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Entry version 130 (26 Feb 2020)
Sequence version 3 (18 May 2010)
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Protein

Rho guanine nucleotide exchange factor 40

Gene

ARHGEF40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 40
Alternative name(s):
Protein SOLO
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF40
Synonyms:SOLO
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25516 ARHGEF40

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610018 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TER5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55701

Open Targets

More...
OpenTargetsi
ENSG00000165801

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TER5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF40

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452953

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148221 – 1519Rho guanine nucleotide exchange factor 40Add BLAST1519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei262PhosphoserineCombined sources1
Modified residuei371PhosphothreonineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei931PhosphoserineCombined sources1
Modified residuei961PhosphoserineCombined sources1
Modified residuei1082PhosphoserineCombined sources1
Modified residuei1433PhosphoserineCombined sources1
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1474PhosphoserineCombined sources1
Modified residuei1492PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TER5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TER5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TER5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TER5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TER5

PeptideAtlas

More...
PeptideAtlasi
Q8TER5

PRoteomics IDEntifications database

More...
PRIDEi
Q8TER5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74485 [Q8TER5-1]
74486 [Q8TER5-2]
74487 [Q8TER5-3]
74488 [Q8TER5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TER5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TER5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at higher level in the central nervous system and skeletal muscle and greater abundance in fetal than adult brain (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165801 Expressed in buccal mucosa cell and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TER5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TER5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030745
HPA030746
HPA030757

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q8NA613EBI-10275150,EBI-741724

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120826, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TER5, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298694

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TER5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TER5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1085 – 1253DHPROSITE-ProRule annotationAdd BLAST169
Domaini1265 – 1372PHPROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili828 – 871Sequence analysisAdd BLAST44
Coiled coili934 – 961Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi276 – 395Gly-richAdd BLAST120
Compositional biasi706 – 711Poly-Glu6
Compositional biasi966 – 969Poly-Arg4

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0689 Eukaryota
ENOG410XSWY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161599

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001356_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TER5

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWVETHQ

Database of Orthologous Groups

More...
OrthoDBi
578732at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TER5

