UniProtKB - Q8TES7 (FBF1_HUMAN)
Protein
Fas-binding factor 1
Gene
FBF1
Organism
Homo sapiens (Human)
Status
Functioni
Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis.2 Publications
GO - Biological processi
- apical junction assembly Source: UniProtKB
- ciliary basal body-plasma membrane docking Source: Reactome
- cilium assembly Source: UniProtKB
- establishment of epithelial cell polarity Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q8TES7 |
Reactomei | R-HSA-5620912, Anchoring of the basal body to the plasma membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Fas-binding factor 1Short name: FBF-1 Alternative name(s): Protein albatross |
Gene namesi | Name:FBF1 Synonyms:ALB, KIAA1863 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24674, FBF1 |
neXtProti | NX_Q8TES7 |
VEuPathDBi | HostDB:ENSG00000188878.17 HostDB:ENSG00000281844.1 |
Subcellular locationi
Cytoskeleton
Other locations
Note: Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to the apical junction complex (AJC) in epithelial cells.
Cytoskeleton
- centriole Source: UniProtKB
- centrosome Source: HPA
- ciliary basal body Source: GO_Central
- spindle pole Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Other locations
- cell junction Source: UniProtKB-SubCell
- ciliary transition fiber Source: MGI
Keywords - Cellular componenti
Cell junction, Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 85302 |
OpenTargetsi | ENSG00000188878 |
Miscellaneous databases
Pharosi | Q8TES7, Tbio |
Genetic variation databases
BioMutai | FBF1 |
DMDMi | 156630449 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297646 | 1 – 1133 | Fas-binding factor 1Add BLAST | 1133 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Cross-linki | 960 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q8TES7 |
MassIVEi | Q8TES7 |
MaxQBi | Q8TES7 |
PaxDbi | Q8TES7 |
PeptideAtlasi | Q8TES7 |
PRIDEi | Q8TES7 |
ProteomicsDBi | 74489 [Q8TES7-1] 74490 [Q8TES7-2] 74491 [Q8TES7-3] 74492 [Q8TES7-4] 74493 [Q8TES7-5] 74494 [Q8TES7-6] |
PTM databases
iPTMneti | Q8TES7 |
PhosphoSitePlusi | Q8TES7 |
Expressioni
Tissue specificityi
Present in various epithelial cells (at protein level).
Gene expression databases
Bgeei | ENSG00000188878, Expressed in right testis and 112 other tissues |
ExpressionAtlasi | Q8TES7, baseline and differential |
Genevisiblei | Q8TES7, HS |
Organism-specific databases
HPAi | ENSG00000188878, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsIsoform 6 [Q8TES7-6]
Protein-protein interaction databases
BioGRIDi | 124465, 154 interactors |
IntActi | Q8TES7, 138 interactors |
STRINGi | 9606.ENSP00000324292 |
Miscellaneous databases
RNActi | Q8TES7, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 577 – 727 | Sequence analysisAdd BLAST | 151 | |
Coiled coili | 773 – 870 | Sequence analysisAdd BLAST | 98 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 999 – 1045 | Gln-richAdd BLAST | 47 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQFR, Eukaryota |
GeneTreei | ENSGT00720000108861 |
InParanoidi | Q8TES7 |
OMAi | QYRKFSF |
OrthoDBi | 399859at2759 |
PhylomeDBi | Q8TES7 |
TreeFami | TF328742 |
Family and domain databases
InterProi | View protein in InterPro IPR033561, FBF1 |
PANTHERi | PTHR33689, PTHR33689, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TES7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPKTKKGCK VTLPEKPVKL ASHTRDTTGV SQMFPSSKAR TKSLLGDDVF
60 70 80 90 100
STMAGLEEAD AEVSGISEAD PQALLQAMKD LDGMDADILG LKKSNSAPSK
