Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 129 (18 Sep 2019)
Sequence version 2 (21 Aug 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Fas-binding factor 1

Gene

FBF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5620912 Anchoring of the basal body to the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fas-binding factor 1
Short name:
FBF-1
Alternative name(s):
Protein albatross
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBF1
Synonyms:ALB, KIAA1863
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24674 FBF1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TES7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
85302

Open Targets

More...
OpenTargetsi
ENSG00000188878

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FBF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156630449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002976461 – 1133Fas-binding factor 1Add BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei142PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki960Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TES7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TES7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TES7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TES7

PeptideAtlas

More...
PeptideAtlasi
Q8TES7

PRoteomics IDEntifications database

More...
PRIDEi
Q8TES7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74489 [Q8TES7-1]
74490 [Q8TES7-2]
74491 [Q8TES7-3]
74492 [Q8TES7-4]
74493 [Q8TES7-5]
74494 [Q8TES7-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TES7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TES7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in various epithelial cells (at protein level).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188878 Expressed in 86 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TES7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TES7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023677

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with FAS cytoplasmic domain (By similarity).

Interacts with PARD3.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124465, 149 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TES7, 130 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000324292

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TES7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili577 – 727Sequence analysisAdd BLAST151
Coiled coili773 – 870Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi999 – 1045Gln-richAdd BLAST47

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFRT Eukaryota
ENOG4111RN4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00720000108861

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060115

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TES7

KEGG Orthology (KO)

More...
KOi
K16471

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKASYNM

Database of Orthologous Groups

More...
OrthoDBi
399859at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TES7

TreeFam database of animal gene trees

More...
TreeFami
TF328742

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033561 FBF1

The PANTHER Classification System

More...
PANTHERi
PTHR33689 PTHR33689, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TES7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKTKKGCK VTLPEKPVKL ASHTRDTTGV SQMFPSSKAR TKSLLGDDVF
60 70 80 90 100
STMAGLEEAD AEVSGISEAD PQALLQAMKD LDGMDADILG LKKSNSAPSK
110 120 130 140 150
KAAKDPGKGE LPNHPKPAGG AIPTKKSLPS PSSSGHQNRR FSSEDLEDPL
160 170 180 190 200
RGLLSYDEGG ITKQPPVTQS KTASDKSPST VRDQGPSIPL TPGDTPIRKK
210 220 230 240 250
EELLFDDGDD IMATLGFGDS PKAEKRQIGD QEGPRPARST LDELLGRGMA
260 270 280 290 300
TKLLARPGTG EHREFKLDKK YQRPQDSEDM WGDEDFTFGA YQPTVVSSEG
310 320 330 340 350
RQSRRQSVSR FFADSGADPK GEPGSKQSPP MASSPIQPRK GGADWLGLKD
360 370 380 390 400
EDLDLFPASP TREAHRESSV PVTPSVPPPA SQHSTPAGLP PSRAKPPTEG
410 420 430 440 450
AGSPAKASQA SKLRASKEEK EDWLSHALSR KKSQGLAREQ HAGTSEGLHL
460 470 480 490 500
AGTAGHPPSG SQPLTSTQGL EHAAAGGSSG TTARERPCVR PGVSGSPVTQ
510 520 530 540 550
NHAASALPTG SPKRGTAPGD LSATEPATCF PSTQKPTEPS VPVQPLLPES
560 570 580 590 600
LARSLLPSTE YQKQLLAAQV QLQCSPAELQ AELLHSQARL AELEAQVRKL
610 620 630 640 650
ELERAQHELL LGSLQQQHQA DLELIESAHR SRIKVLETSY QQREERLRRE
660 670 680 690 700
NEELSARYLS QCQEAEQARA ELTAQHQRRL AAIAQEKDQE MERLRELQRA
710 720 730 740 750
SILDMRRDHE EQLQRLKLLK DREVDAATSA TSHTRSLNSI IHQMEKFSSS
760 770 780 790 800
LHELSSRVEA SHLTTSQERE LGIRQRDEQL RALQERLGQQ QRDMEEERSR
810 820 830 840 850
QQEVIGKMEA RLNEQSRLLE QERWRVTAEQ SKAESMQRAL EEQRKVTAQQ
860 870 880 890 900
MAMERAELER AKSALLEEQK SVMLKCGEER RRLAAEWAEF SAQQKLSKER
910 920 930 940 950
AEREAERALQ VDTQREGTLI SLAKQAELKI RASELRAEEK QLAAERAALE
960 970 980 990 1000
QERQELRLEK ERINATALRV KLRAEEVESM SKVASEKYEE GERALREAQQ
1010 1020 1030 1040 1050
VQAEQQARLQ AVQQQQERLR KQEQHMHQEH LSLAQQRLQL DRARQDLPSS
1060 1070 1080 1090 1100
LVGLFPRAQG PAASSQSALM PPAPTTRWCS QPPTGLDPSP LHLHARLALL
1110 1120 1130
RHMAEQDRDF LENEQFFLET LKKGSYNLTS HSA
Length:1,133
Mass (Da):125,446
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58FA2446CBA3C6B7
GO
Isoform 2 (identifier: Q8TES7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     897-899: SKE → RAG
     900-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:899
Mass (Da):98,643
Checksum:i3C216940C6ED257C
GO
Isoform 3 (identifier: Q8TES7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     599-662: KLELERAQHE...ELSARYLSQC → GSGAVGAGGR...AEAGARTGPA
     663-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):69,178
Checksum:i46F943597FC16193
GO
Isoform 4 (identifier: Q8TES7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-517: QPLTSTQGLE...PTGSPKRGTA → LTWAFCHLHL...VSGLVSRGPL
     518-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:514
Mass (Da):54,791
Checksum:iEC7D6EF77AE2AE30
GO
Isoform 5 (identifier: Q8TES7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-309: Missing.
     924-924: K → KE