TreeFam database of animal gene trees

More...
TreeFami
TF334329

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TER5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY REDALRYTLD
60 70 80 90 100
FLVPAKHLLA KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL
110 120 130 140 150
RPGDFYLQVV PSAAQAPRLA LKCLAPGGGR VQEVPVPNEA CAYLFTPEWL
160 170 180 190 200
QGINKDRPTG RLSTCLLSAP SGIQRLPWAE LICPRFVHKE GLMVGHQPST
210 220 230 240 250
LPPELPSGPP GLPSPPLPEE ALGTRSPGDG HNAPVEGPEG EYVELLEVTL
260 270 280 290 300
PVRGSPTDAE GSPGLSRVRT VPTRKGAGGK GRHRRHRAWM HQKGLGPRGQ
310 320 330 340 350
DGARPPGEGS STGASPESPP GAEAVPEAAV LEVSEPPAEA VGEASGSCPL
360 370 380 390 400
RPGELRGGGG GGQGAEGPPG TPRRTGKGNR RKKRAAGRGA LSRGGDSAPL
410 420 430 440 450
SPGDKEDASH QEALGNLPSP SEHKLPECHL VKEEYEGSGK PESEPKELKT
460 470 480 490 500
AGEKEPQLSE ACGPTEEGAG ERELEGPGLL CMAGHTGPEG PLSDTPTPPL
510 520 530 540 550
ETVQEGKGDN IPEEALAVSV SDHPDVAWDL MASGFLILTG GVDQSGRALL
560 570 580 590 600
TITPPCPPEE PPPSRDTLNT TLHYLHSLLR PDLQTLGLSV LLDLRQAPPL
610 620 630 640 650
PPALIPALSQ LQDSGDPPLV QRLLILIHDD LPTELCGFQG AEVLSENDLK
660 670 680 690 700
RVAKPEELQW ELGGHRDPSP SHWVEIHQEV VRLCRLCQGV LGSVRQAIEE
710 720 730 740 750
LEGAAEPEEE EAVGMPKPLQ KVLADPRLTA LQRDGGAILM RLRSTPSSKL
760 770 780 790 800
EGQGPATLYQ EVDEAIHQLV RLSNLHVQQQ EQRQCLRRLQ QVLQWLSGPG
810 820 830 840 850
EEQLASFAMP GDTLSALQET ELRFRAFSAE VQERLAQARE ALALEENATS
860 870 880 890 900
QKVLDIFEQR LEQVESGLHR ALRLQRFFQQ AHEWVDEGFA RLAGAGPGRE
910 920 930 940 950
AVLAALALRR APEPSAGTFQ EMRALALDLG SPAALREWGR CQARCQELER
960 970 980 990 1000
RIQQHVGEEA SPRGYRRRRA DGASSGGAQW GPRSPSPSLS SLLLPSSPGP
1010 1020 1030 1040 1050
RPAPSHCSLA PCGEDYEEEG PELAPEAEGR PPRAVLIRGL EVTSTEVVDR
1060 1070 1080 1090 1100
TCSPREHVLL GRARGPDGPW GVGTPRMERK RSISAQQRLV SELIACEQDY
1110 1120 1130 1140 1150
VATLSEPVPP PGPELTPELR GTWAAALSAR ERLRSFHRTH FLRELQGCAT
1160 1170 1180 1190 1200
HPLRIGACFL RHGDQFSLYA QYVKHRHKLE NGLAALSPLS KGSMEAGPYL
1210 1220 1230 1240 1250
PRALQQPLEQ LTRYGRLLEE LLREAGPELS SECRALGAAV QLLREQEARG
1260 1270 1280 1290 1300
RDLLAVEAVR GCEIDLKEQG QLLHRDPFTV ICGRKKCLRH VFLFEHLLLF
1310 1320 1330 1340 1350
SKLKGPEGGS EMFVYKQAFK TADMGLTENI GDSGLCFELW FRRRRAREAY
1360 1370 1380 1390 1400
TLQATSPEIK LKWTSSIAQL LWRQAAHNKE LRVQQMVSMG IGNKPFLDIK
1410 1420 1430 1440 1450
ALGERTLSAL LTGRAARTRA SVAVSSFEHA GPSLPGLSPG ACSLPARVEE
1460 1470 1480 1490 1500
EAWDLDVKQI SLAPETLDSS GDVSPGPRNS PSLQPPHPGS STPTLASRGI
1510
LGLSRQSHAR ALSDPTTPL
Length:1,519
Mass (Da):164,658
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE59DD53AE399E2E6
GO
Isoform 2 (identifier: Q8TER5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-714: Missing.

Show »
Length:805
Mass (Da):88,758
Checksum:i7DA3D9DEED3284A3
GO
Isoform 3 (identifier: Q8TER5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1415-1519: AARTRASVAV...RALSDPTTPL → GEGQGAGGWP...HPGLRGRVIL

Show »
Length:1,498
Mass (Da):162,800
Checksum:i43FB91E06285706E
GO
Isoform 4 (identifier: Q8TER5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1415-1462: Missing.

Show »
Length:1,471
Mass (Da):159,698
Checksum:i5FC596887113AA2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V485G3V485_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF40
502Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3N2G3V3N2_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF40
557Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5C1G3V5C1_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF40
620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91563 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15753 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB84883 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti293K → E in BAB15753 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038061956V → LCombined sources2 PublicationsCorresponds to variant dbSNP:rs7143633Ensembl.1
Natural variantiVAR_0380621189L → S3 PublicationsCorresponds to variant dbSNP:rs1958396Ensembl.1
Natural variantiVAR_0380631312M → T. Corresponds to variant dbSNP:rs943992Ensembl.1
Natural variantiVAR_0605411418T → P1 PublicationCorresponds to variant dbSNP:rs17855344Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0303811 – 714Missing in isoform 2. 1 PublicationAdd BLAST714
Alternative sequenceiVSP_0303821415 – 1519AARTR…PTTPL → GEGQGAGGWPPGVKTLTMRI QRGGMVESQERHLVPKSVGL AGRPSVRLRVIPGSQEGFPT PAPHPPLPTLCSRPHPGLRG RVIL in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_0303831415 – 1462Missing in isoform 4. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK001219 mRNA Translation: BAA91563.1 Different initiation.
AK024463 mRNA Translation: BAB15753.1 Different initiation.
AK074057 mRNA Translation: BAB84883.1 Different initiation.
AL161668 Genomic DNA No translation available.
BC000084 mRNA Translation: AAH00084.4
BC142692 mRNA Translation: AAI42693.1
AL137291 mRNA Translation: CAB70682.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32041.1 [Q8TER5-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46359

