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Entry version 155 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Gene

NSUN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) (PubMed:26160102, PubMed:27703015, PubMed:28531330).

In vitro also methylates tRNA(Thr)(AGT) (PubMed:27703015, PubMed:26160102).

Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates (PubMed:26160102, PubMed:27703015).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.02 µM for tRNA(Thr)(TGT)1 Publication
  2. KM=1.58 µM for tRNA(Thr)(AGT)1 Publication
  3. KM=0.89 µM for tRNA(Cys)(GCA)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei266S-adenosyl-L-methioninePROSITE-ProRule annotationCombined sources1 Publication1
    Binding sitei293S-adenosyl-L-methioninePROSITE-ProRule annotation1
    Binding sitei323S-adenosyl-L-methioninePROSITE-ProRule annotationCombined sources1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei373NucleophilePROSITE-ProRule annotationCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • tRNA (cytosine-5-)-methyltransferase activity Source: UniProtKB
    • tRNA binding Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMethyltransferase, RNA-binding, Transferase
    LigandS-adenosyl-L-methionine

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.1.1.202, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q8TEA1

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-6782315, tRNA modification in the nucleus and cytosol

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    tRNA (cytosine(72)-C(5))-methyltransferase NSUN6Curated (EC:2.1.1.-3 Publications)
    Alternative name(s):
    NOL1/NOP2/Sun and PUA domain-containing protein 1
    NOL1/NOP2/Sun domain family member 6
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NSUN6Imported
    Synonyms:NOPD1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:23529, NSUN6

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8TEA1

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000241058.3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi126R → A: Decreases substantially tRNA methyltransferase activity. 1 Publication1
    Mutagenesisi131Y → A: Abolishes methylation of tRNA (Cys). 1 Publication1
    Mutagenesisi159K → A: Decreases tRNA methyltransferase activiry. Abolishes tRNA methyltransferase activiry; when associated with A-181. 1 Publication1
    Mutagenesisi160K → A: Decreases tRNA methyltransferase activiry. Abolishes tRNA methyltransferase activiry; when associated with A-181. 1 Publication1
    Mutagenesisi181R → A: Decreases subtantially tRNA methyltransferase activiry. 1 Publication1
    Mutagenesisi218L → A: Decreases substantially tRNA methyltransferase activity. 1 Publication1
    Mutagenesisi220N → A: Decreases substantially tRNA methyltransferase activity. 1 Publication1
    Mutagenesisi223S → A: Dose not affect tRNA methyltransferase activity. 1 Publication1
    Mutagenesisi248K → A: Abolishes tRNA methyltransferase activity. Does not affect S-Adenosylmethionine binding. 1 Publication1
    Mutagenesisi266D → A: Loss of S-Adenosylmethionine binding. Loss of tRNA methyltransferase activity. 1 Publication1
    Mutagenesisi271K → A: Loss of S-Adenosylmethionine binding. Loss of tRNA methyltransferase activity. 1 Publication1
    Mutagenesisi293D → A: Loss of S-Adenosylmethionine binding. Loss of tRNA methyltransferase activity. 1 Publication1
    Mutagenesisi323D → A: Abolishes tRNA methyltransferase activity. Abolishes S-Adenosylmethionine binding. 1 Publication1
    Mutagenesisi373C → A: Does not impair target RNA binding. Abolishes tRNA (cytosine-5-)-methyltransferase activity. 2 Publications1
    Mutagenesisi458F → A: Abolishes tRNA methyltransferase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    221078

    Open Targets

    More...
    OpenTargetsi
    ENSG00000241058

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134986220

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8TEA1, Tbio

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    NSUN6

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74751440

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002631141 – 469tRNA (cytosine(72)-C(5))-methyltransferase NSUN6Add BLAST469

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei419N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8TEA1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8TEA1

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8TEA1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8TEA1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8TEA1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8TEA1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8TEA1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    74429

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...
    CarbonylDBi
    Q8TEA1

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8TEA1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8TEA1

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q8TEA1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000241058, Expressed in oviduct epithelium and 190 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8TEA1, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8TEA1, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000241058, Tissue enhanced (liver)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    128682, 5 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8TEA1, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000366519

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8TEA1, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1469
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8TEA1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 203PUAPROSITE-ProRule annotationAdd BLAST93

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni242 – 248S-adenosyl-L-methionine bindingPROSITE-ProRule annotationCombined sources1 Publication7

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The PUA domain plays a role in tRNA recognition through precisely recognizing the CCA end and the D-stem region of tRNA.1 Publication

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1122, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155370

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_005316_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8TEA1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FCYDGTK

    Database of Orthologous Groups

    More...
    OrthoDBi
    1040075at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8TEA1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF324225

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.30.130.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR018314, Fmu/NOL1/Nop2p_CS
    IPR001678, MeTrfase_RsmB/NOP2
    IPR002478, PUA
    IPR015947, PUA-like_sf
    IPR036974, PUA_sf
    IPR023267, RCMT
    IPR029063, SAM-dependent_MTases

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01189, Methyltr_RsmB-F, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR02008, RCMTFAMILY