Note: No experimental confirmation available.
Show »
Length:1,133
Mass (Da):125,488
Checksum:i0FA5464A6C80D1A4
GO
Isoform 6 (identifier: Q8TES7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: V → GSIDDFLGDLLGDDM
     924-924: K → KE

Show »
Length:1,148
Mass (Da):127,041
Checksum:i030249D5E297C457
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENL6K7ENL6_HUMAN
Fas-binding factor 1
FBF1
1,147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2E4A0A0R4J2E4_HUMAN
Fas-binding factor 1
FBF1
1,092Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPQ1K7EPQ1_HUMAN
Fas-binding factor 1
FBF1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESG2K7ESG2_HUMAN
Fas-binding factor 1
FBF1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL64K7EL64_HUMAN
Fas-binding factor 1
FBF1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPW3U3KPW3_HUMAN
Fas-binding factor 1
FBF1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71400 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB84871 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti801Q → R in BAB71400 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03465965G → V1 PublicationCorresponds to variant dbSNP:rs1135889Ensembl.1
Natural variantiVAR_034660151R → G2 PublicationsCorresponds to variant dbSNP:rs2305913Ensembl.1
Natural variantiVAR_034661371P → S. Corresponds to variant dbSNP:rs7218738Ensembl.1
Natural variantiVAR_034662574C → S. Corresponds to variant dbSNP:rs7213548Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04155511V → GSIDDFLGDLLGDDM in isoform 6. 1 Publication1
Alternative sequenceiVSP_040769309Missing in isoform 5. Curated1
Alternative sequenceiVSP_027318462 – 517QPLTS…KRGTA → LTWAFCHLHLERCLSSANLS PAHKGLSTQLLEGVLEQLHE KDRVSGLVSRGPL in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_027319518 – 1133Missing in isoform 4. 1 PublicationAdd BLAST616
Alternative sequenceiVSP_027320599 – 662KLELE…YLSQC → GSGAVGAGGRVATGGDTESG WKLPQEGGRAVGTGQRGVQP PPLPGCWPSCCLPGAEAGAR TGPA in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_027321663 – 1133Missing in isoform 3. 1 PublicationAdd BLAST471
Alternative sequenceiVSP_027322897 – 899SKE → RAG in isoform 2. 1 Publication3
Alternative sequenceiVSP_027323900 – 1133Missing in isoform 2. 1 PublicationAdd BLAST234
Alternative sequenceiVSP_040770924K → KE in isoform 5 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB354594 mRNA Translation: BAG71501.1
AK057261 mRNA Translation: BAB71400.1 Different initiation.
AK074045 mRNA Translation: BAB84871.1 Different initiation.
AC087289 Genomic DNA No translation available.
AB058766 mRNA Translation: BAB47492.1
BC007570 mRNA Translation: AAH07570.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45779.2 [Q8TES7-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001306122.1, NM_001319193.1 [Q8TES7-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000586717; ENSP00000465132; ENSG00000188878 [Q8TES7-1]
ENST00000636174; ENSP00000490726; ENSG00000188878 [Q8TES7-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85302