NCBI Reference Sequences

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RefSeqi
NP_001265458.1, NM_001278529.1 [Q8TER5-2]
NP_060541.3, NM_018071.4 [Q8TER5-1]
XP_005267901.1, XM_005267844.2 [Q8TER5-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000298694; ENSP00000298694; ENSG00000165801 [Q8TER5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55701

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55701

UCSC genome browser

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UCSCi
uc001vzp.5 human [Q8TER5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001219 mRNA Translation: BAA91563.1 Different initiation.
AK024463 mRNA Translation: BAB15753.1 Different initiation.
AK074057 mRNA Translation: BAB84883.1 Different initiation.
AL161668 Genomic DNA No translation available.
BC000084 mRNA Translation: AAH00084.4
BC142692 mRNA Translation: AAI42693.1
AL137291 mRNA Translation: CAB70682.1
CCDSiCCDS32041.1 [Q8TER5-1]
PIRiT46359
RefSeqiNP_001265458.1, NM_001278529.1 [Q8TER5-2]
NP_060541.3, NM_018071.4 [Q8TER5-1]
XP_005267901.1, XM_005267844.2 [Q8TER5-4]

3D structure databases

SMRiQ8TER5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120826, 11 interactors
IntActiQ8TER5, 6 interactors
STRINGi9606.ENSP00000298694

PTM databases

iPTMnetiQ8TER5
PhosphoSitePlusiQ8TER5

Polymorphism and mutation databases

BioMutaiARHGEF40
DMDMi296452953

Proteomic databases

EPDiQ8TER5
jPOSTiQ8TER5
MassIVEiQ8TER5
MaxQBiQ8TER5
PaxDbiQ8TER5
PeptideAtlasiQ8TER5
PRIDEiQ8TER5
ProteomicsDBi74485 [Q8TER5-1]
74486 [Q8TER5-2]
74487 [Q8TER5-3]
74488 [Q8TER5-4]

Genome annotation databases

EnsembliENST00000298694; ENSP00000298694; ENSG00000165801 [Q8TER5-1]
GeneIDi55701
KEGGihsa:55701
UCSCiuc001vzp.5 human [Q8TER5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55701
DisGeNETi55701

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGEF40
HGNCiHGNC:25516 ARHGEF40
HPAiHPA030745
HPA030746
HPA030757
MIMi610018 gene
neXtProtiNX_Q8TER5
OpenTargetsiENSG00000165801

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0689 Eukaryota
ENOG410XSWY LUCA
GeneTreeiENSGT00940000161599
HOGENOMiCLU_001356_2_1_1
InParanoidiQ8TER5
OMAiHWVETHQ
OrthoDBi578732at2759
PhylomeDBiQ8TER5
TreeFamiTF334329

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGEF40 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55701
PharosiQ8TER5 Tdark

Protein Ontology

More...
PROi
PR:Q8TER5
RNActiQ8TER5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165801 Expressed in buccal mucosa cell and 224 other tissues
ExpressionAtlasiQ8TER5 baseline and differential
GenevisibleiQ8TER5 HS

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARH40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TER5
Secondary accession number(s): A5PL07
, Q9BWP5, Q9H7L6, Q9NTF9, Q9NW24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: February 26, 2020
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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