and mutation databases

BioMutaiRAPGEF6
DMDMi313104174

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688761 – 1601Rap guanine nucleotide exchange factor 6Add BLAST1601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TEU7
MaxQBiQ8TEU7
PaxDbiQ8TEU7
PeptideAtlasiQ8TEU7
PRIDEiQ8TEU7
ProteomicsDBi74497
74498 [Q8TEU7-2]
74499 [Q8TEU7-3]
74500 [Q8TEU7-4]
74501 [Q8TEU7-5]

PTM databases

iPTMnetiQ8TEU7
PhosphoSitePlusiQ8TEU7

Expressioni

Tissue specificityi

Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000158987 Expressed in 205 organ(s), highest expression level in corpus callosum
CleanExiHS_RAPGEF6
ExpressionAtlasiQ8TEU7 baseline and differential
GenevisibleiQ8TEU7 HS

Organism-specific databases

HPAiHPA037982
HPA037983

Interactioni

Subunit structurei

Interacts with the second PDZ domain of human PTP1e.Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN13Q129234EBI-2693017,EBI-355227

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119705, 22 interactors
ELMiQ8TEU7
IntActiQ8TEU7, 13 interactors
MINTiQ8TEU7
STRINGi9606.ENSP00000296859

Structurei

Secondary structure

11601
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TEU7
SMRiQ8TEU7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TEU7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini412 – 526N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST115
Domaini530 – 615PDZPROSITE-ProRule annotationCuratedAdd BLAST86
Domaini749 – 835Ras-associatingPROSITE-ProRule annotationAdd BLAST87
Domaini860 – 1088Ras-GEFPROSITE-ProRule annotationAdd BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1229 – 1440Ser-richAdd BLAST212

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000247009
HOVERGENiHBG056658
InParanoidiQ8TEU7
KOiK08020
OMAiQPSHPKL
OrthoDBiEOG091G00NU
PhylomeDBiQ8TEU7
TreeFamiTF313184

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TEU7-1) [UniParc]FASTAAdd to basket
Also known as: PDZ-GEF2A1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS
60 70 80 90 100
ARARYERYSG NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG
110 120 130 140 150
GKRGCDCLVL EPSEMIVVEN AKDNEDSILQ REIPARQSRR RFRKINYKGE
160 170 180 190 200
RQTITDDVEV NSYLSLPADL TKMHLTENPH PQVTHVSSSQ SGCSIASDSG
210 220 230 240 250
SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI DRTDPLQGRD
260 270 280 290 300
LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
310 320 330 340 350
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL
360 370 380 390 400
DKQYMHGIVR TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH
410 420 430 440 450
EHRELDRSGT RKGHIVIKAT PERLIMHLIE EHSIVDPTYI EDFLLTYRTF
460 470 480 490 500
LESPLDVGIK LLEWFKIDSL RDKVTRIVLL WVNNHFNDFE GDPAMTRFLE
510 520 530 540 550
EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES PLQFSLNGGS
560 570 580 590 600
EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
610 620 630 640 650
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG
660 670 680 690 700
DIEQTSQEKG SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ
710 720 730 740 750
SQDDSIVGTR HCRHSLAIMP IPGTLSSSSP DLLQPTTSML DFSNPSDIPD
760 770 780 790 800
QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA VHEFGLTGAS DTYSLCEVSV
810 820 830 840 850
TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC SDEDAQELVK
860 870 880 890 900
ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
910 920 930 940 950
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM
960 970 980 990 1000
FAIISGLNLA SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL
1010 1020 1030 1040 1050
SSQSMQPPII PLFPVVKKDM TFLHEGNDSK VDGLVNFEKL RMISKEIRQV
1060 1070 1080 1090 1100
VRMTSANMDP AMMFRQRSLS QGSTNSNMLD VQGGAHKKRA RRSSLLNAKK
1110 1120 1130 1140 1150
LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT LTKNLSEKRS
1160 1170 1180 1190 1200
AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
1210 1220 1230 1240 1250
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY
1260 1270 1280 1290 1300
TLIPSAKSDN LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV
1310 1320 1330 1340 1350
PESTGALEKT EHASGIGDHS QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ
1360 1370 1380 1390 1400
EHIIIEAADS GRGSWTSCSS SSHDNFQSLP NPKSWDFLNS YRHTHLDDPI
1410 1420 1430 1440 1450
AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS DTYEPNYGTV
1460 1470 1480 1490 1500
KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
1510 1520 1530 1540 1550
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP
1560 1570 1580 1590 1600
PASLSSNLVA CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA

V
Length:1,601
Mass (Da):179,423
Last modified:November 30, 2010 - v2
Checksum:iCF4C5407EB61EEE2
GO
Isoform 2 (identifier: Q8TEU7-2) [UniParc]FASTAAdd to basket
Also known as: PDZ-GEF2B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1391: GYTLIPSAKS...PKSWDFLNSY → VGSIISDHSS...RFKSKRRKTL
     1392-1601: Missing.

