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Protein

Histone deacetylase complex subunit SAP25

Gene

SAP25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase complex subunit SAP25
Alternative name(s):
25 kDa Sin3-associated polypeptide
Sin3 corepressor complex subunit SAP25
Gene namesi
Name:SAP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000205307.11
HGNCiHGNC:41908 SAP25
neXtProtiNX_Q8TEE9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205307

Polymorphism and mutation databases

BioMutaiSAP25
DMDMi206558307

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003508731 – 199Histone deacetylase complex subunit SAP25Add BLAST199

Proteomic databases

PaxDbiQ8TEE9
PRIDEiQ8TEE9
ProteomicsDBi74456

PTM databases

iPTMnetiQ8TEE9
PhosphoSitePlusiQ8TEE9

Expressioni

Gene expression databases

BgeeiENSG00000205307 Expressed in 83 organ(s), highest expression level in blood
ExpressionAtlasiQ8TEE9 baseline and differential
GenevisibleiQ8TEE9 HS

Organism-specific databases

HPAiHPA062610

Interactioni

Subunit structurei

May be a component of the mSIN3A corepressor complex. Interacts with SIN3A. Interacts with HDAC2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi941018, 28 interactors
IntActiQ8TEE9, 3 interactors
MINTiQ8TEE9
STRINGi9606.ENSP00000442339

Structurei

3D structure databases

ProteinModelPortaliQ8TEE9
SMRiQ8TEE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXUR Eukaryota
ENOG4111EFG LUCA
GeneTreeiENSGT00390000007899
HOGENOMiHOG000154253
HOVERGENiHBG108457
InParanoidiQ8TEE9
KOiK19193
OrthoDBiEOG091G0OLB
PhylomeDBiQ8TEE9
TreeFamiTF350622

Family and domain databases

InterProiView protein in InterPro
IPR029163 SAP25
PANTHERiPTHR39231 PTHR39231, 1 hit
PfamiView protein in Pfam
PF15476 SAP25, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8TEE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPLAPWDPK YEAKAGPRPV WGANCSSGAS FSGRTLCHPS FWPLYEAASG
60 70 80 90 100
RGLRPVAPAT GHWNGQQAPP DAGFPVVCCE DVFLSDPLLP RGQRVPLYLS
110 120 130 140 150
KAPQQMMGSL KLLPPPPIMS ARVLPRPSPS RGPSTAWLSG PELIALTGLL
160 170 180 190
QMSQGEPRPS SSAVGPPDHT SDPPSPCGSP SSSQGADLSL PQTPDTHCP
Length:199
Mass (Da):20,873
Last modified:September 23, 2008 - v2
Checksum:iF0ADC8A992B40BE2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYF9A0A087WYF9_HUMAN
Histone deacetylase complex subunit...
SAP25
297Annotation score:

Sequence cautioni

The sequence BAB85001 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074175 mRNA Translation: BAB85001.1 Sequence problems.
BC046135 mRNA No translation available.
CCDSiCCDS55137.1
RefSeqiNP_001335606.1, NM_001348677.1
UniGeneiHs.633863

Genome annotation databases

EnsembliENST00000538735; ENSP00000442339; ENSG00000205307
ENST00000614631; ENSP00000481351; ENSG00000205307
GeneIDi100316904
KEGGihsa:100316904
UCSCiuc022aip.2 human

Similar proteinsi

Entry informationi

Entry nameiSAP25_HUMAN
AccessioniPrimary (citable) accession number: Q8TEE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 12, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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