UniProtKB - Q8TEQ0 (SNX29_HUMAN)
Protein
Sorting nexin-29
Gene
SNX29
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- phosphatidylinositol binding Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q8TEQ0 |
Names & Taxonomyi
Protein namesi | Recommended name: Sorting nexin-29Alternative name(s): RUN domain-containing protein 2A |
Gene namesi | Name:SNX29 Synonyms:RUNDC2A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000048471.13 |
HGNCi | HGNC:30542, SNX29 |
neXtProti | NX_Q8TEQ0 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 92017 |
OpenTargetsi | ENSG00000048471 |
PharmGKBi | PA162404312 |
Miscellaneous databases
Pharosi | Q8TEQ0, Tdark |
Polymorphism and mutation databases
BioMutai | SNX29 |
DMDMi | 353526314 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297565 | 1 – 813 | Sorting nexin-29Add BLAST | 813 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 268 | PhosphoserineCombined sources | 1 | |
Modified residuei | 291 | PhosphoserineBy similarity | 1 | |
Modified residuei | 292 | PhosphoserineBy similarity | 1 | |
Modified residuei | 330 | PhosphoserineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineBy similarity | 1 | |
Modified residuei | 445 | PhosphoserineBy similarity | 1 | |
Modified residuei | 450 | PhosphoserineBy similarity | 1 | |
Modified residuei | 639 | PhosphoserineBy similarity | 1 | |
Modified residuei | 641 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 642 | PhosphoserineBy similarity | 1 | |
Modified residuei | 646 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8TEQ0 |
jPOSTi | Q8TEQ0 |
MassIVEi | Q8TEQ0 |
MaxQBi | Q8TEQ0 |
PaxDbi | Q8TEQ0 |
PeptideAtlasi | Q8TEQ0 |
PRIDEi | Q8TEQ0 |
ProteomicsDBi | 74476 [Q8TEQ0-1] 74477 [Q8TEQ0-2] |
PTM databases
iPTMneti | Q8TEQ0 |
PhosphoSitePlusi | Q8TEQ0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000048471, Expressed in sural nerve and 207 other tissues |
ExpressionAtlasi | Q8TEQ0, baseline and differential |
Genevisiblei | Q8TEQ0, HS |
Organism-specific databases
HPAi | ENSG00000048471, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124903, 14 interactors |
IntActi | Q8TEQ0, 10 interactors |
STRINGi | 9606.ENSP00000456480 |
Miscellaneous databases
RNActi | Q8TEQ0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 180 | RUNPROSITE-ProRule annotationAdd BLAST | 145 | |
Domaini | 656 – 779 | PXPROSITE-ProRule annotationAdd BLAST | 124 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 466 – 545 | Sequence analysisAdd BLAST | 80 |
Sequence similaritiesi
Belongs to the sorting nexin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2101, Eukaryota KOG4381, Eukaryota |
GeneTreei | ENSGT00730000110975 |
HOGENOMi | CLU_020563_1_0_1 |
InParanoidi | Q8TEQ0 |
OMAi | HEQERFS |
OrthoDBi | 543799at2759 |
Family and domain databases
CDDi | cd07277, PX_RUN, 1 hit |
Gene3Di | 1.20.58.900, 1 hit 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR001683, PX_dom IPR036871, PX_dom_sf IPR004012, Run_dom IPR037213, Run_dom_sf IPR037916, SNX29_PX |
Pfami | View protein in Pfam PF00787, PX, 1 hit PF02759, RUN, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit SM00593, RUN, 1 hit |
SUPFAMi | SSF140741, SSF140741, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit PS50826, RUN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TEQ0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGSQNNDKR QFLLERLLDA VKQCQIRFGG RKEIASDSDS RVTCLCAQFE
60 70 80 90 100
AVLQHGLKRS RGLALTAAAI KQAAGFASKT ETEPVFWYYV KEVLNKHELQ
110 120 130 140 150
RFYSLRHIAS DVGRGRAWLR CALNEHSLER YLHMLLADRC RLSTFYEDWS
160 170 180 190 200
FVMDEERSSM LPTMAAGLNS ILFAINIDNK DLNGQSKFAP TVSDLLKEST
210 220 230 240 250
QNVTSLLKES TQGVSSLFRE ITASSAVSIL IKPEQETDPL PVVSRNVSAD
260 270 280 290 300
AKCKKERKKK KKVTNIISFD DEEDEQNSGD VFKKTPGAGE SSEDNSDRSS
310 320 330 340 350
VNIMSAFESP FGPNSNGSQS SNSWKIDSLS LNGEFGYQKL DVKSIDDEDV
360 370 380 390 400
DENEDDVYGN SSGRKHRGHS ESPEKPLEGN TCLSQMHSWA PLKVLHNDSD
410 420 430 440 450
ILFPVSGVGS YSPADAPLGS LENGTGPEDH VLPDPGLRYS VEASSPGHGS
460 470 480 490 500
PLSSLLPSAS VPESMTISEL RQATVAMMNR KDELEEENRS LRNLLDGEME
510 520 530 540 550
HSAALRQEVD TLKRKVAEQE ERQGMKVQAL ARENEVLKVQ LKKYVGAVQM
560 570 580 590 600
LKREGQTAEV PNLWSVDGEV TVAEQKPGEI AEELASSYER KLIEVAEMHG
610 620 630 640 650
ELIEFNERLH RALVAKEALV SQMRQELIDL RGPVPGDLSQ TSEDQSLSDF
660 670 680 690 700
EISNRALINV WIPSVFLRGK AANAFHVYQV YIRIKDDEWN IYRRYTEFRS
710 720 730 740 750
LHHKLQNKYP QVRAYNFPPK KAIGNKDAKF VEERRKQLQN YLRSVMNKVI
