Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynein heavy chain 5, axonemal

Gene

DNAH5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1980 – 1987ATPSequence analysis8
Nucleotide bindingi2262 – 2269ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 5, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 5
Ciliary dynein heavy chain 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH5
Synonyms:DNAHC5, HL1, KIAA1603
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000039139.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2950 DNAH5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603335 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TE73

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 3 (CILD3)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
See also OMIM:608644
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0724691454R → Q in CILD3. 1 PublicationCorresponds to variant dbSNP:rs542708170EnsemblClinVar.1
Natural variantiVAR_0307051716R → L in CILD3. 2 PublicationsCorresponds to variant dbSNP:rs74799487Ensembl.1
Natural variantiVAR_0307062264S → N in CILD3. 2 PublicationsCorresponds to variant dbSNP:rs78484669EnsemblClinVar.1
Natural variantiVAR_0307072347E → K in CILD3. 1 Publication1
Natural variantiVAR_0307082501R → P in CILD3. 1 PublicationCorresponds to variant dbSNP:rs78853309EnsemblClinVar.1
Natural variantiVAR_0307092843F → S in CILD3. 1 PublicationCorresponds to variant dbSNP:rs77377082EnsemblClinVar.1
Natural variantiVAR_0724702881A → G in CILD3. 1 PublicationCorresponds to variant dbSNP:rs727502973EnsemblClinVar.1
Natural variantiVAR_0307103409W → S in CILD3. 1 PublicationCorresponds to variant dbSNP:rs755407407EnsemblClinVar.1
Natural variantiVAR_0196083519G → R in CILD3; disease phenotype consistent with Kartagener syndrome. 1 PublicationCorresponds to variant dbSNP:rs79967166EnsemblClinVar.1
Natural variantiVAR_0724713605D → N in CILD3. 1 Publication1
Natural variantiVAR_0307113843S → L in CILD3. 1 PublicationCorresponds to variant dbSNP:rs78346432Ensembl.1
Natural variantiVAR_0307124205G → V in CILD3. 1 PublicationCorresponds to variant dbSNP:rs79185772EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...
DisGeNETi
1767

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DNAH5

MalaCards human disease database

More...
MalaCardsi
DNAH5
MIMi608644 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000039139

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
244 Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27403

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNAH5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241343

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146301 – 4624Dynein heavy chain 5, axonemalAdd BLAST4624

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TE73

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TE73

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TE73

PeptideAtlas

More...
PeptideAtlasi
Q8TE73

PRoteomics IDEntifications database

More...
PRIDEi
Q8TE73

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74412

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TE73

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TE73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000039139 Expressed in 128 organ(s), highest expression level in bronchial epithelial cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_DNAH5

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TE73 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037469
HPA037470

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DNAL1 (PubMed:21496787). Consists of at least two heavy chains and a number of intermediate and light chains.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265104

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TE73

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TE73

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1941StemBy similarityAdd BLAST1941
Regioni1942 – 2164AAA 1By similarityAdd BLAST223
Regioni2224 – 2443AAA 2By similarityAdd BLAST220
Regioni2550 – 2803AAA 3By similarityAdd BLAST254
Regioni2916 – 3170AAA 4By similarityAdd BLAST255
Regioni3185 – 3482StalkBy similarityAdd BLAST298
Regioni3567 – 3797AAA 5By similarityAdd BLAST231
Regioni4012 – 4226AAA 6By similarityAdd BLAST215

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili284 – 305Sequence analysisAdd BLAST22
Coiled coili740 – 825Sequence analysisAdd BLAST86
Coiled coili1435 – 1465Sequence analysisAdd BLAST31
Coiled coili3195 – 3302Sequence analysisAdd BLAST108
Coiled coili3426 – 3491Sequence analysisAdd BLAST66
Coiled coili3732 – 3817Sequence analysisAdd BLAST86
Coiled coili4392 – 4420Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155533

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000257779

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005543

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TE73

KEGG Orthology (KO)

More...
KOi
K10408

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKWVQYL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G001E

