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Protein

Neutral alpha-glucosidase C

Gene

GANC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has alpha-glucosidase activity.1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei511NucleophilePROSITE-ProRule annotation1
Active sitei514By similarity1
Active sitei587Proton donorBy similarity1

GO - Molecular functioni

  • alpha-1,4-glucosidase activity Source: UniProtKB
  • carbohydrate binding Source: InterPro
  • maltose alpha-glucosidase activity Source: UniProtKB-EC

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH31 Glycoside Hydrolase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral alpha-glucosidase C (EC:3.2.1.20)
Gene namesi
Name:GANC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000214013.9
HGNCiHGNC:4139 GANC
MIMi104180 gene
neXtProtiNX_Q8TET4

Pathology & Biotechi

Organism-specific databases

DisGeNETi2595
OpenTargetsiENSG00000214013
PharmGKBiPA28552

Chemistry databases

ChEMBLiCHEMBL2520
DrugBankiDB00491 Miglitol

Polymorphism and mutation databases

BioMutaiGANC
DMDMi296439340

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853641 – 914Neutral alpha-glucosidase CAdd BLAST914

Proteomic databases

EPDiQ8TET4
MaxQBiQ8TET4
PaxDbiQ8TET4
PeptideAtlasiQ8TET4
PRIDEiQ8TET4
ProteomicsDBi74496

PTM databases

iPTMnetiQ8TET4
PhosphoSitePlusiQ8TET4

Expressioni

Gene expression databases

BgeeiENSG00000214013
ExpressionAtlasiQ8TET4 baseline and differential
GenevisibleiQ8TET4 HS

Organism-specific databases

HPAiHPA016949

Interactioni

Protein-protein interaction databases

BioGridi108866, 2 interactors
IntActiQ8TET4, 2 interactors
STRINGi9606.ENSP00000326227

Chemistry databases

BindingDBiQ8TET4

Structurei

3D structure databases

ProteinModelPortaliQ8TET4
SMRiQ8TET4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Phylogenomic databases

eggNOGiKOG1066 Eukaryota
COG1501 LUCA
GeneTreeiENSGT00760000119229
HOGENOMiHOG000115864
HOVERGENiHBG051683
InParanoidiQ8TET4
KOiK12317
OMAiRWNYEDE
OrthoDBiEOG091G01CC
PhylomeDBiQ8TET4
TreeFamiTF300337

Family and domain databases

Gene3Di2.60.40.1180, 2 hits
InterProiView protein in InterPro
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR025887 Glyco_hydro_31_N_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF13802 Gal_mutarotas_2, 1 hit
PF01055 Glyco_hydro_31, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF74650 SSF74650, 2 hits
PROSITEiView protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TET4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAVKEEIS LEDEAVDKNI FRDCNKIAFY RRQKQWLSKK STYQALLDSV
60 70 80 90 100
TTDEDSTRFQ IINEASKVPL LAEIYGIEGN IFRLKINEET PLKPRFEVPD
110 120 130 140 150
VLTSKPSTVR LISCSGDTGS LILADGKGDL KCHITANPFK VDLVSEEEVV
160 170 180 190 200
ISINSLGQLY FEHLQILHKQ RAAKENEEET SVDTSQENQE DLGLWEEKFG
210 220 230 240 250
KFVDIKANGP SSIGLDFSLH GFEHLYGIPQ HAESHQLKNT GDGDAYRLYN
260 270 280 290 300
LDVYGYQIYD KMGIYGSVPY LLAHKLGRTI GIFWLNASET LVEINTEPAV
310 320 330 340 350
EYTLTQMGPV AAKQKVRSRT HVHWMSESGI IDVFLLTGPT PSDVFKQYSH
360 370 380 390 400
LTGTQAMPPL FSLGYHQCRW NYEDEQDVKA VDAGFDEHDI PYDAMWLDIE
410 420 430 440 450
HTEGKRYFTW DKNRFPNPKR MQELLRSKKR KLVVISDPHI KIDPDYSVYV
460 470 480 490 500
KAKDQGFFVK NQEGEDFEGV CWPGLSSYLD FTNPKVREWY SSLFAFPVYQ
510 520 530 540 550
GSTDILFLWN DMNEPSVFRG PEQTMQKNAI HHGNWEHREL HNIYGFYHQM
560 570 580 590 600
ATAEGLIKRS KGKERPFVLT RSFFAGSQKY GAVWTGDNTA EWSNLKISIP
610 620 630 640 650
MLLTLSITGI SFCGADIGGF IGNPETELLV RWYQAGAYQP FFRGHATMNT
660 670 680 690 700
KRREPWLFGE EHTRLIREAI RERYGLLPYW YSLFYHAHVA SQPVMRPLWV
710 720 730 740 750
EFPDELKTFD MEDEYMLGSA LLVHPVTEPK ATTVDVFLPG SNEVWYDYKT
760 770 780 790 800
FAHWEGGCTV KIPVALDTIP VFQRGGSVIP IKTTVGKSTG WMTESSYGLR
810 820 830 840 850
VALSTKGSSV GELYLDDGHS FQYLHQKQFL HRKFSFCSSV LINSFADQRG
860 870 880 890 900
HYPSKCVVEK ILVLGFRKEP SSVTTHSSDG KDQPVAFTYC AKTSILSLEK
910
LSLNIATDWE VRII
Length:914
Mass (Da):104,334
Last modified:May 18, 2010 - v3
Checksum:i7AA10E180DA7FDC2
GO

Sequence cautioni

The sequence BAB84863 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180T → A in AAO14993 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01898411L → V3 PublicationsCorresponds to variant dbSNP:rs8043515Ensembl.1
Natural variantiVAR_01898544Q → R3 PublicationsCorresponds to variant dbSNP:rs8024732Ensembl.1
Natural variantiVAR_018986153I → M1 PublicationCorresponds to variant dbSNP:rs75876980Ensembl.1
Natural variantiVAR_056237166I → V. Corresponds to variant dbSNP:rs16973015Ensembl.1
Natural variantiVAR_018987443D → E1 PublicationCorresponds to variant dbSNP:rs2578652Ensembl.1
Natural variantiVAR_018988845F → S1 PublicationCorresponds to variant dbSNP:rs7181742Ensembl.1
Natural variantiVAR_018989848Q → R1 PublicationCorresponds to variant dbSNP:rs7180279Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF545044 mRNA Translation: AAN74755.1
AF545045 mRNA Translation: AAN74756.1
AF545046 mRNA Translation: AAN74757.1
AK074037 mRNA Translation: BAB84863.1 Different initiation.
AC012651 Genomic DNA No translation available.
AC022468 Genomic DNA No translation available.
BC059406 mRNA Translation: AAH59406.1
BC093833 mRNA Translation: AAH93833.1
AF525397 mRNA Translation: AAO14993.1
CCDSiCCDS10084.1
RefSeqiNP_937784.2, NM_198141.2
UniGeneiHs.730806

Genome annotation databases

EnsembliENST00000318010; ENSP00000326227; ENSG00000214013
GeneIDi2595
KEGGihsa:2595
UCSCiuc001zpi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGANC_HUMAN
AccessioniPrimary (citable) accession number: Q8TET4
Secondary accession number(s): Q52LQ4
, Q8IWZ0, Q8IZM4, Q8IZM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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