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Entry version 156 (29 Sep 2021)
Sequence version 1 (01 Jun 2002)
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Protein

tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Gene

NSUN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) (PubMed:26160102, PubMed:27703015, PubMed:28531330).

In vitro also methylates tRNA(Thr)(AGT) (PubMed:27703015, PubMed:26160102).

Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates (PubMed:26160102, PubMed:27703015).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.02 µM for tRNA(Thr)(TGT)1 Publication
  2. KM=1.58 µM for tRNA(Thr)(AGT)1 Publication
  3. KM=0.89 µM for tRNA(Cys)(GCA)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei266S-adenosyl-L-methioninePROSITE-ProRule annotationCombined sources1 Publication1
Binding sitei293S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei323S-adenosyl-L-methioninePROSITE-ProRule annotationCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei373NucleophilePROSITE-ProRule annotationCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • tRNA (cytosine-5-)-methyltransferase activity Source: UniProtKB
  • tRNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.202, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TEA1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6782315, tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6Curated (EC:2.1.1.-3 Publications)
Alternative name(s):
NOL1/NOP2/Sun and PUA domain-containing protein 1
NOL1/NOP2/Sun domain family member 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NSUN6Imported
Synonyms:NOPD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23529, NSUN6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TEA1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000241058

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi126R → A: Decreases substantially tRNA methyltransferase activity. 1 Publication1
Mutagenesisi131Y → A: Abolishes methylation of tRNA (Cys). 1 Publication1
Mutagenesisi159K → A: Decreases tRNA methyltransferase activiry. Abolishes tRNA methyltransferase activiry; when associated with A-181. 1 Publication1
Mutagenesisi160K → A: Decreases tRNA methyltransferase activiry. Abolishes tRNA methyltransferase activiry; when associated with A-181. 1 Publication1
Mutagenesisi181R → A: Decreases subtantially tRNA methyltransferase activiry. 1 Publication1
Mutagenesisi218L → A: Decreases substantially tRNA methyltransferase activity. 1 Publication1
Mutagenesisi220N → A: Decreases substantially tRNA methyltransferase activity. 1 Publication1
Mutagenesisi223S → A: Dose not affect tRNA methyltransferase activity. 1 Publication1
Mutagenesisi248K → A: Abolishes tRNA methyltransferase activity. Does not affect S-Adenosylmethionine binding. 1 Publication1
Mutagenesisi266D → A: Loss of S-Adenosylmethionine binding. Loss of tRNA methyltransferase activity. 1 Publication1
Mutagenesisi271K → A: Loss of S-Adenosylmethionine binding. Loss of tRNA methyltransferase activity. 1 Publication1
Mutagenesisi293D → A: Loss of S-Adenosylmethionine binding. Loss of tRNA methyltransferase activity. 1 Publication1
Mutagenesisi323D → A: Abolishes tRNA methyltransferase activity. Abolishes S-Adenosylmethionine binding. 1 Publication1
Mutagenesisi373C → A: Does not impair target RNA binding. Abolishes tRNA (cytosine-5-)-methyltransferase activity. 2 Publications1
Mutagenesisi458F → A: Abolishes tRNA methyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
221078

Open Targets

More...
OpenTargetsi
ENSG00000241058

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134986220

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TEA1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NSUN6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751440

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002631141 – 469tRNA (cytosine(72)-C(5))-methyltransferase NSUN6Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei419N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TEA1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TEA1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TEA1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TEA1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TEA1

PeptideAtlas

More...
PeptideAtlasi
Q8TEA1

PRoteomics IDEntifications database

More...
PRIDEi
Q8TEA1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74429

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8TEA1

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TEA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TEA1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TEA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000241058, Expressed in oviduct epithelium and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TEA1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TEA1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000241058, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128682, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TEA1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366519

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TEA1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1469
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TEA1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 203PUAPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni242 – 248S-adenosyl-L-methionine bindingPROSITE-ProRule annotationCombined sources1 Publication7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PUA domain plays a role in tRNA recognition through precisely recognizing the CCA end and the D-stem region of tRNA.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1122, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155370

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005316_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TEA1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YQGAMLY

Database of Orthologous Groups

More...
OrthoDBi
1040075at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TEA1