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TE73

TreeFam database of animal gene trees

More...
TreeFami
TF316836

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR026983 DHC_fam
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676 PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TE73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRIGRRQLW KHSVTRVLTQ RLKGEKEAKR ALLDARHNYL FAIVASCLDL
60 70 80 90 100
NKTEVEDAIL EGNQIERIDQ LFAVGGLRHL MFYYQDVEEA ETGQLGSLGG
110 120 130 140 150
VNLVSGKIKK PKVFVTEGND VALTGVCVFF IRTDPSKAIT PDNIHQEVSF
160 170 180 190 200
NMLDAADGGL LNSVRRLLSD IFIPALRATS HGWGELEGLQ DAANIRQEFL
210 220 230 240 250
SSLEGFVNVL SGAQESLKEK VNLRKCDILE LKTLKEPTDY LTLANNPETL
260 270 280 290 300
GKIEDCMKVW IKQTEQVLAE NNQLLKEADD VGPRAELEHW KKRLSKFNYL
310 320 330 340 350
LEQLKSPDVK AVLAVLAAAK SKLLKTWREM DIRITDATNE AKDNVKYLYT
360 370 380 390 400
LEKCCDPLYS SDPLSMMDAI PTLINAIKMI YSISHYYNTS EKITSLFVKV
410 420 430 440 450
TNQIISACKA YITNNGTASI WNQPQDVVEE KILSAIKLKQ EYQLCFHKTK
460 470 480 490 500
QKLKQNPNAK QFDFSEMYIF GKFETFHRRL AKIIDIFTTL KTYSVLQDST
510 520 530 540 550
IEGLEDMATK YQGIVATIKK KEYNFLDQRK MDFDQDYEEF CKQTNDLHNE
560 570 580 590 600
LRKFMDVTFA KIQNTNQALR MLKKFERLNI PNLGIDDKYQ LILENYGADI
610 620 630 640 650
DMISKLYTKQ KYDPPLARNQ PPIAGKILWA RQLFHRIQQP MQLFQQHPAV
660 670 680 690 700
LSTAEAKPII RSYNRMAKVL LEFEVLFHRA WLRQIEEIHV GLEASLLVKA
710 720 730 740 750
PGTGELFVNF DPQILILFRE TECMAQMGLE VSPLATSLFQ KRDRYKRNFS
760 770 780 790 800
NMKMMLAEYQ RVKSKIPAAI EQLIVPHLAK VDEALQPGLA ALTWTSLNIE
810 820 830 840 850
AYLENTFAKI KDLELLLDRV NDLIEFRIDA ILEEMSSTPL CQLPQEEPLT
860 870 880 890 900
CEEFLQMTKD LCVNGAQILH FKSSLVEEAV NELVNMLLDV EVLSEEESEK
910 920 930 940 950
ISNENSVNYK NESSAKREEG NFDTLTSSIN ARANALLLTT VTRKKKETEM
960 970 980 990 1000
LGEEARELLS HFNHQNMDAL LKVTRNTLEA IRKRIHSSHT INFRDSNSAS
1010 1020 1030 1040 1050
NMKQNSLPIF RASVTLAIPN IVMAPALEDV QQTLNKAVEC IISVPKGVRQ
1060 1070 1080 1090 1100
WSSELLSKKK IQERKMAALQ SNEDSDSDVE MGENELQDTL EIASVNLPIP
1110 1120 1130 1140 1150
VQTKNYYKNV SENKEIVKLV SVLSTIINST KKEVITSMDC FKRYNHIWQK
1160 1170 1180 1190 1200
GKEEAIKTFI TQSPLLSEFE SQILYFQNLE QEINAEPEYV CVGSIALYTA
1210 1220 1230 1240 1250
DLKFALTAET KAWMVVIGRH CNKKYRSEME NIFMLIEEFN KKLNRPIKDL
1260 1270 1280 1290 1300
DDIRIAMAAL KEIREEQISI DFQVGPIEES YALLNRYGLL IAREEIDKVD
1310 1320 1330 1340 1350
TLHYAWEKLL ARAGEVQNKL VSLQPSFKKE LISAVEVFLQ DCHQFYLDYD
1360 1370 1380 1390 1400
LNGPMASGLK PQEASDRLIM FQNQFDNIYR KYITYTGGEE LFGLPATQYP
1410 1420 1430 1440 1450
QLLEIKKQLN LLQKIYTLYN SVIETVNSYY DILWSEVNIE KINNELLEFQ
1460 1470 1480 1490 1500
NRCRKLPRAL KDWQAFLDLK KIIDDFSECC PLLEYMASKA MMERHWERIT
1510 1520 1530 1540 1550
TLTGHSLDVG NESFKLRNIM EAPLLKYKEE IEDICISAVK ERDIEQKLKQ
1560 1570 1580 1590 1600
VINEWDNKTF TFGSFKTRGE LLLRGDSTSE IIANMEDSLM LLGSLLSNRY
1610 1620 1630 1640 1650
NMPFKAQIQK WVQYLSNSTD IIESWMTVQN LWIYLEAVFV GGDIAKQLPK
1660 1670 1680 1690 1700
EAKRFSNIDK SWVKIMTRAH EVPSVVQCCV GDETLGQLLP HLLDQLEICQ
1710 1720 1730 1740 1750
KSLTGYLEKK RLCFPRFFFV SDPALLEILG QASDSHTIQA HLLNVFDNIK
1760 1770 1780 1790 1800
SVKFHEKIYD RILSISSQEG ETIELDKPVM AEGNVEVWLN SLLEESQSSL
1810 1820 1830 1840 1850
HLVIRQAAAN IQETGFQLTE FLSSFPAQVG LLGIQMIWTR DSEEALRNAK
1860 1870 1880 1890 1900
FDKKIMQKTN QAFLELLNTL IDVTTRDLSS TERVKYETLI TIHVHQRDIF
1910 1920 1930 1940 1950
DDLCHMHIKS PMDFEWLKQC RFYFNEDSDK MMIHITDVAF IYQNEFLGCT
1960 1970 1980 1990 2000
DRLVITPLTD RCYITLAQAL GMSMGGAPAG PAGTGKTETT KDMGRCLGKY
2010 2020 2030 2040 2050
VVVFNCSDQM DFRGLGRIFK GLAQSGSWGC FDEFNRIDLP VLSVAAQQIS
2060 2070 2080 2090 2100
IILTCKKEHK KSFIFTDGDN VTMNPEFGLF LTMNPGYAGR QELPENLKIN
2110 2120 2130 2140 2150
FRSVAMMVPD RQIIIRVKLA SCGFIDNVVL ARKFFTLYKL CEEQLSKQVH
2160 2170 2180 2190 2200
YDFGLRNILS VLRTLGAAKR ANPMDTESTI VMRVLRDMNL SKLIDEDEPL
2210 2220 2230 2240 2250
FLSLIEDLFP NILLDKAGYP ELEAAISRQV EEAGLINHPP WKLKVIQLFE
2260 2270 2280 2290 2300
TQRVRHGMMT LGPSGAGKTT CIHTLMRAMT DCGKPHREMR MNPKAITAPQ
2310 2320 2330 2340 2350
MFGRLDVATN DWTDGIFSTL WRKTLRAKKG EHIWIILDGP VDAIWIENLN
2360 2370 2380 2390 2400
SVLDDNKTLT LANGDRIPMA PNCKIIFEPH NIDNASPATV SRNGMVFMSS
2410 2420 2430 2440 2450
SILDWSPILE GFLKKRSPQE AEILRQLYTE SFPDLYRFCI QNLEYKMEVL
2460 2470 2480 2490 2500
EAFVITQSIN MLQGLIPLKE QGGEVSQAHL GRLFVFALLW SAGAALELDG
2510 2520 2530 2540 2550
RRRLELWLRS RPTGTLELPP PAGPGDTAFD YYVAPDGTWT HWNTRTQEYL
2560 2570 2580 2590 2600
YPSDTTPEYG SILVPNVDNV RTDFLIQTIA KQGKAVLLIG EQGTAKTVII
2610 2620 2630 2640 2650
KGFMSKYDPE CHMIKSLNFS SATTPLMFQR TIESYVDKRM GTTYGPPAGK
2660 2670 2680 2690 2700
KMTVFIDDVN MPIINEWGDQ VTNEIVRQLM EQNGFYNLEK PGEFTSIVDI
2710 2720 2730 2740 2750
QFLAAMIHPG GGRNDIPQRL KRQFSIFNCT LPSEASVDKI FGVIGVGHYC
2760 2770 2780 2790 2800
TQRGFSEEVR DSVTKLVPLT RRLWQMTKIK MLPTPAKFHY VFNLRDLSRV
2810 2820 2830 2840 2850
WQGMLNTTSE VIKEPNDLLK LWKHECKRVI ADRFTVSSDV TWFDKALVSL
2860 2870 2880 2890 2900
VEEEFGEEKK LLVDCGIDTY FVDFLRDAPE AAGETSEEAD AETPKIYEPI
2910 2920 2930 2940 2950
ESFSHLKERL NMFLQLYNES IRGAGMDMVF FADAMVHLVK ISRVIRTPQG
2960 2970 2980 2990 3000
NALLVGVGGS GKQSLTRLAS FIAGYVSFQI TLTRSYNTSN LMEDLKVLYR
3010 3020 3030 3040 3050
TAGQQGKGIT FIFTDNEIKD ESFLEYMNNV LSSGEVSNLF ARDEIDEINS
3060 3070 3080 3090 3100
DLASVMKKEF PRCLPTNENL HDYFMSRVRQ NLHIVLCFSP VGEKFRNRAL
3110 3120 3130 3140 3150
KFPALISGCT IDWFSRWPKD ALVAVSEHFL TSYDIDCSLE IKKEVVQCMG
3160 3170 3180 3190 3200
SFQDGVAEKC VDYFQRFRRS THVTPKSYLS FIQGYKFIYG EKHVEVRTLA
3210 3220 3230 3240 3250
NRMNTGLEKL KEASESVAAL SKELEAKEKE LQVANDKADM VLKEVTMKAQ
3260 3270 3280 3290 3300
AAEKVKAEVQ KVKDRAQAIV DSISKDKAIA EEKLEAAKPA LEEAEAALQT
3310 3320 3330 3340 3350
IRPSDIATVR TLGRPPHLIM RIMDCVLLLF QRKVSAVKID LEKSCTMPSW
3360 3370 3380 3390 3400
QESLKLMTAG NFLQNLQQFP KDTINEEVIE FLSPYFEMPD YNIETAKRVC
3410 3420 3430 3440 3450
GNVAGLCSWT KAMASFFSIN KEVLPLKANL VVQENRHLLA MQDLQKAQAE
3460 3470 3480 3490 3500
LDDKQAELDV VQAEYEQAMT EKQTLLEDAE RCRHKMQTAS TLISGLAGEK
3510 3520 3530 3540 3550
ERWTEQSQEF AAQTKRLVGD VLLATAFLSY SGPFNQEFRD LLLNDWRKEM
3560 3570 3580 3590 3600
KARKIPFGKN LNLSEMLIDA PTISEWNLQG LPNDDLSIQN GIIVTKASRY
3610 3620 3630 3640 3650
PLLIDPQTQG KIWIKNKESR NELQITSLNH KYFRNHLEDS LSLGRPLLIE
3660 3670 3680 3690 3700
DVGEELDPAL DNVLERNFIK TGSTFKVKVG DKEVDVLDGF RLYITTKLPN
3710 3720 3730 3740 3750
PAYTPEISAR TSIIDFTVTM KGLEDQLLGR VILTEKQELE KERTHLMEDV
3760 3770 3780 3790 3800
TANKRRMKEL EDNLLYRLTS TQGSLVEDES LIVVLSNTKR TAEEVTQKLE
3810 3820 3830 3840 3850
ISAETEVQIN SAREEYRPVA TRGSILYFLI TEMRLVNEMY QTSLRQFLGL
3860 3870 3880 3890 3900
FDLSLARSVK SPITSKRIAN IIEHMTYEVY KYAARGLYEE HKFLFTLLLT
3910 3920 3930 3940 3950
LKIDIQRNRV KHEEFLTLIK GGASLDLKAC PPKPSKWILD ITWLNLVELS
3960 3970 3980 3990 4000
KLRQFSDVLD QISRNEKMWK IWFDKENPEE EPLPNAYDKS LDCFRRLLLI
4010 4020 4030 4040 4050
RSWCPDRTIA QARKYIVDSM GEKYAEGVIL DLEKTWEESD PRTPLICLLS
4060 4070 4080 4090 4100
MGSDPTDSII ALGKRLKIET RYVSMGQGQE VHARKLLQQT MANGGWALLQ
4110 4120 4130 4140 4150
NCHLGLDFMD ELMDIIIETE LVHDAFRLWM TTEAHKQFPI TLLQMSIKFA
4160 4170 4180 4190 4200
NDPPQGLRAG LKRTYSGVSQ DLLDVSSGSQ WKPMLYAVAF LHSTVQERRK
4210 4220 4230 4240 4250
FGALGWNIPY EFNQADFNAT VQFIQNHLDD MDVKKGVSWT TIRYMIGEIQ
4260 4270 4280 4290 4300
YGGRVTDDYD KRLLNTFAKV WFSENMFGPD FSFYQGYNIP KCSTVDNYLQ
4310 4320 4330 4340 4350
YIQSLPAYDS PEVFGLHPNA DITYQSKLAK DVLDTILGIQ PKDTSGGGDE
4360 4370 4380 4390 4400
TREAVVARLA DDMLEKLPPD YVPFEVKERL QKMGPFQPMN IFLRQEIDRM
4410 4420 4430 4440 4450
QRVLSLVRST LTELKLAIDG TIIMSENLRD ALDCMFDARI PAWWKKASWI
4460 4470 4480 4490 4500
SSTLGFWFTE LIERNSQFTS WVFNGRPHCF WMTGFFNPQG FLTAMRQEIT
4510 4520 4530 4540 4550
RANKGWALDN MVLCNEVTKW MKDDISAPPT EGVYVYGLYL EGAGWDKRNM
4560 4570 4580 4590 4600
KLIESKPKVL FELMPVIRIY AENNTLRDPR FYSCPIYKKP VRTDLNYIAA
4610 4620
VDLRTAQTPE HWVLRGVALL CDVK
Length:4,624
Mass (Da):529,021
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9BC9F20A4C581BE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15543 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2000Y → D in AAC50699 (PubMed:8812413).Curated1
Sequence conflicti2027S → A in AAL06603 (PubMed:11062149).Curated1
Sequence conflicti2027S → A in AAC50699 (PubMed:8812413).Curated1
Sequence conflicti2207D → N in AAL06603 (PubMed:11062149).Curated1
Sequence conflicti2227S → N in AAL06603 (PubMed:11062149).Curated1
Sequence conflicti2232E → K in AAL06603 (PubMed:11062149).Curated1
Sequence conflicti2248 – 2250LFE → QTK in AAL06603 (PubMed:11062149).Curated3
Sequence conflicti4429R → Q in BAB15543 (PubMed:14702039).Curated1
Sequence conflicti4451S → F in BAB15543 (PubMed:14702039).Curated1
Sequence conflicti4527A → T in BAB15543 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01960312H → Q. Corresponds to variant dbSNP:rs339445EnsemblClinVar.1
Natural variantiVAR_01960424G → E. Corresponds to variant dbSNP:rs1530496EnsemblClinVar.1
Natural variantiVAR_019605558T → A. Corresponds to variant dbSNP:rs1530498EnsemblClinVar.1
Natural variantiVAR_053840591L → R. Corresponds to variant dbSNP:rs35090077EnsemblClinVar.1
Natural variantiVAR_053841591L → V. Corresponds to variant dbSNP:rs35090077EnsemblClinVar.1
Natural variantiVAR_053842620Q → K. Corresponds to variant dbSNP:rs34076967EnsemblClinVar.1
Natural variantiVAR_053843765K → N. Corresponds to variant dbSNP:rs4701997EnsemblClinVar.1
Natural variantiVAR_027903766I → L. Corresponds to variant dbSNP:rs4701997EnsemblClinVar.1
Natural variantiVAR_0279041006S → G. Corresponds to variant dbSNP:rs16902886EnsemblClinVar.1
Natural variantiVAR_0279051081M → V. Corresponds to variant dbSNP:rs16902880EnsemblClinVar.1
Natural variantiVAR_0724691454R → Q in CILD3. 1 PublicationCorresponds to variant dbSNP:rs542708170EnsemblClinVar.1
Natural variantiVAR_0307051716R → L in CILD3. 2 PublicationsCorresponds to variant dbSNP:rs74799487Ensembl.1
Natural variantiVAR_0307062264S → N in CILD3. 2 PublicationsCorresponds to variant dbSNP:rs78484669EnsemblClinVar.1
Natural variantiVAR_0307072347E → K in CILD3. 1 Publication1
Natural variantiVAR_0538442425R → H. Corresponds to variant dbSNP:rs35900306EnsemblClinVar.1
Natural variantiVAR_0196062463Q → R. Corresponds to variant dbSNP:rs10078391EnsemblClinVar.1
Natural variantiVAR_0307082501R → P in CILD3. 1 PublicationCorresponds to variant dbSNP:rs78853309EnsemblClinVar.1
Natural variantiVAR_0307092843F → S in CILD3. 1 PublicationCorresponds to variant dbSNP:rs77377082EnsemblClinVar.1
Natural variantiVAR_0196072862L → F. Corresponds to variant dbSNP:rs10513155EnsemblClinVar.1
Natural variantiVAR_0724702881A → G in CILD3. 1 PublicationCorresponds to variant dbSNP:rs727502973EnsemblClinVar.1
Natural variantiVAR_0307103409W → S in CILD3. 1 PublicationCorresponds to variant dbSNP:rs755407407EnsemblClinVar.1
Natural variantiVAR_0196083519G → R in CILD3; disease phenotype consistent with Kartagener syndrome. 1 PublicationCorresponds to variant dbSNP:rs79967166EnsemblClinVar.1
Natural variantiVAR_0724713605D → N in CILD3. 1 Publication1
Natural variantiVAR_0279063791T → I. Corresponds to variant dbSNP:rs17263496EnsemblClinVar.1
Natural variantiVAR_0307113843S → L in CILD3. 1 PublicationCorresponds to variant dbSNP:rs78346432Ensembl.1
Natural variantiVAR_0196094134A → V1 PublicationCorresponds to variant dbSNP:rs30168EnsemblClinVar.1
Natural variantiVAR_0307124205G → V in CILD3. 1 PublicationCorresponds to variant dbSNP:rs79185772EnsemblClinVar.1
Natural variantiVAR_0196104220T → A. Corresponds to variant dbSNP:rs2277046EnsemblClinVar.1
Natural variantiVAR_0196114450I → V2 PublicationsCorresponds to variant dbSNP:rs3734110EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY045575 mRNA Translation: AAK92217.1
AY049075 mRNA Translation: AAL06603.1
U61735 mRNA Translation: AAC50699.1
AB046823 mRNA Translation: BAB13429.2
AK026756 mRNA Translation: BAB15543.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3882.1

