Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (16 Oct 2019)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

SH3 domain and tetratricopeptide repeat-containing protein 1

Gene

SH3TC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain and tetratricopeptide repeat-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3TC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26009 SH3TC1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TE82

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54436

Open Targets

More...
OpenTargetsi
ENSG00000125089

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394666

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TE82

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SH3TC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104192

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063551 – 1336SH3 domain and tetratricopeptide repeat-containing protein 1Add BLAST1336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei1248PhosphotyrosineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TE82

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TE82

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TE82

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TE82

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TE82

PeptideAtlas

More...
PeptideAtlasi
Q8TE82

PRoteomics IDEntifications database

More...
PRIDEi
Q8TE82

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74419

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8TE82

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TE82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TE82

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TE82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125089 Expressed in 92 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TE82 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038132
HPA056807

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119952, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TE82, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8TE82

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000245105

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini305 – 368SH3PROSITE-ProRule annotationAdd BLAST64
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati560 – 593TPR 1Add BLAST34
Repeati601 – 634TPR 2Add BLAST34
Repeati665 – 698TPR 3Add BLAST34
Repeati786 – 819TPR 4Add BLAST34
Repeati863 – 896TPR 5Add BLAST34
Repeati946 – 979TPR 6Add BLAST34
Repeati1027 – 1063TPR 7Add BLAST37
Repeati1192 – 1225TPR 8Add BLAST34
Repeati1277 – 1311TPR 9Add BLAST35

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFSQ Eukaryota
ENOG410Y8HX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063812

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000121783

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TE82

Identification of Orthologs from Complete Genome Data

More...
OMAi
IPFHQWF

Database of Orthologous Groups

More...
OrthoDBi
39940at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TE82

TreeFam database of animal gene trees

More...
TreeFami
TF333167

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00018 SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit
SM00028 TPR, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 4 hits
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q8TE82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENLPAVTTE EPTPMGRGPV GPSGGGSTRD QVRTVVMRPS VSWEKAGPEE
60 70 80 90 100
AKAPVRGDEA PPARVAGPAA GTPPCQMGVY PTDLTLQLLA VRRKSRLRDP
110 120 130 140 150
GLQQTLRGQL RLLENDSREM ARVLGELSAR LLSIHSDQDR IVVTFKTFEE
160 170 180 190 200
IWKFSTYHAL GFTHHCLANL LMDQAFWLLL PSEEEETAIQ VHVDENALRL
210 220 230 240 250
THESLLIQEG PFFVLCPDHH VRVMTGPRDA GNGPQALRQA SGAPQGEAAP
260 270 280 290 300
ETDSSPPSPS VSSEEVAVAA APEPLIPFHQ WALRIPQDPI DDAMGGPVMP
310 320 330 340 350
GNPLMAVGLA SALADFQGSG PEEMTFRGGD LIEILGAQVP SLPWCVGRHA
360 370 380 390 400
ASGRVGFVRS SLISMQGPVS ELESAIFLNE EEKSFFSEGC FSEEDARQLL
410 420 430 440 450
RRMSGTDVCS VYSLDSVEEA ETEQPQEKEI PPPCLSLEPQ ETLQKVKNVL
460 470 480 490 500
EQCKTCPGCP QEPASWGLCA ASSDVSLQDP EEPSFCLEAE DDWEDPEALS
510 520 530 540 550
SLLLFLNAPG YKASFRGLYD VALPWLSSVF RSFSDEEELT GRLAQARGAA
560 570 580 590 600
KKAGLLMALA RLCFLLGRLC SRRLKLSQAR VYFEEALGAL EGSFGDLFLV
610 620 630 640 650
VAVYANLASI YRKQKNREKC AQVVPKAMAL LLGTPDHICS TEAEGELLQL
660 670 680 690 700
ALRRAVGGQS LQAEARACFL LARHHVHLKQ PEEALPFLER LLLLHRDSGA
710 720 730 740 750
PEAAWLSDCY LLLADIYSRK CLPHLVLSCV KVASLRTRGS LAGSLRSVNL
760 770 780 790 800
VLQNAPQPHS LPAQTSHYLR QALASLTPGT GQALRGPLYT SLAQLYSHHG
810 820 830 840 850
CHGPAITFMT QAVEASAIAG VRAIVDHLVA LAWLHVLHGQ SPVALDILQS
860 870 880 890 900
VRDAVVASED QEGVIANMVA VALKRTGRTR QAAESYYRAL RVARDLGQQR
910 920 930 940 950
NQAVGLANFG ALCLHAGASR LAQHYLLEAV RLFSRLPLGE CGRDFTHVLL
960 970 980 990 1000
QLGHLCTRQG PAQQGKGYYE WALLVAVEMG HVESQLRAVQ RLCHFYSAVM
1010 1020 1030 1040 1050
PSEAQCVIYH ELQLSLACKV ADKVLEGQLL ETISQLYLSL GTERAYKSAL
1060 1070 1080 1090 1100
DYTKRSLGIF IDLQKKEKEA HAWLQAGKIY YILRQSELVD LYIQVAQNVA
1110 1120 1130 1140 1150
LYTGDPNLGL ELFEAAGDIF FDGAWEREKA VSFYRDRALP LAVTTGNRKA
1160 1170 1180 1190 1200
ELRLCNKLVA LLATLEEPQE GLEFAHMALA LSITLGDRLN ERVAYHRLAA
1210 1220 1230 1240 1250
LQHRLGHGEL AEHFYLKALS LCNSPLEFDE ETLYYVKVYL VLGDIIFYDL
1260 1270 1280 1290 1300
KDPFDAAGYY QLALAAAVDL GNKKAQLKIY TRLATIYHNF LLDREKSLFF
1310 1320 1330
YQKARTFATE LNVRRVNLPP LPLCGWAPWL APSHPR
Length:1,336
Mass (Da):146,961
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0653B347D6B2500A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REB6D6REB6_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA34H0YA34_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6NVH2Q6NVH2_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQR1E7EQR1_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RI07D6RI07_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9A4H0Y9A4_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC98D6RC98_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ04U3KQ04_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAJ7H0YAJ7_HUMAN
SH3 domain and tetratricopeptide re...
SH3TC1
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1016L → P in BAB85071 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034127291D → N. Corresponds to variant dbSNP:rs1281138Ensembl.1
Natural variantiVAR_034128437L → P1 PublicationCorresponds to variant dbSNP:rs1281145Ensembl.1
Natural variantiVAR_035866719R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs201295499Ensembl.1
Natural variantiVAR_021934785R → C. Corresponds to variant dbSNP:rs1281149Ensembl.1
Natural variantiVAR_0358671130A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1348201855Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074402 mRNA Translation: BAB85071.1
AC104650 Genomic DNA Translation: AAY40932.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3399.1

