GRHL3

Functionⁱ

Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).By similarity4 Publications

Miscellaneous

GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxical lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related, but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development.By similarity

GO - Molecular functionⁱ

chromatin DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21081122
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding Source: UniProtKB
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: HGNC
Inferred from direct assayⁱ
- 23685552

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

central nervous system development Source: Ensembl
cochlea morphogenesis Source: Ensembl
ectoderm development Source: Ensembl
epidermis development Source: UniProtKB
establishment of planar polarity Source: Ensembl
establishment of skin barrier Source: Ensembl
eyelid development in camera-type eye Source: Ensembl
neural tube closure Source: UniProtKB
pattern specification process Source: Ensembl
planar cell polarity pathway involved in neural tube closure Source: Ensembl
positive regulation of GTPase activity Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: HGNC
Inferred from direct assayⁱ
- 23685552
regulation of actin cytoskeleton organization
Source: MGI
Inferred from genetic interactionⁱ
- 20643356
wound healing Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Grainyhead-like protein 3 homologImported Alternative name(s): Sister of mammalian grainyhead Transcription factor CP2-like 4
Gene namesⁱ	Name:GRHL3Imported Synonyms:SOM, TFCP2L4Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158055.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25839 GRHL3
MIMⁱ	608317 gene
neXtProtⁱ	NX_Q8TE85

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Van der Woude syndrome 2 (VWS2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_072616	298	R → H in VWS2. 1 PublicationCorresponds to variant dbSNP:rs752673677EnsemblClinVar.	1
Natural variantⁱVAR_072617	391	R → C in VWS2. 1 PublicationCorresponds to variant dbSNP:rs879255245EnsemblClinVar.	1
Natural variantⁱVAR_072618	520	R → Q in VWS2. 1 PublicationCorresponds to variant dbSNP:rs946439477Ensembl.	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57822
MalaCards human disease database More...MalaCardsⁱ	GRHL3
MIMⁱ	606713 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000158055
Orphanetⁱ	888 Van der Woude syndrome
PharmGKBⁱ	PA134987320

Polymorphism and mutation databases

BioMutaⁱ	GRHL3
DMDMⁱ	116242504

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000227997	1 – 626	Grainyhead-like protein 3 homologAdd BLAST		626

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TE85
PaxDbⁱ	Q8TE85
PeptideAtlas More...PeptideAtlasⁱ	Q8TE85
PRIDEⁱ	Q8TE85
ProteomicsDBⁱ	74420 74421 [Q8TE85-2] 74422 [Q8TE85-3] 74423 [Q8TE85-4]

PTM databases

iPTMnetⁱ	Q8TE85
PhosphoSitePlusⁱ	Q8TE85

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000158055 Expressed in 94 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_GRHL3
ExpressionAtlasⁱ	Q8TE85 baseline and differential
Genevisibleⁱ	Q8TE85 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059960

HPAⁱ

HPA059960

Interactionⁱ

Subunit structureⁱ

Homodimer, also forms heterodimers with GRHL1 and GRHL2 (PubMed:12549979). Interacts with LMO4 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PRMT5	O14744	2	EBI-8469396,EBI-351098
PRMT6	Q96LA8	2	EBI-8469396,EBI-912440

Protein-protein interaction databases

BioGridⁱ	121781, 7 interactors
IntActⁱ	Q8TE85, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q8TE85
STRINGⁱ	9606.ENSP00000288955

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TE85
SMRⁱ	Q8TE85
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	30 – 95	Transcription activation1 PublicationAdd BLAST		66

Sequence similaritiesⁱ

Belongs to the grh/CP2 family. Grainyhead subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG4091 Eukaryota ENOG410XNZ6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119235
HOGENOMⁱ	HOG000220859
HOVERGENⁱ	HBG054154
InParanoidⁱ	Q8TE85
KEGG Orthology (KO) More...KOⁱ	K09275
OMAⁱ	KRTCSPF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03ME
PhylomeDBⁱ	Q8TE85
TreeFamⁱ	TF314132