110 120 130 140 150
KAAKDPGKGE LPNHPKPAGG AIPTKKSLPS PSSSGHQNRR FSSEDLEDPL
160 170 180 190 200
RGLLSYDEGG ITKQPPVTQS KTASDKSPST VRDQGPSIPL TPGDTPIRKK
210 220 230 240 250
EELLFDDGDD IMATLGFGDS PKAEKRQIGD QEGPRPARST LDELLGRGMA
260 270 280 290 300
TKLLARPGTG EHREFKLDKK YQRPQDSEDM WGDEDFTFGA YQPTVVSSEG
310 320 330 340 350
RQSRRQSVSR FFADSGADPK GEPGSKQSPP MASSPIQPRK GGADWLGLKD
360 370 380 390 400
EDLDLFPASP TREAHRESSV PVTPSVPPPA SQHSTPAGLP PSRAKPPTEG
410 420 430 440 450
AGSPAKASQA SKLRASKEEK EDWLSHALSR KKSQGLAREQ HAGTSEGLHL
460 470 480 490 500
AGTAGHPPSG SQPLTSTQGL EHAAAGGSSG TTARERPCVR PGVSGSPVTQ
510 520 530 540 550
NHAASALPTG SPKRGTAPGD LSATEPATCF PSTQKPTEPS VPVQPLLPES
560 570 580 590 600
LARSLLPSTE YQKQLLAAQV QLQCSPAELQ AELLHSQARL AELEAQVRKL
610 620 630 640 650
ELERAQHELL LGSLQQQHQA DLELIESAHR SRIKVLETSY QQREERLRRE
660 670 680 690 700
NEELSARYLS QCQEAEQARA ELTAQHQRRL AAIAQEKDQE MERLRELQRA
710 720 730 740 750
SILDMRRDHE EQLQRLKLLK DREVDAATSA TSHTRSLNSI IHQMEKFSSS
760 770 780 790 800
LHELSSRVEA SHLTTSQERE LGIRQRDEQL RALQERLGQQ QRDMEEERSR
810 820 830 840 850
QQEVIGKMEA RLNEQSRLLE QERWRVTAEQ SKAESMQRAL EEQRKVTAQQ
860 870 880 890 900
MAMERAELER AKSALLEEQK SVMLKCGEER RRLAAEWAEF SAQQKLSKER
910 920 930 940 950
AEREAERALQ VDTQREGTLI SLAKQAELKI RASELRAEEK QLAAERAALE
960 970 980 990 1000
QERQELRLEK ERINATALRV KLRAEEVESM SKVASEKYEE GERALREAQQ
1010 1020 1030 1040 1050
VQAEQQARLQ AVQQQQERLR KQEQHMHQEH LSLAQQRLQL DRARQDLPSS
1060 1070 1080 1090 1100
LVGLFPRAQG PAASSQSALM PPAPTTRWCS QPPTGLDPSP LHLHARLALL
1110 1120 1130
RHMAEQDRDF LENEQFFLET LKKGSYNLTS HSA
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ENL6 | K7ENL6_HUMAN | Fas-binding factor 1 | FBF1 | 1,147 | Annotation score: | ||
A0A0R4J2E4 | A0A0R4J2E4_HUMAN | Fas-binding factor 1 | FBF1 | 1,092 | Annotation score: | ||
K7ESG2 | K7ESG2_HUMAN | Fas-binding factor 1 | FBF1 | 92 | Annotation score: | ||
K7EPQ1 | K7EPQ1_HUMAN | Fas-binding factor 1 | FBF1 | 150 | Annotation score: | ||
K7EL64 | K7EL64_HUMAN | Fas-binding factor 1 | FBF1 | 88 | Annotation score: | ||
U3KPW3 | U3KPW3_HUMAN | Fas-binding factor 1 | FBF1 | 50 | Annotation score: |
Sequence cautioni
The sequence BAB71400 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB84871 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 801 | Q → R in BAB71400 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034659 | 65 | G → V1 PublicationCorresponds to variant dbSNP:rs1135889Ensembl. | 1 | |
Natural variantiVAR_034660 | 151 | R → G2 PublicationsCorresponds to variant dbSNP:rs2305913Ensembl. | 1 | |
Natural variantiVAR_034661 | 371 | P → S. Corresponds to variant dbSNP:rs7218738Ensembl. | 1 | |
Natural variantiVAR_034662 | 574 | C → S. Corresponds to variant dbSNP:rs7213548Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041555 | 11 | V → GSIDDFLGDLLGDDM in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_040769 | 309 | Missing in isoform 5. Curated | 1 | |
Alternative sequenceiVSP_027318 | 462 – 517 | QPLTS…KRGTA → LTWAFCHLHLERCLSSANLS PAHKGLSTQLLEGVLEQLHE KDRVSGLVSRGPL in isoform 4. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_027319 | 518 – 1133 | Missing in isoform 4. 1 PublicationAdd BLAST | 616 | |
Alternative sequenceiVSP_027320 | 599 – 662 | KLELE…YLSQC → GSGAVGAGGRVATGGDTESG WKLPQEGGRAVGTGQRGVQP PPLPGCWPSCCLPGAEAGAR TGPA in isoform 3. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_027321 | 663 – 1133 | Missing in isoform 3. 1 PublicationAdd BLAST | 471 | |
