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Protein

Glucose-6-phosphate exchanger SLC37A2

Gene

SLC37A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.1 Publication

Activity regulationi

Inhibited by vanadate but not by chlorogenic acid.1 Publication

GO - Molecular functioni

  • glucose 6-phosphate:inorganic phosphate antiporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processAntiport, Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-70263 Gluconeogenesis

Protein family/group databases

TCDBi2.A.1.4.8 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate exchanger SLC37A21 Publication
Alternative name(s):
Solute carrier family 37 member 2Imported
Gene namesi
Name:SLC37A2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000134955.11
HGNCiHGNC:20644 SLC37A2
neXtProtiNX_Q8TED4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi219855
OpenTargetsiENSG00000134955
PharmGKBiPA134917577

Polymorphism and mutation databases

BioMutaiSLC37A2
DMDMi160185473

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083221 – 501Glucose-6-phosphate exchanger SLC37A2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TED4
PeptideAtlasiQ8TED4
PRIDEiQ8TED4
ProteomicsDBi74448
74449 [Q8TED4-2]
74450 [Q8TED4-3]
74451 [Q8TED4-4]

PTM databases

iPTMnetiQ8TED4
PhosphoSitePlusiQ8TED4

Expressioni

Tissue specificityi

Detected in intestine and pancreas. Lower expression is also detected in liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000134955 Expressed in 170 organ(s), highest expression level in right adrenal gland
CleanExiHS_SLC37A2
ExpressionAtlasiQ8TED4 baseline and differential
GenevisibleiQ8TED4 HS

Organism-specific databases

HPAiHPA014948

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311833

Structurei

3D structure databases

ProteinModelPortaliQ8TED4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP3Z Eukaryota
COG2271 LUCA
GeneTreeiENSGT00530000062949
HOGENOMiHOG000230522
HOVERGENiHBG005851
InParanoidiQ8TED4
KOiK13783
OMAiQWGLSFV
OrthoDBiEOG091G06AK
PhylomeDBiQ8TED4
TreeFamiTF314991

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TED4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSSLAPGVW FFRAFSRDSW FRGLILLLTF LIYACYHMSR KPISIVKSRL
60 70 80 90 100
HQNCSEQIKP INDTHSLNDT MWCSWAPFDK DNYKELLGGV DNAFLIAYAI
110 120 130 140 150
GMFISGVFGE RLPLRYYLSA GMLLSGLFTS LFGLGYFWNI HELWYFVVIQ
160 170 180 190 200
VCNGLVQTTG WPSVVTCVGN WFGKGKRGFI MGIWNSHTSV GNILGSLIAG
210 220 230 240 250
IWVNGQWGLS FIVPGIITAV MGVITFLFLI EHPEDVDCAP PQHHGEPAEN
260 270 280 290 300
QDNPEDPGNS PCSIRESGLE TVAKCSKGPC EEPAAISFFG ALRIPGVVEF
310 320 330 340 350
SLCLLFAKLV SYTFLYWLPL YIANVAHFSA KEAGDLSTLF DVGGIIGGIV
360 370 380 390 400
AGLVSDYTNG RATTCCVMLI LAAPMMFLYN YIGQDGIASS IVMLIICGGL
410 420 430 440 450
VNGPYALITT AVSADLGTHK SLKGNAKALS TVTAIIDGTG SIGAALGPLL
460 470 480 490 500
AGLISPTGWN NVFYMLISAD VLACLLLCRL VYKEILAWKV SLSRGSGYKE

I
Length:501
Mass (Da):54,436
Last modified:October 23, 2007 - v2
Checksum:i5B19560992231164
GO
Isoform 2 (identifier: Q8TED4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     498-501: YKEI → SSMVLTHQ

Show »
Length:505
Mass (Da):54,787
Checksum:i34853B4BC984C087
GO
Isoform 3 (identifier: Q8TED4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-385: GGIVAGLVSD...MFLYNYIGQD → DVPVQLHWPG...IRAHHHCCLC
     386-501: Missing.

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):42,925
Checksum:iD8F1AD92C7BB31BC
GO
Isoform 4 (identifier: Q8TED4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.

