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Protein

Gem-associated protein 5

Gene

GEMIN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:16857593, PubMed:18984161, PubMed:20513430). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:18984161). GEMIN5 acts as the snRNA-binding protein of the SMN complex (PubMed:11714716, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref. 25). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887).12 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • import into nucleus Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
  • protein-containing complex assembly Source: UniProtKB
  • regulation of translation Source: UniProtKB
  • spliceosomal snRNP assembly Source: UniProtKB
  • translation Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, Protein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-191859 snRNP Assembly

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q8TEQ6

SIGNOR Signaling Network Open Resource

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SIGNORi
Q8TEQ6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gem-associated protein 5
Short name:
Gemin5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GEMIN5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000082516.8

Human Gene Nomenclature Database

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HGNCi
HGNC:20043 GEMIN5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607005 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8TEQ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi14W → A: Abolishes interaction with U4 snRNA. No effect on interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. No effect on interaction with 80S ribosomes. 4 Publications1
Mutagenesisi15Y → A: Abolishes interaction with U4 snRNA. No effect on interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. No effect on interaction with 80S ribosomes. 4 Publications1
Mutagenesisi33R → A: Abolishes interaction with U4 snRNA. 1 Publication1
Mutagenesisi197E → A: Abolishes interaction with U4 snRNA. 1 Publication1
Mutagenesisi271 – 273KRR → AAA: No effect in interaction with U4 snRNA. No effect on interaction with SMN complex. 1 Publication3
Mutagenesisi286W → A: Abolishes interaction with U4 snRNA. Abolishes interaction with the 7-methylguanosine cap of RNA molecules. No effect on interaction with SMN complex. 2 Publications1
Mutagenesisi290H → A: No effect in interaction with U4 snRNA. No effect on interaction with SMN complex. 1 Publication1
Mutagenesisi335R → E: Abolishes interaction with U4 snRNA. 1 Publication1
Mutagenesisi359R → A: Abolishes interaction with U4 snRNA. 1 Publication1
Mutagenesisi381F → A: Strongly decreases interaction with U4 snRNA. No effect on interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. Abolishes interaction with 80S ribosomes. 3 Publications1
Mutagenesisi381F → D: Abolishes interaction with U4 snRNA. 1 Publication1
Mutagenesisi422W → E: Abolishes interaction with U4 snRNA. 1 Publication1
Mutagenesisi474Y → A: Abolishes interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. 2 Publications1
Mutagenesisi641K → A: Abolishes interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. 2 Publications1
Mutagenesisi660Y → A: Abolishes interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. 1 Publication1
Mutagenesisi684R → A: Abolishes interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. 1 Publication1

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000082516

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134945791

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GEMIN5

Domain mapping of disease mutations (DMDM)

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DMDMi
296439335

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000510041 – 1508Gem-associated protein 5Add BLAST1508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48PhosphoserineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei751PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki754Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei757PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei847PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TEQ6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TEQ6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TEQ6

PeptideAtlas

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PeptideAtlasi
Q8TEQ6

PRoteomics IDEntifications database

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PRIDEi
Q8TEQ6

ProteomicsDB human proteome resource

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ProteomicsDBi
74478

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8TEQ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TEQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000082516 Expressed in 183 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_GEMIN5

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TEQ6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA037392
HPA037393

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (PubMed:20513430, PubMed:27507887). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (PubMed:11714716, PubMed:20513430). Interacts directly with SMN1, SNRPB, SNRPD1, SNRPD2, SNRPD3 and SNRPE (PubMed:11714716). Identified in a SMN complex that contains GEMIN2/SIP1 (PubMed:19377484). Interacts with cytosolic DDX20/GEMIN3 and GEMIN4 (PubMed:19750007, PubMed:27507887). Interacts with SNRNP70 and HNRNPU (PubMed:27507887). Identified in a complex with 80S ribosomes; binds to the 60S large ribosomal subunit (PubMed:27507887). Interacts with the ribosomal subunits RPL3 and RPL4 (PubMed:27507887).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei33Interaction with U4 snRNACombined sources3 Publications1
Sitei284Interaction with U4 snRNACombined sources2 Publications1
Sitei335Interaction with U4 snRNACombined sources2 Publications1
Sitei359Interaction with U4 snRNACombined sources3 Publications1
Sitei381Interaction with U4 snRNACombined sources3 Publications1
Sitei422Interaction with U4 snRNACombined sources2 Publications1
Sitei426Interaction with U4 snRNACombined sources1 Publication1
Sitei470Interaction with U4 snRNACombined sources1 Publication1
Sitei474Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesCombined sources3 Publications1
Sitei556Interaction with U4 snRNACombined sources1 Publication1
Sitei579Interaction with U4 snRNACombined sources1 Publication1
Sitei641Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesCombined sources3 Publications1
Sitei660Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesCombined sources3 Publications1
Sitei684Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesCombined sources3 Publications1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117429, 87 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8TEQ6

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q8TEQ6

Protein interaction database and analysis system

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IntActi
Q8TEQ6, 46 interactors

Molecular INTeraction database

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MINTi
Q8TEQ6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000285873

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8TEQ6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TEQ6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 104WD 1Add BLAST43
Repeati107 – 148WD 2Add BLAST42
Repeati150 – 189WD 3Add BLAST40
Repeati193 – 264WD 4Add BLAST72
Repeati280 – 321WD 5Add BLAST42
Repeati333 – 374WD 6Add BLAST42
Repeati377 – 417WD 7Add BLAST41
Repeati424 – 464WD 8Add BLAST41
Repeati468 – 509WD 9Add BLAST42
Repeati533 – 573WD 10Add BLAST41
Repeati576 – 622WD 11Add BLAST47
Repeati637 – 677WD 12Add BLAST41
Repeati680 – 720WD 13Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 124Important for interaction with U1 snRNA1 PublicationAdd BLAST124
Regioni13 – 15Interaction with U4 snRNACombined sources3 Publications3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1362 – 1393Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi738 – 746Poly-Lys9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WD repeat domain mediates binding to U1 snRNA and to U4 snRNA (PubMed:19377484, PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601). The WD repeat domain also mediates binding to the 7-methylguanosine cap that is found both on mRNA and snRNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref. 25). The regions that bind snRNA molecules and the isolated 7-methylguanosine cap overlap at least partially (PubMed:27834343, PubMed:27881600, PubMed:27881601). Besides, the WD repeat domain mediates interaction with the 60S large ribosomal subunit (PubMed:27507887).7 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat gemin-5 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJDN Eukaryota
ENOG410XTH3 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00620000088064

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231391

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051721

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TEQ6

KEGG Orthology (KO)