760 770 780 790 800
QMVPEFAASP KKETLIQLMP FFVDITPPGE PVNSRPKAAS RFPKLSRGQP
810
RETRNVEPQS GDL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGM3 | A0A0C4DGM3_HUMAN | Sorting nexin-29 | SNX29 | 282 | Annotation score: | ||
H3BQF0 | H3BQF0_HUMAN | Sorting nexin-29 | SNX29 | 175 | Annotation score: | ||
H3BT98 | H3BT98_HUMAN | Sorting nexin-29 | SNX29 | 96 | Annotation score: | ||
H3BPI1 | H3BPI1_HUMAN | Sorting nexin-29 | SNX29 | 69 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 183 | N → D in BAB14033 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 344 | S → G in BAB14033 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027281 | 775 – 813 | ITPPG…QSGDL → WISLFGNGRDSSREEFSSS in isoform 2. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007216 Genomic DNA No translation available. AC007598 Genomic DNA No translation available. AC007601 Genomic DNA No translation available. AC010333 Genomic DNA No translation available. AC092365 Genomic DNA No translation available. AC131391 Genomic DNA No translation available. AK022425 mRNA Translation: BAB14033.1 Sequence problems. AK074072 mRNA Translation: BAB84898.1 BC029857 mRNA Translation: AAH29857.1 |
CCDSi | CCDS10553.2 [Q8TEQ0-1] |
RefSeqi | NP_115543.3, NM_032167.4 [Q8TEQ0-1] |
Genome annotation databases
Ensembli | ENST00000566228; ENSP00000456480; ENSG00000048471 [Q8TEQ0-1] |
GeneIDi | 92017 |
KEGGi | hsa:92017 |
UCSCi | uc002dby.6, human [Q8TEQ0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007216 Genomic DNA No translation available. AC007598 Genomic DNA No translation available. AC007601 Genomic DNA No translation available. AC010333 Genomic DNA No translation available. AC092365 Genomic DNA No translation available. AC131391 Genomic DNA No translation available. AK022425 mRNA Translation: BAB14033.1 Sequence problems. AK074072 mRNA Translation: BAB84898.1 BC029857 mRNA Translation: AAH29857.1 |
CCDSi | CCDS10553.2 [Q8TEQ0-1] |
RefSeqi | NP_115543.3, NM_032167.4 [Q8TEQ0-1] |
3D structure databases
SMRi | Q8TEQ0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124903, 14 interactors |
IntActi | Q8TEQ0, 10 interactors |
STRINGi | 9606.ENSP00000456480 |
PTM databases
iPTMneti | Q8TEQ0 |
PhosphoSitePlusi | Q8TEQ0 |
Polymorphism and mutation databases
BioMutai | SNX29 |
DMDMi | 353526314 |
Proteomic databases
EPDi | Q8TEQ0 |
jPOSTi | Q8TEQ0 |
MassIVEi | Q8TEQ0 |
MaxQBi | Q8TEQ0 |
PaxDbi | Q8TEQ0 |
PeptideAtlasi | Q8TEQ0 |
PRIDEi | Q8TEQ0 |
ProteomicsDBi | 74476 [Q8TEQ0-1] 74477 [Q8TEQ0-2] |
Protocols and materials databases
Antibodypediai | 2225, 121 antibodies |
DNASUi | 92017 |
Genome annotation databases
Ensembli | ENST00000566228; ENSP00000456480; ENSG00000048471 [Q8TEQ0-1] |
GeneIDi | 92017 |
KEGGi | hsa:92017 |
UCSCi | uc002dby.6, human [Q8TEQ0-1] |
Organism-specific databases
CTDi | 92017 |
DisGeNETi | 92017 |
EuPathDBi | HostDB:ENSG00000048471.13 |
GeneCardsi | SNX29 |
HGNCi | HGNC:30542, SNX29 |
HPAi | ENSG00000048471, Low tissue specificity |
neXtProti | NX_Q8TEQ0 |
OpenTargetsi | ENSG00000048471 |
PharmGKBi | PA162404312 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2101, Eukaryota KOG4381, Eukaryota |
GeneTreei | ENSGT00730000110975 |
HOGENOMi | CLU_020563_1_0_1 |
InParanoidi | Q8TEQ0 |
OMAi | HEQERFS |
OrthoDBi | 543799at2759 |
Enzyme and pathway databases
PathwayCommonsi | Q8TEQ0 |
Miscellaneous databases
BioGRID-ORCSi | 92017, 4 hits in 840 CRISPR screens |
ChiTaRSi | SNX29, human |
GenomeRNAii | 92017 |
Pharosi | Q8TEQ0, Tdark |
PROi | PR:Q8TEQ0 |
RNActi | Q8TEQ0, protein |
Gene expression databases
Bgeei | ENSG00000048471, Expressed in sural nerve and 207 other tissues |
ExpressionAtlasi | Q8TEQ0, baseline and differential |
Genevisiblei | Q8TEQ0, HS |
Family and domain databases
CDDi | cd07277, PX_RUN, 1 hit |
Gene3Di | 1.20.58.900, 1 hit 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR001683, PX_dom IPR036871, PX_dom_sf IPR004012, Run_dom IPR037213, Run_dom_sf IPR037916, SNX29_PX |
Pfami | View protein in Pfam PF00787, PX, 1 hit PF02759, RUN, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit SM00593, RUN, 1 hit |
SUPFAMi | SSF140741, SSF140741, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit PS50826, RUN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNX29_HUMAN | |
Accessioni | Q8TEQ0Primary (citable) accession number: Q8TEQ0 Secondary accession number(s): B5MDW2, Q8N2X2, Q9HA26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM