UniProtKB - Q8TEQ6 (GEMI5_HUMAN)

BLAST

>sp|Q8TEQ6|GEMI5_HUMAN Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3
MGQEPRTLPPSPNWYCARCSDAVPGGLFGFAARTSVFLVRVGPGAGESPGTPPFRVIGEL
VGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPR
VKDLIVSGDEKGVVFCYWFNRNDSQHLFIEPRTIFCLTCSPHHEDLVAIGYKDGIVVIID
ISKKGEVIHRLRGHDDEIHSIAWCPLPGEDCLSINQEETSEEAEITNGNAVAQAPVTKGC
YLATGSKDQTIRIWSCSRGRGVMILKLPFLKRRGGGIDPTVKERLWLTLHWPSNQPTQLV
SSCFGGELLQWDLTQSWRRKYTLFSASSEGQNHSRIVFNLCPLQTEDDKQLLLSTSMDRD
VKCWDIATLECSWTLPSLGGFAYSLAFSSVDIGSLAIGVGDGMIRVWNTLSIKNNYDVKN
FWQGVKSKVTALCWHPTKEGCLAFGTDDGKVGLYDTYSNKPPQISSTYHKKTVYTLAWGP
PVPPMSLGGEGDRPSLALYSCGGEGIVLQHNPWKLSGEAFDINKLIRDTNSIKYKLPVHT
EISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISWHHEHGSQPELSYLM
ASGSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAKITSVAWSPHHDGRLVSASY
DGTAQVWDALREEPLCNFRGHRGRLLCVAWSPLDPDCIYSGADDFCVHKWLTSMQDHSRP
PQGKKSIELEKKRLSQPKAKPKKKKKPTLRTPVKLESIDGNEEESMKENSGPVENGVSDQ
EGEEQAREPELPCGLAPAVSREPVICTPVSSGFEKSKVTINNKVILLKKEPPKEKPETLI
KKRKARSLLPLSTSLDHRSKEELHQDCLVLATAKHSRELNEDVSADVEERFHLGLFTDRA
TLYRMIDIEGKGHLENGHPELFHQLMLWKGDLKGVLQTAAERGELTDNLVAMAPAAGYHV
WLWAVEAFAKQLCFQDQYVKAASHLLSIHKVYEAVELLKSNHFYREAIAIAKARLRPEDP
VLKDLYLSWGTVLERDGHYAVAAKCYLGATCAYDAAKVLAKKGDAASLRTAAELAAIVGE
DELSASLALRCAQELLLANNWVGAQEALQLHESLQGQRLVFCLLELLSRHLEEKQLSEGK
SSSSYHTWNTGTEGPFVERVTAVWKSIFSLDTPEQYQEAFQKLQNIKYPSATNNTPAKQL
LLHICHDLTLAVLSQQMASWDEAVQALLRAVVRSYDSGSFTIMQEVYSAFLPDGCDHLRD
KLGDHQSPATPAFKSLEAFFLYGRLYEFWWSLSRPCPNSSVWVRAGHRTLSVEPSQQLDT
ASTEETDPETSQPEPNRPSELDLRLTEEGERMLSTFKELFSEKHASLQNSQRTVAEVQET
LAEMIRQHQKSQLCKSTANGPDKNEPEVEAEQPLCSSQSQCKEEKNEPLSLPELTKRLTE
ANQRMAKFPESIKAWPFPDVLECCLVLLLIRSHFPGCLAQEMQQQAQELLQKYGNTKTYR
RHCQTFCM

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History
Entry version 164 (10 Oct 2018)
Sequence version 3 (18 May 2010)
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Protein

Gem-associated protein 5

Gene

GEMIN5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:16857593, PubMed:18984161, PubMed:20513430). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:18984161). GEMIN5 acts as the snRNA-binding protein of the SMN complex (PubMed:11714716, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref. 25). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887).12 Publications

GO - Molecular functionⁱ

mRNA 3'-UTR binding
Source: UniProtKB
Inferred from direct assayⁱ
- 25911097
ribosome binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27507887
RNA 7-methylguanosine cap binding
Source: UniProtKB
Inferred from direct assayⁱ
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
snRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16857593
U1 snRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
U4atac snRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20513430
U4 snRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19377484
- 27881601

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

import into nucleus Source: Reactome
mRNA splicing, via spliceosome
Source: UniProtKB
Traceable author statementⁱ
- 11714716
protein-containing complex assembly
Source: UniProtKB
Traceable author statementⁱ
- 11714716
regulation of translation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25911097
- 27507887
spliceosomal snRNP assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 18984161
translation Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing, Protein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-191859 snRNP Assembly
SignaLinkⁱ	Q8TEQ6
SIGNORⁱ	Q8TEQ6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gem-associated protein 5 Short name: Gemin5
Gene namesⁱ	Name:GEMIN5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000082516.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20043 GEMIN5
MIMⁱ	607005 gene
neXtProtⁱ	NX_Q8TEQ6

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	14	W → A: Abolishes interaction with U4 snRNA. No effect on interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. No effect on interaction with 80S ribosomes. 4 Publications	1
Mutagenesisⁱ	15	Y → A: Abolishes interaction with U4 snRNA. No effect on interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. No effect on interaction with 80S ribosomes. 4 Publications	1
Mutagenesisⁱ	33	R → A: Abolishes interaction with U4 snRNA. 1 Publication	1
Mutagenesisⁱ	197	E → A: Abolishes interaction with U4 snRNA. 1 Publication	1
Mutagenesisⁱ	271 – 273	KRR → AAA: No effect in interaction with U4 snRNA. No effect on interaction with SMN complex. 1 Publication	3
Mutagenesisⁱ	286	W → A: Abolishes interaction with U4 snRNA. Abolishes interaction with the 7-methylguanosine cap of RNA molecules. No effect on interaction with SMN complex. 2 Publications	1
Mutagenesisⁱ	290	H → A: No effect in interaction with U4 snRNA. No effect on interaction with SMN complex. 1 Publication	1
Mutagenesisⁱ	335	R → E: Abolishes interaction with U4 snRNA. 1 Publication	1
Mutagenesisⁱ	359	R → A: Abolishes interaction with U4 snRNA. 1 Publication	1
Mutagenesisⁱ	381	F → A: Strongly decreases interaction with U4 snRNA. No effect on interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. Abolishes interaction with 80S ribosomes. 3 Publications	1
Mutagenesisⁱ	381	F → D: Abolishes interaction with U4 snRNA. 1 Publication	1
Mutagenesisⁱ	422	W → E: Abolishes interaction with U4 snRNA. 1 Publication	1
Mutagenesisⁱ	474	Y → A: Abolishes interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. 2 Publications	1
Mutagenesisⁱ	641	K → A: Abolishes interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. 2 Publications	1
Mutagenesisⁱ	660	Y → A: Abolishes interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. 1 Publication	1
Mutagenesisⁱ	684	R → A: Abolishes interaction with the isolated 7-methylguanosine cap that is normally part of RNA molecules. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000082516
PharmGKBⁱ	PA134945791

Polymorphism and mutation databases

BioMutaⁱ	GEMIN5
DMDMⁱ	296439335

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051004	1 – 1508	Gem-associated protein 5Add BLAST		1508

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	48	PhosphoserineCombined sources	1
Modified residueⁱ	51	PhosphothreonineCombined sources	1
Modified residueⁱ	624	PhosphoserineCombined sources	1
Modified residueⁱ	751	PhosphothreonineCombined sources	1
Cross-linkⁱ	754	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	757	PhosphoserineCombined sources	1
Modified residueⁱ	770	PhosphoserineCombined sources	1
Modified residueⁱ	778	PhosphoserineCombined sources	1
Modified residueⁱ	847	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8TEQ6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TEQ6
PaxDbⁱ	Q8TEQ6
PeptideAtlas More...PeptideAtlasⁱ	Q8TEQ6
PRIDEⁱ	Q8TEQ6
ProteomicsDBⁱ	74478

PTM databases

iPTMnetⁱ	Q8TEQ6
PhosphoSitePlusⁱ	Q8TEQ6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000082516 Expressed in 183 organ(s), highest expression level in oocyte
CleanExⁱ	HS_GEMIN5
Genevisibleⁱ	Q8TEQ6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037392 HPA037393

HPAⁱ

HPA037392
HPA037393

Interactionⁱ

Subunit structureⁱ

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (PubMed:20513430, PubMed:27507887). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (PubMed:11714716, PubMed:20513430). Interacts directly with SMN1, SNRPB, SNRPD1, SNRPD2, SNRPD3 and SNRPE (PubMed:11714716). Identified in a SMN complex that contains GEMIN2/SIP1 (PubMed:19377484). Interacts with cytosolic DDX20/GEMIN3 and GEMIN4 (PubMed:19750007, PubMed:27507887). Interacts with SNRNP70 and HNRNPU (PubMed:27507887). Identified in a complex with 80S ribosomes; binds to the 60S large ribosomal subunit (PubMed:27507887). Interacts with the ribosomal subunits RPL3 and RPL4 (PubMed:27507887).6 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	33	Interaction with U4 snRNACombined sources3 Publications	1
Siteⁱ	284	Interaction with U4 snRNACombined sources2 Publications	1
Siteⁱ	335	Interaction with U4 snRNACombined sources2 Publications	1
Siteⁱ	359	Interaction with U4 snRNACombined sources3 Publications	1
Siteⁱ	381	Interaction with U4 snRNACombined sources3 Publications	1
Siteⁱ	422	Interaction with U4 snRNACombined sources2 Publications	1
Siteⁱ	426	Interaction with U4 snRNACombined sources1 Publication	1
Siteⁱ	470	Interaction with U4 snRNACombined sources1 Publication	1
Siteⁱ	474	Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesCombined sources3 Publications	1
Siteⁱ	556	Interaction with U4 snRNACombined sources1 Publication	1
Siteⁱ	579	Interaction with U4 snRNACombined sources1 Publication	1
Siteⁱ	641	Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesCombined sources3 Publications	1
Siteⁱ	660	Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesCombined sources3 Publications	1
Siteⁱ	684	Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesCombined sources3 Publications	1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EIF4E	P06730	3	EBI-443630,EBI-73440
SMN2	Q16637	7	EBI-443630,EBI-395421
SNRPE	P62304	2	EBI-443630,EBI-348082

Protein-protein interaction databases

BioGridⁱ	117429, 87 interactors
CORUMⁱ	Q8TEQ6
ELMⁱ	Q8TEQ6
IntActⁱ	Q8TEQ6, 46 interactors
Molecular INTeraction database More...MINTⁱ	Q8TEQ6
STRINGⁱ	9606.ENSP00000285873

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 8	Combined sources	3
Beta strandⁱ	19 – 23	Combined sources	5
Turnⁱ	24 – 26	Combined sources	3
Beta strandⁱ	27 – 32	Combined sources	6
Beta strandⁱ	35 – 42	Combined sources	8
Helixⁱ	43 – 45	Combined sources	3
Beta strandⁱ	49 – 51	Combined sources	3
Beta strandⁱ	53 – 60	Combined sources	8
Beta strandⁱ	67 – 72	Combined sources	6
Beta strandⁱ	81 – 86	Combined sources	6
Turnⁱ	87 – 89	Combined sources	3
Beta strandⁱ	91 – 95	Combined sources	5
Turnⁱ	96 – 99	Combined sources	4
Beta strandⁱ	100 – 105	Combined sources	6
Beta strandⁱ	112 – 117	Combined sources	6
Beta strandⁱ	119 – 121	Combined sources	3
Beta strandⁱ	124 – 129	Combined sources	6
Beta strandⁱ	132 – 138	Combined sources	7
Helixⁱ	139 – 141	Combined sources	3
Beta strandⁱ	143 – 148	Combined sources	6
Beta strandⁱ	154 – 159	Combined sources	6
Beta strandⁱ	166 – 171	Combined sources	6
Beta strandⁱ	176 – 180	Combined sources	5
Helixⁱ	181 – 183	Combined sources	3
Beta strandⁱ	187 – 191	Combined sources	5
Beta strandⁱ	198 – 203	Combined sources	6
Beta strandⁱ	205 – 207	Combined sources	3
Beta strandⁱ	208 – 212	Combined sources	5
Beta strandⁱ	241 – 246	Combined sources	6
Beta strandⁱ	249 – 255	Combined sources	7
Turnⁱ	256 – 259	Combined sources	4
Beta strandⁱ	260 – 266	Combined sources	7
Beta strandⁱ	279 – 281	Combined sources	3
Beta strandⁱ	298 – 302	Combined sources	5
Helixⁱ	304 – 306	Combined sources	3
Beta strandⁱ	308 – 312	Combined sources	5
Turnⁱ	314 – 319	Combined sources	6
Beta strandⁱ	320 – 323	Combined sources	4
Turnⁱ	324 – 327	Combined sources	4
Beta strandⁱ	328 – 330	Combined sources	3
Beta strandⁱ	337 – 345	Combined sources	9
Beta strandⁱ	350 – 356	Combined sources	7
Beta strandⁱ	359 – 365	Combined sources	7
Turnⁱ	366 – 368	Combined sources	3
Beta strandⁱ	371 – 376	Combined sources	6
Beta strandⁱ	378 – 380	Combined sources	3
Beta strandⁱ	382 – 387	Combined sources	6
Beta strandⁱ	389 – 391	Combined sources	3
Beta strandⁱ	394 – 399	Combined sources	6
Beta strandⁱ	404 – 408	Combined sources	5
Beta strandⁱ	418 – 421	Combined sources	4
Turnⁱ	423 – 425	Combined sources	3
Beta strandⁱ	429 – 434	Combined sources	6
Beta strandⁱ	436 – 438	Combined sources	3
Beta strandⁱ	441 – 446	Combined sources	6
Beta strandⁱ	451 – 455	Combined sources	5
Beta strandⁱ	458 – 460	Combined sources	3
Beta strandⁱ	463 – 468	Combined sources	6
Beta strandⁱ	473 – 479	Combined sources	7
Helixⁱ	485 – 487	Combined sources	3
Turnⁱ	490 – 492	Combined sources	3
Beta strandⁱ	497 – 502	Combined sources	6
Beta strandⁱ	507 – 510	Combined sources	4
Helixⁱ	512 – 514	Combined sources	3
Beta strandⁱ	519 – 521	Combined sources	3
Helixⁱ	523 – 530	Combined sources	8
Beta strandⁱ	539 – 544	Combined sources	6
Beta strandⁱ	548 – 555	Combined sources	8
Beta strandⁱ	560 – 564	Combined sources	5
Turnⁱ	565 – 568	Combined sources	4
Beta strandⁱ	569 – 574	Combined sources	6
Beta strandⁱ	581 – 586	Combined sources	6
Beta strandⁱ	591 – 593	Combined sources	3
Helixⁱ	594 – 598	Combined sources	5
Beta strandⁱ	599 – 607	Combined sources	9
Beta strandⁱ	609 – 613	Combined sources	5
Helixⁱ	615 – 620	Combined sources	6
Beta strandⁱ	626 – 628	Combined sources	3
Beta strandⁱ	632 – 635	Combined sources	4
Beta strandⁱ	642 – 647	Combined sources	6
Beta strandⁱ	651 – 659	Combined sources	9
Beta strandⁱ	664 – 668	Combined sources	5
Helixⁱ	669 – 671	Combined sources	3
Beta strandⁱ	673 – 678	Combined sources	6
Beta strandⁱ	685 – 690	Combined sources	6
Beta strandⁱ	697 – 702	Combined sources	6
Beta strandⁱ	707 – 711	Combined sources	5
Helixⁱ	712 – 714	Combined sources	3
Beta strandⁱ	717 – 719	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8TEQ6
SMRⁱ	Q8TEQ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	62 – 104	WD 1Add BLAST	43
Repeatⁱ	107 – 148	WD 2Add BLAST	42
Repeatⁱ	150 – 189	WD 3Add BLAST	40
Repeatⁱ	193 – 264	WD 4Add BLAST	72
Repeatⁱ	280 – 321	WD 5Add BLAST	42
Repeatⁱ	333 – 374	WD 6Add BLAST	42
Repeatⁱ	377 – 417	WD 7Add BLAST	41
Repeatⁱ	424 – 464	WD 8Add BLAST	41
Repeatⁱ	468 – 509	WD 9Add BLAST	42
Repeatⁱ	533 – 573	WD 10Add BLAST	41
Repeatⁱ	576 – 622	WD 11Add BLAST	47
Repeatⁱ	637 – 677	WD 12Add BLAST	41
Repeatⁱ	680 – 720	WD 13Add BLAST	41

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 124	Important for interaction with U1 snRNA1 PublicationAdd BLAST		124
Regionⁱ	13 – 15	Interaction with U4 snRNACombined sources3 Publications		3

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1362 – 1393	Sequence analysisAdd BLAST		32

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	738 – 746	Poly-Lys		9

Domainⁱ

The WD repeat domain mediates binding to U1 snRNA and to U4 snRNA (PubMed:19377484, PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601). The WD repeat domain also mediates binding to the 7-methylguanosine cap that is found both on mRNA and snRNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref. 25). The regions that bind snRNA molecules and the isolated 7-methylguanosine cap overlap at least partially (PubMed:27834343, PubMed:27881600, PubMed:27881601). Besides, the WD repeat domain mediates interaction with the 60S large ribosomal subunit (PubMed:27507887).7 Publications

Sequence similaritiesⁱ

Belongs to the WD repeat gemin-5 family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IJDN Eukaryota ENOG410XTH3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00620000088064
HOGENOMⁱ	HOG000231391
HOVERGENⁱ	HBG051721
InParanoidⁱ	Q8TEQ6
KEGG Orthology (KO) More...KOⁱ	K13133
OMAⁱ	AKQLCFQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03O1
PhylomeDBⁱ	Q8TEQ6
TreeFamⁱ	TF328886

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR024977 Apc4_WD40_dom IPR020472 G-protein_beta_WD-40_rep IPR011047 Quinoprotein_ADH-like_supfam IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12894 ANAPC4_WD40, 2 hits PF00400 WD40, 3 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 12 hits
SUPFAMⁱ	SSF50978 SSF50978, 2 hits SSF50998 SSF50998, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 3 hits PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8TEQ6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG 
        60         70         80         90        100
TPPFRVIGEL VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT 
       110        120        130        140        150
VVTEHALHQH TISTLHWSPR VKDLIVSGDE KGVVFCYWFN RNDSQHLFIE 
       160        170        180        190        200
PRTIFCLTCS PHHEDLVAIG YKDGIVVIID ISKKGEVIHR LRGHDDEIHS 
       210        220        230        240        250
IAWCPLPGED CLSINQEETS EEAEITNGNA VAQAPVTKGC YLATGSKDQT 
       260        270        280        290        300
IRIWSCSRGR GVMILKLPFL KRRGGGIDPT VKERLWLTLH WPSNQPTQLV 
       310        320        330        340        350
SSCFGGELLQ WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ 
       360        370        380        390        400
LLLSTSMDRD VKCWDIATLE CSWTLPSLGG FAYSLAFSSV DIGSLAIGVG 
       410        420        430        440        450
DGMIRVWNTL SIKNNYDVKN FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK 
       460        470        480        490        500
VGLYDTYSNK PPQISSTYHK KTVYTLAWGP PVPPMSLGGE GDRPSLALYS 
       510        520        530        540        550
CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT EISWKADGKI 
       560        570        580        590        600
MALGNEDGSI EIFQIPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM 
       610        620        630        640        650
ASGSNNAVIY VHNLKTVIES SPESPVTITE PYRTLSGHTA KITSVAWSPH 
       660        670        680        690        700
HDGRLVSASY DGTAQVWDAL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS 
       710        720        730        740        750
GADDFCVHKW LTSMQDHSRP PQGKKSIELE KKRLSQPKAK PKKKKKPTLR 
       760        770        780        790        800
TPVKLESIDG NEEESMKENS GPVENGVSDQ EGEEQAREPE LPCGLAPAVS 
       810        820        830        840        850
REPVICTPVS SGFEKSKVTI NNKVILLKKE PPKEKPETLI KKRKARSLLP 
       860        870        880        890        900
LSTSLDHRSK EELHQDCLVL ATAKHSRELN EDVSADVEER FHLGLFTDRA 
       910        920        930        940        950
TLYRMIDIEG KGHLENGHPE LFHQLMLWKG DLKGVLQTAA ERGELTDNLV 
       960        970        980        990       1000
AMAPAAGYHV WLWAVEAFAK QLCFQDQYVK AASHLLSIHK VYEAVELLKS 
      1010       1020       1030       1040       1050
NHFYREAIAI AKARLRPEDP VLKDLYLSWG TVLERDGHYA VAAKCYLGAT 
      1060       1070       1080       1090       1100
CAYDAAKVLA KKGDAASLRT AAELAAIVGE DELSASLALR CAQELLLANN 
      1110       1120       1130       1140       1150
WVGAQEALQL HESLQGQRLV FCLLELLSRH LEEKQLSEGK SSSSYHTWNT 
      1160       1170       1180       1190       1200
GTEGPFVERV TAVWKSIFSL DTPEQYQEAF QKLQNIKYPS ATNNTPAKQL 
      1210       1220       1230       1240       1250
LLHICHDLTL AVLSQQMASW DEAVQALLRA VVRSYDSGSF TIMQEVYSAF 
      1260       1270       1280       1290       1300
LPDGCDHLRD KLGDHQSPAT PAFKSLEAFF LYGRLYEFWW SLSRPCPNSS 
      1310       1320       1330       1340       1350
VWVRAGHRTL SVEPSQQLDT ASTEETDPET SQPEPNRPSE LDLRLTEEGE 
      1360       1370       1380       1390       1400
RMLSTFKELF SEKHASLQNS QRTVAEVQET LAEMIRQHQK SQLCKSTANG 
      1410       1420       1430       1440       1450
PDKNEPEVEA EQPLCSSQSQ CKEEKNEPLS LPELTKRLTE ANQRMAKFPE 
      1460       1470       1480       1490       1500
SIKAWPFPDV LECCLVLLLI RSHFPGCLAQ EMQQQAQELL QKYGNTKTYR 

RHCQTFCM

Length:1,508

Mass (Da):168,589

Last modified:May 18, 2010 - v3

Checksum:ⁱEA5293F395BBF14E

Sequence cautionⁱ

The sequence BAB84892 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	299	L → P in BAB14222 (PubMed:14702039).Curated		1
Sequence conflictⁱ	456	T → A in BAB14222 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033807	682	R → Q5 PublicationsCorresponds to variant dbSNP:rs1974777Ensembl.		1
Natural variantⁱVAR_057604	1155	P → S. Corresponds to variant dbSNP:rs6865950Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY063750 mRNA Translation: AAL38980.1 AK074066 mRNA Translation: BAB84892.2 Different initiation. AC008421 Genomic DNA No translation available. BC008776 mRNA Translation: AAH08776.2 BC014147 mRNA Translation: AAH14147.2 BC113614 mRNA Translation: AAI13615.1 AK022748 mRNA Translation: BAB14222.1 AL117665 mRNA Translation: CAB56035.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4330.1
PIRⁱ	T17345
NCBI Reference Sequences More...RefSeqⁱ	NP_001239085.1, NM_001252156.1 NP_056280.2, NM_015465.4
UniGeneⁱ	Hs.483921

Genome annotation databases

Ensemblⁱ	ENST00000285873; ENSP00000285873; ENSG00000082516
GeneIDⁱ	25929
KEGGⁱ	hsa:25929
UCSC genome browser More...UCSCⁱ	uc003lvx.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TEQ6	GEMIN5 protein (Fragment)		HUMAN		746	UniRef100_Q8TEQ6
UPI0009468C8F		HUMAN		740

Protein	Similar proteins		Species	Score	Length	Source
Q8TEQ6	GEMIN5 protein (Fragment)		HUMAN		746	UniRef90_Q8TEQ6
Gem nuclear organelle associated protein 5		CALJA		1523
Uncharacterized protein		MACMU		1512
Uncharacterized protein		COLAP		1512
Uncharacterized protein		CHLSB		1512
+36

Protein	Similar proteins		Species	Score	Length	Source
Q8TEQ6	Gem-associated protein 5		MOUSE		1502	UniRef50_Q8TEQ6
GEMIN5 protein (Fragment)		HUMAN		746
Gem nuclear organelle associated protein 5		CALJA		1523
Uncharacterized protein		MACMU		1512
Uncharacterized protein		COLAP		1512
+267

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY063750 mRNA Translation: AAL38980.1 AK074066 mRNA Translation: BAB84892.2 Different initiation. AC008421 Genomic DNA No translation available. BC008776 mRNA Translation: AAH08776.2 BC014147 mRNA Translation: AAH14147.2 BC113614 mRNA Translation: AAI13615.1 AK022748 mRNA Translation: BAB14222.1 AL117665 mRNA Translation: CAB56035.2
CCDSⁱ	CCDS4330.1
PIRⁱ	T17345
RefSeqⁱ	NP_001239085.1, NM_001252156.1 NP_056280.2, NM_015465.4
UniGeneⁱ	Hs.483921