Alternative sequenceiVSP_027322 | 897 – 899 | SKE → RAG in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_027323 | 900 – 1133 | Missing in isoform 2. 1 PublicationAdd BLAST | 234 | |
Alternative sequenceiVSP_040770 | 924 | K → KE in isoform 5 and isoform 6. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB354594 mRNA Translation: BAG71501.1 AK057261 mRNA Translation: BAB71400.1 Different initiation. AK074045 mRNA Translation: BAB84871.1 Different initiation. AC087289 Genomic DNA No translation available. AB058766 mRNA Translation: BAB47492.1 BC007570 mRNA Translation: AAH07570.1 |
CCDSi | CCDS45779.2 [Q8TES7-6] |
RefSeqi | NP_001306122.1, NM_001319193.1 [Q8TES7-6] |
Genome annotation databases
Ensembli | ENST00000586717; ENSP00000465132; ENSG00000188878 [Q8TES7-1] ENST00000636174; ENSP00000490726; ENSG00000188878 [Q8TES7-6] |
GeneIDi | 85302 |
KEGGi | hsa:85302 |
UCSCi | uc002jqd.2, human [Q8TES7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB354594 mRNA Translation: BAG71501.1 AK057261 mRNA Translation: BAB71400.1 Different initiation. AK074045 mRNA Translation: BAB84871.1 Different initiation. AC087289 Genomic DNA No translation available. AB058766 mRNA Translation: BAB47492.1 BC007570 mRNA Translation: AAH07570.1 |
CCDSi | CCDS45779.2 [Q8TES7-6] |
RefSeqi | NP_001306122.1, NM_001319193.1 [Q8TES7-6] |
3D structure databases
SMRi | Q8TES7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124465, 154 interactors |
IntActi | Q8TES7, 138 interactors |
STRINGi | 9606.ENSP00000324292 |
PTM databases
iPTMneti | Q8TES7 |
PhosphoSitePlusi | Q8TES7 |
Genetic variation databases
BioMutai | FBF1 |
DMDMi | 156630449 |
Proteomic databases
jPOSTi | Q8TES7 |
MassIVEi | Q8TES7 |
MaxQBi | Q8TES7 |
PaxDbi | Q8TES7 |
PeptideAtlasi | Q8TES7 |
PRIDEi | Q8TES7 |
ProteomicsDBi | 74489 [Q8TES7-1] 74490 [Q8TES7-2] 74491 [Q8TES7-3] 74492 [Q8TES7-4] 74493 [Q8TES7-5] 74494 [Q8TES7-6] |
Protocols and materials databases
Antibodypediai | 80115, 84 antibodies |
Genome annotation databases
Ensembli | ENST00000586717; ENSP00000465132; ENSG00000188878 [Q8TES7-1] ENST00000636174; ENSP00000490726; ENSG00000188878 [Q8TES7-6] |
GeneIDi | 85302 |
KEGGi | hsa:85302 |
UCSCi | uc002jqd.2, human [Q8TES7-1] |
Organism-specific databases
CTDi | 85302 |
DisGeNETi | 85302 |
GeneCardsi | FBF1 |
HGNCi | HGNC:24674, FBF1 |
HPAi | ENSG00000188878, Tissue enhanced (testis) |
neXtProti | NX_Q8TES7 |
OpenTargetsi | ENSG00000188878 |
VEuPathDBi | HostDB:ENSG00000188878.17 HostDB:ENSG00000281844.1 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQFR, Eukaryota |
GeneTreei | ENSGT00720000108861 |
InParanoidi | Q8TES7 |
OMAi | QYRKFSF |
OrthoDBi | 399859at2759 |
PhylomeDBi | Q8TES7 |
TreeFami | TF328742 |
Enzyme and pathway databases
PathwayCommonsi | Q8TES7 |
Reactomei | R-HSA-5620912, Anchoring of the basal body to the plasma membrane |
Miscellaneous databases
BioGRID-ORCSi | 85302, 3 hits in 991 CRISPR screens |
GenomeRNAii | 85302 |
Pharosi | Q8TES7, Tbio |
PROi | PR:Q8TES7 |
RNActi | Q8TES7, protein |
Gene expression databases
Bgeei | ENSG00000188878, Expressed in right testis and 112 other tissues |
ExpressionAtlasi | Q8TES7, baseline and differential |
Genevisiblei | Q8TES7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033561, FBF1 |
PANTHERi | PTHR33689, PTHR33689, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBF1_HUMAN | |
Accessioni | Q8TES7Primary (citable) accession number: Q8TES7 Secondary accession number(s): B5MEM5 Q96MA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports