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Protein

MORC family CW-type zinc finger protein 4

Gene

MORC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 472CW-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 4
Alternative name(s):
Zinc finger CW-type coiled-coil domain protein 2
Zinc finger CW-type domain protein 4
Gene namesi
Name:MORC4
Synonyms:ZCW4, ZCWCC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000133131.14
HGNCiHGNC:23485 MORC4
MIMi300970 gene
neXtProtiNX_Q8TE76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79710
OpenTargetsiENSG00000133131
PharmGKBiPA128394718

Polymorphism and mutation databases

BioMutaiMORC4
DMDMi73920232

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000965391 – 937MORC family CW-type zinc finger protein 4Add BLAST937

Proteomic databases

EPDiQ8TE76
MaxQBiQ8TE76
PaxDbiQ8TE76
PeptideAtlasiQ8TE76
PRIDEiQ8TE76
ProteomicsDBi74413

PTM databases

iPTMnetiQ8TE76
PhosphoSitePlusiQ8TE76

Expressioni

Tissue specificityi

Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.1 Publication

Gene expression databases

BgeeiENSG00000133131 Expressed in 200 organ(s), highest expression level in placenta
CleanExiHS_MORC4
ExpressionAtlasiQ8TE76 baseline and differential
GenevisibleiQ8TE76 HS

Organism-specific databases

HPAiHPA000395
HPA015547
HPA050250

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-3940432,EBI-518675

Protein-protein interaction databases

BioGridi122827, 13 interactors
IntActiQ8TE76, 7 interactors
MINTiQ8TE76
STRINGi9606.ENSP00000347821

Structurei

3D structure databases

ProteinModelPortaliQ8TE76
SMRiQ8TE76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili762 – 876Sequence analysisAdd BLAST115

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 472CW-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00530000062983
HOGENOMiHOG000246950
HOVERGENiHBG103357
InParanoidiQ8TE76
OMAiARPIPKI
OrthoDBiEOG091G018P
PhylomeDBiQ8TE76
TreeFamiTF329118

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TE76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP
60 70 80 90 100
FSAIAELLDN AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR
110 120 130 140 150
MLSFGFTDKV IKKSQCPIGV FGNGFKSGSM RLGKDALVFT KNGGTLTVGL
160 170 180 190 200
LSQTYLECVQ AQAVIVPIVP FNQQNKKMII TEDSLPSLEA ILNYSIFNRE
210 220 230 240 250
NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY DILVSDFDTE
260 270 280 290 300
EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA
310 320 330 340 350
NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ
360 370 380 390 400
VKPTRGEGVG VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW
410 420 430 440 450
KEKTSQDNFE TSTVARPIPK VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR
460 470 480 490 500
WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS KAKKQEQTVE EKKKMPMENE
510 520 530 540 550
NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG EESRSPSLQL
560 570 580 590 600
KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE
610 620 630 640 650
APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK
660 670 680 690 700
DQRQGSLLPE ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG
710 720 730 740 750
VRDSGAPIQL IPFNREELAE RRKAVESWNP VPYSVASAAI PAAAIGEKAR
760 770 780 790 800
GYEESEGHNT PKLKNQRELE ELKRTTEKLE RVLAERNLFQ QKVEELEQER
810 820 830 840 850
NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ ILKAELERTK
860 870 880 890 900
EEKQELKEKL KETETHLEML QKAQVSYRTP EGDDLERALA KLTRLRIHVS
910 920 930
YLLTSVLPHL ELREIGYDSE QVDGILYTVL EANHILD
Length:937
Mass (Da):106,348
Last modified:August 30, 2005 - v2
Checksum:i7AABDA01596475D2
GO
Isoform 2 (identifier: Q8TE76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Show »
Length:648
Mass (Da):74,353
Checksum:i828D6D1DAC45BA7F
GO
Isoform 3 (identifier: Q8TE76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Show »
Length:900
Mass (Da):101,877
Checksum:iACBD1DEB6E46671C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3U3S4R3U3_HUMAN
MORC family CW-type zinc finger pro...
MORC4
38Annotation score:

