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Entry version 139 (31 Jul 2019)
Sequence version 3 (18 May 2010)
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Protein

E3 ubiquitin-protein ligase SH3RF2

Gene

SH3RF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri12 – 53RING-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein phosphatase inhibitor, Transferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase SH3RF2 (EC:2.3.2.271 Publication)
Alternative name(s):
Heart protein phosphatase 1-binding protein
Short name:
HEPP1
POSH-eliminating RING protein1 Publication
Protein phosphatase 1 regulatory subunit 39
RING finger protein 158
RING-type E3 ubiquitin transferase SH3RF2Curated
SH3 domain-containing RING finger protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3RF2
Synonyms:POSH31 Publication, POSHER1 Publication, PPP1R39, RNF158
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26299 SH3RF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613377 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TEC5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi643V → G: Significant loss of interaction with PPP1CA. Significant loss of interaction with PPP1CA; when associated with G-645. 1 Publication1
Mutagenesisi645F → G: Significant loss of interaction with PPP1CA. Significant loss of interaction with PPP1CA; when associated with G-643. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000156463

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944983

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SH3RF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452957

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002695121 – 729E3 ubiquitin-protein ligase SH3RF2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei649PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoubiquitinated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TEC5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TEC5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TEC5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TEC5

PeptideAtlas

More...
PeptideAtlasi
Q8TEC5

PRoteomics IDEntifications database

More...
PRIDEi
Q8TEC5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74443 [Q8TEC5-1]
74444 [Q8TEC5-2]
74445 [Q8TEC5-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8TEC5-1 [Q8TEC5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TEC5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TEC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level). Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156463 Expressed in 154 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TEC5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035903
HPA058119

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FASLG and PPP1CA (PubMed:19389623, PubMed:19807924, PubMed:19945436).

Interacts with PAK4 and TNFRSF1A (PubMed:24130170).

Interacts with DLK1, MAP3K10/MLK2, MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3.

Interacts with RAC1 (both active GTP- or inactive GDP-bound forms) (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127517, 34 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TEC5, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000424497

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TEC5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 184SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini187 – 252SH3 2PROSITE-ProRule annotationAdd BLAST66
Domaini380 – 441SH3 3PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni370 – 459Interaction with PAK41 PublicationAdd BLAST90
Regioni641 – 646Interaction with PPP1CA6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH3RF family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 53RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITG6 Eukaryota
ENOG410XS5R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160067

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060125

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TEC5

KEGG Orthology (KO)

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KOi
K12171

Identification of Orthologs from Complete Genome Data

More...
OMAi
PILFVEP

Database of Orthologous Groups

More...
OrthoDBi
291531at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TEC5

