Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 165 (29 Sep 2021)
Sequence version 2 (24 Nov 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Probable glutathione peroxidase 8

Gene

GPX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei79By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.11.1.9, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TED1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3299685, Detoxification of Reactive Oxygen Species

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable glutathione peroxidase 8 (EC:1.11.1.9)
Short name:
GPx-8
Short name:
GSHPx-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPX8
ORF Names:UNQ847/PRO1785
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33100, GPX8

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TED1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000164294

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 40HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
493869

Open Targets

More...
OpenTargetsi
ENSG00000164294

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720300

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TED1, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00143, Glutathione
DB03310, Glutathione disulfide

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPX8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849565

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003177561 – 209Probable glutathione peroxidase 8Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TED1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TED1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TED1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TED1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TED1

PeptideAtlas

More...
PeptideAtlasi
Q8TED1

PRoteomics IDEntifications database

More...
PRIDEi
Q8TED1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74447

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TED1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TED1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TED1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164294, Expressed in metanephros and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TED1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TED1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164294, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TED1
With#Exp.IntAct
AGTRAP - isoform 2 [Q6RW13-2]3EBI-11721746,EBI-11522760
AIG1 - isoform 1 [Q9NVV5-2]3EBI-11721746,EBI-11957045
ALG8 [Q9BVK2]3EBI-11721746,EBI-3921603
APOC3 [P02656]3EBI-11721746,EBI-1220113
APOD [P05090]3EBI-11721746,EBI-715495
AQP1 [P29972]3EBI-11721746,EBI-745213
AQP2 [P41181]3EBI-11721746,EBI-12701138
AQP3 [Q92482]3EBI-11721746,EBI-2808854
ASGR1 [P07306]3EBI-11721746,EBI-1172335
ASPH - isoform 6 [Q12797-6]3EBI-11721746,EBI-12092171
BCL2L2 [Q92843]3EBI-11721746,EBI-707714
BET1 [O15155]3EBI-11721746,EBI-749204
BIK [Q13323]3EBI-11721746,EBI-700794
BMP10 [O95393]3EBI-11721746,EBI-3922513
BNIP2 [Q12982]3EBI-11721746,EBI-752094
BTN2A2 [Q8WVV5]3EBI-11721746,EBI-8648738
CACNG1 [Q06432]3EBI-11721746,EBI-9686780
CD302 [Q8IX05]3EBI-11721746,EBI-14259393
CD53 [P19397]3EBI-11721746,EBI-6657396
CD81 [P60033]3EBI-11721746,EBI-712921
CDIPT [O14735]3EBI-11721746,EBI-358858
CDS2 [O95674]3EBI-11721746,EBI-3913685
CFHR5 [Q9BXR6]3EBI-11721746,EBI-11579371
CHST1 [O43916]3EBI-11721746,EBI-748017
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-11721746,EBI-12256978
CLEC1A [Q8NC01]3EBI-11721746,EBI-11996768
CLEC2A [Q6UVW9]3EBI-11721746,EBI-15839595
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-11721746,EBI-11522780
CNIH1 [O95406]3EBI-11721746,EBI-12172273
CNIH3 [Q8TBE1]3EBI-11721746,EBI-12208021
COL4A5 - isoform 2 [P29400-2]3EBI-11721746,EBI-12211159
COL8A2 [Q4VAQ0]3EBI-11721746,EBI-10241815
CORIN [Q9Y5Q5]3EBI-11721746,EBI-17876114
CYB561 [P49447]3EBI-11721746,EBI-8646596
CYB561A3 [Q8NBI2]3EBI-11721746,EBI-10269179
CYB561D2 [O14569]3EBI-11721746,EBI-717654
DNAJC30 [Q96LL9]3EBI-11721746,EBI-8639143
DOLK [Q9UPQ8]3EBI-11721746,EBI-8645574
EDDM3B [P56851]3EBI-11721746,EBI-10215665
ERG28 [Q9UKR5]3EBI-11721746,EBI-711490
FA2H [Q7L5A8]3EBI-11721746,EBI-11337888
FAM3C [Q92520]3EBI-11721746,EBI-2876774
FAXDC2 [Q96IV6]3EBI-11721746,EBI-12142299
GET3 [O43681]3EBI-11721746,EBI-2515857