Family and domain databases

InterProⁱ	View protein in InterPro IPR007604 CP2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04516 CP2, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TE85-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNELDFRSV RLLKNDPVNL QKFSYTSEDE AWKTYLENPL TAATKAMMRV 
        60         70         80         90        100
NGDDDSVAAL SFLYDYYMGP KEKRILSSST GGRNDQGKRY YHGMEYETDL 
       110        120        130        140        150
TPLESPTHLM KFLTENVSGT PEYPDLLKKN NLMSLEGALP TPGKAAPLPA 
       160        170        180        190        200
GPSKLEAGSV DSYLLPTTDM YDNGSLNSLF ESIHGVPPTQ RWQPDSTFKD 
       210        220        230        240        250
DPQESMLFPD ILKTSPEPPC PEDYPSLKSD FEYTLGSPKA IHIKSGESPM 
       260        270        280        290        300
AYLNKGQFYP VTLRTPAGGK GLALSSNKVK SVVMVVFDNE KVPVEQLRFW 
       310        320        330        340        350
KHWHSRQPTA KQRVIDVADC KENFNTVEHI EEVAYNALSF VWNVNEEAKV 
       360        370        380        390        400
FIGVNCLSTD FSSQKGVKGV PLNLQIDTYD CGLGTERLVH RAVCQIKIFC 
       410        420        430        440        450
DKGAERKMRD DERKQFRRKV KCPDSSNSGV KGCLLSGFRG NETTYLRPET 
       460        470        480        490        500
DLETPPVLFI PNVHFSSLQR SGGAAPSAGP SSSNRLPLKR TCSPFTEEFE 
       510        520        530        540        550
PLPSKQAKEG DLQRVLLYVR RETEEVFDAL MLKTPDLKGL RNAISEKYGF 
       560        570        580        590        600
PEENIYKVYK KCKRGETSLL HPRLSRHPPP DCLECSHPVT QVRNMGFGDG 
       610        620 
FWRQRDLDSN PSPTTVNSLH FTVNSE

Length:626

Mass (Da):70,345

Last modified:October 17, 2006 - v3

Checksum:ⁱ225C0E2049FF0CE6

GO

Isoform 2 (identifier: Q8TE85-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-6: MSNELD → MWMNSILPIFL
566-626: ETSLLHPRLS...NSLHFTVNSE → ILVNMDNNII...GKIQIILKEL

« Hide

        10         20         30         40         50
MWMNSILPIF LFRSVRLLKN DPVNLQKFSY TSEDEAWKTY LENPLTAATK 
        60         70         80         90        100
AMMRVNGDDD SVAALSFLYD YYMGPKEKRI LSSSTGGRND QGKRYYHGME 
       110        120        130        140        150
YETDLTPLES PTHLMKFLTE NVSGTPEYPD LLKKNNLMSL EGALPTPGKA 
       160        170        180        190        200
APLPAGPSKL EAGSVDSYLL PTTDMYDNGS LNSLFESIHG VPPTQRWQPD 
       210        220        230        240        250
STFKDDPQES MLFPDILKTS PEPPCPEDYP SLKSDFEYTL GSPKAIHIKS 
       260        270        280        290        300
GESPMAYLNK GQFYPVTLRT PAGGKGLALS SNKVKSVVMV VFDNEKVPVE 
       310        320        330        340        350
QLRFWKHWHS RQPTAKQRVI DVADCKENFN TVEHIEEVAY NALSFVWNVN 
       360        370        380        390        400
EEAKVFIGVN CLSTDFSSQK GVKGVPLNLQ IDTYDCGLGT ERLVHRAVCQ 
       410        420        430        440        450
IKIFCDKGAE RKMRDDERKQ FRRKVKCPDS SNSGVKGCLL SGFRGNETTY 
       460        470        480        490        500
LRPETDLETP PVLFIPNVHF SSLQRSGGAA PSAGPSSSNR LPLKRTCSPF 
       510        520        530        540        550
TEEFEPLPSK QAKEGDLQRV LLYVRRETEE VFDALMLKTP DLKGLRNAIS 
       560        570        580        590        600
EKYGFPEENI YKVYKKCKRG ILVNMDNNII QHYSNHVAFL LDMGELDGKI 