Show »
Length:1,391
Mass (Da):157,540
Checksum:i479E95ACE48D3938
GO
Isoform 3 (identifier: Q8TEU7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     747-747: D → AVGFYY
     1067-1067: R → RKKRWRSLG
     1489-1593: Missing.

Show »
Length:1,509
Mass (Da):169,500
Checksum:i726CDBA718C65649
GO
Isoform 4 (identifier: Q8TEU7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1067: R → RKKRWRSLG

Note: No experimental confirmation available.
Show »
Length:1,609
Mass (Da):180,435
Checksum:i2674B9180DEB7FCC
GO
Isoform 5 (identifier: Q8TEU7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1067: R → RKKRWRSLG
     1489-1593: Missing.

Show »
Length:1,504
Mass (Da):168,914
Checksum:i52E76A090032E29F
GO
Isoform 6 (identifier: Q8TEU7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     828-1601: Missing.

Note: No experimental confirmation available.
Show »
Length:827
Mass (Da):93,442
Checksum:i2EF5931EDE350449
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RE77D6RE77_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
1,114Annotation score:
B7Z7Y1B7Z7Y1_HUMAN
cDNA FLJ53249, highly similar to Ra...
RAPGEF6
1,204Annotation score:
D6RB02D6RB02_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
155Annotation score:
D6RIH0D6RIH0_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
155Annotation score:
D6RD23D6RD23_HUMAN
Rap guanine nucleotide exchange fac...
RAPGEF6
149Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti566K → E in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti566K → E in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti619L → P in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti619L → P in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti637E → K in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti637E → K in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti669V → A in AAL79915 (PubMed:12581858).Curated1
Sequence conflicti669V → A in AAL79916 (PubMed:12581858).Curated1
Sequence conflicti749P → A in AAI42965 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057168570S → A. Corresponds to variant dbSNP:rs3756293Ensembl.1
Natural variantiVAR_057169594A → P. Corresponds to variant dbSNP:rs34112735Ensembl.1
Natural variantiVAR_0571701353I → V. Corresponds to variant dbSNP:rs7717835Ensembl.1
Natural variantiVAR_0597931452Q → R3 PublicationsCorresponds to variant dbSNP:rs1291602Ensembl.1
Natural variantiVAR_0571711559V → E. Corresponds to variant dbSNP:rs1064539Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050607747D → AVGFYY in isoform 3. 1 Publication1
Alternative sequenceiVSP_045027828 – 1601Missing in isoform 6. 1 PublicationAdd BLAST774
Alternative sequenceiVSP_0506081067R → RKKRWRSLG in isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_0506101249 – 1391GYTLI…FLNSY → VGSIISDHSSKISGQSCPGI GGAYLQKKILQITRSTAKRT DSTEKATEENRDRTSCENTT RKRMTSPFRRLRERMLSRER LVNSQKEDTDHNQATESCEK VKDVGSNIKDEKGSAIFNSN SQGNSNTLNCFYTRFKSKRR KTL in isoform 2. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_0506111392 – 1601Missing in isoform 2. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_0506091489 – 1593Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478468 mRNA Translation: AAL79915.1
AF478469 mRNA Translation: AAL79916.1
AF478567 mRNA Translation: AAM21637.1
AF394782 mRNA Translation: AAK83368.1
AC004227 Genomic DNA No translation available.
AC004622 Genomic DNA No translation available.
AC008497 Genomic DNA No translation available.
AC008695 Genomic DNA No translation available.
AC026754 Genomic DNA No translation available.
BC133703 mRNA Translation: AAI33704.1
BC142964 mRNA Translation: AAI42965.1
BC144627 mRNA Translation: AAI44628.1
CCDSiCCDS34225.1 [Q8TEU7-1]
CCDS54897.1 [Q8TEU7-6]
CCDS54898.1 [Q8TEU7-2]
CCDS54899.1 [Q8TEU7-5]
CCDS54900.1 [Q8TEU7-4]
CCDS54901.1 [Q8TEU7-3]
RefSeqiNP_001157858.1, NM_001164386.1 [Q8TEU7-4]
NP_001157859.1, NM_001164387.1 [Q8TEU7-3]
NP_001157860.1, NM_001164388.1 [Q8TEU7-5]
NP_001157861.1, NM_001164389.1 [Q8TEU7-2]
NP_001157862.1, NM_001164390.1 [Q8TEU7-6]
NP_057424.3, NM_016340.5 [Q8TEU7-1]
UniGeneiHs.483329