GOSR2 [O14653]3EBI-11721746,EBI-4401517
GPR151 [Q8TDV0]3EBI-11721746,EBI-11955647
GPR37L1 [O60883]3EBI-11721746,EBI-2927498
GRINA [Q7Z429]3EBI-11721746,EBI-2832909
GYPA [P02724]3EBI-11721746,EBI-702665
HHATL [Q9HCP6]3EBI-11721746,EBI-5916693
HMOX2 [P30519]3EBI-11721746,EBI-712096
IGFBP5 [P24593]3EBI-11721746,EBI-720480
INSIG2 [Q9Y5U4]3EBI-11721746,EBI-8503746
KIR2DL3 [P43628]3EBI-11721746,EBI-8632435
KLRG1 [Q96E93]3EBI-11721746,EBI-750770
LAPTM4B [Q86VI4]3EBI-11721746,EBI-3267258
LEPROTL1 [O95214]3EBI-11721746,EBI-750776
LHFPL5 [Q8TAF8]3EBI-11721746,EBI-2820517
LNPEP - isoform 2 [Q9UIQ6-2]3EBI-11721746,EBI-12133176
LPAR3 [Q9UBY5]3EBI-11721746,EBI-12033434
MAN2B2 [Q9Y2E5]3EBI-11721746,EBI-12243024
MARCHF2 [Q9P0N8]3EBI-11721746,EBI-10317612
MARCHF5 [Q9NX47]3EBI-11721746,EBI-2341610
MFSD5 [Q6N075]3EBI-11721746,EBI-3920969
MFSD6 [Q6ZSS7]3EBI-11721746,EBI-2858252
MGST2 [Q99735]3EBI-11721746,EBI-11324706
MGST3 [O14880]3EBI-11721746,EBI-724754
MIP [P30301]3EBI-11721746,EBI-8449636
MMD [Q15546]3EBI-11721746,EBI-17873222
MYADML2 [A6NDP7]3EBI-11721746,EBI-17641390
NEU1 [Q99519]3EBI-11721746,EBI-721517
NINJ1 [Q92982]3EBI-11721746,EBI-2802124
NIPAL3 [Q6P499]3EBI-11721746,EBI-10252783
NKG7 [Q16617]3EBI-11721746,EBI-3919611
NRAC [Q8N912]3EBI-11721746,EBI-12051377
NRM [Q8IXM6]3EBI-11721746,EBI-10262547
OCLN [Q16625]3EBI-11721746,EBI-2903088
PAEP [P09466]3EBI-11721746,EBI-465167
PAQR5 [Q9NXK6]3EBI-11721746,EBI-10316423
PAQR6 [Q6TCH4]3EBI-11721746,EBI-17265310
PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-11721746,EBI-12092917
PLLP [Q9Y342]3EBI-11721746,EBI-3919291
PLN [P26678]3EBI-11721746,EBI-692836
PLP2 [Q04941]3EBI-11721746,EBI-608347
PLPP4 [Q5VZY2]3EBI-11721746,EBI-10485931
PLPP6 [Q8IY26]3EBI-11721746,EBI-11721828
PNLIPRP1 [P54315]3EBI-11721746,EBI-8652812
PRB1 [A5D903]3EBI-11721746,EBI-10173935
RBFA [Q8N0V3]3EBI-11721746,EBI-3232108
RND1 [Q92730]3EBI-11721746,EBI-448618
RTP2 [Q5QGT7]3EBI-11721746,EBI-10244780
SCARB2 [Q14108]3EBI-11721746,EBI-1564650
SCARF1 [Q14162]3EBI-11721746,EBI-12056025
SCD [O00767]3EBI-11721746,EBI-2684237
SEC22B [O75396]3EBI-11721746,EBI-1058865
SELENOK [Q9Y6D0]3EBI-11721746,EBI-9679163
SERINC1 [Q9NRX5]3EBI-11721746,EBI-2683145
SERP1 [Q9Y6X1]3EBI-11721746,EBI-10329948
SERTM1 [A2A2V5]3EBI-11721746,EBI-17284533
SFTPC [P11686]3EBI-11721746,EBI-10197617
SGMS2 [Q8NHU3]3EBI-11721746,EBI-10977284
SLC13A3 [Q8WWT9]3EBI-11721746,EBI-12938720
SLC30A3 [Q99726]3EBI-11721746,EBI-10294651
SLC34A3 [Q8N130]3EBI-11721746,EBI-17769653
SLC35A1 [P78382]3EBI-11721746,EBI-12870360
SLC35B4 [Q969S0]3EBI-11721746,EBI-10281213
SLC41A2 [Q96JW4]3EBI-11721746,EBI-10290130
SMAGP [Q0VAQ4]3EBI-11721746,EBI-10226799
SNORC [Q6UX34]3EBI-11721746,EBI-11957067
ST6GAL2 - isoform 2 [Q96JF0-2]3EBI-11721746,EBI-12908338
STX3 [Q13277]3EBI-11721746,EBI-1394295
STX8 [Q9UNK0]3EBI-11721746,EBI-727240
SYT15 - isoform 2 [Q9BQS2-2]3EBI-11721746,EBI-13373352
TF [P02787]3EBI-11721746,EBI-714319
THBD [P07204]3EBI-11721746,EBI-941422
TIMMDC1 [Q9NPL8]3EBI-11721746,EBI-6268651
TM4SF4 [P48230]3EBI-11721746,EBI-8650934
TMBIM6 [P55061]3EBI-11721746,EBI-1045825
TMEM107 [Q6UX40]3EBI-11721746,EBI-12845616
TMEM109 [Q9BVC6]3EBI-11721746,EBI-1057733
TMEM120B [A0PK00]3EBI-11721746,EBI-10171534
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-11721746,EBI-10694905
TMEM14B [Q9NUH8]3EBI-11721746,EBI-8638294
TMEM19 [Q96HH6]3EBI-11721746,EBI-741829
TMEM218 [A2RU14]3EBI-11721746,EBI-10173151
TMEM229B [Q8NBD8]3EBI-11721746,EBI-12195227
TMEM243 [Q9BU79]3EBI-11721746,EBI-12887458
TMEM254 [Q8TBM7]3EBI-11721746,EBI-11956809
TMEM42 [Q69YG0]3EBI-11721746,EBI-12038591
TMEM50B [P56557]3EBI-11721746,EBI-12366453
TMEM60 [Q9H2L4]3EBI-11721746,EBI-2852148
TMEM86B [Q8N661]3EBI-11721746,EBI-2548832
TMEM97 [Q5BJF2]3EBI-11721746,EBI-12111910
TMPRSS4 [Q9NRS4]3EBI-11721746,EBI-10313040
TMUB2 [Q71RG4]3EBI-11721746,EBI-2820477
TRAM1L1 [Q8N609]3EBI-11721746,EBI-11996766
TSPAN33 [Q86UF1]3EBI-11721746,EBI-12045841
UNC50 [Q53HI1]3EBI-11721746,EBI-7601760
UPK1B [O75841]3EBI-11721746,EBI-12237619
VAMP3 [Q15836]3EBI-11721746,EBI-722343
VAMP4 [O75379]3EBI-11721746,EBI-744953
VAMP5 [O95183]3EBI-11721746,EBI-10191195
VKORC1L1 [Q8N0U8]3EBI-11721746,EBI-11337915
VSTM1 - isoform 3 [Q6UX27-3]3EBI-11721746,EBI-12190699
VTI1B [Q9UEU0]3EBI-11721746,EBI-723716
YIF1A [O95070]3EBI-11721746,EBI-2799703
YIPF6 [Q96EC8]3EBI-11721746,EBI-751210
ZDHHC22 [Q8N966]3EBI-11721746,EBI-10268111