QIILKEL

Show »

Length:607

Mass (Da):68,353

Checksum:ⁱD750D50275F999B2

GO

Isoform 3 (identifier: Q8TE85-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-46: Missing.
566-626: ETSLLHPRLS...NSLHFTVNSE → ILVNMDNNII...GKIQIILKEL

« Hide

        10         20         30         40         50
MMRVNGDDDS VAALSFLYDY YMGPKEKRIL SSSTGGRNDQ GKRYYHGMEY 
        60         70         80         90        100
ETDLTPLESP THLMKFLTEN VSGTPEYPDL LKKNNLMSLE GALPTPGKAA 
       110        120        130        140        150
PLPAGPSKLE AGSVDSYLLP TTDMYDNGSL NSLFESIHGV PPTQRWQPDS 
       160        170        180        190        200
TFKDDPQESM LFPDILKTSP EPPCPEDYPS LKSDFEYTLG SPKAIHIKSG 
       210        220        230        240        250
ESPMAYLNKG QFYPVTLRTP AGGKGLALSS NKVKSVVMVV FDNEKVPVEQ 
       260        270        280        290        300
LRFWKHWHSR QPTAKQRVID VADCKENFNT VEHIEEVAYN ALSFVWNVNE 
       310        320        330        340        350
EAKVFIGVNC LSTDFSSQKG VKGVPLNLQI DTYDCGLGTE RLVHRAVCQI 
       360        370        380        390        400
KIFCDKGAER KMRDDERKQF RRKVKCPDSS NSGVKGCLLS GFRGNETTYL 
       410        420        430        440        450
RPETDLETPP VLFIPNVHFS SLQRSGGAAP SAGPSSSNRL PLKRTCSPFT 
       460        470        480        490        500
EEFEPLPSKQ AKEGDLQRVL LYVRRETEEV FDALMLKTPD LKGLRNAISE 
       510        520        530        540        550
KYGFPEENIY KVYKKCKRGI LVNMDNNIIQ HYSNHVAFLL DMGELDGKIQ 

IILKEL

Note: No experimental confirmation available.

Show »

Length:556

Mass (Da):62,378

Checksum:ⁱ6D343D56FA89947C

GO

Isoform 4 (identifier: Q8TE85-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-93: Missing.
566-626: ETSLLHPRLS...NSLHFTVNSE → ILVNMDNNII...GKIQIILKEL

« Hide

        10         20         30         40         50
MEYETDLTPL ESPTHLMKFL TENVSGTPEY PDLLKKNNLM SLEGALPTPG 
        60         70         80         90        100
KAAPLPAGPS KLEAGSVDSY LLPTTDMYDN GSLNSLFESI HGVPPTQRWQ 
       110        120        130        140        150
PDSTFKDDPQ ESMLFPDILK TSPEPPCPED YPSLKSDFEY TLGSPKAIHI 
       160        170        180        190        200
KSGESPMAYL NKGQFYPVTL RTPAGGKGLA LSSNKVKSVV MVVFDNEKVP 
       210        220        230        240        250
VEQLRFWKHW HSRQPTAKQR VIDVADCKEN FNTVEHIEEV AYNALSFVWN 
       260        270        280        290        300
VNEEAKVFIG VNCLSTDFSS QKGVKGVPLN LQIDTYDCGL GTERLVHRAV 
       310        320        330        340        350
CQIKIFCDKG AERKMRDDER KQFRRKVKCP DSSNSGVKGC LLSGFRGNET 
       360        370        380        390        400
TYLRPETDLE TPPVLFIPNV HFSSLQRSGG AAPSAGPSSS NRLPLKRTCS 
       410        420        430        440        450
PFTEEFEPLP SKQAKEGDLQ RVLLYVRRET EEVFDALMLK TPDLKGLRNA 
       460        470        480        490        500
ISEKYGFPEE NIYKVYKKCK RGILVNMDNN IIQHYSNHVA FLLDMGELDG 

KIQIILKEL

Show »

