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Protein

Protein CXorf40A

Gene

CXorf40A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have an important role of cell protection in inflammation reaction.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CXorf40A
Alternative name(s):
Endothelial-overexpressed lipopolysaccharide-associated factor 1
Gene namesi
Name:CXorf40A
Synonyms:CXorf40, EOLA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000197620.10
HGNCiHGNC:28089 CXorf40A
MIMi300954 gene
neXtProtiNX_Q8TE69

Pathology & Biotechi

Organism-specific databases

DisGeNETi91966
OpenTargetsiENSG00000197620
PharmGKBiPA134915038

Polymorphism and mutation databases

BioMutaiCXorf40A
DMDMi519668664

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797401 – 158Protein CXorf40AAdd BLAST158

Proteomic databases

EPDiQ8TE69
MaxQBiQ8TE69
PaxDbiQ8TE69
PeptideAtlasiQ8TE69
PRIDEiQ8TE69
ProteomicsDBi74411

Expressioni

Tissue specificityi

Expressed primarily in heart, skeletal muscle, kidney, liver and placenta. Relatively high level of expression in spleen, colon and small intestine. Almost no expression in brain, thymus, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000197620
CleanExiHS_CXorf40A
ExpressionAtlasiQ8TE69 baseline and differential
GenevisibleiQ8TE69 HS

Organism-specific databases

HPAiHPA060897

Interactioni

Subunit structurei

Interacts with MT2A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MT2AP027952EBI-996609,EBI-996616

Protein-protein interaction databases

BioGridi124897, 3 interactors
IntActiQ8TE69, 1 interactor
STRINGi9606.ENSP00000420882

Structurei

3D structure databases

ProteinModelPortaliQ8TE69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVVW Eukaryota
ENOG4111IPV LUCA
GeneTreeiENSGT00390000012182
HOGENOMiHOG000231371
HOVERGENiHBG054454
InParanoidiQ8TE69
OrthoDBiEOG091G0NYV
PhylomeDBiQ8TE69
TreeFamiTF332845

Family and domain databases

InterProiView protein in InterPro
IPR007374 ASCH_domain
IPR033615 CXorf40
IPR015947 PUA-like_sf
PANTHERiPTHR31666 PTHR31666, 1 hit
SMARTiView protein in SMART
SM01022 ASCH, 1 hit
SUPFAMiSSF88697 SSF88697, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TE69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG
60 70 80 90 100
DAWRELLVER LGMTPAQIQA LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT
110 120 130 140 150
PDEVVELENQ AVLTNLKQKY LTVISNPRWL LEPIPRKGGK DVFQVDIPEH

LIPLGHEV
Length:158
Mass (Da):17,891
Last modified:March 28, 2018 - v3
Checksum:i0C06424E1953F1B1
GO
Isoform 2 (identifier: Q8TE69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-158: VDIPEHLIPLGHEV → NP

Show »
Length:146
Mass (Da):16,552
Checksum:iBB432BC3D12E1488
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2K → E in BAH13262 (PubMed:14702039).Curated1
Sequence conflicti7S → P in BAH13262 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047240145 – 158VDIPE…LGHEV → NP in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43580 mRNA No translation available.
AY074889 mRNA Translation: AAL71889.1
AC244197 Genomic DNA No translation available.
AK291899 mRNA Translation: BAF84588.1
AK300334 mRNA Translation: BAH13262.1
BC065539 mRNA Translation: AAH65539.1
BC104930 mRNA Translation: AAI04931.1
BC104932 mRNA Translation: AAI04933.1
BC143660 mRNA Translation: AAI43661.1
BC143661 mRNA Translation: AAI43662.1
BC143662 mRNA Translation: AAI43663.1
CCDSiCCDS14687.1 [Q8TE69-1]
CCDS55522.1 [Q8TE69-2]
RefSeqiNP_001165378.1, NM_001171907.2 [Q8TE69-1]
NP_001165379.1, NM_001171908.2 [Q8TE69-1]
NP_001165380.1, NM_001171909.3 [Q8TE69-2]
NP_001311203.1, NM_001324274.1 [Q8TE69-1]
NP_001311204.1, NM_001324275.1 [Q8TE69-1]
NP_001311205.1, NM_001324276.1 [Q8TE69-2]
NP_001311206.1, NM_001324277.1 [Q8TE69-1]
NP_001311207.1, NM_001324278.1 [Q8TE69-1]
NP_001311208.1, NM_001324279.1 [Q8TE69-2]
NP_001311209.1, NM_001324280.1 [Q8TE69-1]
NP_835225.2, NM_178124.5 [Q8TE69-1]
XP_005262406.2, XM_005262349.4 [Q8TE69-1]
UniGeneiHs.458216
Hs.534641
Hs.719441

Genome annotation databases

EnsembliENST00000359293; ENSP00000420882; ENSG00000197620 [Q8TE69-1]
ENST00000393985; ENSP00000421745; ENSG00000197620 [Q8TE69-1]
ENST00000422892; ENSP00000422312; ENSG00000197620 [Q8TE69-2]
ENST00000423421; ENSP00000422512; ENSG00000197620 [Q8TE69-1]
ENST00000423540; ENSP00000425520; ENSG00000197620 [Q8TE69-1]
ENST00000434353; ENSP00000423160; ENSG00000197620 [Q8TE69-2]
ENST00000441248; ENSP00000423099; ENSG00000197620 [Q8TE69-1]
ENST00000450602; ENSP00000427540; ENSG00000197620 [Q8TE69-1]
ENST00000514208; ENSP00000423708; ENSG00000197620 [Q8TE69-2]
GeneIDi91966
KEGGihsa:91966
UCSCiuc022cgi.2 human
uc033ezo.2 human [Q8TE69-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCX04A_HUMAN
AccessioniPrimary (citable) accession number: Q8TE69
Secondary accession number(s): A0A0A0MTB5
, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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