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
138926, 183 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TED1, 169 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000423822

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TED1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TED1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TED1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1651, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159371

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TED1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNQFGDS

Database of Orthologous Groups

More...
OrthoDBi
1483113at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TED1

TreeFam database of animal gene trees

More...
TreeFami
TF331942

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00340, GSH_Peroxidase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013376, Glut_perox_Gpx7
IPR000889, Glutathione_peroxidase
IPR029760, GPX_CS
IPR036249, Thioredoxin-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11592, PTHR11592, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00255, GSHPx, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000303, Glutathion_perox, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01011, GLUTPROXDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833, SSF52833, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02540, gpx7, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00763, GLUTATHIONE_PEROXID_2, 1 hit
PS51355, GLUTATHIONE_PEROXID_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TED1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLAAYPLK CSGPRAKVFA VLLSIVLCTV TLFLLQLKFL KPKINSFYAF
60 70 80 90 100
EVKDAKGRTV SLEKYKGKVS LVVNVASDCQ LTDRNYLGLK ELHKEFGPSH
110 120 130 140 150
FSVLAFPCNQ FGESEPRPSK EVESFARKNY GVTFPIFHKI KILGSEGEPA
160 170 180 190 200
FRFLVDSSKK EPRWNFWKYL VNPEGQVVKF WKPEEPIEVI RPDIAALVRQ

VIIKKKEDL
Length:209
Mass (Da):23,881
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82DACC1A85FDF6D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ETY7E7ETY7_HUMAN
Glutathione peroxidase
GPX8
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNB5J3KNB5_HUMAN
Probable glutathione peroxidase 8
GPX8
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060456182K → R4 PublicationsCorresponds to variant dbSNP:rs381852Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358715 mRNA Translation: AAQ89077.1
AK074216 mRNA Translation: BAB85019.1
AC091977 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54908.1
BC029424 mRNA Translation: AAH29424.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34156.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008398.2, NM_001008397.3
NP_001293126.1, NM_001306197.1
NP_001293127.1, NM_001306198.1
NP_001293130.1, NM_001306201.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000503787; ENSP00000423822; ENSG00000164294

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
493869

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:493869

UCSC genome browser

More...
UCSCi
uc003jpq.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358715 mRNA Translation: AAQ89077.1
AK074216 mRNA Translation: BAB85019.1
AC091977 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54908.1
BC029424 mRNA Translation: AAH29424.1
CCDSiCCDS34156.1
RefSeqiNP_001008398.2, NM_001008397.3
NP_001293126.1, NM_001306197.1
NP_001293127.1, NM_001306198.1
NP_001293130.1, NM_001306201.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CYNX-ray2.00A/B/C44-209[»]
3KIJX-ray1.80A/B/C38-209[»]
SMRiQ8TED1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi138926, 183 interactors
IntActiQ8TED1, 169 interactors
STRINGi9606.ENSP00000423822

Chemistry databases

DrugBankiDB00143, Glutathione
DB03310, Glutathione disulfide

PTM databases

iPTMnetiQ8TED1
PhosphoSitePlusiQ8TED1
SwissPalmiQ8TED1

Genetic variation databases

BioMutaiGPX8
DMDMi269849565

Proteomic databases

EPDiQ8TED1
jPOSTiQ8TED1
MassIVEiQ8TED1
MaxQBiQ8TED1
PaxDbiQ8TED1
PeptideAtlasiQ8TED1
PRIDEiQ8TED1
ProteomicsDBi74447

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23390, 117 antibodies

The DNASU plasmid repository

More...
DNASUi
493869

Genome annotation databases

EnsembliENST00000503787; ENSP00000423822; ENSG00000164294
GeneIDi493869
KEGGihsa:493869
UCSCiuc003jpq.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
493869
DisGeNETi493869

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GPX8
HGNCiHGNC:33100, GPX8
HPAiENSG00000164294, Low tissue specificity
neXtProtiNX_Q8TED1
OpenTargetsiENSG00000164294
PharmGKBiPA164720300
VEuPathDBiHostDB:ENSG00000164294

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1651, Eukaryota
GeneTreeiENSGT00940000159371
InParanoidiQ8TED1
OMAiCNQFGDS
OrthoDBi1483113at2759
PhylomeDBiQ8TED1
TreeFamiTF331942

Enzyme and pathway databases

BRENDAi1.11.1.9, 2681
PathwayCommonsiQ8TED1
ReactomeiR-HSA-3299685, Detoxification of Reactive Oxygen Species

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
493869, 22 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GPX8, human
EvolutionaryTraceiQ8TED1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GPX8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
493869
PharosiQ8TED1, Tbio

Protein Ontology

More...
PROi
PR:Q8TED1
RNActiQ8TED1, protein

Gene expression databases

BgeeiENSG00000164294, Expressed in metanephros and 183 other tissues
ExpressionAtlasiQ8TED1, baseline and differential
GenevisibleiQ8TED1, HS

Family and domain databases

CDDicd00340, GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR013376, Glut_perox_Gpx7
IPR000889, Glutathione_peroxidase
IPR029760, GPX_CS
IPR036249, Thioredoxin-like_sf
PANTHERiPTHR11592, PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255, GSHPx, 1 hit
PIRSFiPIRSF000303, Glutathion_perox, 1 hit
PRINTSiPR01011, GLUTPROXDASE
SUPFAMiSSF52833, SSF52833, 1 hit
TIGRFAMsiTIGR02540, gpx7, 1 hit
PROSITEiView protein in PROSITE
PS00763, GLUTATHIONE_PEROXID_2, 1 hit
PS51355, GLUTATHIONE_PEROXID_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPX8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TED1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: September 29, 2021
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again