Length:509

Mass (Da):57,045

Checksum:ⁱECE5E4685D8B223D

GO

Isoform 5 (identifier: Q8TE85-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
566-626: ETSLLHPRLS...NSLHFTVNSE → ILVNMDNNII...GKIQIILKEL

« Hide

        10         20         30         40         50
MSNELDFRSV RLLKNDPVNL QKFSYTSEDE AWKTYLENPL TAATKAMMRV 
        60         70         80         90        100
NGDDDSVAAL SFLYDYYMGP KEKRILSSST GGRNDQGKRY YHGMEYETDL 
       110        120        130        140        150
TPLESPTHLM KFLTENVSGT PEYPDLLKKN NLMSLEGALP TPGKAAPLPA 
       160        170        180        190        200
GPSKLEAGSV DSYLLPTTDM YDNGSLNSLF ESIHGVPPTQ RWQPDSTFKD 
       210        220        230        240        250
DPQESMLFPD ILKTSPEPPC PEDYPSLKSD FEYTLGSPKA IHIKSGESPM 
       260        270        280        290        300
AYLNKGQFYP VTLRTPAGGK GLALSSNKVK SVVMVVFDNE KVPVEQLRFW 
       310        320        330        340        350
KHWHSRQPTA KQRVIDVADC KENFNTVEHI EEVAYNALSF VWNVNEEAKV 
       360        370        380        390        400
FIGVNCLSTD FSSQKGVKGV PLNLQIDTYD CGLGTERLVH RAVCQIKIFC 
       410        420        430        440        450
DKGAERKMRD DERKQFRRKV KCPDSSNSGV KGCLLSGFRG NETTYLRPET 
       460        470        480        490        500
DLETPPVLFI PNVHFSSLQR SGGAAPSAGP SSSNRLPLKR TCSPFTEEFE 
       510        520        530        540        550
PLPSKQAKEG DLQRVLLYVR RETEEVFDAL MLKTPDLKGL RNAISEKYGF 
       560        570        580        590        600
PEENIYKVYK KCKRGILVNM DNNIIQHYSN HVAFLLDMGE LDGKIQIILK 

EL

Note: No experimental confirmation available.

Show »

Length:602

Mass (Da):67,696

Checksum:ⁱ036BE44B3F448A93

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PLT6	E9PLT6_HUMAN	Grainyhead-like protein 3 homolog Grainyhead-like protein 3 homolog	GRHL3	81	Annotation score:
E9PLG9	E9PLG9_HUMAN	Grainyhead-like protein 3 homolog Grainyhead-like protein 3 homolog	GRHL3	52	Annotation score:

Sequence cautionⁱ

The sequence AAH36890 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAG37608 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	20	L → S in BAB85067 (PubMed:14702039).Curated	1
Sequence conflictⁱ	396	I → V in BAG37608 (PubMed:14702039).Curated	1
Sequence conflictⁱ	533	K → R in BAB85067 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_027907	55	D → E. Corresponds to variant dbSNP:rs2486668Ensembl.	1
Natural variantⁱVAR_055881	160	V → A. Corresponds to variant dbSNP:rs34637004Ensembl.	1
Natural variantⁱVAR_072616	298	R → H in VWS2. 1 PublicationCorresponds to variant dbSNP:rs752673677EnsemblClinVar.	1
Natural variantⁱVAR_072617	391	R → C in VWS2. 1 PublicationCorresponds to variant dbSNP:rs879255245EnsemblClinVar.	1
Natural variantⁱVAR_072618	520	R → Q in VWS2. 1 PublicationCorresponds to variant dbSNP:rs946439477Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_017643	1 – 93	Missing in isoform 4. 1 PublicationAdd BLAST	93
Alternative sequenceⁱVSP_017644	1 – 46	Missing in isoform 3. 1 PublicationAdd BLAST	46
Alternative sequenceⁱVSP_017645	1 – 6	MSNELD → MWMNSILPIFL in isoform 2. 1 Publication	6
Alternative sequenceⁱVSP_017646	566 – 626	ETSLL…TVNSE → ILVNMDNNIIQHYSNHVAFL LDMGELDGKIQIILKEL in isoform 2, isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST	61