NCBI Reference Sequences

More...
RefSeqi
NP_001360.1, NM_001369.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.212360

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265104; ENSP00000265104; ENSG00000039139

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1767

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1767

UCSC genome browser

More...
UCSCi
uc003jfd.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY045575 mRNA Translation: AAK92217.1
AY049075 mRNA Translation: AAL06603.1
U61735 mRNA Translation: AAC50699.1
AB046823 mRNA Translation: BAB13429.2
AK026756 mRNA Translation: BAB15543.1 Different initiation.
CCDSiCCDS3882.1
RefSeqiNP_001360.1, NM_001369.2
UniGeneiHs.212360

3D structure databases

ProteinModelPortaliQ8TE73
SMRiQ8TE73
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265104

PTM databases

iPTMnetiQ8TE73
PhosphoSitePlusiQ8TE73

Polymorphism and mutation databases

BioMutaiDNAH5
DMDMi116241343

Proteomic databases

EPDiQ8TE73
MaxQBiQ8TE73
PaxDbiQ8TE73
PeptideAtlasiQ8TE73
PRIDEiQ8TE73
ProteomicsDBi74412

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265104; ENSP00000265104; ENSG00000039139
GeneIDi1767
KEGGihsa:1767
UCSCiuc003jfd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1767
DisGeNETi1767
EuPathDBiHostDB:ENSG00000039139.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNAH5
GeneReviewsiDNAH5
HGNCiHGNC:2950 DNAH5
HPAiHPA037469
HPA037470
MalaCardsiDNAH5
MIMi603335 gene
608644 phenotype
neXtProtiNX_Q8TE73
OpenTargetsiENSG00000039139
Orphaneti244 Primary ciliary dyskinesia
PharmGKBiPA27403

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000155533
HOGENOMiHOG000257779
HOVERGENiHBG005543
InParanoidiQ8TE73
KOiK10408
OMAiQKWVQYL
OrthoDBiEOG091G001E
PhylomeDBiQ8TE73
TreeFamiTF316836

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DNAH5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1767

Protein Ontology

More...
PROi
PR:Q8TE73

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000039139 Expressed in 128 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_DNAH5
GenevisibleiQ8TE73 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR026983 DHC_fam
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TE73
Secondary accession number(s): Q92860
, Q96L74, Q9H5S7, Q9HCG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 17, 2006
Last modified: December 5, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again