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Protein

Probable glutathione peroxidase 8

Gene

GPX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8 (EC:1.11.1.9)
Short name:
GPx-8
Short name:
GSHPx-8
Gene namesi
Name:GPX8
ORF Names:UNQ847/PRO1785
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164294.13
HGNCiHGNC:33100 GPX8
neXtProtiNX_Q8TED1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 40HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi493869
OpenTargetsiENSG00000164294
PharmGKBiPA164720300

Chemistry databases

DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGPX8
DMDMi269849565

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003177561 – 209Probable glutathione peroxidase 8Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8TED1
MaxQBiQ8TED1
PaxDbiQ8TED1
PeptideAtlasiQ8TED1
PRIDEiQ8TED1
ProteomicsDBi74447

PTM databases

iPTMnetiQ8TED1
PhosphoSitePlusiQ8TED1
SwissPalmiQ8TED1

Expressioni

Gene expression databases

BgeeiENSG00000164294 Expressed in 171 organ(s), highest expression level in metanephros
CleanExiHS_GPX8
ExpressionAtlasiQ8TED1 baseline and differential
GenevisibleiQ8TED1 HS

Organism-specific databases

HPAiHPA036720

Interactioni

Protein-protein interaction databases

BioGridi138926, 9 interactors
IntActiQ8TED1, 153 interactors
MINTiQ8TED1
STRINGi9606.ENSP00000423822

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TED1
SMRiQ8TED1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TED1

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277054
HOVERGENiHBG004333
InParanoidiQ8TED1
KOiK00432
OMAiFGDSEPR
OrthoDBiEOG091G0OJG
PhylomeDBiQ8TED1
TreeFamiTF331942

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR013376 Glut_perox_Gpx7
IPR000889 Glutathione_peroxidase
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02540 gpx7, 1 hit
PROSITEiView protein in PROSITE
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TED1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLAAYPLK CSGPRAKVFA VLLSIVLCTV TLFLLQLKFL KPKINSFYAF
60 70 80 90 100
EVKDAKGRTV SLEKYKGKVS LVVNVASDCQ LTDRNYLGLK ELHKEFGPSH
110 120 130 140 150
FSVLAFPCNQ FGESEPRPSK EVESFARKNY GVTFPIFHKI KILGSEGEPA
160 170 180 190 200
FRFLVDSSKK EPRWNFWKYL VNPEGQVVKF WKPEEPIEVI RPDIAALVRQ

VIIKKKEDL
Length:209
Mass (Da):23,881
Last modified:November 24, 2009 - v2
Checksum:i82DACC1A85FDF6D7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ETY7E7ETY7_HUMAN
Glutathione peroxidase
GPX8
158Annotation score:
J3KNB5J3KNB5_HUMAN
Probable glutathione peroxidase 8
GPX8
90Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060456182K → R4 PublicationsCorresponds to variant dbSNP:rs381852Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358715 mRNA Translation: AAQ89077.1
AK074216 mRNA Translation: BAB85019.1
AC091977 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54908.1
BC029424 mRNA Translation: AAH29424.1
CCDSiCCDS34156.1
RefSeqiNP_001008398.2, NM_001008397.3
NP_001293126.1, NM_001306197.1
NP_001293127.1, NM_001306198.1
NP_001293130.1, NM_001306201.1
UniGeneiHs.289044

Genome annotation databases

EnsembliENST00000503787; ENSP00000423822; ENSG00000164294
GeneIDi493869
KEGGihsa:493869
UCSCiuc003jpq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358715 mRNA Translation: AAQ89077.1
AK074216 mRNA Translation: BAB85019.1
AC091977 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54908.1
BC029424 mRNA Translation: AAH29424.1
CCDSiCCDS34156.1
RefSeqiNP_001008398.2, NM_001008397.3
NP_001293126.1, NM_001306197.1
NP_001293127.1, NM_001306198.1
NP_001293130.1, NM_001306201.1
UniGeneiHs.289044

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CYNX-ray2.00A/B/C44-209[»]
3KIJX-ray1.80A/B/C38-209[»]
ProteinModelPortaliQ8TED1
SMRiQ8TED1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138926, 9 interactors
IntActiQ8TED1, 153 interactors
MINTiQ8TED1
STRINGi9606.ENSP00000423822

Chemistry databases

DrugBankiDB00143 Glutathione

PTM databases

iPTMnetiQ8TED1
PhosphoSitePlusiQ8TED1
SwissPalmiQ8TED1

Polymorphism and mutation databases

BioMutaiGPX8
DMDMi269849565

Proteomic databases

EPDiQ8TED1
MaxQBiQ8TED1
PaxDbiQ8TED1
PeptideAtlasiQ8TED1
PRIDEiQ8TED1
ProteomicsDBi74447

Protocols and materials databases

DNASUi493869
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503787; ENSP00000423822; ENSG00000164294
GeneIDi493869
KEGGihsa:493869
UCSCiuc003jpq.3 human

Organism-specific databases

CTDi493869
DisGeNETi493869
EuPathDBiHostDB:ENSG00000164294.13
GeneCardsiGPX8
HGNCiHGNC:33100 GPX8
HPAiHPA036720
neXtProtiNX_Q8TED1
OpenTargetsiENSG00000164294
PharmGKBiPA164720300
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277054
HOVERGENiHBG004333
InParanoidiQ8TED1
KOiK00432
OMAiFGDSEPR
OrthoDBiEOG091G0OJG
PhylomeDBiQ8TED1
TreeFamiTF331942

Enzyme and pathway databases

BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

EvolutionaryTraceiQ8TED1
GeneWikiiGPX8
GenomeRNAii493869
PROiPR:Q8TED1

Gene expression databases

BgeeiENSG00000164294 Expressed in 171 organ(s), highest expression level in metanephros
CleanExiHS_GPX8
ExpressionAtlasiQ8TED1 baseline and differential
GenevisibleiQ8TED1 HS

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR013376 Glut_perox_Gpx7
IPR000889 Glutathione_peroxidase
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02540 gpx7, 1 hit
PROSITEiView protein in PROSITE
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPX8_HUMAN
AccessioniPrimary (citable) accession number: Q8TED1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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