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY231160 mRNA Translation: AAO67370.1 AY231161 mRNA No translation available. AK074386 mRNA Translation: BAB85067.1 AK315164 mRNA Translation: BAG37608.1 Different initiation. AL031431 Genomic DNA No translation available. AL138902 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW95121.1 BC036890 mRNA Translation: AAH36890.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS251.1 [Q8TE85-2] CCDS252.2 [Q8TE85-1] CCDS44088.1 [Q8TE85-5] CCDS53284.1 [Q8TE85-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001181939.1, NM_001195010.1 [Q8TE85-3] NP_067003.2, NM_021180.3 [Q8TE85-2] NP_937816.1, NM_198173.2 [Q8TE85-5] NP_937817.3, NM_198174.2 [Q8TE85-1] XP_011540171.1, XM_011541869.1 [Q8TE85-3] XP_011540172.1, XM_011541870.2 [Q8TE85-4]
UniGeneⁱ	Hs.657920

Genome annotation databases

Ensemblⁱ	ENST00000236255; ENSP00000236255; ENSG00000158055 [Q8TE85-2] ENST00000350501; ENSP00000288955; ENSG00000158055 [Q8TE85-1] ENST00000356046; ENSP00000348333; ENSG00000158055 [Q8TE85-3] ENST00000361548; ENSP00000354943; ENSG00000158055 [Q8TE85-5]
GeneIDⁱ	57822
KEGGⁱ	hsa:57822
UCSC genome browser More...UCSCⁱ	uc001bix.3 human [Q8TE85-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8TE85	Grainyhead like transcription factor 3		SAIBB		641	UniRef90_Q8TE85
Grainyhead-like protein 3 homolog (Fragment)		HUMAN		81
GRHL3 isoform 9 (Fragment)		PANTR		81
Uncharacterized protein		MANLE		626
Grainyhead like transcription factor 3		GORGO		626
+15
Q8TE85-2	Isoform 3 of Grainyhead-like protein 3 homolog		HUMAN		556	UniRef90_Q8TE85-2
Sister-of-mammalian grainyhead protein-like protein		CAMFR		663
Uncharacterized protein		SHEEP		623
Grainyhead like transcription factor 3		AILME		615
Uncharacterized protein		FELCA		614
+193
Q8TE85-3	Isoform 2 of Grainyhead-like protein 3 homolog		HUMAN		607	UniRef90_Q8TE85-2
Sister-of-mammalian grainyhead protein-like protein		CAMFR		663
Uncharacterized protein		SHEEP		623
Grainyhead like transcription factor 3		AILME		615
Uncharacterized protein		FELCA		614
+193
Q8TE85-4	Isoform 2 of Grainyhead-like protein 3 homolog		HUMAN		607	UniRef90_Q8TE85-2
Sister-of-mammalian grainyhead protein-like protein		CAMFR		663
Uncharacterized protein		SHEEP		623
Grainyhead like transcription factor 3		AILME		615
Uncharacterized protein		FELCA		614
+193
Q8TE85-5	Isoform 2 of Grainyhead-like protein 3 homolog		HUMAN		607	UniRef90_Q8TE85-2
Sister-of-mammalian grainyhead protein-like protein		CAMFR		663
Uncharacterized protein		SHEEP		623
Grainyhead like transcription factor 3		AILME		615
Uncharacterized protein		FELCA		614
+193

Protein	Similar proteins		Species	Score	Length	Source
Q8TE85	Grainyhead-like protein 3 homolog		MOUSE		603	UniRef50_Q5FWH3
Grainyhead-like protein 3 homolog		XENLA		595
Grainyhead-like protein 3 homolog		XENTR		594
grainyhead-like protein 3 homolog		MESAU		561
Uncharacterized protein		AOTNA		609
+413

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY231160 mRNA Translation: AAO67370.1 AY231161 mRNA No translation available. AK074386 mRNA Translation: BAB85067.1 AK315164 mRNA Translation: BAG37608.1 Different initiation. AL031431 Genomic DNA No translation available. AL138902 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW95121.1 BC036890 mRNA Translation: AAH36890.1 Different initiation.
CCDSⁱ	CCDS251.1 [Q8TE85-2] CCDS252.2 [Q8TE85-1] CCDS44088.1 [Q8TE85-5] CCDS53284.1 [Q8TE85-3]
RefSeqⁱ	NP_001181939.1, NM_001195010.1 [Q8TE85-3] NP_067003.2, NM_021180.3 [Q8TE85-2] NP_937816.1, NM_198173.2 [Q8TE85-5] NP_937817.3, NM_198174.2 [Q8TE85-1] XP_011540171.1, XM_011541869.1 [Q8TE85-3] XP_011540172.1, XM_011541870.2 [Q8TE85-4]
UniGeneⁱ	Hs.657920

3D structure databases

ProteinModelPortalⁱ	Q8TE85
SMRⁱ	Q8TE85
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121781, 7 interactors
IntActⁱ	Q8TE85, 6 interactors
MINTⁱ	Q8TE85
STRINGⁱ	9606.ENSP00000288955

PTM databases

iPTMnetⁱ	Q8TE85
PhosphoSitePlusⁱ	Q8TE85

Polymorphism and mutation databases

BioMutaⁱ	GRHL3
DMDMⁱ	116242504

Proteomic databases

MaxQBⁱ	Q8TE85
PaxDbⁱ	Q8TE85
PeptideAtlasⁱ	Q8TE85
PRIDEⁱ	Q8TE85
ProteomicsDBⁱ	74420 74421 [Q8TE85-2] 74422 [Q8TE85-3] 74423 [Q8TE85-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57822
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000236255; ENSP00000236255; ENSG00000158055 [Q8TE85-2] ENST00000350501; ENSP00000288955; ENSG00000158055 [Q8TE85-1] ENST00000356046; ENSP00000348333; ENSG00000158055 [Q8TE85-3] ENST00000361548; ENSP00000354943; ENSG00000158055 [Q8TE85-5]
GeneIDⁱ	57822
KEGGⁱ	hsa:57822
UCSCⁱ	uc001bix.3 human [Q8TE85-1]

Organism-specific databases

CTDⁱ	57822
DisGeNETⁱ	57822
EuPathDBⁱ	HostDB:ENSG00000158055.15
GeneCardsⁱ	GRHL3
HGNCⁱ	HGNC:25839 GRHL3
HPAⁱ	HPA059960
MalaCardsⁱ	GRHL3
MIMⁱ	606713 phenotype 608317 gene
neXtProtⁱ	NX_Q8TE85
OpenTargetsⁱ	ENSG00000158055
Orphanetⁱ	888 Van der Woude syndrome
PharmGKBⁱ	PA134987320
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4091 Eukaryota ENOG410XNZ6 LUCA
GeneTreeⁱ	ENSGT00760000119235
HOGENOMⁱ	HOG000220859
HOVERGENⁱ	HBG054154
InParanoidⁱ	Q8TE85
KOⁱ	K09275
OMAⁱ	KRTCSPF
OrthoDBⁱ	EOG091G03ME
PhylomeDBⁱ	Q8TE85
TreeFamⁱ	TF314132

Miscellaneous databases

GenomeRNAiⁱ	57822
Protein Ontology More...PROⁱ	PR:Q8TE85
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158055 Expressed in 94 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_GRHL3
ExpressionAtlasⁱ	Q8TE85 baseline and differential
Genevisibleⁱ	Q8TE85 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007604 CP2
Pfamⁱ	View protein in Pfam PF04516 CP2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRHL3_HUMAN
Accessionⁱ	Q8TE85Primary (citable) accession number: Q8TE85 Secondary accession number(s): A2A297 , B2RCL1, G3XAF0, Q5TH78, Q86Y06, Q8N407
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	October 17, 2006
	Last modified:	September 12, 2018
	This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8TE85 (GRHL3_HUMAN)

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Grainyhead-like protein 3 homolog

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Functionⁱ

GO - Molecular functionⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

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Keywords - Coding sequence diversityⁱ

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