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5GXH	X-ray	1.80	A	1-739	[»]
	5GXI	X-ray	1.85	A	1-739	[»]
	5H1J	X-ray	2.00	A	1-726	[»]
	5H1K	X-ray	1.90	A/B	1-726	[»]
	5H1L	X-ray	2.10	A	1-726	[»]
	5H1M	X-ray	2.49	A	1-726	[»]
	5H3S	X-ray	3.00	A/B	1-740	[»]
	5H3T	X-ray	2.57	A/B/C/D	1-740	[»]
	5H3U	X-ray	2.50	A/B	1-740	[»]
	5TEE	X-ray	1.65	A	1-739	[»]
	5TEF	X-ray	1.95	A	1-739	[»]
	5THA	X-ray	1.80	A	1-739	[»]
ProteinModelPortalⁱ	Q8TEQ6
SMRⁱ	Q8TEQ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117429, 87 interactors
CORUMⁱ	Q8TEQ6
ELMⁱ	Q8TEQ6
IntActⁱ	Q8TEQ6, 46 interactors
MINTⁱ	Q8TEQ6
STRINGⁱ	9606.ENSP00000285873

PTM databases

iPTMnetⁱ	Q8TEQ6
PhosphoSitePlusⁱ	Q8TEQ6

Polymorphism and mutation databases

BioMutaⁱ	GEMIN5
DMDMⁱ	296439335

Proteomic databases

EPDⁱ	Q8TEQ6
MaxQBⁱ	Q8TEQ6
PaxDbⁱ	Q8TEQ6
PeptideAtlasⁱ	Q8TEQ6
PRIDEⁱ	Q8TEQ6
ProteomicsDBⁱ	74478

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000285873; ENSP00000285873; ENSG00000082516
GeneIDⁱ	25929
KEGGⁱ	hsa:25929
UCSCⁱ	uc003lvx.4 human

Organism-specific databases

CTDⁱ	25929
EuPathDBⁱ	HostDB:ENSG00000082516.8
GeneCardsⁱ	GEMIN5
H-InvDBⁱ	HIX0005347
HGNCⁱ	HGNC:20043 GEMIN5
HPAⁱ	HPA037392 HPA037393
MIMⁱ	607005 gene
neXtProtⁱ	NX_Q8TEQ6
OpenTargetsⁱ	ENSG00000082516
PharmGKBⁱ	PA134945791
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJDN Eukaryota ENOG410XTH3 LUCA
GeneTreeⁱ	ENSGT00620000088064
HOGENOMⁱ	HOG000231391
HOVERGENⁱ	HBG051721
InParanoidⁱ	Q8TEQ6
KOⁱ	K13133
OMAⁱ	AKQLCFQ
OrthoDBⁱ	EOG091G03O1
PhylomeDBⁱ	Q8TEQ6
TreeFamⁱ	TF328886

Enzyme and pathway databases

Reactomeⁱ	R-HSA-191859 snRNP Assembly
SignaLinkⁱ	Q8TEQ6
SIGNORⁱ	Q8TEQ6

Miscellaneous databases

ChiTaRSⁱ	GEMIN5 human
GeneWikiⁱ	GEMIN5
GenomeRNAiⁱ	25929
Protein Ontology More...PROⁱ	PR:Q8TEQ6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000082516 Expressed in 183 organ(s), highest expression level in oocyte
CleanExⁱ	HS_GEMIN5
Genevisibleⁱ	Q8TEQ6 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR024977 Apc4_WD40_dom IPR020472 G-protein_beta_WD-40_rep IPR011047 Quinoprotein_ADH-like_supfam IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF12894 ANAPC4_WD40, 2 hits PF00400 WD40, 3 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 12 hits
SUPFAMⁱ	SSF50978 SSF50978, 2 hits SSF50998 SSF50998, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 3 hits PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GEMI5_HUMAN
Accessionⁱ	Q8TEQ6Primary (citable) accession number: Q8TEQ6 Secondary accession number(s): Q14CV0 , Q8WWV4, Q969W4, Q9H9K3, Q9UFI5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
	Last sequence update:	May 18, 2010
	Last modified:	October 10, 2018
	This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8TEQ6 (GEMI5_HUMAN)

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Gem-associated protein 5

GEMIN5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

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Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Proteomic databases

Protocols and materials databases

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Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