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KOi
K13133

Identification of Orthologs from Complete Genome Data

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OMAi
ELHQDCL

Database of Orthologous Groups

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OrthoDBi
EOG091G03O1

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TEQ6

TreeFam database of animal gene trees

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TreeFami
TF328886

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024977 Apc4_WD40_dom
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF12894 ANAPC4_WD40, 2 hits
PF00400 WD40, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 12 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TEQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG
60 70 80 90 100
TPPFRVIGEL VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT
110 120 130 140 150
VVTEHALHQH TISTLHWSPR VKDLIVSGDE KGVVFCYWFN RNDSQHLFIE
160 170 180 190 200
PRTIFCLTCS PHHEDLVAIG YKDGIVVIID ISKKGEVIHR LRGHDDEIHS
210 220 230 240 250
IAWCPLPGED CLSINQEETS EEAEITNGNA VAQAPVTKGC YLATGSKDQT
260 270 280 290 300
IRIWSCSRGR GVMILKLPFL KRRGGGIDPT VKERLWLTLH WPSNQPTQLV
310 320 330 340 350
SSCFGGELLQ WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ
360 370 380 390 400
LLLSTSMDRD VKCWDIATLE CSWTLPSLGG FAYSLAFSSV DIGSLAIGVG
410 420 430 440 450
DGMIRVWNTL SIKNNYDVKN FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK
460 470 480 490 500
VGLYDTYSNK PPQISSTYHK KTVYTLAWGP PVPPMSLGGE GDRPSLALYS
510 520 530 540 550
CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT EISWKADGKI
560 570 580 590 600
MALGNEDGSI EIFQIPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM
610 620 630 640 650
ASGSNNAVIY VHNLKTVIES SPESPVTITE PYRTLSGHTA KITSVAWSPH
660 670 680 690 700
HDGRLVSASY DGTAQVWDAL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS
710 720 730 740 750
GADDFCVHKW LTSMQDHSRP PQGKKSIELE KKRLSQPKAK PKKKKKPTLR
760 770 780 790 800
TPVKLESIDG NEEESMKENS GPVENGVSDQ EGEEQAREPE LPCGLAPAVS
810 820 830 840 850
REPVICTPVS SGFEKSKVTI NNKVILLKKE PPKEKPETLI KKRKARSLLP
860 870 880 890 900
LSTSLDHRSK EELHQDCLVL ATAKHSRELN EDVSADVEER FHLGLFTDRA
910 920 930 940 950
TLYRMIDIEG KGHLENGHPE LFHQLMLWKG DLKGVLQTAA ERGELTDNLV
960 970 980 990 1000
AMAPAAGYHV WLWAVEAFAK QLCFQDQYVK AASHLLSIHK VYEAVELLKS
1010 1020 1030 1040 1050
NHFYREAIAI AKARLRPEDP VLKDLYLSWG TVLERDGHYA VAAKCYLGAT
1060 1070 1080 1090 1100
CAYDAAKVLA KKGDAASLRT AAELAAIVGE DELSASLALR CAQELLLANN
1110 1120 1130 1140 1150
WVGAQEALQL HESLQGQRLV FCLLELLSRH LEEKQLSEGK SSSSYHTWNT
1160 1170 1180 1190 1200
GTEGPFVERV TAVWKSIFSL DTPEQYQEAF QKLQNIKYPS ATNNTPAKQL
1210 1220 1230 1240 1250
LLHICHDLTL AVLSQQMASW DEAVQALLRA VVRSYDSGSF TIMQEVYSAF
1260 1270 1280 1290 1300
LPDGCDHLRD KLGDHQSPAT PAFKSLEAFF LYGRLYEFWW SLSRPCPNSS
1310 1320 1330 1340 1350
VWVRAGHRTL SVEPSQQLDT ASTEETDPET SQPEPNRPSE LDLRLTEEGE
1360 1370 1380 1390 1400
RMLSTFKELF SEKHASLQNS QRTVAEVQET LAEMIRQHQK SQLCKSTANG
1410 1420 1430 1440 1450
PDKNEPEVEA EQPLCSSQSQ CKEEKNEPLS LPELTKRLTE ANQRMAKFPE
1460 1470 1480 1490 1500
SIKAWPFPDV LECCLVLLLI RSHFPGCLAQ EMQQQAQELL QKYGNTKTYR

RHCQTFCM
Length:1,508
Mass (Da):168,589
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA5293F395BBF14E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84892 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti299L → P in BAB14222 (PubMed:14702039).Curated1
Sequence conflicti456T → A in BAB14222 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033807682R → Q5 PublicationsCorresponds to variant dbSNP:rs1974777Ensembl.1
Natural variantiVAR_0576041155P → S. Corresponds to variant dbSNP:rs6865950Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY063750 mRNA Translation: AAL38980.1
AK074066 mRNA Translation: BAB84892.2 Different initiation.
AC008421 Genomic DNA No translation available.
BC008776 mRNA Translation: AAH08776.2
BC014147 mRNA Translation: AAH14147.2
BC113614 mRNA Translation: AAI13615.1
AK022748 mRNA Translation: BAB14222.1
AL117665 mRNA Translation: CAB56035.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4330.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17345