Genome annotation databases

EnsembliENST00000296859; ENSP00000296859; ENSG00000158987 [Q8TEU7-4]
ENST00000308008; ENSP00000311419; ENSG00000158987 [Q8TEU7-2]
ENST00000507093; ENSP00000426081; ENSG00000158987 [Q8TEU7-3]
ENST00000509018; ENSP00000421684; ENSG00000158987 [Q8TEU7-1]
ENST00000510071; ENSP00000425389; ENSG00000158987 [Q8TEU7-6]
ENST00000627212; ENSP00000487439; ENSG00000158987 [Q8TEU7-5]
GeneIDi51735
KEGGihsa:51735
UCSCiuc003kvn.2 human [Q8TEU7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478468 mRNA Translation: AAL79915.1
AF478469 mRNA Translation: AAL79916.1
AF478567 mRNA Translation: AAM21637.1
AF394782 mRNA Translation: AAK83368.1
AC004227 Genomic DNA No translation available.
AC004622 Genomic DNA No translation available.
AC008497 Genomic DNA No translation available.
AC008695 Genomic DNA No translation available.
AC026754 Genomic DNA No translation available.
BC133703 mRNA Translation: AAI33704.1
BC142964 mRNA Translation: AAI42965.1
BC144627 mRNA Translation: AAI44628.1
CCDSiCCDS34225.1 [Q8TEU7-1]
CCDS54897.1 [Q8TEU7-6]
CCDS54898.1 [Q8TEU7-2]
CCDS54899.1 [Q8TEU7-5]
CCDS54900.1 [Q8TEU7-4]
CCDS54901.1 [Q8TEU7-3]
RefSeqiNP_001157858.1, NM_001164386.1 [Q8TEU7-4]
NP_001157859.1, NM_001164387.1 [Q8TEU7-3]
NP_001157860.1, NM_001164388.1 [Q8TEU7-5]
NP_001157861.1, NM_001164389.1 [Q8TEU7-2]
NP_001157862.1, NM_001164390.1 [Q8TEU7-6]
NP_057424.3, NM_016340.5 [Q8TEU7-1]
UniGeneiHs.483329

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D93NMR-A265-385[»]
3LNYX-ray1.30B1596-1601[»]
ProteinModelPortaliQ8TEU7
SMRiQ8TEU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119705, 22 interactors
ELMiQ8TEU7
IntActiQ8TEU7, 13 interactors
MINTiQ8TEU7
STRINGi9606.ENSP00000296859

PTM databases

iPTMnetiQ8TEU7
PhosphoSitePlusiQ8TEU7

Polymorphism and mutation databases

BioMutaiRAPGEF6
DMDMi313104174

Proteomic databases

EPDiQ8TEU7
MaxQBiQ8TEU7
PaxDbiQ8TEU7
PeptideAtlasiQ8TEU7
PRIDEiQ8TEU7
ProteomicsDBi74497
74498 [Q8TEU7-2]
74499 [Q8TEU7-3]
74500 [Q8TEU7-4]
74501 [Q8TEU7-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296859; ENSP00000296859; ENSG00000158987 [Q8TEU7-4]
ENST00000308008; ENSP00000311419; ENSG00000158987 [Q8TEU7-2]
ENST00000507093; ENSP00000426081; ENSG00000158987 [Q8TEU7-3]
ENST00000509018; ENSP00000421684; ENSG00000158987 [Q8TEU7-1]
ENST00000510071; ENSP00000425389; ENSG00000158987 [Q8TEU7-6]
ENST00000627212; ENSP00000487439; ENSG00000158987 [Q8TEU7-5]
GeneIDi51735
KEGGihsa:51735
UCSCiuc003kvn.2 human [Q8TEU7-1]

Organism-specific databases

CTDi51735
DisGeNETi51735
EuPathDBiHostDB:ENSG00000158987.20
GeneCardsiRAPGEF6
H-InvDBiHIX0005150
HIX0078163
HGNCiHGNC:20655 RAPGEF6
HPAiHPA037982
HPA037983
MIMi610499 gene
neXtProtiNX_Q8TEU7
OpenTargetsiENSG00000158987
PharmGKBiPA134885793
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000247009
HOVERGENiHBG056658
InParanoidiQ8TEU7
KOiK08020
OMAiQPSHPKL
OrthoDBiEOG091G00NU
PhylomeDBiQ8TEU7
TreeFamiTF313184

Enzyme and pathway databases

SIGNORiQ8TEU7

Miscellaneous databases

ChiTaRSiRAPGEF6 human
EvolutionaryTraceiQ8TEU7
GeneWikiiRAPGEF6
GenomeRNAii51735
PROiPR:Q8TEU7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158987 Expressed in 205 organ(s), highest expression level in corpus callosum
CleanExiHS_RAPGEF6
ExpressionAtlasiQ8TEU7 baseline and differential
GenevisibleiQ8TEU7 HS

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPGF6_HUMAN
AccessioniPrimary (citable) accession number: Q8TEU7
Secondary accession number(s): A3KN82
, A5PLL6, B7ZML2, E9PDV7, Q8NI21, Q8TEU6, Q96PC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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