NCBI Reference Sequences

More...
RefSeqi
NP_001305409.1, NM_001318480.1
NP_061859.3, NM_018986.4
XP_011511790.1, XM_011513488.1
XP_016863789.1, XM_017008300.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000245105; ENSP00000245105; ENSG00000125089

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54436

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54436

UCSC genome browser

More...
UCSCi
uc003gkv.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074402 mRNA Translation: BAB85071.1
AC104650 Genomic DNA Translation: AAY40932.1
CCDSiCCDS3399.1
RefSeqiNP_001305409.1, NM_001318480.1
NP_061859.3, NM_018986.4
XP_011511790.1, XM_011513488.1
XP_016863789.1, XM_017008300.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119952, 2 interactors
IntActiQ8TE82, 1 interactor
MINTiQ8TE82
STRINGi9606.ENSP00000245105

PTM databases

iPTMnetiQ8TE82
PhosphoSitePlusiQ8TE82
SwissPalmiQ8TE82

Polymorphism and mutation databases

BioMutaiSH3TC1
DMDMi313104192

Proteomic databases

EPDiQ8TE82
jPOSTiQ8TE82
MassIVEiQ8TE82
MaxQBiQ8TE82
PaxDbiQ8TE82
PeptideAtlasiQ8TE82
PRIDEiQ8TE82
ProteomicsDBi74419
TopDownProteomicsiQ8TE82

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54436

Genome annotation databases

EnsembliENST00000245105; ENSP00000245105; ENSG00000125089
GeneIDi54436
KEGGihsa:54436
UCSCiuc003gkv.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54436
DisGeNETi54436

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SH3TC1
HGNCiHGNC:26009 SH3TC1
HPAiHPA038132
HPA056807
neXtProtiNX_Q8TE82
OpenTargetsiENSG00000125089
PharmGKBiPA128394666

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFSQ Eukaryota
ENOG410Y8HX LUCA
GeneTreeiENSGT00530000063812
HOGENOMiHOG000121783
InParanoidiQ8TE82
OMAiIPFHQWF
OrthoDBi39940at2759
PhylomeDBiQ8TE82
TreeFamiTF333167

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SH3TC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54436
PharosiQ8TE82

Protein Ontology

More...
PROi
PR:Q8TE82

Gene expression databases

BgeeiENSG00000125089 Expressed in 92 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ8TE82 baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 4 hits
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS3TC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TE82
Secondary accession number(s): Q4W5G5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 30, 2010
Last modified: October 16, 2019
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again