UCSC genome browser

More...
UCSCi
uc002jqd.2 human [Q8TES7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB354594 mRNA Translation: BAG71501.1
AK057261 mRNA Translation: BAB71400.1 Different initiation.
AK074045 mRNA Translation: BAB84871.1 Different initiation.
AC087289 Genomic DNA No translation available.
AB058766 mRNA Translation: BAB47492.1
BC007570 mRNA Translation: AAH07570.1
CCDSiCCDS45779.2 [Q8TES7-6]
RefSeqiNP_001306122.1, NM_001319193.1 [Q8TES7-6]

3D structure databases

SMRiQ8TES7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124465, 149 interactors
IntActiQ8TES7, 130 interactors
STRINGi9606.ENSP00000324292

PTM databases

iPTMnetiQ8TES7
PhosphoSitePlusiQ8TES7

Polymorphism and mutation databases

BioMutaiFBF1
DMDMi156630449

Proteomic databases

jPOSTiQ8TES7
MassIVEiQ8TES7
MaxQBiQ8TES7
PaxDbiQ8TES7
PeptideAtlasiQ8TES7
PRIDEiQ8TES7
ProteomicsDBi74489 [Q8TES7-1]
74490 [Q8TES7-2]
74491 [Q8TES7-3]
74492 [Q8TES7-4]
74493 [Q8TES7-5]
74494 [Q8TES7-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000586717; ENSP00000465132; ENSG00000188878 [Q8TES7-1]
ENST00000636174; ENSP00000490726; ENSG00000188878 [Q8TES7-6]
GeneIDi85302
KEGGihsa:85302
UCSCiuc002jqd.2 human [Q8TES7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85302
DisGeNETi85302

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FBF1
HGNCiHGNC:24674 FBF1
HPAiHPA023677
neXtProtiNX_Q8TES7
OpenTargetsiENSG00000188878

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFRT Eukaryota
ENOG4111RN4 LUCA
GeneTreeiENSGT00720000108861
HOGENOMiHOG000060115
InParanoidiQ8TES7
KOiK16471
OMAiKKASYNM
OrthoDBi399859at2759
PhylomeDBiQ8TES7
TreeFamiTF328742

Enzyme and pathway databases

ReactomeiR-HSA-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FBF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85302

Pharos

More...
Pharosi
Q8TES7

Protein Ontology

More...
PROi
PR:Q8TES7

Gene expression databases

BgeeiENSG00000188878 Expressed in 86 organ(s), highest expression level in right testis
ExpressionAtlasiQ8TES7 baseline and differential
GenevisibleiQ8TES7 HS

Family and domain databases

InterProiView protein in InterPro
IPR033561 FBF1
PANTHERiPTHR33689 PTHR33689, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TES7
Secondary accession number(s): B5MEM5
, Q96IF6, Q96JG4, Q96MA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 18, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again