TreeFam database of animal gene trees

More...
TreeFami
TF105571

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11929 SH3_SH3RF2_1, 1 hit
cd11932 SH3_SH3RF2_2, 1 hit
cd11784 SH3_SH3RF2_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028511 SH3RF2
IPR035792 SH3RF2_SH3_1
IPR035794 SH3RF2_SH3_2
IPR035822 SH3RF2_SH3_3
IPR027370 Znf-RING_LisH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR14167:SF60 PTHR14167:SF60, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00184 RING, 1 hit
SM00326 SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 3 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TEC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRV FKAHKELRCP
60 70 80 90 100
ECRTPVFSNI EALPANLLLV RLLDGVRSGQ SSGRGGSFRR PGTMTLQDGR
110 120 130 140 150
KSRTNPRRLQ ASPFRLVPNV RIHMDGVPRA KALCNYRGQN PGDLRFNKGD
160 170 180 190 200
IILLRRQLDE NWYQGEINGI SGNFPASSVE VIKQLPQPPP LCRALYNFDL
210 220 230 240 250
RGKDKSENQD CLTFLKDDII TVISRVDENW AEGKLGDKVG IFPILFVEPN
260 270 280 290 300
LTARHLLEKN KGRQSSRTKN LSLVSSSSRG NTSTLRRGPG SRRKVPGQFS
310 320 330 340 350
ITTALNTLNR MVHSPSGRHM VEISTPVLIS SSNPSVITQP MEKADVPSSC
360 370 380 390 400
VGQVSTYHPA PVSPGHSTAV VSLPGSQQHL SANMFVALHS YSAHGPDELD
410 420 430 440 450
LQKGEGVRVL GKCQDGWLRG VSLVTGRVGI FPNNYVIPIF RKTSSFPDSR
460 470 480 490 500
SPGLYTTWTL STSSVSSQGS ISEGDPRQSR PFKSVFVPTA IVNPVRSTAG
510 520 530 540 550
PGTLGQGSLR KGRSSMRKNG SLQRPLQSGI PTLVVGSLRR SPTMVLRPQQ
560 570 580 590 600
FQFYQPQGIP SSPSAVVVEM GSKPALTGEP ALTCISRGSE AWIHSAASSL
610 620 630 640 650
IMEDKEIPIK SEPLPKPPAS APPSILVKPE NSRNGIEKQV KTVRFQNYSP
660 670 680 690 700
PPTKHYTSHP TSGKPEQPAT LKASQPEAAS LGPEMTVLFA HRSGCHSGQQ
710 720
TDLRRKSALG KATTLVSTAS GTQTVFPSK
Length:729
Mass (Da):79,320
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF85CCC0188DA8477
GO
Isoform 2 (identifier: Q8TEC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-508: Missing.
     509-519: LRKGRSSMRKN → MRKSKWWQRD

Show »
Length:220
Mass (Da):23,799
Checksum:i299343322F39CAB2
GO
Isoform 3 (identifier: Q8TEC5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-543: Missing.

Show »
Length:186
Mass (Da):19,895
Checksum:i1FCF3EE1BF6C9316
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH31650 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB85025 differs from that shown. Reason: Erroneous termination at position 458. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti148K → R in BAB85025 (PubMed:14702039).Curated1
Sequence conflicti168N → S in BAB85025 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05211816F → S. Corresponds to variant dbSNP:rs34739859Ensembl.1
Natural variantiVAR_052119174F → V. Corresponds to variant dbSNP:rs34942619Ensembl.1
Natural variantiVAR_029788267R → C2 PublicationsCorresponds to variant dbSNP:rs758037Ensembl.1
Natural variantiVAR_052120477R → Q. Corresponds to variant dbSNP:rs35165046Ensembl.1
Natural variantiVAR_029789592W → R2 PublicationsCorresponds to variant dbSNP:rs2962525Ensembl.1
Natural variantiVAR_029790687V → I1 PublicationCorresponds to variant dbSNP:rs11435Ensembl.1
Natural variantiVAR_029791710G → A2 PublicationsCorresponds to variant dbSNP:rs1056149Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0406621 – 543Missing in isoform 3. 1 PublicationAdd BLAST543
Alternative sequenceiVSP_0220581 – 508Missing in isoform 2. 2 PublicationsAdd BLAST508
Alternative sequenceiVSP_022059509 – 519LRKGRSSMRKN → MRKSKWWQRD in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK058046 mRNA Translation: BAB71639.1
AK074234 mRNA Translation: BAB85025.1 Different termination.
AK292576 mRNA Translation: BAF85265.1
AC005216 Genomic DNA No translation available.
AC005351 Genomic DNA No translation available.
AC011359 Genomic DNA No translation available.
AC091887 Genomic DNA No translation available.
BC031650 mRNA Translation: AAH31650.2 Different initiation.
BC073914 mRNA Translation: AAH73914.1
BC125106 mRNA Translation: AAI25107.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4280.1 [Q8TEC5-1]