NCBI Reference Sequences

More...
RefSeqi
NP_001239085.1, NM_001252156.1
NP_056280.2, NM_015465.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.483921

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000285873; ENSP00000285873; ENSG00000082516

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25929

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25929

UCSC genome browser

More...
UCSCi
uc003lvx.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY063750 mRNA Translation: AAL38980.1
AK074066 mRNA Translation: BAB84892.2 Different initiation.
AC008421 Genomic DNA No translation available.
BC008776 mRNA Translation: AAH08776.2
BC014147 mRNA Translation: AAH14147.2
BC113614 mRNA Translation: AAI13615.1
AK022748 mRNA Translation: BAB14222.1
AL117665 mRNA Translation: CAB56035.2
CCDSiCCDS4330.1
PIRiT17345
RefSeqiNP_001239085.1, NM_001252156.1
NP_056280.2, NM_015465.4
UniGeneiHs.483921

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GXHX-ray1.80A1-739[»]
5GXIX-ray1.85A1-739[»]
5H1JX-ray2.00A1-726[»]
5H1KX-ray1.90A/B1-726[»]
5H1LX-ray2.10A1-726[»]
5H1MX-ray2.49A1-726[»]
5H3SX-ray3.00A/B1-740[»]
5H3TX-ray2.57A/B/C/D1-740[»]
5H3UX-ray2.50A/B1-740[»]
5TEEX-ray1.65A1-739[»]
5TEFX-ray1.95A1-739[»]
5THAX-ray1.80A1-739[»]
ProteinModelPortaliQ8TEQ6
SMRiQ8TEQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117429, 87 interactors
CORUMiQ8TEQ6
ELMiQ8TEQ6
IntActiQ8TEQ6, 46 interactors
MINTiQ8TEQ6
STRINGi9606.ENSP00000285873

PTM databases

iPTMnetiQ8TEQ6
PhosphoSitePlusiQ8TEQ6

Polymorphism and mutation databases

BioMutaiGEMIN5
DMDMi296439335

Proteomic databases

EPDiQ8TEQ6
MaxQBiQ8TEQ6
PaxDbiQ8TEQ6
PeptideAtlasiQ8TEQ6
PRIDEiQ8TEQ6
ProteomicsDBi74478

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285873; ENSP00000285873; ENSG00000082516
GeneIDi25929
KEGGihsa:25929
UCSCiuc003lvx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25929
EuPathDBiHostDB:ENSG00000082516.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GEMIN5

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005347
HGNCiHGNC:20043 GEMIN5
HPAiHPA037392
HPA037393
MIMi607005 gene
neXtProtiNX_Q8TEQ6
OpenTargetsiENSG00000082516
PharmGKBiPA134945791

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJDN Eukaryota
ENOG410XTH3 LUCA
GeneTreeiENSGT00620000088064
HOGENOMiHOG000231391
HOVERGENiHBG051721
InParanoidiQ8TEQ6
KOiK13133
OMAiELHQDCL
OrthoDBiEOG091G03O1
PhylomeDBiQ8TEQ6
TreeFamiTF328886

Enzyme and pathway databases

ReactomeiR-HSA-191859 snRNP Assembly
SignaLinkiQ8TEQ6
SIGNORiQ8TEQ6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GEMIN5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GEMIN5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25929

Protein Ontology

More...
PROi
PR:Q8TEQ6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000082516 Expressed in 183 organ(s), highest expression level in oocyte
CleanExiHS_GEMIN5
GenevisibleiQ8TEQ6 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 2 hits
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 12 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGEMI5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEQ6
Secondary accession number(s): Q14CV0
, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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