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53335, SSF53335, 1 hit
    SSF88697, SSF88697, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01153, NOL1_NOP2_SUN, 1 hit
    PS50890, PUA, 1 hit
    PS51686, SAM_MT_RSMB_NOP, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q8TEA1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP
    60 70 80 90 100
    SFTTVRVNTH LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV
    110 120 130 140 150
    IGPRKNIKKQ QCEAIVGAQC GNAVLRGAHV YAPGIVSASQ FMKAGDVISV
    160 170 180 190 200
    YSDIKGKCKK GAKEFDGTKV FLGNGISELS RKEIFSGLPE LKGMGIRMTE
    210 220 230 240 250
    PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD LCAAPGGKTT
    260 270 280 290 300
    HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL
    310 320 330 340 350
    DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL
    360 370 380 390 400
    QRKLFTAAVQ LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE
    410 420 430 440 450
    PQIGGEGMRG AGLSCEQLKQ LQRFDPSAVP LPDTDMDSLR EARREDMLRL
    460
    ANKDSIGFFI AKFVKCKST
    Length:469
    Mass (Da):51,770
    Last modified:June 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB6D383915547CF6
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    U3KQU2U3KQU2_HUMAN
    tRNA (cytosine(72)-C(5))-methyltran...
    NSUN6
    149Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0D9SF14A0A0D9SF14_HUMAN
    tRNA (cytosine(72)-C(5))-methyltran...
    NSUN6
    35Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK074323 mRNA Translation: BAB85051.1
    EF445003 Genomic DNA Translation: ACA06032.1
    EF445003 Genomic DNA Translation: ACA06033.1
    AL512641 Genomic DNA No translation available.
    AL450384 Genomic DNA No translation available.
    CH471072 Genomic DNA Translation: EAW86191.1
    BC035778 mRNA Translation: AAH35778.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS7130.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_872349.1, NM_182543.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000377304; ENSP00000366519; ENSG00000241058

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    221078

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:221078

    UCSC genome browser

    More...
    UCSCi
    uc010qcp.2, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK074323 mRNA Translation: BAB85051.1
    EF445003 Genomic DNA Translation: ACA06032.1
    EF445003 Genomic DNA Translation: ACA06033.1
    AL512641 Genomic DNA No translation available.
    AL450384 Genomic DNA No translation available.
    CH471072 Genomic DNA Translation: EAW86191.1
    BC035778 mRNA Translation: AAH35778.1
    CCDSiCCDS7130.1
    RefSeqiNP_872349.1, NM_182543.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5WWQX-ray2.81A/B1-469[»]
    5WWRX-ray3.10A/B1-469[»]
    5WWSX-ray3.25A/B1-469[»]
    5WWTX-ray3.20A/B1-469[»]
    SMRiQ8TEA1
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi128682, 5 interactors
    IntActiQ8TEA1, 1 interactor
    STRINGi9606.ENSP00000366519

    PTM databases

    CarbonylDBiQ8TEA1
    iPTMnetiQ8TEA1
    PhosphoSitePlusiQ8TEA1
    SwissPalmiQ8TEA1

    Genetic variation databases

    BioMutaiNSUN6
    DMDMi74751440

    Proteomic databases

    EPDiQ8TEA1
    jPOSTiQ8TEA1
    MassIVEiQ8TEA1
    MaxQBiQ8TEA1
    PaxDbiQ8TEA1
    PeptideAtlasiQ8TEA1
    PRIDEiQ8TEA1
    ProteomicsDBi74429

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    25416, 132 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    221078

    Genome annotation databases

    EnsembliENST00000377304; ENSP00000366519; ENSG00000241058
    GeneIDi221078
    KEGGihsa:221078
    UCSCiuc010qcp.2, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    221078
    DisGeNETi221078

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    NSUN6
    HGNCiHGNC:23529, NSUN6
    HPAiENSG00000241058, Tissue enhanced (liver)
    neXtProtiNX_Q8TEA1
    OpenTargetsiENSG00000241058
    PharmGKBiPA134986220
    VEuPathDBiHostDB:ENSG00000241058.3

    GenAtlas: human gene database

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    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1122, Eukaryota
    GeneTreeiENSGT00940000155370
    HOGENOMiCLU_005316_1_1_1
    InParanoidiQ8TEA1
    OMAiFCYDGTK
    OrthoDBi1040075at2759
    PhylomeDBiQ8TEA1
    TreeFamiTF324225

    Enzyme and pathway databases

    BRENDAi2.1.1.202, 2681
    PathwayCommonsiQ8TEA1
    ReactomeiR-HSA-6782315, tRNA modification in the nucleus and cytosol

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    221078, 10 hits in 997 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    NSUN6, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    221078
    PharosiQ8TEA1, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q8TEA1
    RNActiQ8TEA1, protein

    Gene expression databases

    BgeeiENSG00000241058, Expressed in oviduct epithelium and 190 other tissues
    ExpressionAtlasiQ8TEA1, baseline and differential
    GenevisibleiQ8TEA1, HS

    Family and domain databases

    Gene3Di2.30.130.10, 1 hit
    InterProiView protein in InterPro
    IPR018314, Fmu/NOL1/Nop2p_CS
    IPR001678, MeTrfase_RsmB/NOP2
    IPR002478, PUA
    IPR015947, PUA-like_sf
    IPR036974, PUA_sf
    IPR023267, RCMT
    IPR029063, SAM-dependent_MTases
    PfamiView protein in Pfam
    PF01189, Methyltr_RsmB-F, 1 hit
    PRINTSiPR02008, RCMTFAMILY
    SUPFAMiSSF53335, SSF53335, 1 hit
    SSF88697, SSF88697, 1 hit
    PROSITEiView protein in PROSITE
    PS01153, NOL1_NOP2_SUN, 1 hit
    PS50890, PUA, 1 hit
    PS51686, SAM_MT_RSMB_NOP, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSUN6_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEA1
    Secondary accession number(s): B0YJ54
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: June 1, 2002
    Last modified: June 2, 2021
    This is version 155 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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