NCBI Reference Sequences

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RefSeqi
NP_689763.3, NM_152550.3 [Q8TEC5-1]
XP_006714820.1, XM_006714757.1 [Q8TEC5-1]
XP_011535871.1, XM_011537569.2 [Q8TEC5-1]
XP_016864625.1, XM_017009136.1 [Q8TEC5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000359120; ENSP00000352028; ENSG00000156463 [Q8TEC5-1]
ENST00000511217; ENSP00000424497; ENSG00000156463 [Q8TEC5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
153769

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:153769

UCSC genome browser

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UCSCi
uc003lnt.4 human [Q8TEC5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058046 mRNA Translation: BAB71639.1
AK074234 mRNA Translation: BAB85025.1 Different termination.
AK292576 mRNA Translation: BAF85265.1
AC005216 Genomic DNA No translation available.
AC005351 Genomic DNA No translation available.
AC011359 Genomic DNA No translation available.
AC091887 Genomic DNA No translation available.
BC031650 mRNA Translation: AAH31650.2 Different initiation.
BC073914 mRNA Translation: AAH73914.1
BC125106 mRNA Translation: AAI25107.1
CCDSiCCDS4280.1 [Q8TEC5-1]
RefSeqiNP_689763.3, NM_152550.3 [Q8TEC5-1]
XP_006714820.1, XM_006714757.1 [Q8TEC5-1]
XP_011535871.1, XM_011537569.2 [Q8TEC5-1]
XP_016864625.1, XM_017009136.1 [Q8TEC5-1]

3D structure databases

SMRiQ8TEC5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127517, 34 interactors
IntActiQ8TEC5, 17 interactors
STRINGi9606.ENSP00000424497

PTM databases

iPTMnetiQ8TEC5
PhosphoSitePlusiQ8TEC5

Polymorphism and mutation databases

BioMutaiSH3RF2
DMDMi296452957

Proteomic databases

EPDiQ8TEC5
jPOSTiQ8TEC5
MaxQBiQ8TEC5
PaxDbiQ8TEC5
PeptideAtlasiQ8TEC5
PRIDEiQ8TEC5
ProteomicsDBi74443 [Q8TEC5-1]
74444 [Q8TEC5-2]
74445 [Q8TEC5-3]
TopDownProteomicsiQ8TEC5-1 [Q8TEC5-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359120; ENSP00000352028; ENSG00000156463 [Q8TEC5-1]
ENST00000511217; ENSP00000424497; ENSG00000156463 [Q8TEC5-1]
GeneIDi153769
KEGGihsa:153769
UCSCiuc003lnt.4 human [Q8TEC5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
153769

GeneCards: human genes, protein and diseases

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GeneCardsi
SH3RF2
HGNCiHGNC:26299 SH3RF2
HPAiHPA035903
HPA058119
MIMi613377 gene
neXtProtiNX_Q8TEC5
OpenTargetsiENSG00000156463
PharmGKBiPA134944983

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410ITG6 Eukaryota
ENOG410XS5R LUCA
GeneTreeiENSGT00940000160067
HOGENOMiHOG000060125
InParanoidiQ8TEC5
KOiK12171
OMAiPILFVEP
OrthoDBi291531at2759
PhylomeDBiQ8TEC5
TreeFamiTF105571

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SH3RF2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
153769

Protein Ontology

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PROi
PR:Q8TEC5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000156463 Expressed in 154 organ(s), highest expression level in right testis
GenevisibleiQ8TEC5 HS

Family and domain databases

CDDicd11929 SH3_SH3RF2_1, 1 hit
cd11932 SH3_SH3RF2_2, 1 hit
cd11784 SH3_SH3RF2_3, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028511 SH3RF2
IPR035792 SH3RF2_SH3_1
IPR035794 SH3RF2_SH3_2
IPR035822 SH3RF2_SH3_3
IPR027370 Znf-RING_LisH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR14167:SF60 PTHR14167:SF60, 1 hit
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00326 SH3, 3 hits
SUPFAMiSSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 3 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSH3R2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEC5
Secondary accession number(s): A8K961
, Q08AM9, Q6GMR9, Q8N5S8, Q96LP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: July 31, 2019
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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