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Entry version 136 (13 Feb 2019)
Sequence version 2 (30 Aug 2005)
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Protein

MORC family CW-type zinc finger protein 4

Gene

MORC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri420 – 472CW-typePROSITE-ProRule annotationAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 4
Alternative name(s):
Zinc finger CW-type coiled-coil domain protein 2
Zinc finger CW-type domain protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MORC4
Synonyms:ZCW4, ZCWCC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000133131.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23485 MORC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300970 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TE76

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79710

Open Targets

More...
OpenTargetsi
ENSG00000133131

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394718

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MORC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73920232

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000965391 – 937MORC family CW-type zinc finger protein 4Add BLAST937

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TE76

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TE76

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TE76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TE76

PeptideAtlas

More...
PeptideAtlasi
Q8TE76

PRoteomics IDEntifications database

More...
PRIDEi
Q8TE76

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74413

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TE76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TE76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133131 Expressed in 200 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TE76 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TE76 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000395
HPA015547
HPA050250

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-3940432,EBI-518675

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122827, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TE76, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8TE76

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347821

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TE76

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TE76

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili762 – 876Sequence analysisAdd BLAST115

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 472CW-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1845 Eukaryota
ENOG411033B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161221

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246950

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103357

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TE76

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARPIPKI

Database of Orthologous Groups

More...
OrthoDBi
193855at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TE76

TreeFam database of animal gene trees

More...
TreeFami
TF329118

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00075 HATPase_c, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07496 zf-CW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55874 SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51050 ZF_CW, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TE76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP
60 70 80 90 100
FSAIAELLDN AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR
110 120 130 140 150
MLSFGFTDKV IKKSQCPIGV FGNGFKSGSM RLGKDALVFT KNGGTLTVGL
160 170 180 190 200
LSQTYLECVQ AQAVIVPIVP FNQQNKKMII TEDSLPSLEA ILNYSIFNRE
210 220 230 240 250
NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY DILVSDFDTE
260 270 280 290 300
EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA
310 320 330 340 350
NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ
360 370 380 390 400
VKPTRGEGVG VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW
410 420 430 440 450
KEKTSQDNFE TSTVARPIPK VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR
460 470 480 490 500
WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS KAKKQEQTVE EKKKMPMENE
510 520 530 540 550
NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG EESRSPSLQL
560 570 580 590 600
KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE
610 620 630 640 650
APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK
660 670 680 690 700
DQRQGSLLPE ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG
710 720 730 740 750
VRDSGAPIQL IPFNREELAE RRKAVESWNP VPYSVASAAI PAAAIGEKAR
760 770 780 790 800
GYEESEGHNT PKLKNQRELE ELKRTTEKLE RVLAERNLFQ QKVEELEQER
810 820 830 840 850
NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ ILKAELERTK
860 870 880 890 900
EEKQELKEKL KETETHLEML QKAQVSYRTP EGDDLERALA KLTRLRIHVS
910 920 930
YLLTSVLPHL ELREIGYDSE QVDGILYTVL EANHILD
Length:937
Mass (Da):106,348
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AABDA01596475D2
GO
Isoform 2 (identifier: Q8TE76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Show »
Length:648
Mass (Da):74,353
Checksum:i828D6D1DAC45BA7F
GO
Isoform 3 (identifier: Q8TE76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     875-937: VSYRTPEGDD...TVLEANHILD → GFGKAYAATYPRQLSPYFCPPSLGAS

Show »
Length:900
Mass (Da):101,877
Checksum:iACBD1DEB6E46671C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3U3S4R3U3_HUMAN
MORC family CW-type zinc finger pro...
MORC4
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13859 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71125 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti307Y → H in BAB71125 (PubMed:14702039).Curated1
Sequence conflicti480S → G in BAB13859 (PubMed:14702039).Curated1
Sequence conflicti519G → E in ABL84747 (PubMed:17608765).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051197473T → I1 PublicationCorresponds to variant dbSNP:rs6622126Ensembl.1
Natural variantiVAR_051198653R → C. Corresponds to variant dbSNP:rs3827464Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450251 – 252Missing in isoform 2. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_045026875 – 937VSYRT…NHILD → GFGKAYAATYPRQLSPYFCP PSLGAS in isoform 2 and isoform 3. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF125209 mRNA Translation: ABL84747.1
EF125210 mRNA Translation: ABL84748.1
AL158821 Genomic DNA No translation available.
AK021627 mRNA Translation: BAB13859.1 Different initiation.
AK056235 mRNA Translation: BAB71125.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14525.2 [Q8TE76-1]
CCDS48146.1 [Q8TE76-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001078823.1, NM_001085354.2 [Q8TE76-3]
NP_078933.3, NM_024657.4 [Q8TE76-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.496544

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255495; ENSP00000255495; ENSG00000133131 [Q8TE76-3]
ENST00000355610; ENSP00000347821; ENSG00000133131 [Q8TE76-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79710

UCSC genome browser

More...
UCSCi
uc004emu.4 human [Q8TE76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125209 mRNA Translation: ABL84747.1
EF125210 mRNA Translation: ABL84748.1
AL158821 Genomic DNA No translation available.
AK021627 mRNA Translation: BAB13859.1 Different initiation.
AK056235 mRNA Translation: BAB71125.1 Different initiation.
CCDSiCCDS14525.2 [Q8TE76-1]
CCDS48146.1 [Q8TE76-3]
RefSeqiNP_001078823.1, NM_001085354.2 [Q8TE76-3]
NP_078933.3, NM_024657.4 [Q8TE76-1]
UniGeneiHs.496544

3D structure databases

ProteinModelPortaliQ8TE76
SMRiQ8TE76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122827, 15 interactors
IntActiQ8TE76, 8 interactors
MINTiQ8TE76
STRINGi9606.ENSP00000347821

PTM databases

iPTMnetiQ8TE76
PhosphoSitePlusiQ8TE76

Polymorphism and mutation databases

BioMutaiMORC4
DMDMi73920232

Proteomic databases

EPDiQ8TE76
jPOSTiQ8TE76
MaxQBiQ8TE76
PaxDbiQ8TE76
PeptideAtlasiQ8TE76
PRIDEiQ8TE76
ProteomicsDBi74413

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255495; ENSP00000255495; ENSG00000133131 [Q8TE76-3]
ENST00000355610; ENSP00000347821; ENSG00000133131 [Q8TE76-1]
GeneIDi79710
KEGGihsa:79710
UCSCiuc004emu.4 human [Q8TE76-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79710
DisGeNETi79710
EuPathDBiHostDB:ENSG00000133131.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MORC4
HGNCiHGNC:23485 MORC4
HPAiHPA000395
HPA015547
HPA050250
MIMi300970 gene
neXtProtiNX_Q8TE76
OpenTargetsiENSG00000133131
PharmGKBiPA128394718

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00940000161221
HOGENOMiHOG000246950
HOVERGENiHBG103357
InParanoidiQ8TE76
OMAiARPIPKI
OrthoDBi193855at2759
PhylomeDBiQ8TE76
TreeFamiTF329118

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MORC4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79710

Protein Ontology

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PROi
PR:Q8TE76

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000133131 Expressed in 200 organ(s), highest expression level in placenta
ExpressionAtlasiQ8TE76 baseline and differential
GenevisibleiQ8TE76 HS

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMORC4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TE76
Secondary accession number(s): A1YR23
, A1YR24, H7BXF1, Q5JUK7, Q96MZ2, Q9HAI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: August 30, 2005
Last modified: February 13, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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