Note: No experimental confirmation available.
Show »
Length:126
Mass (Da):13,154
Checksum:i38E366A8EE7BDFD6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRJ4E9PRJ4_HUMAN
Glucose-6-phosphate exchanger SLC37...
SLC37A2
150Annotation score:

Sequence cautioni

The sequence BAB84926 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207W → R in BAB85016 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06180396I → V. Corresponds to variant dbSNP:rs55752830Ensembl.1
Natural variantiVAR_036794268G → S. Corresponds to variant dbSNP:rs34485243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0289601 – 375Missing in isoform 4. 1 PublicationAdd BLAST375
Alternative sequenceiVSP_028961347 – 385GGIVA…YIGQD → DVPVQLHWPGRDCQLHSDAD HLWGPGQWPIRAHHHCCLC in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_028962386 – 501Missing in isoform 3. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_028963498 – 501YKEI → SSMVLTHQ in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074100 mRNA Translation: BAB84926.1 Different initiation.
AK074207 mRNA Translation: BAB85016.1
AK290314 mRNA Translation: BAF83003.1
CH471065 Genomic DNA Translation: EAW67622.1
BC051314 mRNA Translation: AAH51314.1
BC062990 mRNA Translation: AAH62990.1
CCDSiCCDS31714.1 [Q8TED4-2]
CCDS44757.1 [Q8TED4-1]
RefSeqiNP_001138762.1, NM_001145290.1 [Q8TED4-1]
NP_938018.1, NM_198277.2 [Q8TED4-2]
UniGeneiHs.352661

Genome annotation databases

EnsembliENST00000308074; ENSP00000311833; ENSG00000134955 [Q8TED4-2]
ENST00000403796; ENSP00000384407; ENSG00000134955 [Q8TED4-1]
GeneIDi219855
KEGGihsa:219855
UCSCiuc001qbn.4 human [Q8TED4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074100 mRNA Translation: BAB84926.1 Different initiation.
AK074207 mRNA Translation: BAB85016.1
AK290314 mRNA Translation: BAF83003.1
CH471065 Genomic DNA Translation: EAW67622.1
BC051314 mRNA Translation: AAH51314.1
BC062990 mRNA Translation: AAH62990.1
CCDSiCCDS31714.1 [Q8TED4-2]
CCDS44757.1 [Q8TED4-1]
RefSeqiNP_001138762.1, NM_001145290.1 [Q8TED4-1]
NP_938018.1, NM_198277.2 [Q8TED4-2]
UniGeneiHs.352661

3D structure databases

ProteinModelPortaliQ8TED4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311833

Protein family/group databases

TCDBi2.A.1.4.8 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8TED4
PhosphoSitePlusiQ8TED4

Polymorphism and mutation databases

BioMutaiSLC37A2
DMDMi160185473

Proteomic databases

PaxDbiQ8TED4
PeptideAtlasiQ8TED4
PRIDEiQ8TED4
ProteomicsDBi74448
74449 [Q8TED4-2]
74450 [Q8TED4-3]
74451 [Q8TED4-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308074; ENSP00000311833; ENSG00000134955 [Q8TED4-2]
ENST00000403796; ENSP00000384407; ENSG00000134955 [Q8TED4-1]
GeneIDi219855
KEGGihsa:219855
UCSCiuc001qbn.4 human [Q8TED4-1]

Organism-specific databases

CTDi219855
DisGeNETi219855
EuPathDBiHostDB:ENSG00000134955.11
GeneCardsiSLC37A2
HGNCiHGNC:20644 SLC37A2
HPAiHPA014948
neXtProtiNX_Q8TED4
OpenTargetsiENSG00000134955
PharmGKBiPA134917577
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP3Z Eukaryota
COG2271 LUCA
GeneTreeiENSGT00530000062949
HOGENOMiHOG000230522
HOVERGENiHBG005851
InParanoidiQ8TED4
KOiK13783
OMAiQWGLSFV
OrthoDBiEOG091G06AK
PhylomeDBiQ8TED4
TreeFamiTF314991

Enzyme and pathway databases

ReactomeiR-HSA-70263 Gluconeogenesis

Miscellaneous databases

GenomeRNAii219855
PROiPR:Q8TED4

Gene expression databases

BgeeiENSG00000134955 Expressed in 170 organ(s), highest expression level in right adrenal gland
CleanExiHS_SLC37A2
ExpressionAtlasiQ8TED4 baseline and differential
GenevisibleiQ8TED4 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG6PT3_HUMAN
AccessioniPrimary (citable) accession number: Q8TED4
Secondary accession number(s): A8K2P9
, Q6P599, Q7Z7P8, Q8TEM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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