Sequence cautioni

The sequence BAB13859 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71125 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307Y → H in BAB71125 (PubMed:14702039).Curated1
Sequence conflicti480S → G in BAB13859 (PubMed:14702039).Curated1
Sequence conflicti519G → E in ABL84747 (PubMed:17608765).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051197473T → I1 PublicationCorresponds to variant dbSNP:rs6622126Ensembl.1
Natural variantiVAR_051198653R → C. Corresponds to variant dbSNP:rs3827464Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0450251 – 252Missing in isoform 2. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_045026875 – 937VSYRT…NHILD → GFGKAYAATYPRQLSPYFCP PSLGAS in isoform 2 and isoform 3. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125209 mRNA Translation: ABL84747.1
EF125210 mRNA Translation: ABL84748.1
AL158821 Genomic DNA No translation available.
AK021627 mRNA Translation: BAB13859.1 Different initiation.
AK056235 mRNA Translation: BAB71125.1 Different initiation.
CCDSiCCDS14525.2 [Q8TE76-1]
CCDS48146.1 [Q8TE76-3]
RefSeqiNP_001078823.1, NM_001085354.2 [Q8TE76-3]
NP_078933.3, NM_024657.4 [Q8TE76-1]
UniGeneiHs.496544

Genome annotation databases

EnsembliENST00000255495; ENSP00000255495; ENSG00000133131 [Q8TE76-3]
ENST00000355610; ENSP00000347821; ENSG00000133131 [Q8TE76-1]
GeneIDi79710
KEGGihsa:79710
UCSCiuc004emu.4 human [Q8TE76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125209 mRNA Translation: ABL84747.1
EF125210 mRNA Translation: ABL84748.1
AL158821 Genomic DNA No translation available.
AK021627 mRNA Translation: BAB13859.1 Different initiation.
AK056235 mRNA Translation: BAB71125.1 Different initiation.
CCDSiCCDS14525.2 [Q8TE76-1]
CCDS48146.1 [Q8TE76-3]
RefSeqiNP_001078823.1, NM_001085354.2 [Q8TE76-3]
NP_078933.3, NM_024657.4 [Q8TE76-1]
UniGeneiHs.496544

3D structure databases

ProteinModelPortaliQ8TE76
SMRiQ8TE76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122827, 13 interactors
IntActiQ8TE76, 7 interactors
MINTiQ8TE76
STRINGi9606.ENSP00000347821

PTM databases

iPTMnetiQ8TE76
PhosphoSitePlusiQ8TE76

Polymorphism and mutation databases

BioMutaiMORC4
DMDMi73920232

Proteomic databases

EPDiQ8TE76
MaxQBiQ8TE76
PaxDbiQ8TE76
PeptideAtlasiQ8TE76
PRIDEiQ8TE76
ProteomicsDBi74413

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255495; ENSP00000255495; ENSG00000133131 [Q8TE76-3]
ENST00000355610; ENSP00000347821; ENSG00000133131 [Q8TE76-1]
GeneIDi79710
KEGGihsa:79710
UCSCiuc004emu.4 human [Q8TE76-1]

Organism-specific databases

CTDi79710
DisGeNETi79710
EuPathDBiHostDB:ENSG00000133131.14
GeneCardsiMORC4
HGNCiHGNC:23485 MORC4
HPAiHPA000395
HPA015547
HPA050250
MIMi300970 gene
neXtProtiNX_Q8TE76
OpenTargetsiENSG00000133131
PharmGKBiPA128394718
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00530000062983
HOGENOMiHOG000246950
HOVERGENiHBG103357
InParanoidiQ8TE76
OMAiARPIPKI
OrthoDBiEOG091G018P
PhylomeDBiQ8TE76
TreeFamiTF329118

Miscellaneous databases

ChiTaRSiMORC4 human
GenomeRNAii79710
PROiPR:Q8TE76
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133131 Expressed in 200 organ(s), highest expression level in placenta
CleanExiHS_MORC4
ExpressionAtlasiQ8TE76 baseline and differential
GenevisibleiQ8TE76 HS

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMORC4_HUMAN
AccessioniPrimary (citable) accession number: Q8TE76
Secondary accession number(s): A1YR23
, A1YR24, H7BXF1, Q5JUK7, Q96MZ2, Q9HAI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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