TreeFam database of animal gene trees

More...
TreeFami
TF324225

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018314, Fmu/NOL1/Nop2p_CS
IPR001678, MeTrfase_RsmB/NOP2
IPR015947, PUA-like_sf
IPR036974, PUA_sf
IPR023267, RCMT
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01189, Methyltr_RsmB-F, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02008, RCMTFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit
SSF88697, SSF88697, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01153, NOL1_NOP2_SUN, 1 hit
PS50890, PUA, 1 hit
PS51686, SAM_MT_RSMB_NOP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TEA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP
60 70 80 90 100
SFTTVRVNTH LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV
110 120 130 140 150
IGPRKNIKKQ QCEAIVGAQC GNAVLRGAHV YAPGIVSASQ FMKAGDVISV
160 170 180 190 200
YSDIKGKCKK GAKEFDGTKV FLGNGISELS RKEIFSGLPE LKGMGIRMTE
210 220 230 240 250
PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD LCAAPGGKTT
260 270 280 290 300
HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL
310 320 330 340 350
DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL
360 370 380 390 400
QRKLFTAAVQ LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE
410 420 430 440 450
PQIGGEGMRG AGLSCEQLKQ LQRFDPSAVP LPDTDMDSLR EARREDMLRL
460
ANKDSIGFFI AKFVKCKST
Length:469
Mass (Da):51,770
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB6D383915547CF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQU2U3KQU2_HUMAN
tRNA (cytosine(72)-C(5))-methyltran...
NSUN6
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SF14A0A0D9SF14_HUMAN
tRNA (cytosine(72)-C(5))-methyltran...
NSUN6
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074323 mRNA Translation: BAB85051.1
EF445003 Genomic DNA Translation: ACA06032.1
EF445003 Genomic DNA Translation: ACA06033.1
AL512641 Genomic DNA No translation available.
AL450384 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86191.1
BC035778 mRNA Translation: AAH35778.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7130.1

NCBI Reference Sequences

More...
RefSeqi
NP_872349.1, NM_182543.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377304; ENSP00000366519; ENSG00000241058

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
221078

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221078

UCSC genome browser

More...
UCSCi
uc010qcp.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074323 mRNA Translation: BAB85051.1
EF445003 Genomic DNA Translation: ACA06032.1
EF445003 Genomic DNA Translation: ACA06033.1
AL512641 Genomic DNA No translation available.
AL450384 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86191.1
BC035778 mRNA Translation: AAH35778.1
CCDSiCCDS7130.1
RefSeqiNP_872349.1, NM_182543.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WWQX-ray2.81A/B1-469[»]
5WWRX-ray3.10A/B1-469[»]
5WWSX-ray3.25A/B1-469[»]
5WWTX-ray3.20A/B1-469[»]
SMRiQ8TEA1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128682, 5 interactors
IntActiQ8TEA1, 1 interactor
STRINGi9606.ENSP00000366519

PTM databases

CarbonylDBiQ8TEA1
iPTMnetiQ8TEA1
PhosphoSitePlusiQ8TEA1
SwissPalmiQ8TEA1

Genetic variation databases

BioMutaiNSUN6
DMDMi74751440

Proteomic databases

EPDiQ8TEA1
jPOSTiQ8TEA1
MassIVEiQ8TEA1
MaxQBiQ8TEA1
PaxDbiQ8TEA1
PeptideAtlasiQ8TEA1
PRIDEiQ8TEA1
ProteomicsDBi74429

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25416, 132 antibodies

The DNASU plasmid repository

More...
DNASUi
221078

Genome annotation databases

EnsembliENST00000377304; ENSP00000366519; ENSG00000241058
GeneIDi221078
KEGGihsa:221078
UCSCiuc010qcp.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
221078
DisGeNETi221078

GeneCards: human genes, protein and diseases

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GeneCardsi
NSUN6
HGNCiHGNC:23529, NSUN6
HPAiENSG00000241058, Tissue enhanced (liver)
neXtProtiNX_Q8TEA1
OpenTargetsiENSG00000241058
PharmGKBiPA134986220
VEuPathDBiHostDB:ENSG00000241058

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1122, Eukaryota
GeneTreeiENSGT00940000155370
HOGENOMiCLU_005316_1_1_1
InParanoidiQ8TEA1
OMAiYQGAMLY
OrthoDBi1040075at2759
PhylomeDBiQ8TEA1
TreeFamiTF324225

Enzyme and pathway databases

BRENDAi2.1.1.202, 2681
PathwayCommonsiQ8TEA1
ReactomeiR-HSA-6782315, tRNA modification in the nucleus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
221078, 10 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NSUN6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
221078
PharosiQ8TEA1, Tbio

Protein Ontology

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PROi
PR:Q8TEA1
RNActiQ8TEA1, protein

Gene expression databases

BgeeiENSG00000241058, Expressed in oviduct epithelium and 190 other tissues
ExpressionAtlasiQ8TEA1, baseline and differential
GenevisibleiQ8TEA1, HS

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR018314, Fmu/NOL1/Nop2p_CS
IPR001678, MeTrfase_RsmB/NOP2
IPR015947, PUA-like_sf
IPR036974, PUA_sf
IPR023267, RCMT
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF01189, Methyltr_RsmB-F, 1 hit
PRINTSiPR02008, RCMTFAMILY
SUPFAMiSSF53335, SSF53335, 1 hit
SSF88697, SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS01153, NOL1_NOP2_SUN, 1 hit
PS50890, PUA, 1 hit
PS51686, SAM_MT_RSMB_NOP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSUN6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEA1
Secondary accession number(s): B0YJ54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: September 29, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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